Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

 B4M1Z3_DROVI            Unreviewed;       489 AA.
 B4M1Z3;
 23-SEP-2008, integrated into UniProtKB/TrEMBL.
 23-SEP-2008, sequence version 1.
 10-FEB-2021, entry version 88.
 RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
          Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
          Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
 AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
 Name=Dvir\GJ18762 {ECO:0000313|EMBL:EDW65697.1};
 ORFNames=Dvir_GJ18762 {ECO:0000313|EMBL:EDW65697.1};
 Drosophila virilis (Fruit fly).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
 Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
 Drosophilidae; Drosophila.
 NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW65697.1, ECO:0000313|Proteomes:UP000008792};
 [1] {ECO:0000313|EMBL:EDW65697.1, ECO:0000313|Proteomes:UP000008792}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=TSC#15010-1051.87 {ECO:0000313|EMBL:EDW65697.1}, and
 Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
 PubMed=17994087; DOI=10.1038/nature06341;
 Drosophila 12 Genomes Consortium;
 Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
 Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
 Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
 Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
 Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
 Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
 Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
 Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
 Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
 Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
 David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
 Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
 Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
 Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
 Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
 Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
 Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
 Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
 Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
 Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
 Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
 Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
 Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
 Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
 McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
 Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
 Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
 Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
 Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
 Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
 Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
 Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
 Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
 Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
 Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
 Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
 Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
 Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
 Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
 Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
 Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
 Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
 Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
 Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
 Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
 Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
 Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
 Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
 D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
 Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
 Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
 Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
 Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
 Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
 Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
 Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
 Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
 Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
 McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
 Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
 Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
 Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
 Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
 Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
 Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
 Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
 Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
 Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
 Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
 Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
 Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
 "Evolution of genes and genomes on the Drosophila phylogeny.";
 Nature 450:203-218(2007).
 [2] {ECO:0000313|EMBL:EDW65697.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=TSC#15010-1051.87 {ECO:0000313|EMBL:EDW65697.1};
 PubMed=18057021; DOI=10.1093/bioinformatics/btm542;
 Zimin A.V., Smith D.R., Sutton G., Yorke J.A.;
 "Assembly reconciliation.";
 Bioinformatics 24:42-45(2008).
 [3] {ECO:0000313|EMBL:EDW65697.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=TSC#15010-1051.87 {ECO:0000313|EMBL:EDW65697.1};
 FlyBase;
 Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
 [4] {ECO:0000313|EMBL:KRF82345.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=TSC#15010-1051.87 {ECO:0000313|EMBL:KRF82345.1};
 FlyBase;
 Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
     Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361195}.
 -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
     {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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 EMBL; CH940651; EDW65697.1; -; Genomic_DNA.
 EMBL; CH940651; KRF82345.1; -; Genomic_DNA.
 EMBL; CH940651; KRF82346.1; -; Genomic_DNA.
 EMBL; CH940651; KRF82347.1; -; Genomic_DNA.
 RefSeq; XP_002055496.1; XM_002055460.2.
 RefSeq; XP_015026411.1; XM_015170925.1.
 RefSeq; XP_015026412.1; XM_015170926.1.
 RefSeq; XP_015026413.1; XM_015170927.1.
 STRING; 7244.FBpp0233179; -.
 EnsemblMetazoa; FBtr0234687; FBpp0233179; FBgn0205914.
 EnsemblMetazoa; FBtr0433781; FBpp0390895; FBgn0205914.
 EnsemblMetazoa; FBtr0439841; FBpp0396487; FBgn0205914.
 EnsemblMetazoa; FBtr0442473; FBpp0398941; FBgn0205914.
 GeneID; 6632030; -.
 KEGG; dvi:6632030; -.
 eggNOG; KOG3701; Eukaryota.
 HOGENOM; CLU_026736_0_2_1; -.
 InParanoid; B4M1Z3; -.
 OMA; PNNTEYN; -.
 OrthoDB; 608001at2759; -.
 Proteomes; UP000008792; Unassembled WGS sequence.
 Bgee; FBgn0205914; Expressed in adult organism and 1 other tissue.
 GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
 GO; GO:0071144; C:heteromeric SMAD protein complex; IEA:EnsemblMetazoa.
 GO; GO:0031490; F:chromatin DNA binding; IEA:EnsemblMetazoa.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:0032924; P:activin receptor signaling pathway; IEA:EnsemblMetazoa.
 GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
 GO; GO:0071333; P:cellular response to glucose stimulus; IEA:EnsemblMetazoa.
 GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
 GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
 GO; GO:0010507; P:negative regulation of autophagy; IEA:EnsemblMetazoa.
 GO; GO:0045572; P:positive regulation of imaginal disc growth; IEA:EnsemblMetazoa.
 GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
 GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
 GO; GO:0090256; P:regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
 GO; GO:0044719; P:regulation of imaginal disc-derived wing size; IEA:EnsemblMetazoa.
 GO; GO:0050803; P:regulation of synapse structure or activity; IEA:EnsemblMetazoa.
 GO; GO:0060395; P:SMAD protein signal transduction; IEA:EnsemblMetazoa.
 GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
 Gene3D; 2.60.200.10; -; 1.
 Gene3D; 3.90.520.10; -; 1.
 InterPro; IPR013790; Dwarfin.
 InterPro; IPR003619; MAD_homology1_Dwarfin-type.
 InterPro; IPR013019; MAD_homology_MH1.
 InterPro; IPR017855; SMAD-like_dom_sf.
 InterPro; IPR001132; SMAD_dom_Dwarfin-type.
 InterPro; IPR008984; SMAD_FHA_dom_sf.
 InterPro; IPR036578; SMAD_MH1_sf.
 PANTHER; PTHR13703; PTHR13703; 2.
 Pfam; PF03165; MH1; 1.
 Pfam; PF03166; MH2; 1.
 SMART; SM00523; DWA; 1.
 SMART; SM00524; DWB; 1.
 SUPFAM; SSF49879; SSF49879; 1.
 SUPFAM; SSF56366; SSF56366; 1.
 PROSITE; PS51075; MH1; 1.
 PROSITE; PS51076; MH2; 1.
 3: Inferred from homology;
 Cytoplasm {ECO:0000256|RuleBase:RU361195};
 DNA-binding {ECO:0000256|RuleBase:RU361195};
 Metal-binding {ECO:0000256|ARBA:ARBA00022723};
 Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
 Reference proteome {ECO:0000313|Proteomes:UP000008792};
 Transcription {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195};
 Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
 DOMAIN          7..134
                 /note="MH1"
                 /evidence="ECO:0000259|PROSITE:PS51075"
 DOMAIN          296..489
                 /note="MH2"
                 /evidence="ECO:0000259|PROSITE:PS51076"
 REGION          177..268
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        177..223
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        232..256
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 SEQUENCE   489 AA;  54516 MW;  47CE8048B8FC8E73 CRC64;
 MLPFTPQVVK RLLALKKGNE DNSVEGKWSE KAVRNLVKKI KKNSQIEELE RAISTQNCNT
 RCVTVPRSKP AATGESLRKG LPHVIYCRLW RWPDLQSQNE LKPLEHCEYA FHLRKDDICI
 NPYHYKKIEL SILVPKSLPT PPDSIVDYPL DNHTHQIPNN TEYNAAIIRS ASLSPPQYME
 LGGSSSNSSS NNTTATGAGG YQQQQQQQQQ QQQQHSPLSF GSVVGVGQNL PPGSCNMDSQ
 SSVLSVGSSI PNTGTPPPGY MSEDGDPIDP NDNMNMSRLT PPADAAPVMY HEPAFWCSIS
 YYELNTRVGE TFHASQPSIT VDGFTDPSNS ERFCLGLLSN VNRNEVVEQT RRHIGKGVRL
 YYIGGEVFAE CLSDSSIFVQ SPNCNQRYGW HPATVCKIPP GCNLKIFNNQ EFAALLSQSV
 SQGFEAVYQL TRMCTIRMSF VKGWGAEYRR QTVTSTPCWI ELHLNGPLQW LDRVLTQMGS
 PRLPCSSMS

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