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Mitogen-activated protein kinase p38b (MAP kinase p38b) (MAPK p38b) (EC 2.7.11.24)

 MK38B_DROME             Reviewed;         365 AA.
O61443;
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
12-AUG-2020, entry version 190.
RecName: Full=Mitogen-activated protein kinase p38b {ECO:0000303|PubMed:9584193};
Short=MAP kinase p38b {ECO:0000303|PubMed:9584193};
Short=MAPK p38b {ECO:0000303|PubMed:9584193};
EC=2.7.11.24;
Name=p38b {ECO:0000303|PubMed:9584193, ECO:0000312|FlyBase:FBgn0024846};
ORFNames=CG7393 {ECO:0000312|FlyBase:FBgn0024846};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND ACTIVITY REGULATION.
TISSUE=Embryo;
PubMed=9584193; DOI=10.1128/mcb.18.6.3527;
Han Z.S., Enslen H., Hu X., Meng X., Wu I.-H., Barrett T., Davis R.J.,
Ip Y.T.;
"A conserved p38 mitogen-activated protein kinase pathway regulates
Drosophila immunity gene expression.";
Mol. Cell. Biol. 18:3527-3539(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
TISSUE=Imaginal disk;
PubMed=10022918; DOI=10.1128/mcb.19.3.2322;
Adachi-Yamada T., Nakamura M., Irie K., Tomoyasu Y., Sano Y., Mori E.,
Goto S., Ueno N., Nishida Y., Matsumoto K.;
"p38 mitogen-activated protein kinase can be involved in transforming
growth factor beta superfamily signal transduction in Drosophila wing
morphogenesis.";
Mol. Cell. Biol. 19:2322-2329(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10471707;
Ashburner M., Misra S., Roote J., Lewis S.E., Blazej R.G., Davis T.,
Doyle C., Galle R.F., George R.A., Harris N.L., Hartzell G., Harvey D.A.,
Hong L., Houston K.A., Hoskins R.A., Johnson G., Martin C., Moshrefi A.R.,
Palazzolo M., Reese M.G., Spradling A.C., Tsang G., Wan K.H., Whitelaw K.,
Celniker S.E., Rubin G.M.;
"An exploration of the sequence of a 2.9-Mb region of the genome of
Drosophila melanogaster: the Adh region.";
Genetics 153:179-219(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[5]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic
review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley; TISSUE=Embryo;
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-183 AND TYR-185, AND
IDENTIFICATION BY MASS SPECTROMETRY.
TISSUE=Embryo;
PubMed=18327897; DOI=10.1021/pr700696a;
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
J. Proteome Res. 7:1675-1682(2008).
-!- FUNCTION: Kinase involved in dpp signal transduction pathway in the
process of wing morphogenesis when the levels of dpp are enhanced or
inhibited. May down-regulate insect immunity gene expression after
prolonged infection. {ECO:0000269|PubMed:10022918,
ECO:0000269|PubMed:9584193}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.24;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
-!- ACTIVITY REGULATION: Activated by threonine and tyrosine
phosphorylation by Mkk3. {ECO:0000269|PubMed:9584193}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: At mid-embryogenesis, highest expression is seen in
developing anterior and posterior midguts. Almost ubiquitous expression
throughout all development.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically in the
embryo, expression seen in all developmental stages.
-!- DOMAIN: The TXY motif contains the threonine and tyrosine residues
whose phosphorylation activates the MAP kinases.
-!- PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates the
enzyme. {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
protein kinase family. MAP kinase subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; AF035548; AAC39032.1; -; mRNA.
EMBL; AB006364; BAA35141.1; -; mRNA.
EMBL; AE014134; AAF53326.1; -; Genomic_DNA.
EMBL; AY058548; AAL13777.1; -; mRNA.
RefSeq; NP_477361.1; NM_058013.5.
SMR; O61443; -.
BioGRID; 60814; 51.
DIP; DIP-22779N; -.
IntAct; O61443; 6.
STRING; 7227.FBpp0080111; -.
iPTMnet; O61443; -.
PaxDb; O61443; -.
PRIDE; O61443; -.
EnsemblMetazoa; FBtr0080534; FBpp0080111; FBgn0024846.
GeneID; 34780; -.
KEGG; dme:Dmel_CG7393; -.
CTD; 34780; -.
FlyBase; FBgn0024846; p38b.
eggNOG; KOG0660; Eukaryota.
GeneTree; ENSGT00940000155325; -.
HOGENOM; CLU_000288_181_1_1; -.
InParanoid; O61443; -.
KO; K04441; -.
OMA; EITNRYT; -.
OrthoDB; 683132at2759; -.
PhylomeDB; O61443; -.
BRENDA; 2.7.11.24; 1994.
Reactome; R-DME-168638; NOD1/2 Signaling Pathway.
Reactome; R-DME-171007; p38MAPK events.
Reactome; R-DME-198753; ERK/MAPK targets.
Reactome; R-DME-2559580; Oxidative Stress Induced Senescence.
Reactome; R-DME-418592; ADP signalling through P2Y purinoceptor 1.
Reactome; R-DME-4420097; VEGFA-VEGFR2 Pathway.
Reactome; R-DME-450302; activated TAK1 mediates p38 MAPK activation.
Reactome; R-DME-450341; Activation of the AP-1 family of transcription factors.
Reactome; R-DME-525793; Myogenesis.
Reactome; R-DME-6798695; Neutrophil degranulation.
SignaLink; O61443; -.
BioGRID-ORCS; 34780; 0 hits in 5 CRISPR screens.
ChiTaRS; p38b; fly.
GenomeRNAi; 34780; -.
PRO; PR:O61443; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0024846; Expressed in Malpighian tubule and 30 other tissues.
Genevisible; O61443; DM.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004707; F:MAP kinase activity; IDA:FlyBase.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:FlyBase.
GO; GO:0071243; P:cellular response to arsenic-containing substance; IDA:FlyBase.
GO; GO:0071276; P:cellular response to cadmium ion; IDA:FlyBase.
GO; GO:0034614; P:cellular response to reactive oxygen species; IDA:FlyBase.
GO; GO:0007623; P:circadian rhythm; IMP:FlyBase.
GO; GO:0042742; P:defense response to bacterium; IMP:FlyBase.
GO; GO:0050832; P:defense response to fungus; IMP:FlyBase.
GO; GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
GO; GO:0003007; P:heart morphogenesis; IGI:FlyBase.
GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IDA:UniProtKB.
GO; GO:0006955; P:immune response; IMP:FlyBase.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0000165; P:MAPK cascade; IDA:FlyBase.
GO; GO:0035331; P:negative regulation of hippo signaling; IMP:FlyBase.
GO; GO:0038001; P:paracrine signaling; IGI:FlyBase.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IGI:FlyBase.
GO; GO:0045793; P:positive regulation of cell size; IMP:FlyBase.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:FlyBase.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IGI:FlyBase.
GO; GO:0006468; P:protein phosphorylation; IDA:FlyBase.
GO; GO:0048082; P:regulation of adult chitin-containing cuticle pigmentation; IGI:FlyBase.
GO; GO:0030510; P:regulation of BMP signaling pathway; IDA:UniProtKB.
GO; GO:1900407; P:regulation of cellular response to oxidative stress; IMP:FlyBase.
GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
GO; GO:0045088; P:regulation of innate immune response; IDA:UniProtKB.
GO; GO:2000331; P:regulation of terminal button organization; IMP:FlyBase.
GO; GO:0009617; P:response to bacterium; IDA:FlyBase.
GO; GO:0009408; P:response to heat; IMP:FlyBase.
GO; GO:0042542; P:response to hydrogen peroxide; IMP:FlyBase.
GO; GO:0009651; P:response to salt stress; IMP:FlyBase.
GO; GO:0042594; P:response to starvation; IMP:FlyBase.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR003527; MAP_kinase_CS.
InterPro; IPR008352; MAPK_p38-like.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
Pfam; PF00069; Pkinase; 1.
PRINTS; PR01773; P38MAPKINASE.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS01351; MAPK; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
1: Evidence at protein level;
ATP-binding; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein;
Reference proteome; Serine/threonine-protein kinase; Transferase.
CHAIN 1..365
/note="Mitogen-activated protein kinase p38b"
/id="PRO_0000186301"
DOMAIN 24..311
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 30..38
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOTIF 183..185
/note="TXY"
ACT_SITE 153
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
BINDING 53
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 183
/note="Phosphothreonine"
/evidence="ECO:0000269|PubMed:18327897"
MOD_RES 185
/note="Phosphotyrosine"
/evidence="ECO:0000269|PubMed:18327897"
SEQUENCE 365 AA; 42098 MW; 3B3F217E467BAD53 CRC64;
MSRKMAKFYK LDINRTEWEI PETYQNLQPV GQGAYGQVCK AVVRGTSTKV AIKKLARPFQ
SAVHAKRTYR ELRLLKHMDH ENVIGLLDVF HPGQPADSLD QFQQVYMVTH LMDADLNNII
RTQKLSDDHV QFLVYQILRG LKYIHSAGVI HRDLKPSNIA VNEDCELRIL DFGLARPAES
EMTGYVATRW YRAPEIMLNW MHYNQTADIW SVGCIMAELL TGRTLFPGTD HIHQLNLIME
VLGTPADEFM SRISSESARN YIRSLPVMPR RNFRDIFRGA NPLAIDLLEK MLELDADKRI
TAEQALAHPY MEKYHDPTDE QTAALYDQSF EENELPVEKW REMVFSEVTA FKPTAAFAEL
LPKEQ


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Pathways :
WP402: ERK1 - ERK2 MAPK cascade
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WP152: FGF signaling pathway
WP1681: Pantothenate and CoA biosynthesis
WP1946: Cori Cycle
WP1703: Streptomycin biosynthesis
WP1567: Glycolysis and Gluconeogenesis
WP1844: MAP kinase cascade
WP1619: Amino sugar and nucleotide sugar metabolism
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1701: Starch and sucrose metabolism
WP2292: Chemokine signaling pathway
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1653: Galactose metabolism
WP253: Glycolysis
WP32: Translation Factors
WP1675: Nitrogen metabolism
WP2272: Pathogenic Escherichia coli infection
WP778: MAPK Cascade
WP1009: MAPK Cascade
WP1613: 1,4-Dichlorobenzene degradation
WP1845: MAPK targets/ Nuclear events mediated by MAP kinases
WP350: p38 MAPK Signaling Pathway (BioCarta)
WP1337: MAPK signaling pathway

Related Genes :
[p38b CG7393] Mitogen-activated protein kinase p38b (MAP kinase p38b) (MAPK p38b) (EC 2.7.11.24)
[mapk14b mapk14] Mitogen-activated protein kinase 14B (MAP kinase 14B) (MAPK 14B) (EC 2.7.11.24) (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (zp38b)
[mapk14b] Mitogen-activated protein kinase 14B (MAP kinase 14B) (MAPK 14B) (EC 2.7.11.24) (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (cp38b)
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[Mapk11 Prkm11] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK13 PRKM13 SAPK4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk14 Crk1 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk13] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk14 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[MAPK10 JNK3 JNK3A PRKM10 SAPK1B] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
[mapk14a mapk14] Mitogen-activated protein kinase 14A (MAP kinase 14A) (MAPK 14A) (EC 2.7.11.24) (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (zp38a)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[MAPK1 ERK2 PRKM1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK9 JNK2 PRKM9 SAPK1A] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk10 Jnk3 Prkm10 Serk2] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
[Mapk13 Serk4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[MAPK8 JNK1 PRKM8 SAPK1 SAPK1C] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk9 Jnk2 Prkm9] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
[Mapk9 Jnk2 Prkm9] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (SAPK-alpha) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (p54-alpha)
[MAPK7 BMK1 ERK5 PRKM7] Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)
[Mapk8 Jnk1 Prkm8] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)

Bibliography :
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[27402810] Regulation of Hippo signalling by p38 signalling.
[25254641] The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.
[25144774] The MAP kinase p38 is part of Drosophila melanogaster's circadian clock.
[24361691] The role of Litopenaeus vannamei p38 in white spot syndrome virus infection.
[24277934] In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle.
[23438069] Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster.
[22005516] Characterization of p38 MAPKs from orange-spotted grouper, Epinephelus coioides involved in SGIV infection.
[21076039] Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi.
[20551513] The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.