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Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)

 SMAD4_RAT               Reviewed;         552 AA.
O70437;
04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
02-DEC-2020, entry version 152.
RecName: Full=Mothers against decapentaplegic homolog 4;
Short=MAD homolog 4;
Short=Mothers against DPP homolog 4;
AltName: Full=SMAD family member 4;
Short=SMAD 4;
Short=Smad4;
Name=Smad4; Synonyms=Madh4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle;
Miyakita A., Okuno S., Watanabe T.K., Oga K., Tsuji A., Hishigaki H.,
Suto T., Nakagawa K., Nakahara Y., Higashi K.;
"Molecular cloning of rat Smad4 gene.";
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10670756; DOI=10.1507/endocrj.46.695;
Osaki M., Tsukazaki T., Ono N., Yonekura A., Hirota Y., Miyazaki Y.,
Shindo H., Sonta S., Yamashita S.;
"cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their
expression in cultured rat articular chondrocytes.";
Endocr. J. 46:695-701(1999).
[3]
INTERACTION WITH CITED2.
PubMed=16619037; DOI=10.1038/sj.onc.1209552;
Chou Y.T., Wang H., Chen Y., Danielpour D., Yang Y.C.;
"Cited2 modulates TGF-beta-mediated upregulation of MMP9.";
Oncogene 25:5547-5560(2006).
-!- FUNCTION: Common SMAD (co-SMAD) is the coactivator and mediator of
signal transduction by TGF-beta (transforming growth factor). Component
of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the
nucleus and is required for the TGF-mediated signaling. Promotes
binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an
activation function required for SMAD1 or SMAD2 to stimulate
transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex
which forms at the AP1 promoter site; required for synergistic
transcriptional activity in response to TGF-beta. Acts synergistically
with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated
cardiac-specific gene expression. Binds to SMAD binding elements (SBEs)
(5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac
activating regions. May act as a tumor suppressor. Positively regulates
PDPK1 kinase activity by stimulating its dissociation from the 14-3-3
protein YWHAQ which acts as a negative regulator. In muscle physiology,
plays a central role in the balance between atrophy and hypertrophy.
When recruited by MSTN, promotes atrophy response via phosphorylated
SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment
by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer; in the absence of TGF-beta activation (By
similarity). Heterotrimer; on TGF-beta activation (By similarity).
Heterotrimer composed of two molecules of a C-terminally phosphorylated
R-SMAD molecule, SMAD2 or SMAD3, and one molecule of SMAD4 to form the
transcriptional active SMAD2/SMAD3-SMAD4 complex (By similarity). Found
in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Found
in a complex with SMAD1 and YY1. Identified in a complex that contains
at least ZNF451, SMAD2, SMAD3 and SMAD4 (By similarity).Interacts with
ATF2, COPS5, DACH1, MSG1, SKI, STK11/LKB1, STK11IP and TRIM33.
Associates with ZNF423 or ZNF521 in response to BMP2 leading to
activate transcription of BMP target genes. Interacts with USP9X.
Interacts with RBPMS. Interacts with WWTR1 (via coiled-coil domain).
Interacts with CITED1 and CITED2. Interacts with PDPK1 (via PH domain).
Interacts with VPS39; this interaction affects heterodimer formation
with SMAD3, but not with SMAD2, and leads to inhibition of SMAD3-
dependent transcription activation. Interactions with VPS39 and SMAD2
may be mutually exclusive (By similarity). Interacts (via MH2 domain)
with ZNF451 (via N-terminal zinc-finger domains) (By similarity).
Interacts with ZC3H3 (By similarity). Interacts weakly with ZNF8 (By
similarity). Interacts with NUP93 and IPO7; translocates SMAD4 to the
nucleus through the NPC upon BMP7 stimulation resulting in activation
of SMAD4 signaling (By similarity). Interacts with CREB3L1, the
interaction takes place upon TGFB1 induction and SMAD4 acts as CREB3L1
coactivator to induce the expression of genes involved in the assembly
of collagen extracellular matrix (By similarity). Interacts with DLX1
(By similarity). Interacts with ZBTB7A; the interaction is direct and
stimulated by TGFB1 (By similarity). Interacts with CREBBP; the
recruitment of this transcriptional coactivator is negatively regulated
by ZBTB7A (By similarity). Interacts with EP300; the interaction with
this transcriptional coactivator is negatively regulated by ZBTB7A (By
similarity). Interacts with HDAC1 (By similarity). Interacts (via MH2
domain) with ZMIZ1 (via SP-RING-type domain); in the TGF-beta signaling
pathway increases the activity of the SMAD3/SMAD4 transcriptional
complex (By similarity). {ECO:0000250|UniProtKB:P97471,
ECO:0000250|UniProtKB:Q13485, ECO:0000269|PubMed:16619037}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13485}. Nucleus
{ECO:0000250|UniProtKB:Q13485}. Note=In the cytoplasm in the absence of
ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1
prevents its nuclear translocation. {ECO:0000250|UniProtKB:Q13485}.
-!- DOMAIN: The MH1 domain is required for DNA binding. {ECO:0000250}.
-!- DOMAIN: The MH2 domain is required for both homomeric and heteromeric
interactions and for transcriptional regulation. Sufficient for nuclear
import (By similarity). {ECO:0000250}.
-!- PTM: Phosphorylated by PDPK1. {ECO:0000250}.
-!- PTM: Monoubiquitinated on Lys-519 by E3 ubiquitin-protein ligase
TRIM33. Monoubiquitination hampers its ability to form a stable complex
with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP
signaling cascade. Deubiquitination by USP9X restores its competence to
mediate TGF-beta signaling (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the dwarfin/SMAD family. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; AB010954; BAA83092.1; -; mRNA.
EMBL; AF056002; AAC12781.1; -; mRNA.
RefSeq; NP_062148.1; NM_019275.3.
SMR; O70437; -.
IntAct; O70437; 1.
MINT; O70437; -.
STRING; 10116.ENSRNOP00000021113; -.
iPTMnet; O70437; -.
PhosphoSitePlus; O70437; -.
jPOST; O70437; -.
PRIDE; O70437; -.
GeneID; 50554; -.
KEGG; rno:50554; -.
CTD; 4089; -.
RGD; 3033; Smad4.
eggNOG; KOG3701; Eukaryota.
InParanoid; O70437; -.
OrthoDB; 905048at2759; -.
PhylomeDB; O70437; -.
Reactome; R-RNO-1181150; Signaling by NODAL.
Reactome; R-RNO-1502540; Signaling by Activin.
Reactome; R-RNO-201451; Signaling by BMP.
Reactome; R-RNO-2173789; TGF-beta receptor signaling activates SMADs.
Reactome; R-RNO-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
Reactome; R-RNO-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
Reactome; R-RNO-5689880; Ub-specific processing proteases.
Reactome; R-RNO-8941326; RUNX2 regulates bone development.
Reactome; R-RNO-8941855; RUNX3 regulates CDKN1A transcription.
Reactome; R-RNO-9617828; FOXO-mediated transcription of cell cycle genes.
PRO; PR:O70437; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0032444; C:activin responsive factor complex; ISO:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0071144; C:heteromeric SMAD protein complex; IBA:GO_Central.
GO; GO:0000790; C:nuclear chromatin; ISO:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0032991; C:protein-containing complex; IDA:RGD.
GO; GO:0090575; C:RNA polymerase II transcription regulator complex; ISO:RGD.
GO; GO:0071141; C:SMAD protein complex; ISO:RGD.
GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
GO; GO:0003682; F:chromatin binding; ISO:RGD.
GO; GO:0005518; F:collagen binding; ISO:RGD.
GO; GO:0003677; F:DNA binding; IDA:RGD.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
GO; GO:0031005; F:filamin binding; IPI:RGD.
GO; GO:0070411; F:I-SMAD binding; ISO:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
GO; GO:0070412; F:R-SMAD binding; ISO:RGD.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; ISO:RGD.
GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
GO; GO:0046332; F:SMAD binding; IPI:RGD.
GO; GO:0043199; F:sulfate binding; ISO:RGD.
GO; GO:0001223; F:transcription coactivator binding; ISO:RGD.
GO; GO:0008134; F:transcription factor binding; IBA:GO_Central.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISO:RGD.
GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
GO; GO:0030325; P:adrenal gland development; IEP:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
GO; GO:0036302; P:atrioventricular canal development; ISO:RGD.
GO; GO:0003190; P:atrioventricular valve formation; ISO:RGD.
GO; GO:0007411; P:axon guidance; ISO:RGD.
GO; GO:0030509; P:BMP signaling pathway; ISO:RGD.
GO; GO:0003360; P:brainstem development; ISO:RGD.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISO:RGD.
GO; GO:0003279; P:cardiac septum development; ISO:RGD.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0008283; P:cell population proliferation; ISO:RGD.
GO; GO:0006879; P:cellular iron ion homeostasis; ISO:RGD.
GO; GO:0071333; P:cellular response to glucose stimulus; IDA:RGD.
GO; GO:0048589; P:developmental growth; ISO:RGD.
GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
GO; GO:0060956; P:endocardial cell differentiation; ISO:RGD.
GO; GO:0007492; P:endoderm development; ISO:RGD.
GO; GO:0042118; P:endothelial cell activation; ISO:RGD.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; ISO:RGD.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IMP:RGD.
GO; GO:0008585; P:female gonad development; ISO:RGD.
GO; GO:0061040; P:female gonad morphogenesis; ISO:RGD.
GO; GO:0048859; P:formation of anatomical boundary; ISO:RGD.
GO; GO:0007369; P:gastrulation; ISO:RGD.
GO; GO:0001702; P:gastrulation with mouth forming second; ISO:RGD.
GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
GO; GO:0070102; P:interleukin-6-mediated signaling pathway; ISO:RGD.
GO; GO:0035556; P:intracellular signal transduction; ISO:RGD.
GO; GO:0001822; P:kidney development; ISO:RGD.
GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; ISO:RGD.
GO; GO:0008584; P:male gonad development; ISO:RGD.
GO; GO:0007498; P:mesoderm development; ISO:RGD.
GO; GO:0072133; P:metanephric mesenchyme morphogenesis; ISO:RGD.
GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; ISO:RGD.
GO; GO:1905305; P:negative regulation of cardiac myofibril assembly; ISO:RGD.
GO; GO:0060548; P:negative regulation of cell death; ISO:RGD.
GO; GO:0030308; P:negative regulation of cell growth; ISO:RGD.
GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISO:RGD.
GO; GO:0042177; P:negative regulation of protein catabolic process; IMP:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0072134; P:nephrogenic mesenchyme morphogenesis; ISO:RGD.
GO; GO:0014033; P:neural crest cell differentiation; ISO:RGD.
GO; GO:0048663; P:neuron fate commitment; ISO:RGD.
GO; GO:0001649; P:osteoblast differentiation; IMP:RGD.
GO; GO:0003148; P:outflow tract septum morphogenesis; ISO:RGD.
GO; GO:0001541; P:ovarian follicle development; IEP:RGD.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISO:RGD.
GO; GO:0010666; P:positive regulation of cardiac muscle cell apoptotic process; IMP:RGD.
GO; GO:0003251; P:positive regulation of cell proliferation involved in heart valve morphogenesis; ISO:RGD.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISO:RGD.
GO; GO:0046881; P:positive regulation of follicle-stimulating hormone secretion; ISO:RGD.
GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; ISO:RGD.
GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; ISO:RGD.
GO; GO:0033686; P:positive regulation of luteinizing hormone secretion; ISO:RGD.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISO:RGD.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; ISO:RGD.
GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
GO; GO:0051098; P:regulation of binding; ISO:RGD.
GO; GO:0042127; P:regulation of cell population proliferation; ISO:RGD.
GO; GO:0051797; P:regulation of hair follicle development; ISO:RGD.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
GO; GO:0032909; P:regulation of transforming growth factor beta2 production; ISO:RGD.
GO; GO:0001666; P:response to hypoxia; ISO:RGD.
GO; GO:0071559; P:response to transforming growth factor beta; ISO:RGD.
GO; GO:0048733; P:sebaceous gland development; ISO:RGD.
GO; GO:0062009; P:secondary palate development; ISO:RGD.
GO; GO:0072520; P:seminiferous tubule development; ISO:RGD.
GO; GO:0007338; P:single fertilization; ISO:RGD.
GO; GO:0007183; P:SMAD protein complex assembly; ISO:RGD.
GO; GO:0060395; P:SMAD protein signal transduction; ISO:RGD.
GO; GO:0032525; P:somite rostral/caudal axis specification; ISO:RGD.
GO; GO:0007283; P:spermatogenesis; ISO:RGD.
GO; GO:0048729; P:tissue morphogenesis; ISO:RGD.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISO:RGD.
GO; GO:0060065; P:uterus development; ISO:RGD.
GO; GO:0060412; P:ventricular septum morphogenesis; ISO:RGD.
GO; GO:0042060; P:wound healing; IMP:RGD.
Gene3D; 2.60.200.10; -; 1.
Gene3D; 3.90.520.10; -; 1.
InterPro; IPR013790; Dwarfin.
InterPro; IPR003619; MAD_homology1_Dwarfin-type.
InterPro; IPR013019; MAD_homology_MH1.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR001132; SMAD_dom_Dwarfin-type.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036578; SMAD_MH1_sf.
PANTHER; PTHR13703; PTHR13703; 1.
Pfam; PF03165; MH1; 1.
Pfam; PF03166; MH2; 1.
SMART; SM00523; DWA; 1.
SMART; SM00524; DWB; 1.
SUPFAM; SSF49879; SSF49879; 1.
SUPFAM; SSF56366; SSF56366; 1.
PROSITE; PS51075; MH1; 1.
PROSITE; PS51076; MH2; 1.
1: Evidence at protein level;
Acetylation; Cytoplasm; DNA-binding; Isopeptide bond; Metal-binding;
Nucleus; Reference proteome; Transcription; Transcription regulation;
Ubl conjugation; Zinc.
CHAIN 1..552
/note="Mothers against decapentaplegic homolog 4"
/id="PRO_0000090864"
DOMAIN 18..142
/note="MH1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00438"
DOMAIN 323..552
/note="MH2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00439"
REGION 1..322
/note="Mediates interaction with ZBTB7A"
/evidence="ECO:0000250|UniProtKB:Q13485"
REGION 275..320
/note="SAD"
COMPBIAS 451..466
/note="Poly-Ala"
METAL 71
/note="Zinc"
/evidence="ECO:0000250"
METAL 115
/note="Zinc"
/evidence="ECO:0000250"
METAL 127
/note="Zinc"
/evidence="ECO:0000250"
METAL 132
/note="Zinc"
/evidence="ECO:0000250"
SITE 515
/note="Necessary for heterotrimerization"
/evidence="ECO:0000250"
MOD_RES 37
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:Q13485"
MOD_RES 428
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:Q13485"
MOD_RES 507
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:Q13485"
CROSSLNK 113
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2)"
/evidence="ECO:0000250|UniProtKB:Q13485"
CROSSLNK 519
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q13485"
SEQUENCE 552 AA; 60469 MW; 7AE0540AB4DF0E77 CRC64;
MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA
ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD
LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPPSMLVKD EYVHDFEGQP SLPTEGHSIQ
TIQHPPSNRA STETYSAPAL LAPSESNATS TTNFPNIPVA STSQPASILA GSHSEGLLQI
ASGPQPGQQQ NGFTAQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH
YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD
RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR
APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP
AISLSAAAGI GVDDLRRLCI LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL
HTMPIADPQP LD


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E2187m MAD homolog 6,Mad homolog 7,Madh6,Madh7,Mothers against decapentaplegic homolog 6,Mothers against DPP homolog 6,Mouse,Msmad6,Mus musculus,SMAD 6,SMAD family member 6,Smad6,Smad6
E2185h ELISA hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3 96T
U2185h CLIA kit hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3 96T
U2185h CLIA hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3 96T
E2185h ELISA kit hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3 96T
E2184m ELISA MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2185h hMAD-3,Homo sapiens,hSMAD3,Human,JV15-2,MAD homolog 3,Mad3,MADH3,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMAD 3,SMAD family member 3,Smad3,SMAD3
U2184m CLIA kit MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
E2184m ELISA kit MAD homolog 2,Madh2,Madr2,Mad-related protein 2,mMad2,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,Mouse,Mus musculus,SMAD 2,SMAD family member 2,Smad2,Smad2 96T
Pathways :
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP32: Translation Factors
WP1596: Iron Homeostasis
WP1045: TGF-beta Receptor Signaling Pathway
WP230: TGF Beta Signaling Pathway
WP934: Id Signaling Pathway
WP1425: BMP signalling and regulation
WP539: Wnt Signaling Pathway NetPath
WP1591: Heart Development
WP68: Androgen Receptor Signaling Pathway
WP1058: Senescence and Autophagy
WP2377: Integrated Pancreatic Cancer Pathway
WP964: Cell cycle
WP1098: Wnt Signaling Pathway
WP265: Delta-Notch Signaling Pathway
WP179: Cell cycle
WP783: Androgen Receptor Signaling Pathway
WP190: Cell cycle
WP815: Id Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP341: Nodal signaling pathway
WP1180: Delta-Notch Signaling Pathway
WP397: Id Signaling Pathway
WP2039: CDKN1A-EGF-CREB

Related Genes :
[SMAD4 DPC4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
[Smad4 Dpc4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
[SMAD4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
[SMAD7 MADH7 MADH8] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
[Smad1 Madh1 Madr1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)
[Smad7 Madh7 Madh8] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7)
[SMAD3 MADH3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
[SMAD2 MADH2 MADR2] Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
[SMAD6 MADH6] Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
[SMAD3 MADH3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)
[Smad3 Madh3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)
[Smad3 Madh3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3)
[Smad1 Mad1 Madh1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1)
[SMAD1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1)
[Smad7 Madh7] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (SMAD family member 7) (SMAD 7) (Smad7)
[SMAD4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smox Dmel\CG2262 DSMAD2 DSmad2 dSMAD2 dSmad2 dsmad2 l(1)G0348 Sad sad Smad SMAD2 Smad2 smad2 SMOX SmoX smox ted tmp CG2262 Dmel_CG2262] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dcp1a Mitc1 Smif] mRNA-decapping enzyme 1A (EC 3.-.-.-) (MAD homolog 4-interacting transcription coactivator 1) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)
[ZFYVE9 MADHIP SARA SMADIP] Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)
[Mad CG12399] Protein mothers against dpp
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[Dana\GF20979 dana_GLEANR_4213 Dana_GF20979 GF20979] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4] DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
[Dmoj\GI14415 Dmoj_GI14415] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dvir\GJ18762 Dvir_GJ18762 GJ18762] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dyak\GE17479 Dyak_GE17479] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
[Dgri\GH24864 Dgri_GH24864] Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

Bibliography :