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Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

 Q6DIZ6_XENTR            Unreviewed;       466 AA.
Q6DIZ6;
16-AUG-2004, integrated into UniProtKB/TrEMBL.
16-AUG-2004, sequence version 1.
16-OCT-2019, entry version 117.
RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
Name=smad9 {ECO:0000313|EMBL:AAH75389.1,
ECO:0000313|Ensembl:ENSXETP00000003841,
ECO:0000313|Xenbase:XB-GENE-484686};
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Silurana.
NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH75389.1};
[1] {ECO:0000313|EMBL:AAH75389.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Whole body {ECO:0000313|EMBL:AAH75389.1};
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSXETP00000003841}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000003841};
PubMed=20431018; DOI=10.1126/science.1183670;
Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
Rokhsar D.S.;
"The genome of the Western clawed frog Xenopus tropicalis.";
Science 328:633-636(2010).
[3] {ECO:0000313|Ensembl:ENSXETP00000003841}
IDENTIFICATION.
Ensembl;
Submitted (JUN-2011) to UniProtKB.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
Nucleus {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00573677}.
-!- SIMILARITY: Belongs to the dwarfin/SMAD family.
{ECO:0000256|RuleBase:RU361195}.
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EMBL; AAMC01094635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAMC01094636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAMC01094637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAMC01094638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC075389; AAH75389.1; -; mRNA.
RefSeq; NP_001007479.1; NM_001007478.1.
STRING; 8364.ENSXETP00000003841; -.
Ensembl; ENSXETT00000003841; ENSXETP00000003841; ENSXETG00000001820.
GeneID; 493210; -.
KEGG; xtr:493210; -.
CTD; 4093; -.
Xenbase; XB-GENE-484686; smad9.
eggNOG; KOG3701; Eukaryota.
eggNOG; ENOG410XQKU; LUCA.
GeneTree; ENSGT00940000154391; -.
HOGENOM; HOG000286018; -.
KO; K16791; -.
OMA; CSASYPH; -.
OrthoDB; 608001at2759; -.
TreeFam; TF314923; -.
Reactome; R-XTR-201451; Signaling by BMP.
Proteomes; UP000008143; Unassembled WGS sequence.
Bgee; ENSXETG00000001820; Expressed in 12 organ(s), highest expression level in heart.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
Gene3D; 2.60.200.10; -; 1.
Gene3D; 3.90.520.10; -; 1.
InterPro; IPR013790; Dwarfin.
InterPro; IPR003619; MAD_homology1_Dwarfin-type.
InterPro; IPR013019; MAD_homology_MH1.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR001132; SMAD_dom_Dwarfin-type.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036578; SMAD_MH1_sf.
PANTHER; PTHR13703; PTHR13703; 1.
Pfam; PF03165; MH1; 1.
Pfam; PF03166; MH2; 1.
SMART; SM00523; DWA; 1.
SMART; SM00524; DWB; 1.
SUPFAM; SSF49879; SSF49879; 1.
SUPFAM; SSF56366; SSF56366; 1.
PROSITE; PS51075; MH1; 1.
PROSITE; PS51076; MH2; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000008143};
Cytoplasm {ECO:0000256|RuleBase:RU361195};
DNA-binding {ECO:0000256|RuleBase:RU361195};
Nucleus {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00464850};
Reference proteome {ECO:0000313|Proteomes:UP000008143};
Transcription {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00094697};
Transcription regulation {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00094697}.
DOMAIN 16 140 MH1. {ECO:0000259|PROSITE:PS51075}.
DOMAIN 272 466 MH2. {ECO:0000259|PROSITE:PS51076}.
REGION 171 244 Disordered. {ECO:0000256|SAM:MobiDB-
lite}.
COILED 38 58 {ECO:0000256|SAM:Coils}.
COMPBIAS 171 221 Polar. {ECO:0000256|SAM:MobiDB-lite}.
SEQUENCE 466 AA; 52489 MW; BD761CA2AB2A4FC4 CRC64;
MHASTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG AMEELERALS
CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD LQSHHELKPM ECCEFPFGSK
QKDVCINPYH YRRVETPVLP PVLVPRHSEF NPQLSLLAKF RNTSLNNEPL MPHNATFPES
FQQQPPCTPF SSSPSNIFPQ SPTTVGYPDS PQSSADPGSP YQITETPPPP YNAPDIQGNQ
NRPTADPAAC QLVLSALNRD FRPVCYEEPL HWCSVAYYEL NNRVGETFQA SSRSVLIDGF
TDPSNNKNRF CLGLLSNVNR NSTIENTRRH IGKGVHLYYV GGEVYAECVS DSSIFVQSRN
CNYQHGFHPS TVCKIPSGCS LKIFNNQLFA QLLSQSVNQG FEVVYELTKM CTIRMSFVKG
WGAEYHRQDV TSTPCWIEIH LHGPLQWLDK VLTQMGSPHN PISSVS


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WP1780: ABC-family proteins mediated transport
WP1909: Signal regulatory protein (SIRP) family interactions
WP1596: Iron Homeostasis
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[Smad1 Madh1 Madr1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)
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[Smad3 Madh3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)
[SMAD3 MADH3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)
[Smad3 Madh3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3)
[Smad1 Mad1 Madh1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1)
[SMAD4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad7 Madh7] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (SMAD family member 7) (SMAD 7) (Smad7)
[SMAD3 MADH3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)
[SMAD1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1)
[Smox Dmel\CG2262 DSMAD2 DSmad2 dSMAD2 dSmad2 dsmad2 l(1)G0348 Sad sad Smad SMAD2 Smad2 smad2 SMOX SmoX smox ted tmp CG2262 Dmel_CG2262] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD3] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

Bibliography :
[22879948] fussel (fuss)--A negative regulator of BMP signaling in Drosophila melanogaster.