Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

 B4Q0M2_DROYA            Unreviewed;       486 AA.
 B4Q0M2;
 23-SEP-2008, integrated into UniProtKB/TrEMBL.
 23-SEP-2008, sequence version 1.
 10-FEB-2021, entry version 86.
 RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
          Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
          Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
 AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
 Name=Dyak\GE17479 {ECO:0000313|EMBL:EDX02293.1};
 ORFNames=Dyak_GE17479 {ECO:0000313|EMBL:EDX02293.1};
 Drosophila yakuba (Fruit fly).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
 Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
 Drosophilidae; Drosophila; Sophophora.
 NCBI_TaxID=7245 {ECO:0000313|EMBL:EDX02293.1, ECO:0000313|Proteomes:UP000002282};
 [1] {ECO:0000313|EMBL:EDX02293.1, ECO:0000313|Proteomes:UP000002282}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000313|Proteomes:UP000002282};
 PubMed=17994087; DOI=10.1038/nature06341;
 Drosophila 12 Genomes Consortium;
 Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
 Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
 Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
 Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
 Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
 Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
 Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
 Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
 Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
 Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
 David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
 Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
 Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
 Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
 Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
 Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
 Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
 Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
 Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
 Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
 Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
 Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
 Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
 Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
 McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
 Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
 Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
 Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
 Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
 Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
 Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
 Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
 Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
 Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
 Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
 Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
 Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
 Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
 Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
 Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
 Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
 Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
 Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
 Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
 Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
 Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
 Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
 Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
 D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
 Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
 Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
 Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
 Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
 Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
 Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
 Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
 Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
 Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
 McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
 Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
 Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
 Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
 Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
 Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
 Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
 Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
 Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
 Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
 Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
 Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
 Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
 "Evolution of genes and genomes on the Drosophila phylogeny.";
 Nature 450:203-218(2007).
 [2] {ECO:0000313|EMBL:EDX02293.1, ECO:0000313|Proteomes:UP000002282}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000313|Proteomes:UP000002282};
 PubMed=17550304; DOI=10.1371/journal.pbio.0050152;
 Ranz J.M., Maurin D., Chan Y.S., von Grotthuss M., Hillier L.W., Roote J.,
 Ashburner M., Bergman C.M.;
 "Principles of genome evolution in the Drosophila melanogaster species
 group.";
 PLoS Biol. 5:E152-E152(2007).
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
     Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361195}.
 -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
     {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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 EMBL; CM000162; EDX02293.1; -; Genomic_DNA.
 RefSeq; XP_002101185.1; XM_002101149.2.
 SMR; B4Q0M2; -.
 STRING; 7245.FBpp0262489; -.
 EnsemblMetazoa; FBtr0405725; FBpp0364345; FBgn0234944.
 GeneID; 6525349; -.
 KEGG; dya:Dyak_GE17479; -.
 eggNOG; KOG3701; Eukaryota.
 HOGENOM; CLU_026736_0_2_1; -.
 OMA; PNNTEYN; -.
 OrthoDB; 608001at2759; -.
 PhylomeDB; B4Q0M2; -.
 Proteomes; UP000002282; Chromosome X.
 Bgee; FBgn0234944; Expressed in adult organism and 1 other tissue.
 GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
 GO; GO:0071144; C:heteromeric SMAD protein complex; IEA:EnsemblMetazoa.
 GO; GO:0031490; F:chromatin DNA binding; IEA:EnsemblMetazoa.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:0032924; P:activin receptor signaling pathway; IEA:EnsemblMetazoa.
 GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
 GO; GO:0071333; P:cellular response to glucose stimulus; IEA:EnsemblMetazoa.
 GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
 GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
 GO; GO:0010507; P:negative regulation of autophagy; IEA:EnsemblMetazoa.
 GO; GO:0045572; P:positive regulation of imaginal disc growth; IEA:EnsemblMetazoa.
 GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
 GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
 GO; GO:0090256; P:regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
 GO; GO:0044719; P:regulation of imaginal disc-derived wing size; IEA:EnsemblMetazoa.
 GO; GO:0050803; P:regulation of synapse structure or activity; IEA:EnsemblMetazoa.
 GO; GO:0060395; P:SMAD protein signal transduction; IEA:EnsemblMetazoa.
 GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
 Gene3D; 2.60.200.10; -; 1.
 Gene3D; 3.90.520.10; -; 1.
 InterPro; IPR013790; Dwarfin.
 InterPro; IPR003619; MAD_homology1_Dwarfin-type.
 InterPro; IPR013019; MAD_homology_MH1.
 InterPro; IPR017855; SMAD-like_dom_sf.
 InterPro; IPR001132; SMAD_dom_Dwarfin-type.
 InterPro; IPR008984; SMAD_FHA_dom_sf.
 InterPro; IPR036578; SMAD_MH1_sf.
 PANTHER; PTHR13703; PTHR13703; 2.
 Pfam; PF03165; MH1; 1.
 Pfam; PF03166; MH2; 1.
 SMART; SM00523; DWA; 1.
 SMART; SM00524; DWB; 1.
 SUPFAM; SSF49879; SSF49879; 1.
 SUPFAM; SSF56366; SSF56366; 1.
 PROSITE; PS51075; MH1; 1.
 PROSITE; PS51076; MH2; 1.
 3: Inferred from homology;
 Cytoplasm {ECO:0000256|RuleBase:RU361195};
 DNA-binding {ECO:0000256|RuleBase:RU361195};
 Metal-binding {ECO:0000256|ARBA:ARBA00022723};
 Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
 Transcription {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195};
 Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
 ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
 DOMAIN          7..134
                 /note="MH1"
                 /evidence="ECO:0000259|PROSITE:PS51075"
 DOMAIN          293..486
                 /note="MH2"
                 /evidence="ECO:0000259|PROSITE:PS51076"
 REGION          184..277
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 COMPBIAS        187..253
                 /note="Polar"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 SEQUENCE   486 AA;  53677 MW;  2BF312FD13534F98 CRC64;
 MLPFTPQVVK RLLALKKGNE DNSVEGKWSE KAVKNLVKKI KKNSQLEELE RAISTQNCQT
 RCVTVPRSKP APAGEHLRKG LPHVIYCRLW RWPDLQSQNE LKPLDHCEYA FHLRKEEICI
 NPYHYKKIEL SILVPKSLPT PPDSIVDYPL DNHTHQIPNN TDYNAAIIRS ASLSPPQYME
 LGGAGPVSVS SSASSTPATA AGGGGGPSSS SSSSSSAASA YQQQQQQLSF GQNMDSQSSV
 LSVGSSIPNT GTPPPGYMSE DGDPIDPNDN MNMSRLTPPA DAAPVMYHEP AFWCSISYYE
 LNTRVGETFH ASQPSITVDG FTDPSNSERF CLGLLSNVNR NEVVEQTRRH IGKGVRLYYI
 GGEVFAECLS DSSIFVQSPN CNQRYGWHPA TVCKIPPGCN LKIFNNQEFA ALLSQSVSQG
 FEAVYQLTRM CTIRMSFVKG WGAEYRRQTV TSTPCWIELH LNGPLQWLDR VLTQMGSPRL
 PCSSMS

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