Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

 B3MRL0_DROAN            Unreviewed;       471 AA.
 B3MRL0;
 02-SEP-2008, integrated into UniProtKB/TrEMBL.
 02-SEP-2008, sequence version 1.
 10-FEB-2021, entry version 86.
 RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
          Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
          Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
 AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
 Name=Dana\GF20979 {ECO:0000313|EMBL:EDV34415.1};
 Synonyms=dana_GLEANR_4213 {ECO:0000313|EMBL:KPU75127.1};
 ORFNames=Dana_GF20979 {ECO:0000313|EMBL:EDV34415.1},
 GF20979 {ECO:0000313|EMBL:KPU75127.1};
 Drosophila ananassae (Fruit fly).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
 Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
 Drosophilidae; Drosophila; Sophophora.
 NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV34415.1, ECO:0000313|Proteomes:UP000007801};
 [1] {ECO:0000313|EMBL:EDV34415.1, ECO:0000313|Proteomes:UP000007801}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:EDV34415.1}, and
 Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
 PubMed=17994087; DOI=10.1038/nature06341;
 Drosophila 12 Genomes Consortium;
 Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
 Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
 Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
 Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
 Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
 Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
 Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
 Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
 Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
 Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
 David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
 Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
 Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
 Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
 Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
 Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
 Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
 Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
 Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
 Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
 Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
 Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
 Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
 Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
 McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
 Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
 Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
 Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
 Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
 Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
 Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
 Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
 Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
 Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
 Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
 Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
 Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
 Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
 Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
 Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
 Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
 Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
 Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
 Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
 Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
 Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
 Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
 Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
 D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
 Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
 Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
 Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
 Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
 Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
 Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
 Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
 Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
 Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
 McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
 Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
 Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
 Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
 Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
 Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
 Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
 Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
 Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
 Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
 Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
 Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
 Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
 "Evolution of genes and genomes on the Drosophila phylogeny.";
 Nature 450:203-218(2007).
 [2] {ECO:0000313|EMBL:EDV34415.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:EDV34415.1};
 PubMed=18057021; DOI=10.1093/bioinformatics/btm542;
 Zimin A.V., Smith D.R., Sutton G., Yorke J.A.;
 "Assembly reconciliation.";
 Bioinformatics 24:42-45(2008).
 [3] {ECO:0000313|EMBL:EDV34415.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:EDV34415.1};
 FlyBase;
 Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
 [4] {ECO:0000313|EMBL:KPU75127.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:KPU75127.1};
 Gilbert D.G.;
 Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
     Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361195}.
 -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
     {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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 EMBL; CH902622; EDV34415.1; -; Genomic_DNA.
 EMBL; CH902622; KPU75127.1; -; Genomic_DNA.
 RefSeq; XP_001963966.1; XM_001963930.2.
 RefSeq; XP_014761018.1; XM_014905532.1.
 STRING; 7217.FBpp0124171; -.
 EnsemblMetazoa; FBtr0381086; FBpp0341409; FBgn0097984.
 EnsemblMetazoa; FBtr0392791; FBpp0352144; FBgn0097984.
 GeneID; 6503668; -.
 KEGG; dan:6503668; -.
 eggNOG; KOG3701; Eukaryota.
 HOGENOM; CLU_026736_0_2_1; -.
 InParanoid; B3MRL0; -.
 OMA; PNNTEYN; -.
 OrthoDB; 608001at2759; -.
 Proteomes; UP000007801; Unassembled WGS sequence.
 Bgee; FBgn0097984; Expressed in adult organism and 1 other tissue.
 GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
 GO; GO:0071144; C:heteromeric SMAD protein complex; IEA:EnsemblMetazoa.
 GO; GO:0031490; F:chromatin DNA binding; IEA:EnsemblMetazoa.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:0032924; P:activin receptor signaling pathway; IEA:EnsemblMetazoa.
 GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
 GO; GO:0071333; P:cellular response to glucose stimulus; IEA:EnsemblMetazoa.
 GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
 GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
 GO; GO:0010507; P:negative regulation of autophagy; IEA:EnsemblMetazoa.
 GO; GO:0045572; P:positive regulation of imaginal disc growth; IEA:EnsemblMetazoa.
 GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
 GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
 GO; GO:0090256; P:regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
 GO; GO:0044719; P:regulation of imaginal disc-derived wing size; IEA:EnsemblMetazoa.
 GO; GO:0050803; P:regulation of synapse structure or activity; IEA:EnsemblMetazoa.
 GO; GO:0060395; P:SMAD protein signal transduction; IEA:EnsemblMetazoa.
 GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
 Gene3D; 2.60.200.10; -; 1.
 Gene3D; 3.90.520.10; -; 1.
 InterPro; IPR013790; Dwarfin.
 InterPro; IPR003619; MAD_homology1_Dwarfin-type.
 InterPro; IPR013019; MAD_homology_MH1.
 InterPro; IPR017855; SMAD-like_dom_sf.
 InterPro; IPR001132; SMAD_dom_Dwarfin-type.
 InterPro; IPR008984; SMAD_FHA_dom_sf.
 InterPro; IPR036578; SMAD_MH1_sf.
 PANTHER; PTHR13703; PTHR13703; 2.
 Pfam; PF03165; MH1; 1.
 Pfam; PF03166; MH2; 1.
 SMART; SM00523; DWA; 1.
 SMART; SM00524; DWB; 1.
 SUPFAM; SSF49879; SSF49879; 1.
 SUPFAM; SSF56366; SSF56366; 1.
 PROSITE; PS51075; MH1; 1.
 PROSITE; PS51076; MH2; 1.
 3: Inferred from homology;
 Cytoplasm {ECO:0000256|RuleBase:RU361195};
 DNA-binding {ECO:0000256|RuleBase:RU361195};
 Metal-binding {ECO:0000256|ARBA:ARBA00022723};
 Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
 Reference proteome {ECO:0000313|Proteomes:UP000007801};
 Transcription {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195};
 Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
 DOMAIN          7..134
                 /note="MH1"
                 /evidence="ECO:0000259|PROSITE:PS51075"
 DOMAIN          278..471
                 /note="MH2"
                 /evidence="ECO:0000259|PROSITE:PS51076"
 REGION          178..262
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        178..238
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 SEQUENCE   471 AA;  52408 MW;  A0142CB8CA692DA6 CRC64;
 MLPFTPQVVK RLLALKKGSE DNSVEGKWSE KAVKNLVKKI KKNSQLEELE RAISTQNCQT
 RCVTVPRSKP APAGEHLRKG LPHVIYCRLW RWPDLQSQNE LKPLDHCEYA FHLRKDEICI
 NPYHYKKIEL SILVPKSLPT PPDSIVDYPL DNHTHQIPNN TDYNAAIIRS ASLSPPQYME
 LGGSGSGTGA ATSSSTSGAP SSSPSSYQQQ QQLSFGQNMD SQSSVLSVGS SIPNTGTPPP
 GYMSEDGDPI DPNDNMNMSR LTPPADAAPV MYHEPAFWCS ISYYELNTRV GETFHASQPS
 ITVDGFTDPS NSERFCLGLL SNVNRNEVVE QTRRHIGKGV RLYYIGGEVF AECLSDSSIF
 VQSPNCNQRY GWHPATVCKI PPGCNLKIFN NQEFAALLSQ SVSQGFEAVY QLTRMCTIRM
 SFVKGWGAEY RRQTVTSTPC WIELHLNGPL QWLDRVLTQM GSPRLPCSSM S

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