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Mitogen-activated protein kinase kinase kinase 7 (EC 2 7 11 25)

 M3K7_BOVIN              Reviewed;         579 AA.
A2VDU3;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
20-MAR-2007, sequence version 1.
17-JUN-2020, entry version 114.
RecName: Full=Mitogen-activated protein kinase kinase kinase 7;
EC=2.7.11.25 {ECO:0000250|UniProtKB:O43318};
Name=MAP3K7;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Ascending colon;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Serine/threonine kinase which acts as an essential component
of the MAP kinase signal transduction pathway. Plays an important role
in the cascades of cellular responses evoked by changes in the
environment. Mediates signal transduction of TRAF6, various cytokines
including interleukin-1 (IL-1), transforming growth factor-beta (TGFB),
TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR),
tumor necrosis factor receptor CD40 and B-cell receptor (BCR).
Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts
as an upstream activator of the MKK/JNK signal transduction cascade and
the p38 MAPK signal transduction cascade through the phosphorylation
and activation of several MAP kinase kinases like MAP2K1/MEK1,
MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate
p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex
(IKK). Both p38 MAPK and JNK pathways control the transcription factors
activator protein-1 (AP-1), while nuclear factor-kappa B is activated
by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6
signaling and mediates BMP2-induced apoptosis. In osmotic stress
signaling, plays a major role in the activation of MAPK8/JNK1, but not
that of NF-kappa-B (By similarity). Promotes TRIM5 capsid-specific
restriction activity (By similarity). Phosphorylates RIPK1 at 'Ser-321'
which positively regulates RIPK1 interaction with RIPK3 to promote
necroptosis but negatively regulates RIPK1 kinase activity and its
interaction with FADD to mediate apoptosis (By similarity).
{ECO:0000250|UniProtKB:O43318, ECO:0000250|UniProtKB:Q62073}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25;
Evidence={ECO:0000250|UniProtKB:O43318};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.25; Evidence={ECO:0000250|UniProtKB:O43318};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
-!- ACTIVITY REGULATION: Activated by proinflammatory cytokines and in
response to physical and chemical stresses, including osmotic stress,
oxidative stress, arsenic and ultraviolet light irradiation. Activated
by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
Association with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2 promotes activation
through autophosphorylation, whereas PPM1B/PP2CB, PP2A and PPP6C
dephosphorylation leads to inactivation (By similarity). {ECO:0000250}.
-!- SUBUNIT: Can form homodimer. Binds both upstream activators and
downstream substrates in multimolecular complexes. Interacts with
TAB1/MAP3K7IP1, TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3. Identified in the
TRIKA2 complex composed of MAP3K7/TAK1, TAB1/MAP3K7IP1 and
TAB2/MAP3K7IP2. Interacts with PPM1L and PPM1B/PP2CB. Interaction with
PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6
and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and
TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with
IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via
WD domains). Interacts with CYLD and RBCK1. Interacts with TGFBR1;
induces MAP3K7/TAK1 activation by TRAF6. Interacts with MAPK8IP1 and
SMAD6. Interacts with isoform 1 of VRK2. Interacts with DAB2; the
interaction is induced by TGF-beta stimulation and may mediate TGF-beta
stimulated JNK activation. Interacts with TRIM5. Part of a complex
containing ITCH, NDFIP1 and MAP3K7. Interacts with IFIT5; the
interaction synergizes the recruitment of IKK to MAP3K7 and enhances
IKK phosphorylation. Interacts with PLEKHM1 (via N- and C-terminus).
Found in a complex with SH3RF1, RAC2, MAP2K7/MKK7, MAPK8IP1/JIP1,
MAPK8/JNK1 and MAPK9/JNK2. Interacts with SASH1 (By similarity).
Interacts with RIPK1 (By similarity). {ECO:0000250|UniProtKB:O43318,
ECO:0000250|UniProtKB:Q62073}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
{ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
side {ECO:0000250}. Note=Although the majority of MAP3K7/TAK1 is found
in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2,
it is also localized at the cell membrane. {ECO:0000250}.
-!- PTM: Association with TAB1/MAP3K7IP1 promotes autophosphorylation at
Ser-192 and subsequent activation. Association with TAB2/MAP3K7IP2,
itself associated with free unanchored Lys-63 polyubiquitin chain,
promotes autophosphorylation and subsequent activation of MAP3K7.
Dephosphorylation at Ser-192 by PPM1B/PP2CB and at Thr-187 by PP2A and
PPP6C leads to inactivation (By similarity). {ECO:0000250}.
-!- PTM: 'Lys-48'-linked polyubiquitination at Lys-72 is induced by
TNFalpha, and leads to proteasomal degradation. Undergoes 'Lys-48'-
linked polyubiquitination catalyzed by ITCH. 'Lys-63'-linked
polyubiquitination at Lys-158 by TRIM8 does not lead to proteasomal
degradation but contributes to autophosphorylation and activation.
Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-
linked ubiquitin chains. {ECO:0000250|UniProtKB:O43318,
ECO:0000250|UniProtKB:Q62073}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
protein kinase family. MAP kinase kinase kinase subfamily.
{ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; BC133404; AAI33405.1; -; mRNA.
RefSeq; NP_001075064.1; NM_001081595.1.
RefSeq; XP_005210930.1; XM_005210873.3.
SMR; A2VDU3; -.
STRING; 9913.ENSBTAP00000003401; -.
PaxDb; A2VDU3; -.
PRIDE; A2VDU3; -.
Ensembl; ENSBTAT00000003401; ENSBTAP00000003401; ENSBTAG00000002625.
GeneID; 529146; -.
KEGG; bta:529146; -.
CTD; 6885; -.
VGNC; VGNC:31200; MAP3K7.
eggNOG; KOG0192; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00940000157785; -.
HOGENOM; CLU_000288_7_41_1; -.
InParanoid; A2VDU3; -.
KO; K04427; -.
OMA; FQCSQGV; -.
OrthoDB; 635654at2759; -.
TreeFam; TF105116; -.
Reactome; R-BTA-168638; NOD1/2 Signaling Pathway.
Reactome; R-BTA-202424; Downstream TCR signaling.
Reactome; R-BTA-2871837; FCERI mediated NF-kB activation.
Reactome; R-BTA-4086398; Ca2+ pathway.
Reactome; R-BTA-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
Reactome; R-BTA-450302; activated TAK1 mediates p38 MAPK activation.
Reactome; R-BTA-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
Reactome; R-BTA-5357956; TNFR1-induced NFkappaB signaling pathway.
Reactome; R-BTA-5607764; CLEC7A (Dectin-1) signaling.
Reactome; R-BTA-5689880; Ub-specific processing proteases.
Reactome; R-BTA-9020702; Interleukin-1 signaling.
Reactome; R-BTA-937042; IRAK2 mediated activation of TAK1 complex.
Reactome; R-BTA-937072; TRAF6-mediated induction of TAK1 complex within TLR4 complex.
Reactome; R-BTA-9645460; Alpha-protein kinase 1 signaling pathway.
Reactome; R-BTA-975163; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
Proteomes; UP000009136; Chromosome 9.
Bgee; ENSBTAG00000002625; Expressed in spleen and 9 other tissues.
ExpressionAtlas; A2VDU3; baseline.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO; GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.
GO; GO:0007254; P:JNK cascade; ISS:UniProtKB.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR017421; MAPKKK7.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR46716; PTHR46716; 2.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF038168; MAPKKK7; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
Apoptosis; ATP-binding; Cell membrane; Cytoplasm; Isopeptide bond; Kinase;
Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein;
Reference proteome; Serine/threonine-protein kinase; Stress response;
Transcription; Transcription regulation; Transferase; Ubl conjugation.
CHAIN 1..579
/note="Mitogen-activated protein kinase kinase kinase 7"
/id="PRO_0000314284"
DOMAIN 36..291
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 42..50
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 1..300
/note="Interaction with MAPK8IP1"
/evidence="ECO:0000250"
COMPBIAS 8..14
/note="Poly-Ser"
ACT_SITE 156
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 63
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 184
/note="Phosphothreonine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:O43318"
MOD_RES 187
/note="Phosphothreonine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:O43318"
MOD_RES 192
/note="Phosphoserine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:O43318"
MOD_RES 367
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:O43318"
MOD_RES 389
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:O43318"
MOD_RES 412
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:O43318"
MOD_RES 428
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:O43318"
CROSSLNK 72
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:O43318"
CROSSLNK 158
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q62073"
CROSSLNK 209
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q62073"
SEQUENCE 579 AA; 64216 MW; B987EE4700AE63E4 CRC64;
MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV
AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE
PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC
DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM
WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY
PCQYSDEGQS NSATSTGSFM DITSTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ
SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTGNGQPRR RSIQDLTVTG
TDPGQVSSRS SSPSVRMITT SGPTSEKPAR SHPWTPDDST DTNGSDNSIP MAYLTLDHQL
QPLAPCPNSK ESMAVFEQHC KMAQEYMKVQ TEIALLLQRK QELVAELDQD EKDQQNTSRL
VQEHKKLLDE NKSLSTYYQQ CKKQLEVIRS QQQKRQGTS


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Related Genes :
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[dlk-1 F33E2.2] Mitogen-activated protein kinase kinase kinase dlk-1 (EC 2.7.11.25) (DAP kinase-like kinase) (Death-associated protein kinase-like kinase)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[Map3k1 Mekk Mekk1] Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
[nsy-1 F59A6.1] Mitogen-activated protein kinase kinase kinase nsy-1 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (Neuronal symmetry kinase 1)
[Map3k1 Mekk Mekk1] Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
[MAP3K20 MLTK ZAK HCCS4] Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
[MAP3K1 MAPKKK1 MEKK MEKK1] Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
[Map3k2 Mekk2] Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
[MAP3K11 MLK3 PTK1 SPRK] Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)
[Map3k6 Ask2 Mapkkk6 Mekk6] Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)
[MAP3K6 ASK2 MAPKKK6 MEKK6] Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[Mapk14 Crk1 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Map3k7] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25)
[MAP3K5 ASK1 MAPKKK5 MEKK5] Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
[Mapk13] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Map3k5 Ask1 Mekk5] Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Mapk14 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MPK4 At4g01370 F2N1.1 F2N1_2-t] Mitogen-activated protein kinase 4 (AtMPK4) (MAP kinase 4) (EC 2.7.11.24)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK13 PRKM13 SAPK4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[MAP3K9 MLK1 PRKE1] Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1)
[mkkA DDB_G0283265] Mitogen-activated protein kinase kinase kinase A (EC 2.7.11.25) (MAPK/ERK kinase 1) (MEK kinase 1) (MEKK 1) (MAPK/ERK kinase A) (MEK kinase A) (MEKK A) (MEKKalpha)
[pmk-1 B0218.3] Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (Stress-activated protein kinase pmk-1) (p38 MAP kinase 1)

Bibliography :
[32078472] Transforming Growth Factor Beta-Activated Kinase 1-Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke.
[32071228] Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke.
[31995728] AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.
[31885808] Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.
[31825793] MiR-345-3p attenuates apoptosis and inflammation caused by oxidized low-density lipoprotein by targeting TRAF6 via TAK1/p38/NF-kB signaling in endothelial cells.
[31813254] TAK1 deficiency attenuates cisplatin-induced acute kidney injury.
[31668971] TAK1/Map3k7 enhances differentiation of cardiogenic endoderm from mouse embryonic stem cells.
[31665064] BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways.
[31658592] Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from .
[31647008] Curcumin ameliorates peritoneal fibrosis via inhibition of transforming growth factor-activated kinase 1 (TAK1) pathway in a rat model of peritoneal dialysis.