Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

 B4JNQ7_DROGR            Unreviewed;       509 AA.
 B4JNQ7;
 23-SEP-2008, integrated into UniProtKB/TrEMBL.
 23-SEP-2008, sequence version 1.
 10-FEB-2021, entry version 78.
 RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
          Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
          Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
 AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
 Name=Dgri\GH24864 {ECO:0000313|EMBL:EDV92350.1};
 ORFNames=Dgri_GH24864 {ECO:0000313|EMBL:EDV92350.1};
 Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
 Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
 Drosophilidae; Drosophila; Hawaiian Drosophila.
 NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
 [1] {ECO:0000313|EMBL:EDV92350.1, ECO:0000313|Proteomes:UP000001070}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
 PubMed=17994087; DOI=10.1038/nature06341;
 Drosophila 12 Genomes Consortium;
 Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
 Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
 Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
 Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
 Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
 Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
 Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
 Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
 Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
 Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
 David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
 Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
 Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
 Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
 Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
 Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
 Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
 Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
 Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
 Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
 Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
 Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
 Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
 Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
 McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
 Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
 Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
 Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
 Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
 Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
 Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
 Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
 Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
 Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
 Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
 Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
 Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
 Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
 Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
 Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
 Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
 Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
 Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
 Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
 Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
 Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
 Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
 Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
 D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
 Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
 Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
 Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
 Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
 Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
 Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
 Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
 Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
 Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
 McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
 Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
 Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
 Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
 Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
 Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
 Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
 Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
 Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
 Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
 Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
 Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
 Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
 "Evolution of genes and genomes on the Drosophila phylogeny.";
 Nature 450:203-218(2007).
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
     Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361195}.
 -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
     {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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 EMBL; CH916371; EDV92350.1; -; Genomic_DNA.
 RefSeq; XP_001992643.1; XM_001992607.1.
 SMR; B4JNQ7; -.
 STRING; 7222.FBpp0158770; -.
 EnsemblMetazoa; FBtr0160278; FBpp0158770; FBgn0132319.
 KEGG; dgr:Dgri_GH24864; -.
 eggNOG; KOG3701; Eukaryota.
 HOGENOM; CLU_026736_0_2_1; -.
 InParanoid; B4JNQ7; -.
 OMA; PNNTEYN; -.
 OrthoDB; 608001at2759; -.
 PhylomeDB; B4JNQ7; -.
 Proteomes; UP000001070; Unassembled WGS sequence.
 GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
 GO; GO:0071144; C:heteromeric SMAD protein complex; IEA:EnsemblMetazoa.
 GO; GO:0031490; F:chromatin DNA binding; IEA:EnsemblMetazoa.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:0032924; P:activin receptor signaling pathway; IEA:EnsemblMetazoa.
 GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
 GO; GO:0071333; P:cellular response to glucose stimulus; IEA:EnsemblMetazoa.
 GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
 GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
 GO; GO:0010507; P:negative regulation of autophagy; IEA:EnsemblMetazoa.
 GO; GO:0045572; P:positive regulation of imaginal disc growth; IEA:EnsemblMetazoa.
 GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
 GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
 GO; GO:0090256; P:regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
 GO; GO:0044719; P:regulation of imaginal disc-derived wing size; IEA:EnsemblMetazoa.
 GO; GO:0050803; P:regulation of synapse structure or activity; IEA:EnsemblMetazoa.
 GO; GO:0060395; P:SMAD protein signal transduction; IEA:EnsemblMetazoa.
 GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
 Gene3D; 2.60.200.10; -; 1.
 Gene3D; 3.90.520.10; -; 1.
 InterPro; IPR013790; Dwarfin.
 InterPro; IPR003619; MAD_homology1_Dwarfin-type.
 InterPro; IPR013019; MAD_homology_MH1.
 InterPro; IPR017855; SMAD-like_dom_sf.
 InterPro; IPR001132; SMAD_dom_Dwarfin-type.
 InterPro; IPR008984; SMAD_FHA_dom_sf.
 InterPro; IPR036578; SMAD_MH1_sf.
 PANTHER; PTHR13703; PTHR13703; 3.
 Pfam; PF03165; MH1; 1.
 Pfam; PF03166; MH2; 1.
 SMART; SM00523; DWA; 1.
 SMART; SM00524; DWB; 1.
 SUPFAM; SSF49879; SSF49879; 1.
 SUPFAM; SSF56366; SSF56366; 1.
 PROSITE; PS51075; MH1; 1.
 PROSITE; PS51076; MH2; 1.
 3: Inferred from homology;
 Cytoplasm {ECO:0000256|RuleBase:RU361195};
 DNA-binding {ECO:0000256|RuleBase:RU361195};
 Metal-binding {ECO:0000256|ARBA:ARBA00022723};
 Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
 Reference proteome {ECO:0000313|Proteomes:UP000001070};
 Transcription {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195};
 Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
 DOMAIN          7..134
                 /note="MH1"
                 /evidence="ECO:0000259|PROSITE:PS51075"
 DOMAIN          316..509
                 /note="MH2"
                 /evidence="ECO:0000259|PROSITE:PS51076"
 REGION          198..236
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          252..280
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        252..276
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 SEQUENCE   509 AA;  56519 MW;  FD243AB98833FE98 CRC64;
 MLPFTPQVVK RLLALKKGNE DNSVEGKWSE KAVKNLVKKI KKNSQLEELE RAISTQNCNT
 RCVTVPRSKP AATGENLRKG LPHVIYCRLW RWPDLQSQNE LKPLEHCEYA FHLRKDDICI
 NPYHYKKIEL SILVPKSLPT PPDSIVDYPL DNHTHQIPNN TEYNAAIIRS ASLSPPQYME
 LGGGSSSSNS SSIIITTTTT STSNNTNPSA GSTSYQQQQQ QQQLQQQQQQ HSPLSFGGSV
 VGVVGVGQNL PPGSCNMDSQ SSVLSVGSSI PNTGTPPPGY MSEDGDPIDP NDNMNMSRLT
 PPADAAPVMY HEPAFWCSIS YYELNTRVGE TFHASQPSIT VDGFTDPSNS ERFCLGLLSN
 VNRNEVVEQT RRHIGKGVRL YYIGGEVFAE CLSDSSIFVQ SPNCNQRYGW HPATVCKIPP
 GCNLKIFNNQ EFAALLSQSV SQGFEAVYQL TRMCTIRMSF VKGWGAEYRR QTVTSTPCWI
 ELHLNGPLQW LDRVLTQMGS PRLPCSSMS

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