GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

 Q6DIZ6_XENTR            Unreviewed;       466 AA.
Q6DIZ6; F6ZBI0;
16-AUG-2004, integrated into UniProtKB/TrEMBL.
16-AUG-2004, sequence version 1.
26-FEB-2020, entry version 119.
RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
Name=smad9 {ECO:0000313|EMBL:AAH75389.1,
ECO:0000313|Ensembl:ENSXETP00000002189,
ECO:0000313|Xenbase:XB-GENE-484686};
Synonyms=tmem54 {ECO:0000313|Xenbase:XB-GENE-490434};
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH75389.1};
[1] {ECO:0000313|EMBL:AAH75389.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Whole body {ECO:0000313|EMBL:AAH75389.1};
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSXETP00000002189}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000002189};
PubMed=20431018; DOI=10.1126/science.1183670;
Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
Khokha M.K., Richardson P.M., Rokhsar D.S.;
"The genome of the Western clawed frog Xenopus tropicalis.";
Science 328:633-636(2010).
[3] {ECO:0000313|Ensembl:ENSXETP00000002189}
IDENTIFICATION.
Ensembl;
Submitted (JUN-2011) to UniProtKB.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
Nucleus {ECO:0000256|RuleBase:RU361195, ECO:0000256|SAAS:SAAS00573677}.
-!- SIMILARITY: Belongs to the dwarfin/SMAD family.
{ECO:0000256|RuleBase:RU361195}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; BC075389; AAH75389.1; -; mRNA.
RefSeq; NP_001007479.1; NM_001007478.1.
STRING; 8364.ENSXETP00000002189; -.
STRING; 8364.ENSXETP00000003841; -.
Ensembl; ENSXETT00000000616; ENSXETP00000002189; ENSXETG00000005890.
GeneID; 493210; -.
KEGG; xtr:493210; -.
CTD; 4093; -.
Xenbase; XB-GENE-484686; smad9.
Xenbase; XB-GENE-490434; tmem54.
eggNOG; ENOG410IK7W; Eukaryota.
eggNOG; KOG3701; Eukaryota.
eggNOG; ENOG410XQKU; LUCA.
eggNOG; ENOG4111SCR; LUCA.
GeneTree; ENSGT00940000154391; -.
HOGENOM; CLU_026736_0_2_1; -.
KO; K16791; -.
OMA; CSASYPH; -.
OMA; SIPLRWT; -.
OrthoDB; 608001at2759; -.
TreeFam; TF314923; -.
TreeFam; TF332771; -.
Reactome; R-XTR-201451; Signaling by BMP.
Proteomes; UP000008143; Unassembled WGS sequence.
Bgee; ENSXETG00000001004; Expressed in liver and 7 other tissues.
Bgee; ENSXETG00000001820; Expressed in heart and 11 other tissues.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
Gene3D; 2.60.200.10; -; 1.
Gene3D; 3.90.520.10; -; 1.
InterPro; IPR013790; Dwarfin.
InterPro; IPR003619; MAD_homology1_Dwarfin-type.
InterPro; IPR013019; MAD_homology_MH1.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR001132; SMAD_dom_Dwarfin-type.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036578; SMAD_MH1_sf.
PANTHER; PTHR13703; PTHR13703; 1.
Pfam; PF03165; MH1; 1.
Pfam; PF03166; MH2; 1.
SMART; SM00523; DWA; 1.
SMART; SM00524; DWB; 1.
SUPFAM; SSF49879; SSF49879; 1.
SUPFAM; SSF56366; SSF56366; 1.
PROSITE; PS51075; MH1; 1.
PROSITE; PS51076; MH2; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Cytoplasm {ECO:0000256|RuleBase:RU361195};
DNA-binding {ECO:0000256|RuleBase:RU361195};
Nucleus {ECO:0000256|RuleBase:RU361195, ECO:0000256|SAAS:SAAS00464850};
Reference proteome {ECO:0000313|Proteomes:UP000008143};
Transcription {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00094697};
Transcription regulation {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00094697}.
DOMAIN 16..140
/note="MH1"
/evidence="ECO:0000259|PROSITE:PS51075"
DOMAIN 272..466
/note="MH2"
/evidence="ECO:0000259|PROSITE:PS51076"
REGION 171..244
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COILED 38..58
/evidence="ECO:0000256|SAM:Coils"
COMPBIAS 171..221
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 466 AA; 52489 MW; BD761CA2AB2A4FC4 CRC64;
MHASTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG AMEELERALS
CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD LQSHHELKPM ECCEFPFGSK
QKDVCINPYH YRRVETPVLP PVLVPRHSEF NPQLSLLAKF RNTSLNNEPL MPHNATFPES
FQQQPPCTPF SSSPSNIFPQ SPTTVGYPDS PQSSADPGSP YQITETPPPP YNAPDIQGNQ
NRPTADPAAC QLVLSALNRD FRPVCYEEPL HWCSVAYYEL NNRVGETFQA SSRSVLIDGF
TDPSNNKNRF CLGLLSNVNR NSTIENTRRH IGKGVHLYYV GGEVYAECVS DSSIFVQSRN
CNYQHGFHPS TVCKIPSGCS LKIFNNQLFA QLLSQSVNQG FEVVYELTKM CTIRMSFVKG
WGAEYHRQDV TSTPCWIEIH LHGPLQWLDK VLTQMGSPHN PISSVS


Related products :

Catalog number Product name Quantity
EIAAB38719 Deletion target in pancreatic carcinoma 4 homolog,Dpc4,MAD homolog 4,Madh4,Mothers against decapentaplegic homolog 4,Mothers against DPP homolog 4,Mouse,Mus musculus,SMAD 4,SMAD family member 4,Smad4,
U0647h CLIA BSP1,BSP-1,Homo sapiens,hSMAD1,Human,JV4-1,MAD homolog 1,MADH1,MADR1,Mad-related protein 1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,SMAD 1,SMAD family member 1,Smad 96T
E0647h ELISA BSP1,BSP-1,Homo sapiens,hSMAD1,Human,JV4-1,MAD homolog 1,MADH1,MADR1,Mad-related protein 1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,SMAD 1,SMAD family member 1,Sma 96T
E0647h ELISA kit BSP1,BSP-1,Homo sapiens,hSMAD1,Human,JV4-1,MAD homolog 1,MADH1,MADR1,Mad-related protein 1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,SMAD 1,SMAD family member 96T
E2184h ELISA kit hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,S 96T
U2184h CLIA kit hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,Sm 96T
EIAAB38716 Deletion target in pancreatic carcinoma 4,DPC4,Homo sapiens,hSMAD4,Human,MAD homolog 4,MADH4,Mothers against decapentaplegic homolog 4,Mothers against DPP homolog 4,SMAD 4,SMAD family member 4,Smad4,S
E2184h ELISA hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,Smad2, 96T
U2184h CLIA hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,Smad2,S 96T
E2187m ELISA kit MAD homolog 6,Mad homolog 7,Madh6,Madh7,Mothers against decapentaplegic homolog 6,Mothers against DPP homolog 6,Mouse,Msmad6,Mus musculus,SMAD 6,SMAD family member 6,Smad6,Smad6 96T
U2187m CLIA kit MAD homolog 6,Mad homolog 7,Madh6,Madh7,Mothers against decapentaplegic homolog 6,Mothers against DPP homolog 6,Mouse,Msmad6,Mus musculus,SMAD 6,SMAD family member 6,Smad6,Smad6 96T
U2187m CLIA MAD homolog 6,Mad homolog 7,Madh6,Madh7,Mothers against decapentaplegic homolog 6,Mothers against DPP homolog 6,Mouse,Msmad6,Mus musculus,SMAD 6,SMAD family member 6,Smad6,Smad6 96T
E2187m ELISA MAD homolog 6,Mad homolog 7,Madh6,Madh7,Mothers against decapentaplegic homolog 6,Mothers against DPP homolog 6,Mouse,Msmad6,Mus musculus,SMAD 6,SMAD family member 6,Smad6,Smad6 96T
E2187m MAD homolog 6,Mad homolog 7,Madh6,Madh7,Mothers against decapentaplegic homolog 6,Mothers against DPP homolog 6,Mouse,Msmad6,Mus musculus,SMAD 6,SMAD family member 6,Smad6,Smad6
U2185h CLIA hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3 96T
E2185h ELISA hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3 96T
U2185h CLIA kit hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3 96T
E2185h ELISA kit hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3 96T
U2184m CLIA kit MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
U2184m CLIA MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2184m ELISA MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2184m ELISA kit MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2185h hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3
E2184h hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,Smad2,SMAD2
E2184m MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2
Pathways :
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP32: Translation Factors
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1485: Interactions between CFTR and other ion channels
WP1799: Costimulation by the CD28 family
WP1780: ABC-family proteins mediated transport
WP1909: Signal regulatory protein (SIRP) family interactions
WP1596: Iron Homeostasis
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins

Related Genes :
[SMAD7 MADH7 MADH8] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
[Smad1 Madh1 Madr1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)
[Smad7 Madh7 Madh8] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7)
[SMAD4 DPC4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
[SMAD3 MADH3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
[SMAD2 MADH2 MADR2] Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
[SMAD6 MADH6] Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
[Smad4 Dpc4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad3 Madh3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)
[Smad1 Mad1 Madh1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1)
[Smad3 Madh3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3)
[SMAD4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[SMAD1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1)
[Smad4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad7 Madh7] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (SMAD family member 7) (SMAD 7) (Smad7)
[SMAD3 MADH3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)
[Smox Dmel\CG2262 DSMAD2 DSmad2 dSMAD2 dSmad2 dsmad2 l(1)G0348 Sad sad Smad SMAD2 Smad2 smad2 SMOX SmoX smox ted tmp CG2262 Dmel_CG2262] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Mad CG12399] Protein mothers against dpp
[ZFYVE9 MADHIP SARA SMADIP] Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)
[Dana\GF20979 dana_GLEANR_4213 Dana_GF20979 GF20979] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dvir\GJ18762 Dvir_GJ18762 GJ18762] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dgri\GH24864 Dgri_GH24864] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dpse\GA15332 Dpse_GA15332 GA15332] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dyak\GE17479 Dyak_GE17479] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dmoj\GI14415 Dmoj_GI14415] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dsec\GM11208 Dsec_GM11208] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dere\GG17985 Dere_GG17985] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dper\GL20193 Dper_GL20193] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

Bibliography :
[22879948] fussel (fuss)--A negative regulator of BMP signaling in Drosophila melanogaster.