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B4GXV7_DROPE Unreviewed; 474 AA.
B4GXV7;
23-SEP-2008, integrated into UniProtKB/TrEMBL.
23-SEP-2008, sequence version 1.
10-FEB-2021, entry version 79.
RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
Name=Dper\GL20193 {ECO:0000313|EMBL:EDW27584.1};
ORFNames=Dper_GL20193 {ECO:0000313|EMBL:EDW27584.1};
Drosophila persimilis (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7234 {ECO:0000313|Proteomes:UP000008744};
[1] {ECO:0000313|EMBL:EDW27584.1, ECO:0000313|Proteomes:UP000008744}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MSH-3 / Tucson 14011-0111.49 {ECO:0000313|Proteomes:UP000008744};
PubMed=17994087; DOI=10.1038/nature06341;
Drosophila 12 Genomes Consortium;
Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
"Evolution of genes and genomes on the Drosophila phylogeny.";
Nature 450:203-218(2007).
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361195}.
-!- SIMILARITY: Belongs to the dwarfin/SMAD family.
{ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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EMBL; CH479196; EDW27584.1; -; Genomic_DNA.
RefSeq; XP_002023436.1; XM_002023400.1.
STRING; 7234.FBpp0184300; -.
EnsemblMetazoa; FBtr0185808; FBpp0184300; FBgn0157788.
eggNOG; KOG3701; Eukaryota.
HOGENOM; CLU_026736_0_2_1; -.
OMA; PNNTEYN; -.
PhylomeDB; B4GXV7; -.
Proteomes; UP000008744; Unassembled WGS sequence.
GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
GO; GO:0071144; C:heteromeric SMAD protein complex; IEA:EnsemblMetazoa.
GO; GO:0031490; F:chromatin DNA binding; IEA:EnsemblMetazoa.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0032924; P:activin receptor signaling pathway; IEA:EnsemblMetazoa.
GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
GO; GO:0071333; P:cellular response to glucose stimulus; IEA:EnsemblMetazoa.
GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
GO; GO:0010507; P:negative regulation of autophagy; IEA:EnsemblMetazoa.
GO; GO:0045572; P:positive regulation of imaginal disc growth; IEA:EnsemblMetazoa.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
GO; GO:0090256; P:regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
GO; GO:0044719; P:regulation of imaginal disc-derived wing size; IEA:EnsemblMetazoa.
GO; GO:0050803; P:regulation of synapse structure or activity; IEA:EnsemblMetazoa.
GO; GO:0060395; P:SMAD protein signal transduction; IEA:EnsemblMetazoa.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
Gene3D; 2.60.200.10; -; 1.
Gene3D; 3.90.520.10; -; 1.
InterPro; IPR013790; Dwarfin.
InterPro; IPR003619; MAD_homology1_Dwarfin-type.
InterPro; IPR013019; MAD_homology_MH1.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR001132; SMAD_dom_Dwarfin-type.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036578; SMAD_MH1_sf.
PANTHER; PTHR13703; PTHR13703; 2.
Pfam; PF03165; MH1; 1.
Pfam; PF03166; MH2; 1.
SMART; SM00523; DWA; 1.
SMART; SM00524; DWB; 1.
SUPFAM; SSF49879; SSF49879; 1.
SUPFAM; SSF56366; SSF56366; 1.
PROSITE; PS51075; MH1; 1.
PROSITE; PS51076; MH2; 1.
3: Inferred from homology;
Cytoplasm {ECO:0000256|RuleBase:RU361195};
DNA-binding {ECO:0000256|RuleBase:RU361195};
Metal-binding {ECO:0000256|ARBA:ARBA00022723};
Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
Reference proteome {ECO:0000313|Proteomes:UP000008744};
Transcription {ECO:0000256|ARBA:ARBA00023015,
ECO:0000256|RuleBase:RU361195};
Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
DOMAIN 7..134
/note="MH1"
/evidence="ECO:0000259|PROSITE:PS51075"
DOMAIN 281..474
/note="MH2"
/evidence="ECO:0000259|PROSITE:PS51076"
REGION 210..245
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 210..241
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 474 AA; 52734 MW; FBE1D1E146424209 CRC64;
MLPFTPQVVK RLLALKKGNE DNTVEGKWSE KAVKNLVKKI KKNSQLEELE RAISTQNCQT
RCVTVPRSKP VPPGEHLRKG LPHVIYCRLW RWPDLQSQNE LKPLDHCEYA FHLRKDEICI
NPYHYKKIEL SILVPKSLPT PPDSIVDYPL DNHTHQIPNN TDYNAAIIRS ASLSPPQYME
LGGGSGPVTS SSASASASLL VSATSSSSSS SYQQPLSFGQ NMDSQSSVLS VGSSIPNTGT
PPPGYMSEDG DPIDPNDNMN MSRLTPPADA APVMYHEPAF WCSISYYELN TRVGETFHAS
QPSITVDGFT DPSNSERFCL GLLSNVNRND VVEQTRRHIG KGVRLYYIGG EVFAECLSDS
SIFVQSPNCN QRYGWHPATV CKIPPGCNLK IFNNQEFAAL LSQSVSQGFE AVYQLTRMCT
IRMSFVKGWG AEYRRQTVTS TPCWIELHLN GPLQWLDRVL TQMGSPRLPC SSMS
[22879948] fussel (fuss)--A negative regulator of BMP signaling in Drosophila melanogaster. |