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Multifunctional fusion protein [Includes: Phosphoglycerate kinase (EC 2.7.2.3); Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase)]

 A9BII4_PETMO            Unreviewed;       655 AA.
A9BII4;
15-JAN-2008, integrated into UniProtKB/TrEMBL.
15-JAN-2008, sequence version 1.
13-FEB-2019, entry version 100.
RecName: Full=Multifunctional fusion protein {ECO:0000256|HAMAP-Rule:MF_00145, ECO:0000256|HAMAP-Rule:MF_00147};
Includes:
RecName: Full=Triosephosphate isomerase {ECO:0000256|HAMAP-Rule:MF_00147};
Short=TIM {ECO:0000256|HAMAP-Rule:MF_00147};
Short=TPI {ECO:0000256|HAMAP-Rule:MF_00147};
EC=5.3.1.1 {ECO:0000256|HAMAP-Rule:MF_00147};
AltName: Full=Triose-phosphate isomerase {ECO:0000256|HAMAP-Rule:MF_00147};
Includes:
RecName: Full=Phosphoglycerate kinase {ECO:0000256|HAMAP-Rule:MF_00145};
EC=2.7.2.3 {ECO:0000256|HAMAP-Rule:MF_00145};
Name=tpiA {ECO:0000256|HAMAP-Rule:MF_00147};
Synonyms=pgk {ECO:0000256|HAMAP-Rule:MF_00145};
OrderedLocusNames=Pmob_1444 {ECO:0000313|EMBL:ABX32147.1};
Petrotoga mobilis (strain DSM 10674 / SJ95).
Bacteria; Thermotogae; Petrotogales; Petrotogaceae; Petrotoga.
NCBI_TaxID=403833 {ECO:0000313|EMBL:ABX32147.1, ECO:0000313|Proteomes:UP000000789};
[1] {ECO:0000313|EMBL:ABX32147.1, ECO:0000313|Proteomes:UP000000789}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DSM 10674 / SJ95 {ECO:0000313|Proteomes:UP000000789};
US DOE Joint Genome Institute;
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D.,
Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M.,
Hauser L., Kyrpides N., Mikhailova N., Noll K., Richardson P.;
"Complete sequence of Petroga mobilis SJ95.";
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Involved in the gluconeogenesis. Catalyzes
stereospecifically the conversion of dihydroxyacetone phosphate
(DHAP) to D-glyceraldehyde-3-phosphate (G3P). {ECO:0000256|HAMAP-
Rule:MF_00147}.
-!- CATALYTIC ACTIVITY:
Reaction=3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl
phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616,
ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216;
EC=2.7.2.3; Evidence={ECO:0000256|HAMAP-Rule:MF_00145,
ECO:0000256|SAAS:SAAS01120514};
-!- CATALYTIC ACTIVITY:
Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone
phosphate; Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642,
ChEBI:CHEBI:59776; EC=5.3.1.1; Evidence={ECO:0000256|HAMAP-
Rule:MF_00147, ECO:0000256|SAAS:SAAS01116239};
-!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
{ECO:0000256|HAMAP-Rule:MF_00147, ECO:0000256|SAAS:SAAS00728615}.
-!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
phosphate from glycerone phosphate: step 1/1. {ECO:0000256|HAMAP-
Rule:MF_00147, ECO:0000256|SAAS:SAAS00728661}.
-!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
glyceraldehyde 3-phosphate: step 2/5. {ECO:0000256|HAMAP-
Rule:MF_00145, ECO:0000256|RuleBase:RU000695,
ECO:0000256|SAAS:SAAS00041112}.
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00147,
ECO:0000256|SAAS:SAAS00728692}.
-!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00145,
ECO:0000256|SAAS:SAAS00041091}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00147,
ECO:0000256|RuleBase:RU000695, ECO:0000256|SAAS:SAAS00041072}.
-!- SIMILARITY: Belongs to the phosphoglycerate kinase family.
{ECO:0000256|HAMAP-Rule:MF_00145, ECO:0000256|SAAS:SAAS01085159}.
-!- SIMILARITY: Belongs to the triosephosphate isomerase family.
{ECO:0000256|HAMAP-Rule:MF_00147, ECO:0000256|SAAS:SAAS00728708}.
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EMBL; CP000879; ABX32147.1; -; Genomic_DNA.
RefSeq; WP_012209246.1; NC_010003.1.
ProteinModelPortal; A9BII4; -.
STRING; 403833.Pmob_1444; -.
EnsemblBacteria; ABX32147; ABX32147; Pmob_1444.
KEGG; pmo:Pmob_1444; -.
eggNOG; ENOG4105BZA; Bacteria.
eggNOG; COG0126; LUCA.
eggNOG; COG0149; LUCA.
HOGENOM; HOG000227107; -.
KO; K00927; -.
KO; K01803; -.
OMA; FYKNEGA; -.
OrthoDB; 90424at2; -.
BioCyc; PMOB403833:G1GAG-1483-MONOMER; -.
UniPathway; UPA00109; UER00185.
UniPathway; UPA00109; UER00189.
UniPathway; UPA00138; -.
Proteomes; UP000000789; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004618; F:phosphoglycerate kinase activity; IEA:UniProtKB-UniRule.
GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:UniProtKB-UniRule.
GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
CDD; cd00318; Phosphoglycerate_kinase; 1.
CDD; cd00311; TIM; 1.
Gene3D; 3.20.20.70; -; 1.
Gene3D; 3.40.50.1260; -; 2.
HAMAP; MF_00145; Phosphoglyc_kinase; 1.
HAMAP; MF_00147_B; TIM_B; 1.
InterPro; IPR013785; Aldolase_TIM.
InterPro; IPR001576; Phosphoglycerate_kinase.
InterPro; IPR015911; Phosphoglycerate_kinase_CS.
InterPro; IPR015824; Phosphoglycerate_kinase_N.
InterPro; IPR036043; Phosphoglycerate_kinase_sf.
InterPro; IPR035990; TIM_sf.
InterPro; IPR022896; TrioseP_Isoase_bac/euk.
InterPro; IPR000652; Triosephosphate_isomerase.
InterPro; IPR020861; Triosephosphate_isomerase_AS.
PANTHER; PTHR11406; PTHR11406; 1.
Pfam; PF00162; PGK; 1.
Pfam; PF00121; TIM; 1.
PRINTS; PR00477; PHGLYCKINASE.
SUPFAM; SSF51351; SSF51351; 1.
SUPFAM; SSF53748; SSF53748; 1.
TIGRFAMs; TIGR00419; tim; 1.
PROSITE; PS00111; PGLYCERATE_KINASE; 1.
PROSITE; PS00171; TIM_1; 1.
PROSITE; PS51440; TIM_2; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|HAMAP-Rule:MF_00145,
ECO:0000256|SAAS:SAAS00041066};
Complete proteome {ECO:0000313|Proteomes:UP000000789};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00147,
ECO:0000256|SAAS:SAAS00041081};
Gluconeogenesis {ECO:0000256|HAMAP-Rule:MF_00147,
ECO:0000256|SAAS:SAAS00728593};
Glycolysis {ECO:0000256|HAMAP-Rule:MF_00147,
ECO:0000256|RuleBase:RU000695, ECO:0000256|SAAS:SAAS00728672};
Isomerase {ECO:0000256|HAMAP-Rule:MF_00147,
ECO:0000256|SAAS:SAAS00498630, ECO:0000313|EMBL:ABX32147.1};
Kinase {ECO:0000256|HAMAP-Rule:MF_00145,
ECO:0000256|SAAS:SAAS00041108, ECO:0000313|EMBL:ABX32147.1};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00145,
ECO:0000256|SAAS:SAAS00041066};
Reference proteome {ECO:0000313|Proteomes:UP000000789};
Transferase {ECO:0000256|HAMAP-Rule:MF_00145,
ECO:0000256|SAAS:SAAS00041108, ECO:0000313|EMBL:ABX32147.1}.
NP_BIND 353 356 ATP. {ECO:0000256|HAMAP-Rule:MF_00145}.
REGION 21 23 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00145}.
REGION 59 62 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00145}.
REGION 410 412 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00147}.
REGION 635 636 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00147}.
ACT_SITE 496 496 Electrophile. {ECO:0000256|HAMAP-
Rule:MF_00147}.
ACT_SITE 568 568 Proton acceptor. {ECO:0000256|HAMAP-
Rule:MF_00147}.
BINDING 36 36 Substrate. {ECO:0000256|HAMAP-
Rule:MF_00145}.
BINDING 118 118 Substrate. {ECO:0000256|HAMAP-
Rule:MF_00145}.
BINDING 151 151 Substrate. {ECO:0000256|HAMAP-
Rule:MF_00145}.
BINDING 201 201 ATP. {ECO:0000256|HAMAP-Rule:MF_00145}.
BINDING 293 293 ATP; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_00145}.
BINDING 324 324 ATP. {ECO:0000256|HAMAP-Rule:MF_00145}.
BINDING 574 574 Substrate; via amide nitrogen.
{ECO:0000256|HAMAP-Rule:MF_00147}.
BINDING 614 614 Substrate. {ECO:0000256|HAMAP-
Rule:MF_00147}.
SEQUENCE 655 AA; 71720 MW; 5E0A2597F89FB8D5 CRC64;
MEKLTIKDVD LKGKKVIMRV DFNVPIKDGK ITDETRIVAA LDTIQYALDK GAKVILLSHL
GRPKGEKDPQ FSLKPVADRL GELLNNKVYF VDETRGPKVE EAVSELKEGE VLVLENTRFE
KGETKNDPEL AKYWASLADL HVNDAFGTAH RAHASNVGIA DYIPSVAGFL MEKEIEFLQK
AVENPEKPYV VILGGAKVSD KIGVINNLLN KADKILIGGA MMFTFLKALD KKVGSSLVEE
DKLDVAKEIL ENAKAKGVEI VLPIDAVIAQ KIEAGVEKKT VKIDDGIPEG WMGLDIGLET
VSLFKEKISD SKTIVWNGPM GVFEIDDFAF GTEEVAKAIA EVTKKGCISI IGGGDSAAAA
EKFGLASEFS HVSTGGGASL EFLEGIELPG ISSISEKKNL NERIFILAGN WKMNKTNAEA
AEFVSKLIGQ IKTQDKFEVI VCPPFTALEK VRDITSTSSI KVGAQNVYYE DKGAYTGEIS
VNMLKDIGVE YVILGHSERR HIFQESDELI NKKLKKVLAS GLKPILCVGE QLEEREKGLT
FNVVERQIKE ALYGLTEEES KKIIIAYEPV WAIGTGKVAT PNQAQEVHKF IRDLLKDIFN
EEFAKKTTIL YGGSIKPNNY LGLFGKPDID GGLVGGASLT QEFVELANIM KSIIE


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Pathways :
WP1493: Carbon assimilation C4 pathway
WP253: Glycolysis
WP1946: Cori Cycle
WP1684: Pentose phosphate pathway
WP1567: Glycolysis and Gluconeogenesis
WP1657: Glycerolipid metabolism
WP2248: anthocyanin biosynthesis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP305: Glucocorticoid Metabolism
WP1028: Pentose Phosphate Pathway
WP1049: G Protein Signaling Pathways
WP1147: Pentose Phosphate Pathway
WP1165: G Protein Signaling Pathways
WP122: Pentose Phosphate Pathway
WP1231: Pentose Phosphate Pathway
WP134: Pentose Phosphate Pathway
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1619: Amino sugar and nucleotide sugar metabolism

Related Genes :
[Tpi1 Tpi] Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase)
[tpiA tpi b3919 JW3890] Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase)
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BMT53_00170 BUE81_10670 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 CDL37_00765 CG691_19145 CG705_13560 CG706_14580 CIJ94_05515 COD46_23180 CRD98_26150 D3I61_11545 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTL84_23375 DTM25_06080 EC95NR1_00961 ERS085379_01273 ERS085386_05041 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13462_05714 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PU06_24500 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 SAMEA3753106_00003 SAMEA3753391_00513 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[aro-1 aro-2 aro-4 aro-5 aro-9 B14H13.20 NCU016321] Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); Shikimate kinase (SK) (EC 2.7.1.71); 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10); Shikimate dehydrogenase (EC 1.1.1.25)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[trp-1 trpg-trpc-trpf tryp-1 NCU00200] Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2 (AS) (EC 4.1.3.27) (Anthranilate synthase, glutamine amidotransferase component); Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48); N-(5'-phosphoribosyl)anthranilate isomerase (PRAI) (EC 5.3.1.24)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[RPS0 BST61_czeina10g000760] Multifunctional fusion protein [Includes: Pentafunctional AROM polypeptide; 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10); 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4); Shikimate dehydrogenase (EC 1.1.1.25); Shikimate kinase (SK) (EC 2.7.1.71); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); 40S ribosomal protein S0]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[nnrD nnrE DU31_11450 DU33_17155 DU34_07685 DU35_07085 DU36_09790 DU37_12565 DU38_10935 DU39_12815 DU40_12880 DU41_14740 DU42_07270 DU44_01295 DU45_16155 DU46_10990 DU47_01255 DU48_07720 DU49_14655 DU50_12285 DU51_19805 DU54_00670 DU55_05370 DU56_15760 DU57_06830 DU59_03855 DU60_14595 DU61_11015 DU62_06475 DU63_06395 DU64_18510 DU65_03810 DU66_17325 DU68_15815 DU69_04530 DU71_00795 DU72_19440 DU73_09980 DU74_18275 DU75_11940 DU76_10140 DU77_00515 DU78_12025 DU79_00590 DU80_09755 DU81_02350 DU82_01250 DU83_01980 DU84_01080 DU85_13135 DU86_12110 DU88_12415] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[pyrG A6592_02570 A8M42_16405 A9R57_06965 AC067_22330 AC789_1c31020 ACN002_2797 ACN77_07080 ACN81_20385 ACU57_24415 ACU90_23015 AJ318_22735 AKG99_03555 AM270_00945 AM446_06950 AM464_05605 AM465_10605 AML07_12460 AML35_05300 APT94_17890 APU18_18535 APZ14_09290 ARC77_10140 AU473_08010 AUQ13_17535 AUS26_15660 AW059_10675 AW106_00665 AWP75_20610 AZZ83_003241 B1K96_20050 B7C53_10055 B9M99_21725 B9N33_09475 B9T59_19685 BB545_13920 BE963_03670 BEN53_16995 BET08_07180 BH694_13410 BHF46_05050 BHS81_16640 BHS87_15735 BIQ87_15835 BIU72_09520 BIZ41_16885 BJJ90_05265 BK248_12970 BK292_23205 BK334_11935 BK373_15870 BK375_10085 BK383_11680 BK400_05820 BMT49_17330 BMT53_21250 BMT91_11105 BN17_26661 BTQ04_11510 BTQ06_23845 BUE81_06975 BVL39_12970 BW690_04975 BWP17_05185 BXT93_24405 BZL31_00820 BZL69_02125 C1I57_04860 C2M16_17770 C2U48_20025 C3K24_08940 C4J69_11655 C4K41_05275 C4M78_00835 C5715_23540 C5N07_06155 C5P01_05005 C5P43_15935 C5P44_09340 C6669_14670 C6986_17750 C6B13_03370 C7235_05745 C7B02_19400 C7B06_11630 C7B07_14530 C7B08_01430 C9E25_03325 CA593_12975 CCZ14_04445 CCZ17_10850 CDL37_13440 CG691_07365 CG692_07005 CG705_05530 CG706_07860 CIJ94_12220 COD30_01795 COD46_07095 CR538_05495 CR539_18815 CRE06_03485 CRM83_26360 CSB64_15850 CT143_09630 CT146_00680 CV83915_03339 CVH05_06295 CWM24_00790 CWS33_03125 CXB56_08765 D0X26_06660 D1900_12730 D2183_19100 D2F89_14380 D3I61_16000 DD762_13665 DIV22_29760 DIV25_29790 DL545_05995 DL800_20505 DNQ41_18960 DNR41_08670 DQE83_04685 DS732_20695 DS966_06010 DTL43_09355 DTL84_00105 DTL90_02675 DTM10_03745 DTM25_22630 DTM27_13675 DTM45_13530 EC1094V2_904 EC3234A_48c00890 EC95NR1_02021 ECONIH1_15890 ECs3640 EL75_0914 EL79_0915 EL80_0918 ERS085365_02427 ERS085366_03042 ERS085374_03279 ERS085386_03410 ERS085416_02898 ERS139211_02072 ERS150873_02003 ERS150876_01467 FORC28_1110 GJ11_18025 HMPREF3040_01161 HW43_18180 JD73_16335 MJ49_17095 MS6198_30910 MS8345_02965 NCTC10082_03473 NCTC10090_04050 NCTC10418_01701 NCTC10764_00296 NCTC10766_00690 NCTC10767_02309 NCTC11022_02860 NCTC11112_00121 NCTC11181_03277 NCTC12950_01251 NCTC13125_04353 NCTC13127_01436 NCTC13462_04807 NCTC13846_01212 NCTC7152_00995 NCTC7927_01209 NCTC8500_01090 NCTC8960_03783 NCTC9007_03892 NCTC9010_01168 NCTC9036_01135 NCTC9037_01243 NCTC9045_01221 NCTC9050_04166 NCTC9058_00847 NCTC9062_02131 NCTC9075_01630 NCTC9077_01409 NCTC9081_05851 NCTC9117_01609 NCTC9119_01271 NCTC9434_01004 NCTC9706_03296 NCTC9775_04845 NCTC9777_02704 NCTC9969_01292 PU06_02080 RG28_07675 RK56_023165 SAMEA3472033_01264 SAMEA3472044_02272 SAMEA3472047_00339 SAMEA3472056_05455 SAMEA3472067_02540 SAMEA3472070_01673 SAMEA3472080_03155 SAMEA3472090_00131 SAMEA3472108_00527 SAMEA3472110_03462 SAMEA3472112_03722 SAMEA3472114_02432 SAMEA3472147_03296 SAMEA3484427_03298 SAMEA3484429_03415 SAMEA3484433_01660 SAMEA3484434_01581 SAMEA3485101_02257 SAMEA3485113_02257 SAMEA3752372_03639 SAMEA3752557_03040 SAMEA3752559_02995 SAMEA3752620_01282 SAMEA3753064_02287 SAMEA3753097_02219 SAMEA3753106_03183 SAMEA3753164_01192 SAMEA3753290_02847 SAMEA3753300_01107 SAMEA3753391_02580 SAMEA3753397_04005 SK85_03024 SY51_15605 UC41_20365 UN91_03645 WM48_14990 WQ89_10170 WR15_06090 YDC107_1339] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[pol] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[pol] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]

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