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Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)

 M4K2_HUMAN              Reviewed;         820 AA.
Q12851; Q86VU3;
28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
25-NOV-2008, sequence version 2.
12-AUG-2020, entry version 191.
RecName: Full=Mitogen-activated protein kinase kinase kinase kinase 2;
EC=2.7.11.1;
AltName: Full=B lymphocyte serine/threonine-protein kinase;
AltName: Full=Germinal center kinase;
Short=GC kinase;
AltName: Full=MAPK/ERK kinase kinase kinase 2;
Short=MEK kinase kinase 2;
Short=MEKKK 2;
AltName: Full=Rab8-interacting protein;
Name=MAP4K2; Synonyms=GCK, RAB8IP;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606 {ECO:0000312|EMBL:AAA20968.1};
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16554811; DOI=10.1038/nature04632;
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
Hattori M., Rogers J., Lander E.S., Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene
identification.";
Nature 440:497-500(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Uterus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA] OF 2-820 (ISOFORM 1), FUNCTION, DOMAIN, AND
TISSUE SPECIFICITY.
TISSUE=Tonsil;
PubMed=7515885;
Katz P., Whalen G., Kehrl J.H.;
"Differential expression of a novel protein kinase in human B lymphocytes.
Preferential localization in the germinal center.";
J. Biol. Chem. 269:16802-16809(1994).
[5]
FUNCTION, AND ACTIVITY REGULATION.
PubMed=7477268; DOI=10.1038/377750a0;
Pombo C.M., Kehrl J.H., Sanchez I., Katz P., Avruch J., Zon L.I.,
Woodgett J.R., Force T., Kyriakis J.M.;
"Activation of the SAPK pathway by the human STE20 homologue germinal
centre kinase.";
Nature 377:750-754(1995).
[6]
FUNCTION, AUTOPHOSPHORYLATION, AND INTERACTION WITH MAP3K1/MEKK1 AND TRAF2.
PubMed=9712898; DOI=10.1074/jbc.273.35.22681;
Yuasa T., Ohno S., Kehrl J.H., Kyriakis J.M.;
"Tumor necrosis factor signaling to stress-activated protein kinase
(SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase
couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and
SAPK while receptor interacting protein associates with a mitogen-activated
protein kinase kinase kinase upstream of MKK6 and p38.";
J. Biol. Chem. 273:22681-22692(1998).
[7] {ECO:0000305}
FUNCTION, AND INTERACTION WITH TRAF2 AND MAP3K1.
PubMed=11784851; DOI=10.1128/mcb.22.3.737-749.2002;
Chadee D.N., Yuasa T., Kyriakis J.M.;
"Direct activation of mitogen-activated protein kinase kinase kinase MEKK1
by the Ste20p homologue GCK and the adapter protein TRAF2.";
Mol. Cell. Biol. 22:737-749(2002).
[8]
ACTIVITY REGULATION, FUNCTION, UBIQUITINATION, AND INTERACTION WITH TRAF6.
PubMed=15456887; DOI=10.1128/mcb.24.20.9165-9175.2004;
Zhong J., Kyriakis J.M.;
"Germinal center kinase is required for optimal Jun N-terminal kinase
activation by Toll-like receptor agonists and is regulated by the ubiquitin
proteasome system and agonist-induced, TRAF6-dependent stabilization.";
Mol. Cell. Biol. 24:9165-9175(2004).
[9]
FUNCTION, AND INTERACTION WITH MAP3K11/MLK3.
PubMed=17584736; DOI=10.1074/jbc.m703422200;
Zhong J., Kyriakis J.M.;
"Dissection of a signaling pathway by which pathogen-associated molecular
patterns recruit the JNK and p38 MAPKs and trigger cytokine release.";
J. Biol. Chem. 282:24246-24254(2007).
[10]
REVIEW ON FUNCTION.
PubMed=10026130; DOI=10.1074/jbc.274.9.5259;
Kyriakis J.M.;
"Signaling by the germinal center kinase family of protein kinases.";
J. Biol. Chem. 274:5259-5262(1999).
[11]
REVIEW ON FUNCTION.
PubMed=11316611; DOI=10.1016/s0962-8924(01)01980-8;
Dan I., Watanabe N.M., Kusumi A.;
"The Ste20 group kinases as regulators of MAP kinase cascades.";
Trends Cell Biol. 11:220-230(2001).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200;
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
Mann M., Daub H.;
"Large-scale proteomics analysis of the human kinome.";
Mol. Cell. Proteomics 8:1751-1764(2009).
[14]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328 AND SER-394, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[16]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
phosphoproteome.";
J. Proteomics 96:253-262(2014).
-!- FUNCTION: Serine/threonine-protein kinase which acts as an essential
component of the MAP kinase signal transduction pathway. Acts as a MAPK
kinase kinase kinase (MAP4K) and is an upstream activator of the
stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)
signaling pathway and to a lesser extent of the p38 MAPKs signaling
pathway. Required for the efficient activation of JNKs by TRAF6-
dependent stimuli, including pathogen-associated molecular patterns
(PAMPs) such as polyinosine-polycytidine (poly(IC)),
lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial
flagellin. To a lesser degree, IL-1 and engagement of CD40 also
stimulate MAP4K2-mediated JNKs activation. The requirement for
MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS
stimulation of c-Jun phosphorylation and induction of IL-8. Enhances
MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1
autoinhibition and lead to activation following autophosphorylation.
Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling
pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3.
May play a role in the regulation of vesicle targeting or fusion.
regulation of vesicle targeting or fusion.
{ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887,
ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:7477268,
ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
Evidence={ECO:0000269|PubMed:7515885};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1; Evidence={ECO:0000269|PubMed:7515885};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000269|PubMed:7515885};
-!- ACTIVITY REGULATION: The tumor necrosis factor (TNF), as well as
endotoxins and proinflammatory stimuli such as polyinosine-polycytidine
(poly(IC)), lipopolysaccharides (LPS), peptidoglycan (PGN), flagellin,
or lipid A activate MAP4K2 by promoting its autophosphorylation.
{ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:7477268}.
-!- SUBUNIT: Interacts with TRAF2, TRAF6, MAP3K1/MEKK1 and MAP3K11/MLK3.
Interacts with RAB8A (By similarity). {ECO:0000250}.
-!- INTERACTION:
Q12851; Q13233: MAP3K1; NbExp=2; IntAct=EBI-49783, EBI-49776;
Q12851; Q9NUX5: POT1; NbExp=2; IntAct=EBI-49783, EBI-752420;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Basolateral cell
membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein
{ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q12851-1; Sequence=Displayed;
Name=2;
IsoId=Q12851-2; Sequence=VSP_054134;
-!- TISSUE SPECIFICITY: Highly expressed in germinal center but not mantle
zone B-cells. Also expressed in lung, brain and placenta and at lower
levels in other tissues examined. {ECO:0000269|PubMed:7515885}.
-!- DOMAIN: The PEST domains are Pro-, Glu-, Ser-, and Thr-rich domains.
Proteins with PEST domains are frequently targets of degradation by the
ubiquitin proteasome. {ECO:0000269|PubMed:7515885}.
-!- PTM: Polyubiquitinated through 'Lys-48'-polyubiquitin chains, allowing
proteasomal turnover. Ubiquitination requires the kinase activity of
MAP4K2/GCK. {ECO:0000269|PubMed:15456887}.
-!- PTM: Autophosphorylated in response to tumor necrosis factor (TNF),
endotoxins or proinflammatory stimuli. Autophosphorylation leads to
activation.
-!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
protein kinase family. STE20 subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA20968.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
---------------------------------------------------------------------------
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EMBL; AP001462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471076; EAW74302.1; -; Genomic_DNA.
EMBL; BC047865; AAH47865.1; -; mRNA.
EMBL; U07349; AAA20968.1; ALT_SEQ; mRNA.
CCDS; CCDS8082.1; -. [Q12851-1]
CCDS; CCDS81582.1; -. [Q12851-2]
PIR; A53714; A53714.
RefSeq; NP_001294919.1; NM_001307990.1. [Q12851-2]
RefSeq; NP_004570.2; NM_004579.4. [Q12851-1]
SMR; Q12851; -.
BioGRID; 111809; 17.
IntAct; Q12851; 14.
MINT; Q12851; -.
STRING; 9606.ENSP00000294066; -.
BindingDB; Q12851; -.
ChEMBL; CHEMBL5330; -.
DrugBank; DB12010; Fostamatinib.
DrugCentral; Q12851; -.
GuidetoPHARMACOLOGY; 2086; -.
iPTMnet; Q12851; -.
PhosphoSitePlus; Q12851; -.
BioMuta; MAP4K2; -.
DMDM; 215274019; -.
CPTAC; CPTAC-862; -.
CPTAC; CPTAC-863; -.
EPD; Q12851; -.
jPOST; Q12851; -.
MassIVE; Q12851; -.
MaxQB; Q12851; -.
PaxDb; Q12851; -.
PeptideAtlas; Q12851; -.
PRIDE; Q12851; -.
ProteomicsDB; 58984; -. [Q12851-1]
ProteomicsDB; 70069; -.
Antibodypedia; 2060; 234 antibodies.
DNASU; 5871; -.
GeneID; 5871; -.
KEGG; hsa:5871; -.
UCSC; uc001obh.4; human. [Q12851-1]
CTD; 5871; -.
DisGeNET; 5871; -.
EuPathDB; HostDB:ENSG00000168067.11; -.
GeneCards; MAP4K2; -.
HGNC; HGNC:6864; MAP4K2.
HPA; ENSG00000168067; Low tissue specificity.
MIM; 603166; gene.
neXtProt; NX_Q12851; -.
OpenTargets; ENSG00000168067; -.
PharmGKB; PA30610; -.
eggNOG; KOG0576; Eukaryota.
GeneTree; ENSGT00940000162250; -.
InParanoid; Q12851; -.
KO; K04414; -.
OMA; WATMKQQ; -.
OrthoDB; 996262at2759; -.
PhylomeDB; Q12851; -.
TreeFam; TF105121; -.
PathwayCommons; Q12851; -.
SignaLink; Q12851; -.
SIGNOR; Q12851; -.
BioGRID-ORCS; 5871; 28 hits in 877 CRISPR screens.
GeneWiki; MAP4K2; -.
GenomeRNAi; 5871; -.
Pharos; Q12851; Tchem.
PRO; PR:Q12851; -.
Proteomes; UP000005640; Unplaced.
RNAct; Q12851; protein.
Bgee; ENSG00000168067; Expressed in blood and 176 other tissues.
ExpressionAtlas; Q12851; baseline and differential.
Genevisible; Q12851; HS.
GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0000139; C:Golgi membrane; TAS:ProtInc.
GO; GO:0005524; F:ATP binding; IDA:UniProtKB.
GO; GO:0008349; F:MAP kinase kinase kinase kinase activity; IBA:GO_Central.
GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:UniProtKB.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO; GO:0007257; P:activation of JUN kinase activity; IDA:UniProtKB.
GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
GO; GO:0006955; P:immune response; TAS:ProtInc.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO; GO:0007254; P:JNK cascade; TAS:ProtInc.
GO; GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IBA:GO_Central.
GO; GO:0006903; P:vesicle targeting; IEA:Ensembl.
InterPro; IPR001180; CNH_dom.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR021160; MAPKKKK.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
Pfam; PF00780; CNH; 1.
Pfam; PF00069; Pkinase; 1.
PIRSF; PIRSF038172; MAPKKKK; 1.
SMART; SM00036; CNH; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50219; CNH; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
1: Evidence at protein level;
Alternative splicing; ATP-binding; Cell membrane; Cytoplasm;
Golgi apparatus; Immunity; Innate immunity; Kinase; Membrane;
Nucleotide-binding; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Stress response; Transferase;
Ubl conjugation.
CHAIN 1..820
/note="Mitogen-activated protein kinase kinase kinase
kinase 2"
/id="PRO_0000086275"
DOMAIN 16..273
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
DOMAIN 482..793
/note="CNH"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00795"
NP_BIND 22..30
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 294..314
/note="PEST1"
REGION 344..360
/note="PEST2"
REGION 405..448
/note="PEST3"
ACT_SITE 136
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
BINDING 45
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 328
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:23186163"
MOD_RES 394
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19369195, ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163"
VAR_SEQ 426..433
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_054134"
CONFLICT 120
/note="A -> R (in Ref. 4; AAA20968)"
/evidence="ECO:0000305"
SEQUENCE 820 AA; 91556 MW; A59C1E99BFFAEF41 CRC64;
MALLRDVSLQ DPRDRFELLQ RVGAGTYGDV YKARDTVTSE LAAVKIVKLD PGDDISSLQQ
EITILRECRH PNVVAYIGSY LRNDRLWICM EFCGGGSLQE IYHATGPLEE RQIAYVCREA
LKGLHHLHSQ GKIHRDIKGA NLLLTLQGDV KLADFGVSGE LTASVAKRRS FIGTPYWMAP
EVAAVERKGG YNELCDVWAL GITAIELGEL QPPLFHLHPM RALMLMSKSS FQPPKLRDKT
RWTQNFHHFL KLALTKNPKK RPTAEKLLQH PFTTQQLPRA LLTQLLDKAS DPHLGTPSPE
DCELETYDMF PDTIHSRGQH GPAERTPSEI QFHQVKFGAP RRKETDPLNE PWEEEWTLLG
KEELSGSLLQ SVQEALEERS LTIRSASEFQ ELDSPDDTMG TIKRAPFLGP LPTDPPAEEP
LSSPPGTLPP PPSGPNSSPL LPTAWATMKQ REDPERSSCH GLPPTPKVHM GACFSKVFNG
CPLRIHAAVT WIHPVTRDQF LVVGAEEGIY TLNLHELHED TLEKLISHRC SWLYCVNNVL
LSLSGKSTHI WAHDLPGLFE QRRLQQQVPL SIPTNRLTQR IIPRRFALST KIPDTKGCLQ
CRVVRNPYTG ATFLLAALPT SLLLLQWYEP LQKFLLLKNF SSPLPSPAGM LEPLVLDGKE
LPQVCVGAEG PEGPGCRVLF HVLPLEAGLT PDILIPPEGI PGSAQQVIQV DRDTILVSFE
RCVRIVNMQG EPTATLAPEL TFDFPIETVV CLQDSVLAFW SHGMQGRSLD TNEVTQEITD
ETRIFRVLGA HRDIILESIP TDNPEAHSNL YILTGHQSTY


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U1358m CLIA Apoptosis signal-regulating kinase 1,Ask1,ASK-1,Map3k5,MAPK_ERK kinase kinase 5,MEK kinase 5,MEKK 5,Mekk5,Mitogen-activated protein kinase kinase kinase 5,Mouse,Mus musculus 96T
E1358m ELISA kit Apoptosis signal-regulating kinase 1,Ask1,ASK-1,Map3k5,MAPK_ERK kinase kinase 5,MEK kinase 5,MEKK 5,Mekk5,Mitogen-activated protein kinase kinase kinase 5,Mouse,Mus musculus 96T
E1358h ELISA Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
E1358h ELISA kit Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
U1358h CLIA Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.05 mg
18-662-20090 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
18-662-20091 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
18-662-20092 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 mg
10-782-55047 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.05 mg
10-782-55048 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.02 mg
10-782-55048 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.05 mg
10-782-55047 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.02 mg
EIAAB25228 Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,MAP kinase kinase 1,Map2k1,MAPK_ERK kinase 1,MAPKK 1,MEK 1,Mek1,Prkmk1,Rat,Rattus norvegicus
EIAAB25230 Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,MAP kinase kinase 1,Map2k1,MAPK_ERK kinase 1,MAPKK 1,MEK 1,Mek1,Mouse,Mus musculus,Prkmk1
Pathways :
WP1493: Carbon assimilation C4 pathway
WP1619: Amino sugar and nucleotide sugar metabolism
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1701: Starch and sucrose metabolism
WP1653: Galactose metabolism
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP253: Glycolysis
WP32: Translation Factors
WP1681: Pantothenate and CoA biosynthesis
WP1946: Cori Cycle
WP1703: Streptomycin biosynthesis
WP1844: MAP kinase cascade
WP1567: Glycolysis and Gluconeogenesis
WP1659: Glycine, serine and threonine metabolism
WP2292: Chemokine signaling pathway
WP2199: Seed Development
WP1678: Nucleotide excision repair
WP2218: sGC
WP525: Mitochondrial Unfolded-Protein Response
WP1892: Protein folding
WP346: Protein Modifications
WP931: G Protein Signaling Pathways
WP1939: Unfolded Protein Response
WP1689: Porphyrin and chlorophyll metabolism
WP232: G Protein Signaling Pathways

Related Genes :
[MAP4K2 GCK RAB8IP] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
[Map4k2 Rab8ip] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (Germinal center kinase) (GCK) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Map2k1 Mek1 Prkmk1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k1 Mek1 Prkmk1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k5 Mek5 Mkk5 Prkmk5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[MAPK1 ERK2 PRKM1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAP3K5 ASK1 MAPKKK5 MEKK5] Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
[MAP2K2 MEK2 MKK2 PRKMK2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[Map2k2 Mek2 Mkk2 Prkmk2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[Map3k2 Mekk2] Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k2 Mek2 Mkk2 Prkmk2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[Map3k1 Mekk Mekk1] Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
[MAP3K1 MAPKKK1 MEKK MEKK1] Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
[Map3k1 Mekk Mekk1] Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[MAP2K6 MEK6 MKK6 PRKMK6 SKK3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[mkkA DDB_G0283265] Mitogen-activated protein kinase kinase kinase A (EC 2.7.11.25) (MAPK/ERK kinase 1) (MEK kinase 1) (MEKK 1) (MAPK/ERK kinase A) (MEK kinase A) (MEKK A) (MEKKalpha)
[Map2k5 Mek5 Mkk5 Prkmk5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[mekA MEK1 DDB_G0269152] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (DdMEK1) (MEK1) (MAPK/ERK kinase A) (MEKA)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[MAP2K5 MEK5 MKK5 PRKMK5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)

Bibliography :