Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

 B4L8H6_DROMO            Unreviewed;       495 AA.
 B4L8H6;
 23-SEP-2008, integrated into UniProtKB/TrEMBL.
 23-SEP-2008, sequence version 1.
 10-FEB-2021, entry version 83.
 RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
          Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
          Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
 AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
 Name=Dmoj\GI14415 {ECO:0000313|EMBL:EDW07951.1};
 ORFNames=Dmoj_GI14415 {ECO:0000313|EMBL:EDW07951.1};
 Drosophila mojavensis (Fruit fly).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
 Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
 Drosophilidae; Drosophila.
 NCBI_TaxID=7230 {ECO:0000313|EMBL:EDW07951.1, ECO:0000313|Proteomes:UP000009192};
 [1] {ECO:0000313|EMBL:EDW07951.1, ECO:0000313|Proteomes:UP000009192}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
 PubMed=17994087; DOI=10.1038/nature06341;
 Drosophila 12 Genomes Consortium;
 Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
 Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
 Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
 Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
 Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
 Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
 Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
 Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
 Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
 Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
 David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
 Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
 Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
 Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
 Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
 Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
 Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
 Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
 Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
 Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
 Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
 Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
 Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
 Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
 McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
 Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
 Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
 Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
 Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
 Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
 Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
 Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
 Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
 Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
 Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
 Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
 Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
 Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
 Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
 Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
 Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
 Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
 Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
 Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
 Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
 Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
 Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
 Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
 D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
 Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
 Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
 Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
 Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
 Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
 Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
 Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
 Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
 Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
 McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
 Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
 Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
 Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
 Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
 Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
 Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
 Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
 Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
 Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
 Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
 Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
 Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
 "Evolution of genes and genomes on the Drosophila phylogeny.";
 Nature 450:203-218(2007).
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
     Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361195}.
 -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
     {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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 EMBL; CH933815; EDW07951.1; -; Genomic_DNA.
 RefSeq; XP_002011830.1; XM_002011794.2.
 SMR; B4L8H6; -.
 STRING; 7230.FBpp0163632; -.
 EnsemblMetazoa; FBtr0165140; FBpp0163632; FBgn0137167.
 GeneID; 6586207; -.
 KEGG; dmo:Dmoj_GI14415; -.
 eggNOG; KOG3701; Eukaryota.
 HOGENOM; CLU_026736_0_2_1; -.
 InParanoid; B4L8H6; -.
 OMA; PNNTEYN; -.
 OrthoDB; 608001at2759; -.
 PhylomeDB; B4L8H6; -.
 Proteomes; UP000009192; Unassembled WGS sequence.
 Bgee; FBgn0137167; Expressed in head and 2 other tissues.
 GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
 GO; GO:0071144; C:heteromeric SMAD protein complex; IEA:EnsemblMetazoa.
 GO; GO:0031490; F:chromatin DNA binding; IEA:EnsemblMetazoa.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:0032924; P:activin receptor signaling pathway; IEA:EnsemblMetazoa.
 GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
 GO; GO:0071333; P:cellular response to glucose stimulus; IEA:EnsemblMetazoa.
 GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
 GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
 GO; GO:0010507; P:negative regulation of autophagy; IEA:EnsemblMetazoa.
 GO; GO:0045572; P:positive regulation of imaginal disc growth; IEA:EnsemblMetazoa.
 GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
 GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
 GO; GO:0090256; P:regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
 GO; GO:0044719; P:regulation of imaginal disc-derived wing size; IEA:EnsemblMetazoa.
 GO; GO:0050803; P:regulation of synapse structure or activity; IEA:EnsemblMetazoa.
 GO; GO:0060395; P:SMAD protein signal transduction; IEA:EnsemblMetazoa.
 GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
 Gene3D; 2.60.200.10; -; 1.
 Gene3D; 3.90.520.10; -; 1.
 InterPro; IPR013790; Dwarfin.
 InterPro; IPR003619; MAD_homology1_Dwarfin-type.
 InterPro; IPR013019; MAD_homology_MH1.
 InterPro; IPR017855; SMAD-like_dom_sf.
 InterPro; IPR001132; SMAD_dom_Dwarfin-type.
 InterPro; IPR008984; SMAD_FHA_dom_sf.
 InterPro; IPR036578; SMAD_MH1_sf.
 PANTHER; PTHR13703; PTHR13703; 2.
 Pfam; PF03165; MH1; 1.
 Pfam; PF03166; MH2; 1.
 SMART; SM00523; DWA; 1.
 SMART; SM00524; DWB; 1.
 SUPFAM; SSF49879; SSF49879; 1.
 SUPFAM; SSF56366; SSF56366; 1.
 PROSITE; PS51075; MH1; 1.
 PROSITE; PS51076; MH2; 1.
 3: Inferred from homology;
 Cytoplasm {ECO:0000256|RuleBase:RU361195};
 DNA-binding {ECO:0000256|RuleBase:RU361195};
 Metal-binding {ECO:0000256|ARBA:ARBA00022723};
 Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
 Reference proteome {ECO:0000313|Proteomes:UP000009192};
 Transcription {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195};
 Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
 DOMAIN          7..134
                 /note="MH1"
                 /evidence="ECO:0000259|PROSITE:PS51075"
 DOMAIN          302..495
                 /note="MH2"
                 /evidence="ECO:0000259|PROSITE:PS51076"
 REGION          178..281
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        178..229
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        238..262
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 SEQUENCE   495 AA;  55185 MW;  6FBB82F717018825 CRC64;
 MLSFTPQVVK RLLALKKGNE DNSVEGKWSE KAVRNLVKKI KKNSQIEELE RAISTQNCNT
 RCVTVPRSKP AATGESLRKG LPHVIYCRLW RWPDLQSQNE LKPLEHCEYA FHLRKDDICI
 NPYHYKKIEL SILVPKSLPT PPDSIVDYPL DNHTHQIPNN TEYNAAIIRS ASLSPPQYME
 LGGSSSNSSS NTTINSTATG AGGYQQQQQQ QQQHQQLQQQ HSPLSFGSVV GVGQNLPPGS
 CNMDSQSSVL SVGSSIPNTG TPPPGYMSED GDPIDPNDNM NMSRLTPPAD AAPVMYHEPA
 FWCSISYYEL NTRVGETFHA SQPSITVDGF TDPSNSERFC LGLLSNVNRN EVVEQTRRHI
 GKGVRLYYIG GEVFAECLSD SSIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA
 LLSQSVSQGF EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDRV
 LTQMGSPRLP CSSMS

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