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Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (Stress-activated protein kinase pmk-1) (p38 MAP kinase 1)

 PMK1_CAEEL              Reviewed;         377 AA.
Q17446;
30-APR-2003, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
17-JUN-2020, entry version 170.
RecName: Full=Mitogen-activated protein kinase pmk-1;
EC=2.7.11.24 {ECO:0000269|PubMed:11703092, ECO:0000269|PubMed:16166371, ECO:0000269|PubMed:22308034};
AltName: Full=Stress-activated protein kinase pmk-1;
AltName: Full=p38 MAP kinase 1;
Name=pmk-1; ORFNames=B0218.3;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, COFACTOR,
ACTIVITY REGULATION, AND DOMAIN.
STRAIN=Bristol N2;
PubMed=11703092; DOI=10.1006/mcbr.2001.0300;
Berman K., McKay J., Avery L., Cobb M.;
"Isolation and characterization of pmk-(1-3): three p38 homologs in
Caenorhabditis elegans.";
Mol. Cell Biol. Res. Commun. 4:337-344(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating
biology.";
Science 282:2012-2018(1998).
[3]
FUNCTION, PHOSPHORYLATION AT THR-191 AND TYR-193, AND DISRUPTION PHENOTYPE.
STRAIN=Bristol N2;
PubMed=12142542; DOI=10.1126/science.1073759;
Kim D.H., Feinbaum R., Alloing G., Emerson F.E., Garsin D.A., Inoue H.,
Tanaka-Hino M., Hisamoto N., Matsumoto K., Tan M.-W., Ausubel F.M.;
"A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate
immunity.";
Science 297:623-626(2002).
[4]
FUNCTION, CATALYTIC ACTIVITY, PHOSPHORYLATION AT THR-191 AND TYR-193, AND
MUTAGENESIS OF LYS-64.
PubMed=16166371; DOI=10.1101/gad.1324805;
Inoue H., Hisamoto N., An J.H., Oliveira R.P., Nishida E., Blackwell T.K.,
Matsumoto K.;
"The C. elegans p38 MAPK pathway regulates nuclear localization of the
transcription factor SKN-1 in oxidative stress response.";
Genes Dev. 19:2278-2283(2005).
[5]
FUNCTION.
PubMed=18394898; DOI=10.1016/j.cub.2008.02.079;
Pujol N., Cypowyj S., Ziegler K., Millet A., Astrain A., Goncharov A.,
Jin Y., Chisholm A.D., Ewbank J.J.;
"Distinct innate immune responses to infection and wounding in the C.
elegans epidermis.";
Curr. Biol. 18:481-489(2008).
[6]
FUNCTION.
PubMed=19497412; DOI=10.1016/j.cbi.2009.03.012;
Wang S., Wu L., Wang Y., Luo X., Lu Y.;
"Copper-induced germline apoptosis in Caenorhabditis elegans: the
independent roles of DNA damage response signaling and the dependent roles
of MAPK cascades.";
Chem. Biol. Interact. 180:151-157(2009).
[7]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=20062796; DOI=10.1371/journal.ppat.1000717;
Butschi A., Titz A., Waelti M.A., Olieric V., Paschinger K., Noebauer K.,
Guo X., Seeberger P.H., Wilson I.B., Aebi M., Hengartner M.O., Kuenzler M.;
"Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity
towards nematotoxic fungal galectin CGL2.";
PLoS Pathog. 6:E1000717-E1000717(2010).
[8]
FUNCTION, AND PHOSPHORYLATION AT THR-191 AND TYR-193.
PubMed=21212236; DOI=10.1534/genetics.110.124883;
Hayakawa T., Kato K., Hayakawa R., Hisamoto N., Matsumoto K., Takeda K.,
Ichijo H.;
"Regulation of anoxic death in Caenorhabditis elegans by mammalian
apoptosis signal-regulating kinase (ASK) family proteins.";
Genetics 187:785-792(2011).
[9]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=22216003; DOI=10.1371/journal.ppat.1002453;
Hoeven R.V., McCallum K.C., Cruz M.R., Garsin D.A.;
"Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1
activity via p38 MAPK signaling during infection in C. elegans.";
PLoS Pathog. 7:E1002453-E1002453(2011).
[10]
FUNCTION, CATALYTIC ACTIVITY, COFACTOR, AND DISRUPTION PHENOTYPE.
PubMed=22308034; DOI=10.1074/jbc.m111.314146;
Lee K., Shim J., Bae J., Kim Y.J., Lee J.;
"Stabilization of RNT-1 protein, runt-related transcription factor (RUNX)
protein homolog of Caenorhabditis elegans, by oxidative stress through
mitogen-activated protein kinase pathway.";
J. Biol. Chem. 287:10444-10452(2012).
-!- FUNCTION: Serine/threonine kinase which responds to activation by
environmental stress and pro-inflammatory cytokines by phosphorylating
downstream targets. Phosphorylates snk-1 which probably regulates skn-1
nuclear translocation in response to oxidative stress
(PubMed:16166371). Probably by activating skn-1, involved in the up-
regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon
bacteria infection (PubMed:22216003). Up-regulates expression of gcs-1
in intestinal cells upon arsenite treatment (PubMed:16166371).
Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP
kinase which regulates pathogen resistance and responses to oxidative
stress (PubMed:11703092, PubMed:12142542, PubMed:18394898,
PubMed:16166371). Required for expression of antimicrobial peptide nlp-
29 in response to fungal infection or physical injury
(PubMed:18394898). Involved in resistance to the nematotoxic C.cinerea
galectin Cgl2 (PubMed:20062796). May play a redundant role with other
MAP kinases in susceptibility to anoxia, downstream of tir-1/nsy-1
(PubMed:21212236). Phosphorylates transcription factor rnt-1 during
oxidative stress which results in rnt-1 stabilization in the intestine
(PubMed:22308034). Probably downstream of nsy-1 and sek-1, involved in
germline apoptosis induced by heavy metals, such as Cu(2+)
(PubMed:19497412). {ECO:0000269|PubMed:11703092,
ECO:0000269|PubMed:12142542, ECO:0000269|PubMed:16166371,
ECO:0000269|PubMed:18394898, ECO:0000269|PubMed:19497412,
ECO:0000269|PubMed:20062796, ECO:0000269|PubMed:21212236,
ECO:0000269|PubMed:22216003, ECO:0000269|PubMed:22308034}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;
Evidence={ECO:0000269|PubMed:11703092, ECO:0000269|PubMed:16166371,
ECO:0000269|PubMed:22308034};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.24; Evidence={ECO:0000269|PubMed:11703092,
ECO:0000269|PubMed:16166371, ECO:0000269|PubMed:22308034};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000269|PubMed:11703092, ECO:0000269|PubMed:22308034};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000269|PubMed:22308034};
Note=Divalent cations such as magnesium or manganese.
{ECO:0000269|PubMed:22308034};
-!- ACTIVITY REGULATION: Activated by phosphorylation on threonine and
tyrosine. Inhibited by pyridinyl-imidazole related compounds.
{ECO:0000269|PubMed:11703092}.
-!- DOMAIN: The TXY motif contains the threonine and tyrosine residues
whose phosphorylation activates the MAP kinases.
{ECO:0000269|PubMed:11703092}.
-!- PTM: Dually phosphorylated on Thr-191 and Tyr-193, probably by sek-1,
which activates the enzyme. {ECO:0000269|PubMed:12142542,
ECO:0000269|PubMed:16166371, ECO:0000269|PubMed:21212236}.
-!- DISRUPTION PHENOTYPE: Upon infection by P.aeruginosa or E.faecalis,
RNAi-mediated knockdown results in a decrease in survival rate and in a
reduced up-regulation of gst-4 and gcs-1 expression (PubMed:12142542,
PubMed:22216003). Causes a severe reduction in rnt-1 accumulation in
the intestine during oxidative stress mediated by paraquat
(PubMed:22308034). Upon exposure to C.cinerea galectin Cgl2, adults
show reduced survival and larvae do not develop (PubMed:20062796).
Larval development is partially restored in a bre-1, fut-8, gly-13,
galt-1 or ger-1 mutant background (PubMed:20062796).
{ECO:0000269|PubMed:12142542, ECO:0000269|PubMed:20062796,
ECO:0000269|PubMed:22216003, ECO:0000269|PubMed:22308034}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
protein kinase family. MAP kinase subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; FO080124; CCD61386.1; -; Genomic_DNA.
PIR; T29750; T29750.
RefSeq; NP_501365.1; NM_068964.3.
SMR; Q17446; -.
BioGRID; 56238; 5.
DIP; DIP-26892N; -.
IntAct; Q17446; 17.
STRING; 6239.B0218.3; -.
iPTMnet; Q17446; -.
EPD; Q17446; -.
PaxDb; Q17446; -.
PeptideAtlas; Q17446; -.
PRIDE; Q17446; -.
EnsemblMetazoa; B0218.3.1; B0218.3.1; WBGene00004055.
GeneID; 191743; -.
KEGG; cel:CELE_B0218.3; -.
UCSC; B0218.3; c. elegans.
CTD; 191743; -.
WormBase; B0218.3; CE06686; WBGene00004055; pmk-1.
eggNOG; KOG0660; Eukaryota.
eggNOG; ENOG410XNY0; LUCA.
GeneTree; ENSGT00970000196450; -.
HOGENOM; CLU_000288_181_1_1; -.
InParanoid; Q17446; -.
KO; K04441; -.
OMA; EITNRYT; -.
OrthoDB; 683132at2759; -.
PhylomeDB; Q17446; -.
Reactome; R-CEL-168638; NOD1/2 Signaling Pathway.
Reactome; R-CEL-171007; p38MAPK events.
Reactome; R-CEL-2559580; Oxidative Stress Induced Senescence.
Reactome; R-CEL-418592; ADP signalling through P2Y purinoceptor 1.
Reactome; R-CEL-432142; Platelet sensitization by LDL.
Reactome; R-CEL-4420097; VEGFA-VEGFR2 Pathway.
Reactome; R-CEL-450302; activated TAK1 mediates p38 MAPK activation.
Reactome; R-CEL-525793; Myogenesis.
Reactome; R-CEL-6798695; Neutrophil degranulation.
SignaLink; Q17446; -.
PRO; PR:Q17446; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00004055; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IDA:WormBase.
GO; GO:0005634; C:nucleus; IDA:WormBase.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004707; F:MAP kinase activity; IDA:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004672; F:protein kinase activity; IDA:WormBase.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:WormBase.
GO; GO:0008134; F:transcription factor binding; IPI:WormBase.
GO; GO:0035095; P:behavioral response to nicotine; IMP:UniProtKB.
GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB.
GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:UniProtKB.
GO; GO:0006972; P:hyperosmotic response; IGI:WormBase.
GO; GO:0045087; P:innate immune response; IMP:WormBase.
GO; GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO; GO:0000165; P:MAPK cascade; IGI:WormBase.
GO; GO:1901215; P:negative regulation of neuron death; IMP:ParkinsonsUK-UCL.
GO; GO:0038066; P:p38MAPK cascade; IMP:WormBase.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IDA:WormBase.
GO; GO:1900426; P:positive regulation of defense response to bacterium; IGI:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
GO; GO:1900182; P:positive regulation of protein localization to nucleus; IMP:WormBase.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
GO; GO:1902097; P:positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium; IMP:WormBase.
GO; GO:0012501; P:programmed cell death; IMP:WormBase.
GO; GO:0006468; P:protein phosphorylation; IDA:WormBase.
GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
GO; GO:0093002; P:response to nematicide; IMP:UniProtKB.
GO; GO:0006970; P:response to osmotic stress; IDA:UniProtKB.
GO; GO:0000302; P:response to reactive oxygen species; IEP:WormBase.
GO; GO:0000303; P:response to superoxide; IEP:WormBase.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR003527; MAP_kinase_CS.
InterPro; IPR008352; MAPK_p38-like.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
Pfam; PF00069; Pkinase; 1.
PRINTS; PR01773; P38MAPKINASE.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS01351; MAPK; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
1: Evidence at protein level;
ATP-binding; Kinase; Magnesium; Manganese; Metal-binding;
Nucleotide-binding; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Stress response; Transferase.
CHAIN 1..377
/note="Mitogen-activated protein kinase pmk-1"
/id="PRO_0000186303"
DOMAIN 35..319
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 41..49
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOTIF 191..193
/note="TXY"
ACT_SITE 179
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
BINDING 64
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 191
/note="Phosphothreonine"
/evidence="ECO:0000269|PubMed:16166371,
ECO:0000269|PubMed:21212236"
MOD_RES 193
/note="Phosphotyrosine"
/evidence="ECO:0000269|PubMed:16166371,
ECO:0000269|PubMed:21212236"
MUTAGEN 64
/note="K->R: Loss of kinase activity."
/evidence="ECO:0000269|PubMed:16166371"
SEQUENCE 377 AA; 43919 MW; F20BC395B38EFD03 CRC64;
MFPQTTMDHI LHPTPREGYY VVELNRSVWV VPNYYINLTP IGTGAYGTVC AAECTRSGTR
VAIKKFNRPF QSIIHARRTY RELRLLRCMC HENIIDLLDV FTPNENVNDI EDVYFVSMLM
GADLSNILKI QRLNDDHIQF LVYQILRGLK YIHSADIIHR DLKPSNIAVN EDCELKILDF
GLARQTDSEM TGYVATRWYR APEIMLNWMH YTQTVDVWSV GCILAELITG KTLFPGSDHI
DQLTRIMSVT GTPDEEFLKK ISSEEARNYI RNLPKMTRRD FKRLFAQATP QAIDLLEKML
HLDPDRRPTA KEAMEHEYLA AYHDETDEPI AEEMDLNDDV RADTIDEWKK IIWEEISDFQ
KNVAFADEEE DEEKMES


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Pathways :
WP1493: Carbon assimilation C4 pathway
WP1653: Galactose metabolism
WP32: Translation Factors
WP1844: MAP kinase cascade
WP1681: Pantothenate and CoA biosynthesis
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1946: Cori Cycle
WP1703: Streptomycin biosynthesis
WP1567: Glycolysis and Gluconeogenesis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1619: Amino sugar and nucleotide sugar metabolism
WP253: Glycolysis
WP1701: Starch and sucrose metabolism
WP2199: Seed Development
WP1616: ABC transporters
WP1888: Post-translational protein modification
WP731: Sterol regulatory element binding protein related
WP1676: Non-homologous end-joining
WP2324: AGE/RAGE pathway
WP1685: Peptidoglycan biosynthesis
WP2371: Parkinsons Disease Pathway
WP1625: Base excision repair
WP1929: Thrombin signalling through proteinase activated receptors (PARs)
WP2032: TSH signaling pathway
WP1371: G Protein Signaling Pathways

Related Genes :
[pmk-1 B0218.3] Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (Stress-activated protein kinase pmk-1) (p38 MAP kinase 1)
[pmk-3 F42G8.4] Mitogen-activated protein kinase pmk-3 (EC 2.7.11.24) (Stress-activated protein kinase pmk-3) (p38 MAP kinase 3)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK13 PRKM13 SAPK4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk13] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk14 Crk1 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk14 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk13 Serk4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[spm1 pmk1 SPBC119.08] Mitogen-activated protein kinase spm1 (MAP kinase spm1) (EC 2.7.11.24) (MAP kinase pmk1)
[MAPK14 CSBP1 CSBP2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk11 Prkm11] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B)
[mapk14a mapk14] Mitogen-activated protein kinase 14A (MAP kinase 14A) (MAPK 14A) (EC 2.7.11.24) (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (zp38a)
[mapk14b mapk14] Mitogen-activated protein kinase 14B (MAP kinase 14B) (MAPK 14B) (EC 2.7.11.24) (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (zp38b)
[MAPK14 CSBP1] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a)
[mapk14b] Mitogen-activated protein kinase 14B (MAP kinase 14B) (MAPK 14B) (EC 2.7.11.24) (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (cp38b)
[p38b CG7393] Mitogen-activated protein kinase p38b (MAP kinase p38b) (MAPK p38b) (EC 2.7.11.24)
[mapk14a] Mitogen-activated protein kinase 14A (MAP kinase 14A) (MAPK 14A) (EC 2.7.11.24) (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (cp38a)
[MAPKAPK5 PRAK] MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Mapk8 Jnk1 Prkm8] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (SAPK gamma) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (p54 gamma)
[Mapk8 Jnk1 Prkm8] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
[sek-1 R03G5.2] Dual specificity mitogen-activated protein kinase kinase sek-1 (MAP kinase kinase sek-1) (EC 2.7.12.2)
[MPK4 At4g01370 F2N1.1 F2N1_2-t] Mitogen-activated protein kinase 4 (AtMPK4) (MAP kinase 4) (EC 2.7.11.24)
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK10 JNK3 JNK3A PRKM10 SAPK1B] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)

Bibliography :
[21185874] The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses.