GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)

 SMAD1_MOUSE             Reviewed;         465 AA.
P70340; P70442; Q6GT95; Q9CYK6;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
02-DEC-2020, entry version 196.
RecName: Full=Mothers against decapentaplegic homolog 1;
Short=MAD homolog 1;
Short=Mothers against DPP homolog 1;
AltName: Full=Dwarfin-A;
Short=Dwf-A;
AltName: Full=Mothers-against-DPP-related 1;
Short=Mad-related protein 1;
Short=mMad1;
AltName: Full=SMAD family member 1;
Short=SMAD 1;
Short=Smad1;
Name=Smad1; Synonyms=Madh1, Madr1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryo;
PubMed=8799132; DOI=10.1073/pnas.93.17.8940;
Yingling J.M., Das P., Savage C., Zhang M., Padgett R.W., Wang X.-F.;
"Mammalian dwarfins are phosphorylated in response to transforming growth
factor beta and are implicated in control of cell growth.";
Proc. Natl. Acad. Sci. U.S.A. 93:8940-8944(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryonic heart;
PubMed=9076678; DOI=10.1016/s0925-4773(96)00622-3;
Zhao G.-Q., Hogan B.L.M.;
"Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the
initiation and maintenance of spermatogenesis in the mouse.";
Mech. Dev. 61:63-73(1997).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=11111041; DOI=10.1016/s0378-1119(00)00396-6;
Huang S., Flanders K.C., Roberts A.B.;
"Characterization of the mouse Smad1 gene and its expression pattern in
adult mouse tissues.";
Gene 258:43-53(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryo, and Oviduct;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
INTERACTION WITH HGS.
PubMed=11094085; DOI=10.1128/mcb.20.24.9346-9355.2000;
Miura S., Takeshita T., Asao H., Kimura Y., Murata K., Sasaki Y., Hanai J.,
Beppu H., Tsukazaki T., Wrana J.L., Miyazono K., Sugamura K.;
"Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through
cooperation with SARA.";
Mol. Cell. Biol. 20:9346-9355(2000).
[7]
INTERACTION WITH ZNF8.
PubMed=12370310; DOI=10.1128/mcb.22.21.7633-7644.2002;
Jiao K., Zhou Y., Hogan B.L.M.;
"Identification of mZnf8, a mouse Kruppel-like transcriptional repressor,
as a novel nuclear interaction partner of Smad1.";
Mol. Cell. Biol. 22:7633-7644(2002).
[8]
FUNCTION, AND IDENTIFICATION IN A COMPLEX WITH SMAD4 AND YY1.
PubMed=15329343; DOI=10.1242/dev.01344;
Lee K.H., Evans S., Ruan T.Y., Lassar A.B.;
"SMAD-mediated modulation of YY1 activity regulates the BMP response and
cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5
enhancer.";
Development 131:4709-4723(2004).
[9]
INTERACTION WITH ZC3H3.
PubMed=16115198; DOI=10.1111/j.1365-2443.2005.00887.x;
Collart C., Remacle J.E., Barabino S., van Grunsven L.A., Nelles L.,
Schellens A., Van de Putte T., Pype S., Huylebroeck D., Verschueren K.;
"Smicl is a novel Smad interacting protein and cleavage and polyadenylation
specificity factor associated protein.";
Genes Cells 10:897-906(2005).
[10]
INTERACTION WITH NANOG.
PubMed=16801560; DOI=10.1073/pnas.0506945103;
Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K.,
Gage F.H., Rodriguez-Esteban C., Izpisua Belmonte J.C.;
"Nanog binds to Smad1 and blocks bone morphogenetic protein-induced
differentiation of embryonic stem cells.";
Proc. Natl. Acad. Sci. U.S.A. 103:10294-10299(2006).
[11]
INTERACTION WITH ZCCHC12.
PubMed=18160706; DOI=10.1128/mcb.01038-07;
Cho G., Lim Y., Zand D., Golden J.A.;
"Sizn1 is a novel protein that functions as a transcriptional coactivator
of bone morphogenic protein signaling.";
Mol. Cell. Biol. 28:1565-1572(2008).
[12]
INTERACTION WITH TMEM119.
PubMed=21239498; DOI=10.1074/jbc.m110.179127;
Hisa I., Inoue Y., Hendy G.N., Canaff L., Kitazawa R., Kitazawa S.,
Komori T., Sugimoto T., Seino S., Kaji H.;
"Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes
osteoblast differentiation and interacts with the bone morphogenetic
protein-Runx2 pathway.";
J. Biol. Chem. 286:9787-9796(2011).
[13]
INTERACTION WITH RANBP3L, DEPHOSPHORYLATION, AND SUBCELLULAR LOCATION.
PubMed=25755279; DOI=10.1128/mcb.00121-15;
Chen F., Lin X., Xu P., Zhang Z., Chen Y., Wang C., Han J., Zhao B.,
Xiao M., Feng X.H.;
"Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein
signaling and mesenchymal stem cell differentiation.";
Mol. Cell. Biol. 35:1700-1711(2015).
[14]
X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 9-132 IN COMPLEX WITH DNA,
ZINC_BINDING SITES, AND SUBUNIT.
PubMed=20147459; DOI=10.1093/nar/gkq046;
Baburajendran N., Palasingam P., Narasimhan K., Sun W., Prabhakar S.,
Jauch R., Kolatkar P.R.;
"Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of
BMP and TGF-beta effectors.";
Nucleic Acids Res. 38:3477-3488(2010).
-!- FUNCTION: Transcriptional modulator activated by BMP (bone
morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-
regulated SMAD (R-SMAD) (By similarity). May play a role in the
initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex
mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By
similarity). May act synergistically with SMAD4 and YY1 in bone
morphogenetic protein (BMP)-mediated cardiac-specific gene expression
(PubMed:15329343). {ECO:0000250|UniProtKB:Q15797,
ECO:0000269|PubMed:15329343}.
-!- SUBUNIT: Upon C-terminus phosphorylation: forms trimers with another
SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-
binding protein (CBP), p300, SMURF1, SMURF2, USP15 and HOXC8.
Associates with ZNF423 or ZNF521 in response to BMP2 leading to
activate transcription of BMP target genes. Interacts with SKOR1.
Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at
least a partial reduction of receptor-mediated phosphorylation (By
similarity). Also interacts with HGS, NANOG and ZCCHC12. Forms a
ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into
the 20S proteasome (By similarity). Found in a complex with SMAD4 and
YY1. Interacts (via MH2 domain) with FAM83G (via MH2 domain); in a
SMAD4-independent manner. Interacts with ZC3H3 (PubMed:16115198).
Interacts with TMEM119 (PubMed:21239498). Interacts (via MH1 and MH2
domains) with ZNF8 (PubMed:12370310). Interacts with RANBP3L; the
interaction increases when SMAD1 is not phosphorylated and mediates
SMAD1 nuclear export (PubMed:25755279). {ECO:0000250|UniProtKB:Q15797,
ECO:0000269|PubMed:11094085, ECO:0000269|PubMed:12370310,
ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:16115198,
ECO:0000269|PubMed:16801560, ECO:0000269|PubMed:18160706,
ECO:0000269|PubMed:20147459, ECO:0000269|PubMed:21239498,
ECO:0000269|PubMed:25755279}.
-!- INTERACTION:
P70340; Q62073: Map3k7; NbExp=3; IntAct=EBI-6992047, EBI-1775345;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25755279}. Nucleus
{ECO:0000269|PubMed:25755279}. Note=In the cytoplasm in the absence of
ligand. Migration to the nucleus when complexed with SMAD4. Colocalizes
with LEMD3 at the nucleus inner membrane. Exported from the nucleus to
the cytoplasm when dephosphorylated (PubMed:25755279).
{ECO:0000250|UniProtKB:Q15797, ECO:0000269|PubMed:25755279}.
-!- TISSUE SPECIFICITY: Ubiquitous.
-!- DEVELOPMENTAL STAGE: Ubiquitously expressed during embryogenesis.
Expression starts in some seminiferous tubules at 2 weeks of age. After
mid-puberty a stage-specific expression is established. During the
cycling of the seminiferous epithelium, expression initiates in the
pachytene spermatocytes of stage V seminiferous tubules, peaks at stage
X, then decreases as pachytene spermatocytes differentiate into
secondary spermatocytes and then round spermatids.
-!- DOMAIN: The MH2 domain mediates phosphorylation-dependent trimerization
through L3 loop binding of phosphoserines in the adjacent subunit.
{ECO:0000250|UniProtKB:Q15797}.
-!- PTM: Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor
kinase activates SMAD1 by promoting dissociation from the receptor and
trimerization with SMAD4 (By similarity). Dephosphorylation, probably
by PPM1A, induces its export from the nucleus to the cytoplasm
(PubMed:25755279). {ECO:0000250|UniProtKB:Q15797,
ECO:0000269|PubMed:25755279}.
-!- PTM: Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading
to its degradation. Monoubiquitinated, leading to prevent DNA-binding.
Deubiquitination by USP15 alleviates inhibition and promotes activation
of TGF-beta target genes (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the dwarfin/SMAD family. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; U58992; AAC52785.1; -; mRNA.
EMBL; U74359; AAB18256.1; -; mRNA.
EMBL; AF295768; AAG41407.1; -; Genomic_DNA.
EMBL; AF295763; AAG41407.1; JOINED; Genomic_DNA.
EMBL; AF295764; AAG41407.1; JOINED; Genomic_DNA.
EMBL; AF295765; AAG41407.1; JOINED; Genomic_DNA.
EMBL; AF295766; AAG41407.1; JOINED; Genomic_DNA.
EMBL; AF295767; AAG41407.1; JOINED; Genomic_DNA.
EMBL; AK017583; BAB30820.1; -; mRNA.
EMBL; AK054104; BAC35658.1; -; mRNA.
EMBL; BC058693; AAH58693.1; -; mRNA.
CCDS; CCDS22437.1; -.
RefSeq; NP_032565.2; NM_008539.3.
RefSeq; XP_006530809.1; XM_006530746.3.
PDB; 3KMP; X-ray; 2.70 A; A/B=9-132.
PDBsum; 3KMP; -.
SMR; P70340; -.
BioGRID; 201274; 34.
ComplexPortal; CPX-145; SMAD1 homotrimer.
ComplexPortal; CPX-146; SMAD1-SMAD4 complex.
CORUM; P70340; -.
IntAct; P70340; 9.
MINT; P70340; -.
STRING; 10090.ENSMUSP00000071035; -.
ChEMBL; CHEMBL3883282; -.
iPTMnet; P70340; -.
PhosphoSitePlus; P70340; -.
EPD; P70340; -.
MaxQB; P70340; -.
PaxDb; P70340; -.
PeptideAtlas; P70340; -.
PRIDE; P70340; -.
Antibodypedia; 3950; 1300 antibodies.
Ensembl; ENSMUST00000066091; ENSMUSP00000071035; ENSMUSG00000031681.
GeneID; 17125; -.
KEGG; mmu:17125; -.
UCSC; uc009mip.2; mouse.
CTD; 4086; -.
MGI; MGI:109452; Smad1.
eggNOG; KOG3701; Eukaryota.
GeneTree; ENSGT00940000154391; -.
HOGENOM; CLU_026736_0_2_1; -.
InParanoid; P70340; -.
OMA; EVFHCNS; -.
OrthoDB; 608001at2759; -.
TreeFam; TF314923; -.
Reactome; R-MMU-201451; Signaling by BMP.
Reactome; R-MMU-5689880; Ub-specific processing proteases.
Reactome; R-MMU-8941326; RUNX2 regulates bone development.
BioGRID-ORCS; 17125; 2 hits in 19 CRISPR screens.
ChiTaRS; Smad1; mouse.
EvolutionaryTrace; P70340; -.
PRO; PR:P70340; -.
Proteomes; UP000000589; Chromosome 8.
RNAct; P70340; protein.
Bgee; ENSMUSG00000031681; Expressed in pineal body and 342 other tissues.
ExpressionAtlas; P70340; baseline and differential.
Genevisible; P70340; MM.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0071144; C:heteromeric SMAD protein complex; IBA:GO_Central.
GO; GO:0005637; C:nuclear inner membrane; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
GO; GO:0070410; F:co-SMAD binding; ISO:MGI.
GO; GO:0017151; F:DEAD/H-box RNA helicase binding; ISO:MGI.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
GO; GO:0070411; F:I-SMAD binding; ISO:MGI.
GO; GO:0042802; F:identical protein binding; IPI:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0070878; F:primary miRNA binding; IDA:BHF-UCL.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0008134; F:transcription factor binding; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
GO; GO:0060348; P:bone development; IGI:MGI.
GO; GO:0060038; P:cardiac muscle cell proliferation; IMP:MGI.
GO; GO:0051216; P:cartilage development; IGI:MGI.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0071773; P:cellular response to BMP stimulus; IGI:BHF-UCL.
GO; GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.
GO; GO:0009880; P:embryonic pattern specification; ISS:UniProtKB.
GO; GO:0007276; P:gamete generation; IMP:MGI.
GO; GO:0030902; P:hindbrain development; IMP:MGI.
GO; GO:0042592; P:homeostatic process; IMP:MGI.
GO; GO:0006954; P:inflammatory response; IEP:UniProtKB.
GO; GO:0000165; P:MAPK cascade; IMP:MGI.
GO; GO:0001710; P:mesodermal cell fate commitment; IGI:MGI.
GO; GO:0030901; P:midbrain development; IMP:MGI.
GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:MGI.
GO; GO:0002051; P:osteoblast fate commitment; IGI:MGI.
GO; GO:0061036; P:positive regulation of cartilage development; IDA:MGI.
GO; GO:0045597; P:positive regulation of cell differentiation; ISO:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IGI:MGI.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IMP:BHF-UCL.
GO; GO:1903672; P:positive regulation of sprouting angiogenesis; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:1901522; P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; IGI:BHF-UCL.
GO; GO:0006468; P:protein phosphorylation; IDA:MGI.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0042493; P:response to drug; ISO:MGI.
GO; GO:0007183; P:SMAD protein complex assembly; ISO:MGI.
GO; GO:0060395; P:SMAD protein signal transduction; IGI:BHF-UCL.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IBA:GO_Central.
GO; GO:0001657; P:ureteric bud development; IEP:UniProtKB.
Gene3D; 2.60.200.10; -; 1.
Gene3D; 3.90.520.10; -; 1.
InterPro; IPR013790; Dwarfin.
InterPro; IPR003619; MAD_homology1_Dwarfin-type.
InterPro; IPR013019; MAD_homology_MH1.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR001132; SMAD_dom_Dwarfin-type.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036578; SMAD_MH1_sf.
PANTHER; PTHR13703; PTHR13703; 1.
Pfam; PF03165; MH1; 1.
Pfam; PF03166; MH2; 1.
SMART; SM00523; DWA; 1.
SMART; SM00524; DWB; 1.
SUPFAM; SSF49879; SSF49879; 1.
SUPFAM; SSF56366; SSF56366; 1.
PROSITE; PS51075; MH1; 1.
PROSITE; PS51076; MH2; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation; Zinc.
CHAIN 1..465
/note="Mothers against decapentaplegic homolog 1"
/id="PRO_0000090848"
DOMAIN 12..136
/note="MH1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00438"
DOMAIN 271..465
/note="MH2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00439"
REGION 418..428
/note="L3 loop"
/evidence="ECO:0000250|UniProtKB:Q15797"
COMPBIAS 39..45
/note="Poly-Lys"
METAL 64
/note="Zinc"
METAL 109
/note="Zinc"
METAL 121
/note="Zinc"
METAL 126
/note="Zinc"
MOD_RES 1
/note="N-acetylmethionine"
/evidence="ECO:0000250|UniProtKB:Q15797"
MOD_RES 322
/note="Phosphothreonine; by MINK1, TNIK and MAP4K4"
/evidence="ECO:0000250|UniProtKB:Q15797"
MOD_RES 463
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q15797,
ECO:0000255|PROSITE-ProRule:PRU00439"
MOD_RES 465
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q15797,
ECO:0000255|PROSITE-ProRule:PRU00439"
CONFLICT 95
/note="P -> S (in Ref. 1; AAC52785 and 3; AAG41407)"
/evidence="ECO:0000305"
CONFLICT 142
/note="R -> K (in Ref. 1; AAC52785 and 3; AAG41407)"
/evidence="ECO:0000305"
CONFLICT 199..200
/note="SS -> QG (in Ref. 2; AAB18256)"
/evidence="ECO:0000305"
CONFLICT 393
/note="A -> E (in Ref. 2; AAB18256)"
/evidence="ECO:0000305"
HELIX 12..19
/evidence="ECO:0000244|PDB:3KMP"
HELIX 25..41
/evidence="ECO:0000244|PDB:3KMP"
HELIX 47..56
/evidence="ECO:0000244|PDB:3KMP"
STRAND 66..68
/evidence="ECO:0000244|PDB:3KMP"
STRAND 71..73
/evidence="ECO:0000244|PDB:3KMP"
STRAND 75..77
/evidence="ECO:0000244|PDB:3KMP"
STRAND 80..82
/evidence="ECO:0000244|PDB:3KMP"
HELIX 84..92
/evidence="ECO:0000244|PDB:3KMP"
HELIX 100..102
/evidence="ECO:0000244|PDB:3KMP"
STRAND 103..105
/evidence="ECO:0000244|PDB:3KMP"
HELIX 113..115
/evidence="ECO:0000244|PDB:3KMP"
STRAND 118..121
/evidence="ECO:0000244|PDB:3KMP"
HELIX 124..126
/evidence="ECO:0000244|PDB:3KMP"
STRAND 127..129
/evidence="ECO:0000244|PDB:3KMP"
SEQUENCE 465 AA; 52157 MW; 07A56FBEE79A1C2A CRC64;
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE LEKALSCPGQ
PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH HELKPLECCE FPFGSKQKEV
CINPYHYKRV ESPVLPPVLV PRHSEYNPQH SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN
SHPFPHSPNS SYPNSPGGSS STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMAQDGSQ
PMDTNMMAPP LPAEISRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC
NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF ETVYELTKMC TIRMSFVKGW
GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPHNP ISSVS


Related products :

Catalog number Product name Quantity
U0647m CLIA Dwarfin-A,Dwf-A,MAD homolog 1,Madh1,Madr1,Mad-related protein 1,mMad1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,Mothers-against-DPP-related 1,Mouse,Mus musculus,SMAD 96T
U0647h CLIA BSP1,BSP-1,Homo sapiens,hSMAD1,Human,JV4-1,MAD homolog 1,MADH1,MADR1,Mad-related protein 1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,SMAD 1,SMAD family member 1,Smad 96T
E0647h ELISA kit BSP1,BSP-1,Homo sapiens,hSMAD1,Human,JV4-1,MAD homolog 1,MADH1,MADR1,Mad-related protein 1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,SMAD 1,SMAD family member 96T
E0647h ELISA BSP1,BSP-1,Homo sapiens,hSMAD1,Human,JV4-1,MAD homolog 1,MADH1,MADR1,Mad-related protein 1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,SMAD 1,SMAD family member 1,Sma 96T
U2184h CLIA kit hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,Sm 96T
E2184h ELISA kit hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,S 96T
E0647m ELISA kit Dwarfin-A,Dwf-A,MAD homolog 1,Madh1,Madr1,Mad-related protein 1,mMad1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,Mothers-against-DPP-related 1,Mouse,Mus musculu 96T
E0647m ELISA Dwarfin-A,Dwf-A,MAD homolog 1,Madh1,Madr1,Mad-related protein 1,mMad1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,Mothers-against-DPP-related 1,Mouse,Mus musculus,SMA 96T
E2184h ELISA hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,Smad2, 96T
U2184h CLIA hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,Smad2,S 96T
E0647r ELISA kit MAD homolog 1,Mad1,Madh1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,Rat,Rattus norvegicus,SMAD 1,SMAD family member 1,Smad1,Smad1 96T
E0647r ELISA MAD homolog 1,Mad1,Madh1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,Rat,Rattus norvegicus,SMAD 1,SMAD family member 1,Smad1,Smad1 96T
U0647r CLIA MAD homolog 1,Mad1,Madh1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,Rat,Rattus norvegicus,SMAD 1,SMAD family member 1,Smad1,Smad1 96T
U2184m CLIA kit MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
U2184m CLIA MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2184m ELISA kit MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2184m ELISA MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2184h hMAD-2,Homo sapiens,hSMAD2,Human,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,SMAD 2,SMAD family member 2,Smad2,SMAD2
E2184m MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2
U2184r CLIA MAD homolog 2,Madh2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Rat,Rattus norvegicus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2184r ELISA MAD homolog 2,Madh2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Rat,Rattus norvegicus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2184r ELISA kit MAD homolog 2,Madh2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Rat,Rattus norvegicus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
U2184r CLIA kit MAD homolog 2,Madh2,Mad-related protein 2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Rat,Rattus norvegicus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E0647b ELISA Bos taurus,Bovine,MAD homolog 1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,SMAD 1,SMAD family member 1,Smad1,SMAD1 96T
E0647b ELISA kit Bos taurus,Bovine,MAD homolog 1,Mothers against decapentaplegic homolog 1,Mothers against DPP homolog 1,SMAD 1,SMAD family member 1,Smad1,SMAD1 96T
Pathways :
WP731: Sterol regulatory element binding protein related
WP2199: Seed Development
WP2272: Pathogenic Escherichia coli infection
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP32: Translation Factors
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP201: Ptf1a related regulatory pathway
WP2080: TFs Regulate miRNAs related to cardiac hypertrophy
WP1596: Iron Homeostasis
WP1559: TFs Regulate miRNAs related to cardiac hypertrophy
WP211: BMP signaling pathway
WP1937: Transport of vitamins, nucleosides, and related molecules
WP1497: Hedgehog-related genes
WP1770: One carbon metabolism and related pathways
WP1909: Signal regulatory protein (SIRP) family interactions
WP1654: gamma-Hexachlorocyclohexane degradation
WP1493: Carbon assimilation C4 pathway
WP1694: Pyrimidine metabolism
WP2324: AGE/RAGE pathway
WP1048: TGF Beta Signaling Pathway
WP1714: Tyrosine metabolism
WP2371: Parkinsons Disease Pathway
WP1064: Delta-Notch Signaling Pathway
WP1661: Glyoxylate and dicarboxylate metabolism
WP2064: Neural Crest Differentiation

Related Genes :
[Smad1 Madh1 Madr1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
[Smad1 Mad1 Madh1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1)
[SMAD1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1)
[SMAD2 MADH2 MADR2] Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
[SMAD3 MADH3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
[SMAD6 MADH6] Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
[SMAD4 DPC4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
[SMAD7 MADH7 MADH8] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
[Smad4 Dpc4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad3 Madh3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3)
[SMAD4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad7 Madh7 Madh8] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7)
[Smad4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[SMAD3 MADH3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)
[Smad3 Madh3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)
[Smad7 Madh7] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (SMAD family member 7) (SMAD 7) (Smad7)
[Smox Dmel\CG2262 DSMAD2 DSmad2 dSMAD2 dSmad2 dsmad2 l(1)G0348 Sad sad Smad SMAD2 Smad2 smad2 SMOX SmoX smox ted tmp CG2262 Dmel_CG2262] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[SMAD4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Mad CG12399] Protein mothers against dpp
[ZFYVE9 MADHIP SARA SMADIP] Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)
[Dana\GF20979 dana_GLEANR_4213 Dana_GF20979 GF20979] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dvir\GJ18762 Dvir_GJ18762 GJ18762] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dmoj\GI14415 Dmoj_GI14415] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dyak\GE17479 Dyak_GE17479] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dgri\GH24864 Dgri_GH24864] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dper\GL20193 Dper_GL20193] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dsec\GM11208 Dsec_GM11208] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dere\GG17985 Dere_GG17985] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[BUB1B BUBR1 MAD3L SSK1] Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)

Bibliography :