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NAD-dependent protein deacetylase sirtuin-1 (EC 2 3 1 286) (NAD-dependent protein deacylase sirtuin-1) (EC 2 3 1 -)

 SIR1_RAT                Reviewed;         555 AA.
A0A0G2JZ79;
08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
08-JUN-2016, sequence version 2.
02-DEC-2020, entry version 44.
RecName: Full=NAD-dependent protein deacetylase sirtuin-1 {ECO:0000250|UniProtKB:Q923E4};
EC=2.3.1.286 {ECO:0000250|UniProtKB:Q96EB6};
AltName: Full=NAD-dependent protein deacylase sirtuin-1;
EC=2.3.1.- {ECO:0000250|UniProtKB:Q923E4};
Name=Sirt1 {ECO:0000312|RGD:1308542};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
PubMed=15057822; DOI=10.1038/nature02426;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
Mockrin S., Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into mammalian
evolution.";
Nature 428:493-521(2004).
-!- FUNCTION: NAD-dependent protein deacetylase that links transcriptional
regulation directly to intracellular energetics and participates in the
coordination of several separated cellular functions such as cell
cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can
modulate chromatin function through deacetylation of histones and can
promote alterations in the methylation of histones and DNA, leading to
transcriptional repression. Deacetylates a broad range of transcription
factors and coregulators, thereby regulating target gene expression
positively and negatively. Serves as a sensor of the cytosolic ratio of
NAD(+)/NADH which is altered by glucose deprivation and metabolic
changes associated with caloric restriction. Is essential in skeletal
muscle cell differentiation and in response to low nutrients mediates
the inhibitory effect on skeletal myoblast differentiation which also
involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide
phosphoribosyltransferase (NAMPT). Component of the eNoSC (energy-
dependent nucleolar silencing) complex, a complex that mediates
silencing of rDNA in response to intracellular energy status and acts
by recruiting histone-modifying enzymes. The eNoSC complex is able to
sense the energy status of cell: upon glucose starvation, elevation of
NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3
deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by
SUV39H1 and the formation of silent chromatin in the rDNA locus.
Deacetylates 'Lys-266' of SUV39H1, leading to its activation. Inhibits
skeletal muscle differentiation by deacetylating PCAF and MYOD1.
Deacetylates H2A and 'Lys-26' of H1-4. Deacetylates 'Lys-16' of histone
H4 (in vitro). Involved in NR0B2/SHP corepression function through
chromatin remodeling: Recruited to LRH1 target gene promoters by
NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading
to transcriptional repression. Proposed to contribute to genomic
integrity via positive regulation of telomere length; however, reports
on localization to pericentromeric heterochromatin are conflicting.
Proposed to play a role in constitutive heterochromatin (CH) formation
and/or maintenance through regulation of the available pool of nuclear
SUV39H1. Upon oxidative/metabolic stress decreases SUV39H1 degradation
by inhibiting SUV39H1 polyubiquitination by MDM2. This increase in
SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to
accelerate renewal of the heterochromatin which correlates with greater
genomic integrity during stress response. Deacetylates 'Lys-382' of
p53/TP53 and impairs its ability to induce transcription-dependent
proapoptotic program and modulate cell senescence. Deacetylates TAF1B
and thereby represses rDNA transcription by the RNA polymerase I.
Deacetylates MYC, promotes the association of MYC with MAX and
decreases MYC stability leading to compromised transformational
capability. Deacetylates FOXO3 in response to oxidative stress thereby
increasing its ability to induce cell cycle arrest and resistance to
oxidative stress but inhibiting FOXO3-mediated induction of apoptosis
transcriptional activity; also leading to FOXO3 ubiquitination and
protesomal degradation. Appears to have a similar effect on MLLT7/FOXO4
in regulation of transcriptional activity and apoptosis. Deacetylates
DNMT1; thereby impairs DNMT1 methyltransferase-independent
transcription repressor activity, modulates DNMT1 cell cycle regulatory
function and DNMT1-mediated gene silencing. Deacetylates RELA/NF-kappa-
B p65 thereby inhibiting its transactivating potential and augments
apoptosis in response to TNF-alpha. Deacetylates HIF1A, KAT5/TIP60, RB1
and HIC1. Deacetylates FOXO1 resulting in its nuclear retention and
enhancement of its transcriptional activity leading to increased
gluconeogenesis in liver. Inhibits E2F1 transcriptional activity and
apoptotic function, possibly by deacetylation. Involved in HES1- and
HEY2-mediated transcriptional repression. In cooperation with MYCN
seems to be involved in transcriptional repression of DUSP6/MAPK3
leading to MYCN stabilization by phosphorylation at 'Ser-62'.
Deacetylates MEF2D. Required for antagonist-mediated transcription
suppression of AR-dependent genes which may be linked to local
deacetylation of histone H3. Represses HNF1A-mediated transcription.
Required for the repression of ESRRG by CREBZF. Deacetylates NR1H3 AND
NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates
transcription of NR1H3:RXR target genes, promotes NR1H3 proteosomal
degradation and results in cholesterol efflux; a promoter clearing
mechanism after reach round of transcription is proposed. Involved in
lipid metabolism. Implicated in regulation of adipogenesis and fat
mobilization in white adipocytes by repression of PPARG which probably
involves association with NCOR1 and SMRT/NCOR2. Deacetylates p300/EP300
and PRMT1. Deacetylates ACSS2 leading to its activation, and HMGCS1
deacetylation. Involved in liver and muscle metabolism. Through
deacetylation and activation of PPARGC1A is required to activate fatty
acid oxidation in skeletal muscle under low-glucose conditions and is
involved in glucose homeostasis. Involved in regulation of PPARA and
fatty acid beta-oxidation in liver. Involved in positive regulation of
insulin secretion in pancreatic beta cells in response to glucose; the
function seems to imply transcriptional repression of UCP2. Proposed to
deacetylate IRS2 thereby facilitating its insulin-induced tyrosine
phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby
decreasing its stability and transactivation in lipogenic gene
expression. Involved in DNA damage response by repressing genes which
are involved in DNA repair, such as XPC and TP73, deacetylating
XRCC6/Ku70, and facilitating recruitment of additional factors to sites
of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to
initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2.
Also involved in DNA repair of DNA double-strand breaks by homologous
recombination and specifically single-strand annealing independently of
XRCC6/Ku70 and NBN. Transcriptional suppression of XPC probably
involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT)
signaling. Transcriptional suppression of TP73 probably involves E2F4
and PCAF. Deacetylates WRN thereby regulating its helicase and
exonuclease activities and regulates WRN nuclear translocation in
response to DNA damage. Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and
stimulates cellular AP endonuclease activity by promoting the
association of APEX1 to XRCC1. Increases p53/TP53-mediated
transcription-independent apoptosis by blocking nuclear translocation
of cytoplasmic p53/TP53 and probably redirecting it to mitochondria.
Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to
sequester BAX away from mitochondria thereby inhibiting stress-induced
apoptosis. Is involved in autophagy, presumably by deacetylating ATG5,
ATG7 and MAP1LC3B/ATG8. Deacetylates AKT1 which leads to enhanced
binding of AKT1 and PDK1 to PIP3 and promotes their activation.
Proposed to play role in regulation of STK11/LBK1-dependent AMPK
signaling pathways implicated in cellular senescence which seems to
involve the regulation of the acetylation status of STK11/LBK1. Can
deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic
localization and association with STRAD; however, the relevance of such
activity in normal cells is unclear. In endothelial cells is shown to
inhibit STK11/LBK1 activity and to promote its degradation.
Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its
degradation. Deacetylates CIITA and augments its MHC class II
transactivation and contributes to its stability. Deacetylates
MECOM/EVI1. Deacetylates PML at 'Lys-487' and this deacetylation
promotes PML control of PER2 nuclear localization. During the
neurogenic transition, represses selective NOTCH1-target genes through
histone deacetylation in a BCL6-dependent manner and leading to
neuronal differentiation. Regulates the circadian expression of several
core clock genes, including ARNTL/BMAL1, RORC, PER2 and CRY1 and plays
a critical role in maintaining a controlled rhythmicity in histone
acetylation, thereby contributing to circadian chromatin remodeling.
Deacetylates ARNTL/BMAL1 and histones at the circadian gene promoters
in order to facilitate repression by inhibitory components of the
circadian oscillator. Deacetylates PER2, facilitating its
ubiquitination and degradation by the proteosome. Protects
cardiomyocytes against palmitate-induced apoptosis. Deacetylates XBP1
isoform 2; deacetylation decreases protein stability of XBP1 isoform 2
and inhibits its transcriptional activity. Deacetylates PCK1 and
directs its activity toward phosphoenolpyruvate production promoting
gluconeogenesis. Involved in the CCAR2-mediated regulation of PCK1 and
NR1D1. Deacetylates CTNB1 at 'Lys-49'. In POMC (pro-opiomelanocortin)
neurons, required for leptin-induced activation of PI3K signaling. In
addition to protein deacetylase activity, also acts as protein-lysine
deacylase: acts as a protein depropionylase by mediating
depropionylation of Osterix (SP7). Deacetylates SOX9; promoting SOX9
nuclear localization and transactivation activity. Involved in the
regulation of centrosome duplication. Deacetylates CENATAC in G1 phase,
allowing for SASS6 accumulation on the centrosome and subsequent
procentriole assembly (By similarity). {ECO:0000250|UniProtKB:Q923E4,
ECO:0000250|UniProtKB:Q96EB6}.
-!- CATALYTIC ACTIVITY:
Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-
ADP-D-ribose + L-lysyl-[protein] + nicotinamide;
Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731,
ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969,
ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767;
EC=2.3.1.286; Evidence={ECO:0000250|UniProtKB:Q96EB6,
ECO:0000255|PROSITE-ProRule:PRU00236};
-!- CATALYTIC ACTIVITY:
Reaction=H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-
propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide;
Xref=Rhea:RHEA:23500, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13758,
ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969,
ChEBI:CHEBI:57540, ChEBI:CHEBI:138019, ChEBI:CHEBI:145015;
Evidence={ECO:0000250|UniProtKB:Q923E4};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23501;
Evidence={ECO:0000250|UniProtKB:Q923E4};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000250|UniProtKB:Q8IXJ6};
Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:Q8IXJ6};
-!- ACTIVITY REGULATION: Inhibited by nicotinamide. Activated by
resveratrol (3,5,4'-trihydroxy-trans-stilbene), butein (3,4,2',4'-
tetrahydroxychalcone), piceatannol (3,5,3',4'-tetrahydroxy-trans-
stilbene), Isoliquiritigenin (4,2',4'-trihydroxychalcone), fisetin
(3,7,3',4'-tetrahydroxyflavone) and quercetin (3,5,7,3',4'-
pentahydroxyflavone). MAPK8/JNK1 and RPS19BP1/AROS act as positive
regulators of deacetylation activity. Negatively regulated by CCAR2.
{ECO:0000250|UniProtKB:Q96EB6}.
-!- SUBUNIT: Interacts with XBP1 isoform 2 (By similarity). Found in a
complex with PCAF and MYOD1. Interacts with FOXO1; the interaction
deacetylates FOXO1, resulting in its nuclear retention and promotion of
its transcriptional activity Component of the eNoSC complex, composed
of SIRT1, SUV39H1 and RRP8. Interacts with HES1, HEY2 and PML.
Interacts with RPS19BP1/AROS. Interacts with CCAR2 (via N-terminus);
the interaction disrupts the interaction between SIRT1 and p53/TP53.
Interacts with SETD7; the interaction induces the dissociation of SIRT1
from p53/TP53 and increases p53/TP53 activity. Interacts with MYCN,
NR1I2, CREBZF, TSC2, TLE1, FOS, JUN, NR0B2, PPARG, NCOR, IRS1, IRS2 and
NMNAT1. Interacts with HNF1A; the interaction occurs under nutrient
restriction. Interacts with SUZ12; the interaction mediates the
association with the PRC4 histone methylation complex which is specific
as an association with PCR2 and PCR3 complex variants is not found.
Interacts with HIV-1 tat. Interacts with BCL6; leads to a epigenetic
repression of specific target genes. Interacts with CLOCK, ARNTL/BMAL1
and PER2 (By similarity). Interacts with PPARA; the interaction seems
to be modulated by NAD(+) levels. Interacts with NR1H3 and this
interaction is inhibited in the presence of CCAR2. Interacts with
CHEK2. Interacts with p53/TP53. Exhibits a preferential interaction
with sumoylated CCAR2 over its unmodified form (By similarity).
Interacts with PACS2 (By similarity). Interacts with SIRT7 (By
similarity). {ECO:0000250|UniProtKB:Q923E4,
ECO:0000250|UniProtKB:Q96EB6}.
-!- SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000250|UniProtKB:Q96EB6}.
Cytoplasm {ECO:0000250|UniProtKB:Q96EB6}. Nucleus
{ECO:0000250|UniProtKB:Q96EB6}. Note=Recruited to the nuclear bodies
via its interaction with PML. Colocalized with APEX1 in the nucleus.
May be found in nucleolus, nuclear euchromatin, heterochromatin and
inner membrane (By similarity). Shuttles between nucleus and cytoplasm
(By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (By
similarity). {ECO:0000250|UniProtKB:Q923E4,
ECO:0000250|UniProtKB:Q96EB6}.
-!- PTM: Methylated on multiple lysine residues; methylation is enhanced
after DNA damage and is dispensable for deacetylase activity toward
p53/TP53. {ECO:0000250|UniProtKB:Q96EB6}.
-!- PTM: Phosphorylated. Phosphorylated by STK4/MST1, resulting in
inhibition of SIRT1-mediated p53/TP53 deacetylation. Phosphorylation by
MAPK8/JNK1 at Thr-338 leads to increased nuclear localization and
enzymatic activity. Phosphorylation at Thr-338 by DYRK1A and DYRK3
activates deacetylase activity and promotes cell survival.
Phosphorylated by CaMK2, leading to increased p53/TP53 and NF-kappa-B
p65/RELA deacetylation activity (By similarity).
{ECO:0000250|UniProtKB:Q923E4, ECO:0000250|UniProtKB:Q96EB6}.
-!- PTM: S-nitrosylated by GAPDH, leading to inhibit the NAD-dependent
protein deacetylase activity. {ECO:0000250|UniProtKB:Q923E4}.
-!- PTM: Acetylated at various Lys residues. Deacetylated via an
autocatalytic mechanism. Autodeacetylation at Lys-46 promotes its
protein deacetylase activity. {ECO:0000250|UniProtKB:Q923E4}.
-!- MISCELLANEOUS: Red wine, which contains resveratrol, may participate in
activation of sirtuin proteins, and may therefore contribute to an
extended lifespan as has been observed in yeast.
{ECO:0000250|UniProtKB:Q96EB6}.
-!- MISCELLANEOUS: Calf histone H1 is used as substrate in the in vitro
deacetylation assay. As, in vivo, interaction occurs between SIRT1 with
H1-4, deacetylation has been validated only for H1-4.
{ECO:0000250|UniProtKB:Q96EB6}.
-!- MISCELLANEOUS: The reported ADP-ribosyltransferase activity of sirtuins
is likely to be an inefficient side reaction of the deacetylase
activity and may not be physiologically relevant.
{ECO:0000250|UniProtKB:Q96EB6}.
-!- SIMILARITY: Belongs to the sirtuin family. Class I subfamily.
{ECO:0000305}.
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EMBL; AABR07044925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
SMR; A0A0G2JZ79; -.
STRING; 10116.ENSRNOP00000000427; -.
PaxDb; A0A0G2JZ79; -.
RGD; 1308542; Sirt1.
eggNOG; KOG2684; Eukaryota.
Reactome; R-RNO-3371453; Regulation of HSF1-mediated heat shock response.
Reactome; R-RNO-427359; SIRT1 negatively regulates rRNA expression.
Reactome; R-RNO-9617629; Regulation of FOXO transcriptional activity by acetylation.
PRO; PR:A0A0G2JZ79; -.
Proteomes; UP000002494; Unplaced.
Bgee; ENSRNOG00000051592; Expressed in thymus and 20 other tissues.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0000785; C:chromatin; ISO:RGD.
GO; GO:0005677; C:chromatin silencing complex; ISO:RGD.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0030426; C:growth cone; IDA:RGD.
GO; GO:0005739; C:mitochondrion; ISO:RGD.
GO; GO:0000790; C:nuclear chromatin; ISO:RGD.
GO; GO:0005635; C:nuclear envelope; ISO:RGD.
GO; GO:0005719; C:nuclear euchromatin; ISO:RGD.
GO; GO:0005720; C:nuclear heterochromatin; ISO:RGD.
GO; GO:0005637; C:nuclear inner membrane; ISO:RGD.
GO; GO:0005730; C:nucleolus; ISO:RGD.
GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0016605; C:PML body; ISO:RGD.
GO; GO:0032991; C:protein-containing complex; ISO:RGD.
GO; GO:0033553; C:rDNA heterochromatin; ISO:RGD.
GO; GO:0043425; F:bHLH transcription factor binding; ISO:RGD.
GO; GO:0019213; F:deacetylase activity; ISO:RGD.
GO; GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO; GO:0042393; F:histone binding; ISO:RGD.
GO; GO:0004407; F:histone deacetylase activity; ISO:RGD.
GO; GO:0043398; F:HLH domain binding; ISO:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:1990254; F:keratin filament binding; ISO:RGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0051019; F:mitogen-activated protein kinase binding; ISO:RGD.
GO; GO:0070403; F:NAD+ binding; IBA:GO_Central.
GO; GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:RGD.
GO; GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); ISO:RGD.
GO; GO:0034979; F:NAD-dependent protein deacetylase activity; ISO:RGD.
GO; GO:0035257; F:nuclear hormone receptor binding; ISO:RGD.
GO; GO:0002039; F:p53 binding; ISO:RGD.
GO; GO:1990841; F:promoter-specific chromatin binding; ISO:RGD.
GO; GO:0008022; F:protein C-terminus binding; ISO:RGD.
GO; GO:0033558; F:protein deacetylase activity; ISO:RGD.
GO; GO:0019904; F:protein domain specific binding; ISO:RGD.
GO; GO:0043422; F:protein kinase B binding; IDA:RGD.
GO; GO:0106231; F:protein-propionyllysine depropionylase activity; ISS:UniProtKB.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
GO; GO:0003713; F:transcription coactivator activity; ISO:RGD.
GO; GO:0003714; F:transcription corepressor activity; ISO:RGD.
GO; GO:0008134; F:transcription factor binding; ISO:RGD.
GO; GO:0001525; P:angiogenesis; ISO:RGD.
GO; GO:0042595; P:behavioral response to starvation; ISO:RGD.
GO; GO:0007569; P:cell aging; IEP:RGD.
GO; GO:0001678; P:cellular glucose homeostasis; ISO:RGD.
GO; GO:1904646; P:cellular response to amyloid-beta; IMP:ARUK-UCL.
GO; GO:0071236; P:cellular response to antibiotic; IEP:RGD.
GO; GO:1904644; P:cellular response to curcumin; IEP:RGD.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISO:RGD.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
GO; GO:0071456; P:cellular response to hypoxia; ISO:RGD.
GO; GO:0071479; P:cellular response to ionizing radiation; ISO:RGD.
GO; GO:1990830; P:cellular response to leukemia inhibitory factor; ISO:RGD.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
GO; GO:1904648; P:cellular response to rotenone; IEP:RGD.
GO; GO:0009267; P:cellular response to starvation; ISO:RGD.
GO; GO:0071356; P:cellular response to tumor necrosis factor; ISO:RGD.
GO; GO:0071303; P:cellular response to vitamin B3; IEP:RGD.
GO; GO:0035356; P:cellular triglyceride homeostasis; ISO:RGD.
GO; GO:0042632; P:cholesterol homeostasis; ISO:RGD.
GO; GO:0006325; P:chromatin organization; ISO:RGD.
GO; GO:0032922; P:circadian regulation of gene expression; ISO:RGD.
GO; GO:0007623; P:circadian rhythm; ISO:RGD.
GO; GO:0000731; P:DNA synthesis involved in DNA repair; ISO:RGD.
GO; GO:0055089; P:fatty acid homeostasis; ISO:RGD.
GO; GO:0031507; P:heterochromatin assembly; ISO:RGD.
GO; GO:0070829; P:heterochromatin maintenance; ISO:RGD.
GO; GO:0016575; P:histone deacetylation; ISO:RGD.
GO; GO:0070932; P:histone H3 deacetylation; IMP:RGD.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; ISO:RGD.
GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISO:RGD.
GO; GO:0033210; P:leptin-mediated signaling pathway; ISO:RGD.
GO; GO:0010934; P:macrophage cytokine production; ISO:RGD.
GO; GO:0030225; P:macrophage differentiation; ISO:RGD.
GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; ISO:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
GO; GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; ISO:RGD.
GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IMP:RGD.
GO; GO:0060548; P:negative regulation of cell death; IMP:RGD.
GO; GO:0030308; P:negative regulation of cell growth; ISO:RGD.
GO; GO:2000655; P:negative regulation of cellular response to testosterone stimulus; ISO:RGD.
GO; GO:2000773; P:negative regulation of cellular senescence; ISO:RGD.
GO; GO:0043392; P:negative regulation of DNA binding; IMP:RGD.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; ISO:RGD.
GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; ISO:RGD.
GO; GO:0045599; P:negative regulation of fat cell differentiation; ISO:RGD.
GO; GO:2000270; P:negative regulation of fibroblast apoptotic process; IMP:RGD.
GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
GO; GO:0060125; P:negative regulation of growth hormone secretion; IMP:RGD.
GO; GO:0051097; P:negative regulation of helicase activity; ISO:RGD.
GO; GO:0071441; P:negative regulation of histone H3-K14 acetylation; ISO:RGD.
GO; GO:1900113; P:negative regulation of histone H3-K9 trimethylation; ISO:RGD.
GO; GO:2000619; P:negative regulation of histone H4-K16 acetylation; ISO:RGD.
GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; ISO:RGD.
GO; GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISO:RGD.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:ARUK-UCL.
GO; GO:1901215; P:negative regulation of neuron death; ISO:RGD.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISO:RGD.
GO; GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:2000757; P:negative regulation of peptidyl-lysine acetylation; ISO:RGD.
GO; GO:0042326; P:negative regulation of phosphorylation; ISO:RGD.
GO; GO:0031393; P:negative regulation of prostaglandin biosynthetic process; ISO:RGD.
GO; GO:1901984; P:negative regulation of protein acetylation; IMP:RGD.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; ISO:RGD.
GO; GO:1900181; P:negative regulation of protein localization to nucleus; IMP:RGD.
GO; GO:1903427; P:negative regulation of reactive oxygen species biosynthetic process; IMP:RGD.
GO; GO:0032007; P:negative regulation of TOR signaling; ISO:RGD.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IMP:RGD.
GO; GO:0001542; P:ovulation from ovarian follicle; ISO:RGD.
GO; GO:0018394; P:peptidyl-lysine acetylation; ISO:RGD.
GO; GO:0034983; P:peptidyl-lysine deacetylation; ISO:RGD.
GO; GO:0002821; P:positive regulation of adaptive immune response; ISO:RGD.
GO; GO:1904179; P:positive regulation of adipose tissue development; ISO:RGD.
GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
GO; GO:0097755; P:positive regulation of blood vessel diameter; IMP:RGD.
GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISO:RGD.
GO; GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; ISO:RGD.
GO; GO:0061051; P:positive regulation of cell growth involved in cardiac muscle cell development; IMP:RGD.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
GO; GO:2000774; P:positive regulation of cellular senescence; ISO:RGD.
GO; GO:0010875; P:positive regulation of cholesterol efflux; ISO:RGD.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:RGD.
GO; GO:0045739; P:positive regulation of DNA repair; ISO:RGD.
GO; GO:1902237; P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:RGD.
GO; GO:0045722; P:positive regulation of gluconeogenesis; IMP:RGD.
GO; GO:0010460; P:positive regulation of heart rate; IMP:RGD.
GO; GO:0051574; P:positive regulation of histone H3-K9 methylation; ISO:RGD.
GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; ISO:RGD.
GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:RGD.
GO; GO:0016239; P:positive regulation of macroautophagy; ISO:RGD.
GO; GO:2000111; P:positive regulation of macrophage apoptotic process; ISO:RGD.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISO:RGD.
GO; GO:0010976; P:positive regulation of neuron projection development; IMP:RGD.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISO:RGD.
GO; GO:0090312; P:positive regulation of protein deacetylation; IMP:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:RGD.
GO; GO:0014858; P:positive regulation of skeletal muscle cell proliferation; IMP:RGD.
GO; GO:0051152; P:positive regulation of smooth muscle cell differentiation; ISO:RGD.
GO; GO:2000614; P:positive regulation of thyroid-stimulating hormone secretion; IMP:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISO:RGD.
GO; GO:0006476; P:protein deacetylation; IDA:RGD.
GO; GO:0106230; P:protein depropionylation; ISS:UniProtKB.
GO; GO:0031648; P:protein destabilization; ISO:RGD.
GO; GO:0016567; P:protein ubiquitination; ISO:RGD.
GO; GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; ISO:RGD.
GO; GO:0000183; P:rDNA heterochromatin assembly; ISO:RGD.
GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
GO; GO:0070857; P:regulation of bile acid biosynthetic process; ISO:RGD.
GO; GO:0090335; P:regulation of brown fat cell differentiation; ISO:RGD.
GO; GO:0042127; P:regulation of cell population proliferation; ISO:RGD.
GO; GO:0010824; P:regulation of centrosome duplication; ISS:UniProtKB.
GO; GO:0032071; P:regulation of endodeoxyribonuclease activity; ISO:RGD.
GO; GO:0010906; P:regulation of glucose metabolic process; ISO:RGD.
GO; GO:0010883; P:regulation of lipid storage; ISO:RGD.
GO; GO:0007346; P:regulation of mitotic cell cycle; ISO:RGD.
GO; GO:0035358; P:regulation of peroxisome proliferator activated receptor signaling pathway; ISO:RGD.
GO; GO:0071900; P:regulation of protein serine/threonine kinase activity; ISO:RGD.
GO; GO:0034391; P:regulation of smooth muscle cell apoptotic process; ISO:RGD.
GO; GO:0045471; P:response to ethanol; IDA:RGD.
GO; GO:1902617; P:response to fluoride; IEP:RGD.
GO; GO:0042542; P:response to hydrogen peroxide; ISO:RGD.
GO; GO:0032868; P:response to insulin; ISO:RGD.
GO; GO:1904373; P:response to kainic acid; IEP:RGD.
GO; GO:0044321; P:response to leptin; ISO:RGD.
GO; GO:0010046; P:response to mycotoxin; IEP:RGD.
GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
GO; GO:0006979; P:response to oxidative stress; ISO:RGD.
GO; GO:1904638; P:response to resveratrol; IEP:RGD.
GO; GO:0000012; P:single strand break repair; ISO:RGD.
GO; GO:0007283; P:spermatogenesis; ISO:RGD.
GO; GO:0090400; P:stress-induced premature senescence; ISO:RGD.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISO:RGD.
GO; GO:0006642; P:triglyceride mobilization; ISO:RGD.
GO; GO:0070914; P:UV-damage excision repair; ISO:RGD.
GO; GO:0050872; P:white fat cell differentiation; ISO:RGD.
Gene3D; 3.30.1600.10; -; 1.
InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
InterPro; IPR003000; Sirtuin.
InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
InterPro; IPR026590; Ssirtuin_cat_dom.
Pfam; PF02146; SIR2; 1.
SUPFAM; SSF52467; SSF52467; 1.
PROSITE; PS50305; SIRTUIN; 1.
3: Inferred from homology;
Acetylation; Apoptosis; Biological rhythms; Cytoplasm;
Developmental protein; Differentiation; Metal-binding; Methylation;
Myogenesis; NAD; Nucleus; Phosphoprotein; Reference proteome;
S-nitrosylation; Transcription; Transcription regulation; Transferase;
Zinc.
CHAIN 1..555
/note="NAD-dependent protein deacetylase sirtuin-1"
/id="PRO_0000436411"
DOMAIN 52..306
/note="Deacetylase sirtuin-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
NP_BIND 69..88
/note="NAD"
/evidence="ECO:0000250|UniProtKB:Q8IXJ6"
NP_BIND 153..156
/note="NAD"
/evidence="ECO:0000250|UniProtKB:Q8IXJ6"
NP_BIND 248..250
/note="NAD"
/evidence="ECO:0000250|UniProtKB:Q8IXJ6"
NP_BIND 273..275
/note="NAD"
/evidence="ECO:0000250|UniProtKB:Q8IXJ6"
REGION 64..67
/note="Required for interaction with the sumoylated form of
CCAR2"
/evidence="ECO:0000250|UniProtKB:Q96EB6"
MOTIF 39..46
/note="Nuclear localization signal"
/evidence="ECO:0000250|UniProtKB:Q923E4"
MOTIF 241..247
/note="Nuclear export signal"
/evidence="ECO:0000250|UniProtKB:Q923E4"
ACT_SITE 171
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
METAL 179
/note="Zinc"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
METAL 182
/note="Zinc"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
METAL 203
/note="Zinc"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
METAL 206
/note="Zinc"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
BINDING 290
/note="NAD; via amide nitrogen"
/evidence="ECO:0000250"
MOD_RES 46
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:Q923E4"
MOD_RES 185
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:Q923E4"
MOD_RES 203
/note="S-nitrosocysteine"
/evidence="ECO:0000250|UniProtKB:Q923E4"
MOD_RES 206
/note="S-nitrosocysteine"
/evidence="ECO:0000250|UniProtKB:Q923E4"
MOD_RES 238
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:Q923E4"
MOD_RES 321
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:Q923E4"
MOD_RES 338
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q96EB6"
MOD_RES 343
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q96EB6"
MOD_RES 352
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q96EB6"
MOD_RES 417
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:Q923E4"
MOD_RES 466
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q923E4"
MOD_RES 468
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q96EB6"
MOD_RES 552
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q96EB6"
SEQUENCE 555 AA; 62059 MW; A408C8A746AB812F CRC64;
MIGTDPRTIL KDLLPETIPP PELDDMTLWQ IVINILSEPP KRKKRKDINT IEDAVKLLQE
CKKIIVLTGA GVSVSCGIPD FRSRDGIYAR LAVDFPDLPD PQAMFDIEYF RKDPRPFFKF
AKEIYPGQFQ PSLCHKFIAL SDKEGKLLRN YTQNIDTLEQ VAGIQRIIQC HGSFATASCL
ICKYKVDCEA VRGDIFNQVV PRCPRCPADE PLAIMKPEIV FFGENLPEQF HRAMKYDKDE
VDLLIVIGSS LKVRPVALIP SSIPHEVPQI LINREPLPHL HFDVELLGDC DVIINELCHR
LGGEYAKLCC NPVKLSEITE KPPRTQKELV HLSELPPTPL HISEDSSSPE RTVPQDSSVI
ATLVDQTIKN KVDDLEVSEP KSCVEEKSQE VQTYRNVESI NVENPDFKAV GSSTGDKNER
TSVAETVRKC WPNRLAKEQI SKRLDGNQYL FVPPNRYIFH GAEVYSDSED DALSSSSCGS
NSDSGTCQSP SLEEPLEDES EIEEFYNGLE DDADRPECAG GSGADGGDQE AVNEAIAMKQ
ELTDVNCTPD KSEHY


Related products :

Catalog number Product name Quantity
ER1338 NAD-dependent protein deacetylase sirtuin-1 Elisa Kit 96T
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E0430r ELISA NAD-dependent deacetylase sirtuin-2,Rat,Rattus norvegicus,Sir2l2,SIR2-like protein 2,Sirt2 96T
E0430r ELISA kit NAD-dependent deacetylase sirtuin-2,Rat,Rattus norvegicus,Sir2l2,SIR2-like protein 2,Sirt2 96T
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EIAAB38511 Homo sapiens,Human,NAD-dependent deacetylase sirtuin-5,SIR2L5,SIR2-like protein 5,SIRT5
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U0430m CLIA Mouse,mSIR2L2,Mus musculus,NAD-dependent deacetylase sirtuin-2,Sir2l2,SIR2-like protein 2,Sirt2 96T
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Pathways :
WP1672: Mismatch repair
WP1676: Non-homologous end-joining
WP1493: Carbon assimilation C4 pathway
WP1678: Nucleotide excision repair
WP1625: Base excision repair
WP1619: Amino sugar and nucleotide sugar metabolism
WP1049: G Protein Signaling Pathways
WP1694: Pyrimidine metabolism
WP1654: gamma-Hexachlorocyclohexane degradation
WP232: G Protein Signaling Pathways
WP1661: Glyoxylate and dicarboxylate metabolism
WP2371: Parkinsons Disease Pathway
WP1371: G Protein Signaling Pathways
WP1714: Tyrosine metabolism
WP1502: Mitochondrial biogenesis
WP1909: Signal regulatory protein (SIRP) family interactions
WP525: Mitochondrial Unfolded-Protein Response
WP73: G Protein Signaling Pathways
WP1613: 1,4-Dichlorobenzene degradation
WP210: Cytoplasmic Ribosomal Proteins
WP1624: Bacterial secretion system
WP2203: TSLP Signaling Pathway
WP1689: Porphyrin and chlorophyll metabolism
WP1693: Purine metabolism
WP1650: Fluorobenzoate degradation

Related Genes :
[SIRT1 SIR2L1] NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
[Sirt1 Sir2l1] NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
[SIRT7 SIR2L7] NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
[Sirt7 Sir2l7] NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
[Sirt7] NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
[SIRT7] NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
[Sirt1] NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-)
[Sirt2 Sir2l2] NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) (mSIR2L2)
[SIRT3 SIR2L3] NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)
[Sirt3 Sir2l3] NAD-dependent protein deacetylase sirtuin-3 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3) (mSIR2L3)
[SIRT2 SIR2L SIR2L2] NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
[Sirt2 Sir2l2] NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
[SIRT2 QtsA-13614] NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
[SIRT2] NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
[Sirt5 Sir2l5] NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
[HST3 YOR025W OR26.15] NAD-dependent histone deacetylase HST3 (EC 2.3.1.286) (Homologous to SIR2 protein 3) (Regulatory protein SIR2 homolog 3)
[sir2 cobB npdA MSMEG_5175 MSMEI_5041] NAD-dependent protein deacylase Sir2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog)
[HST2 YPL015C LPA2C] NAD-dependent protein deacetylase HST2 (EC 2.3.1.286) (Homologous to SIR2 protein 2) (Regulatory protein SIR2 homolog 2)
[sir-2.1 R11A8.4] NAD-dependent protein deacetylase sir-2.1 (EC 2.3.1.286) (Protein sir-2.1) (Regulatory protein SIR2 homolog 1)
[SIR2 MAR1 YDL042C D2714] NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
[nnrE nnrD A3S59_13690 A3T49_17335 A3T75_18530 A3U47_10225 A3U54_09275 A3U78_16085 A3V15_17065 A3V28_15960 A3W22_12930 A4M41_16600 A5970_12510 A6267_12745 A6T07_15280 A7C55_07720 A7H28_15850 A9591_13875 A9C99_18275 A9S47_10990 A9S88_14770 A9X19_06535 AAA56_09530 AAB90_13650 ABA14_13890 ABP10_07270 ABQ42_14075 ACG84_16195 ACM10_17980 ACT92_14320 ACT96_14390 ADR00_04465 ADS36_15285 AGN17_13430 AGP91_11565 AH461_16240 AHV90_18155 AIE92_07590 AKX49_10100 AL461_13480 ALZ46_15575 AM316_12625 AM321_08345 AM525_15220 AN727_01255 AO198_17430 AO799_11345 AOL87_17660 AOL88_17815 AOU74_07580 APN68_15490 APO02_17555 AQ518_14155 AR267_17095 AS882_13920 ASN84_12635 ASV75_18200 AU760_14795 AU775_10415 AVB14_10850 AVI06_14750 B0A21_09265 B0F61_13105 B1868_15980 B4P96_15895 B4W84_18200 B4Z10_18285 B5C64_17865 B6339_13635 B6379_12905 B6396_17560 B6M83_15130 B6N80_13955 B7136_14330 B7900_15880 B7919_12405 B7C82_16710 B7J34_05280 B7M41_18735 B7Q10_20390 B8V98_15175 B8Y89_12815 B8Y98_13185 B8Z45_12040 B9176_15685 B9672_11375 B9673_18235 B9727_12095 B9756_14295 B9H85_18105 B9I48_18045 B9P12_16640 BB088_18985 BBL75_13960 BCP76_14830 BCP85_15340 BCP91_17540 BH227_14585 BIB62_15765 BJO06_15955 BJO39_11850 BK099_19165 BK864_11970 BKF55_14350 BKO29_15730 BSD53_18530 BSD63_15630 BTC31_13980 BXJ37_18690 BZ670_13760 BZ697_16830 BZ722_12720 BZ742_17225 BZ751_18150 BZ759_12840 BZ809_15460 BZ833_13870 BZ881_13655 BZ894_14830 BZ908_18660 BZ939_15625 BZ955_18375 BZ980_09135 BZT14_03720 CA122_13445 CA124_14440 CAD25_13880 CAD70_18135 CAI12_16660 CB062_10255 CB096_14700 CB217_12805 CB220_14435 CB308_15940 CB345_18040 CB472_13065 CB501_11525 CB588_08220 CB596_12655 CB604_10145 CB666_16595 CB721_20345 CBB04_19195 CBB05_13840 CBK53_19215 CBN66_14655 CBN70_12475 CBP97_18655 CBQ45_13910 CBR92_19970 CBR95_11870 CBS03_20305 CBS08_20655 CBS18_16760 CBS39_20735 CBS55_14975 CBS77_09830 CBS78_13115 CBU16_17980 CC149_15825 CC297_18255 CC421_17090 CC678_12725 CC680_11650 CC754_11940 CC805_16855 CC853_16680 CCG98_12880 CCP20_16675 CD530_14030 CDG21_09565 CEA09_11005 CEI41_16725 CEM11_08675 CER90_13970 CEW05_18215 CFB87_11490 CFC01_18200 CFD56_12055 CRE05_02200 D0175_08570 D0A07_14920 D0W94_21365 D3E03_19475 D4415_18015 D4E56_15415 D4F08_19940 D4X57_18540 D4Z56_20190 D5A37_07260 D5O28_18970 D5O87_18615 D5X06_18105 D6J64_14370 D6K13_17205 D6P81_17650 D6R78_16230 D6S88_17785 D6T13_10065 D8Q93_17795 D8S08_07470 D9O81_17800 DLM07_05510 DLQ89_09585 DM648_22170 DMI96_14640 DN254_16985 DO678_17965 DOB11_13010 DOJ41_18470 DOR31_16660 DP790_14935 DP797_19060 DPF44_17095 DPR73_10030 DQ906_16405 DQY42_21185 DQZ81_15615 DRD18_11105 DRK03_17440 DRM04_20170 DRV81_18170 DRX23_19640 DRX96_13475 DS187_17705 DSH04_16815 DSH32_11170 DSN07_15575 DTD96_08125 DTF75_15870 DTI59_10095 DU772_16825 DU867_16745 DUA99_06710 DUB03_17090 DUG35_21095 DUG37_09455 DW487_05640 DY875_08435 DYT79_05520 E2D06_09125 E3C38_19875 E3C57_04960 E5382_12770 E5B97_15680 EAH10_10215 EBB65_17355 EBB99_17160 EBC54_19500 EBC72_13645 EES12_17090 EGL58_19555 EGM21_17370 EHF05_18050 EI456_17675 EI507_18340 EIL24_18235 EIL34_19605 EJG81_18690 EKH43_18120 EKP78_17715 EL812_18020 ELS48_18010 ELY67_16875 ENE83_16990 ERF73_18615 ETB65_18865 EU248_15750 EUZ49_23140 EVI13_02840 EVU69_19825 EZV86_08115 EZX35_16585 F9O36_14895 F9O65_17665 F9P74_18100 F9Q56_17905 FEE84_12285 FEO32_14500 FI281_14470 FI295_17155 FI296_17695 FII38_15555 FII69_17055 FPF90_15410 FTS15_19435 G0A20_15610 G0D20_21205 G0F92_04370 G0F99_20490 G0G00_15020 G0G01_14620 G0G02_01265 G0G04_14275 G0G05_11320 G0G06_08950 G0G07_03945 G0G14_13450 G0G15_05635 G0G16_18195 G0G17_18550 G0G20_12380 G0G22_03800 G0G23_02895 G0G27_20255 G0G31_04885 G0G32_18695 G0G35_22650 G0G37_21300 G0G38_05325 G0G39_05210 G0G40_00495 G0G41_05320 G0G43_20245 G0G45_03755 G0G49_12345 G0G50_02375 G0G51_12780 G0G52_02055 G0G53_14405 G0G54_12570 G0G55_02745 G0G60_04900 G0G61_21540 G0G62_03530 G0G64_11380 G2169_20120 G2170_17950 G2196_15620 G2210_18475 G2222_16940 G2233_16805 G2235_12530 G2237_14760 G2242_16685 G2243_18305 G2249_18265 G2264_16425 G2266_19975 G2271_14330 G2282_17940 G2286_15060 G2298_18170 G2300_17895 G2301_16625 G2322_17655 G2326_05510 G2331_17485 G2345_14690 G2351_11360 G2395_18425 G2410_17370 G2484_18475 G2668_16905 G2672_18505 G2673_12285 G2674_18195 G2681_14230 G2684_17165 G2685_16660 G2686_18420 G2687_17170 G2689_19715 G2693_13850 G2696_16030 G2699_17735 G2700_17140 G2703_18695 G2705_18350 G2706_16440 G2710_15110 G2716_19115 G2717_19090 G2719_18745 G2723_19745 G2726_18435 G2729_18855 G2730_16180 G2732_14990 G2737_11175 G2740_14430 G2745_14690 G2747_17475 G2749_19595 G2751_17145 G2757_17470 G2767_17765 G2784_16450 G2846_16730 G2849_14480 G2856_16940 G2858_16510 G2859_16270 G2860_18520 G2861_14560 G2862_16635 G2863_16285 G2866_13475 G2872_17555 G2874_18875 G2879_17610 G2880_17495 G2882_11825 G2888_18110 G2889_15285 G2890_17755 G2894_09340 G2896_13570 G2902_20700 G2905_11225 G2914_18010 G2939_05565 G2944_09900 G2954_06260 G2964_16835 G2968_15020 G2971_07585 G2973_04400 G2981_03795 G2984_05660 G2989_12910 G2991_03275 G3259_002224 G3346_003537 G3347_001862 G3348_002116 G3414_001902 G3453_002421 G3972_003350 G3984_004132 G3A07_07855 G3A13_18970 G3A29_16685 G3V00_002516 G3V03_003780 G3W49_001000 G4179_002628 G4B49_002728 G4B62_003839 G4D14_001210 G4G55_002523 G4G70_002745 G4J13_004244 G4J27_003406 G4K89_000861 G4L00_003905 G4L11_003511 G4O33_003194 G4O34_001052 G4O38_002777 G4O43_002653 G4P59_003264 G4P65_002509 G4P71_002341 G4Q33_002605 G4Q34_002222 G4Y16_001057 G4Y74_001950 G4Y75_002585 G9273_003139 G9374_002432 G9375_003558 G9C39_002301 G9G26_004226 G9G29_003563 G9G49_002046 G9W24_002411 G9W26_002811 G9W60_001328 GB008_18185 GB023_19730 GB033_06215 GB073_21190 GB084_15780 GB104_17820 GB108_20855 GB117_12760 GB119_19790 GB125_16930 GB136_14545 GB146_16180 GB163_19015 GB165_16740 GB167_14000 GB172_16190 GB174_14415 GB183_21130 GB184_15005 GB191_20690 GB220_18210 GB222_15290 GB260_14850 GB264_18960 GB267_21450 GB268_17125 GB322_04260 GB328_03375 GB340_20380 GB350_18005 GB366_20965 GB382_13880 GB384_17705 GB389_17130 GB395_14155 GB398_19660 GB400_17165 GB410_19810 GB411_20290 GB424_18050 GB444_15320 GB453_02390 GB458_14190 GB471_14430 GB474_15350 GB512_06355 GB517_16250 GB521_21110 GB522_13565 GB528_15755 GB536_16845 GB545_21125 GB552_05380 GB596_11600 GB605_13600 GB608_14220 GB611_21255 GB617_20665 GB638_12945 GBR90_15875 GBR92_06005 GBR96_18020 GBS02_10665 GBS31_18015 GBS51_18015 GBV48_20440 GBV49_21290 GBV51_16940 GBV59_05205 GBW10_15355 GBW37_21300 GBW40_14450 GBW61_14955 GBW81_14525 GBW91_19925 GBW93_16210 GBW94_20475 GBX02_18175 GBX28_03500 GBX30_16305 GBX44_07655 GBX50_18975 GBX65_09510 GBX79_02640 GBY10_21110 GBY16_20595 GBY22_15800 GBY30_14000 GBY40_12305 GBY43_19015 GBY51_02640 GBY55_13045 GBY69_02100 GBY71_13275 GBY80_15315 GBY98_15310 GBZ02_20775 GBZ07_05340 GBZ09_19665 GBZ19_06355 GBZ20_16245 GBZ21_20920 GBZ57_15255 GBZ88_16205 GBZ96_10620 GCS50_17180 GCY20_17660 GDA07_18585 GDH40_18035 GDI37_18915 GDI50_10605 GDN42_04680 GI500_18260 GI569_18355 GI571_19455 GI574_15255 GI576_17370 GI587_15930 GI598_19450 GI602_19455 GI603_18270 GI605_16665 GI606_17755 GI607_18225 GI610_19850 GI613_18970 GI616_19915 GI617_18250 GI618_19650 GI619_18185 GI623_19925 GI627_19930 GI628_20335 GI635_19450 GI641_19620 GI643_19215 GI648_16180 GI652_19115 GI653_18965 GI656_10830 GI657_16195 GI658_10970 GI661_14545 GI664_14465 GI666_14865 GI667_19440 GI672_16195 GI673_19155 GI678_16820 GI679_18005 GI681_20130 GI682_19670 GI684_16950 GJE23_19345 GJE52_20320 GJE53_18800 GJE57_19140 GJE58_18480 GJE61_19460 GJE63_19120 GJE66_17975 GJE68_19380 GJE69_16935 GJE75_19455 GJE76_19455 GJE78_19465 GJE80_18250 GJE81_19525 GJE83_18265 GJE85_18895 GJE87_17205 GJE88_18245 GJE91_18740 GJE97_17405 GJE99_16230 GJF01_19455 GJF04_19450 GJF05_19445 GJF06_19145 GJF07_16855 GJF11_14795 GJF12_19000 GJF15_18775 GJF17_18765 GJF18_19035 GJF25_18900 GJF26_19420 GJF28_19175 GJF31_18790 GJF33_18960 GJF41_19610 GJF44_19235 GJF47_19445 GJF49_19145 GJF51_20105 GJF54_19450 GJF59_18550 GJF61_19930 GJF63_18475 GJF64_19455 GJF68_18410 GJF69_18870 GJF75_19785 GJF76_19450 GJF77_19140 GJF78_19925 GJF81_16490 GJF83_18960 GJF85_19920 GJF86_18955 GJF88_19445 GJF90_20340 GJF91_20505 GJF93_19465 GJF95_18650 GJF99_17980 GJG01_19920 GJG02_19360 GJG03_14565 GJG05_14715 GJG07_11790 GJG10_16200 GJG11_15865 GJG13_13795 GJG14_16105 GJG15_14705 GJG16_17040 GJG17_14795 GJG18_23365 GJG24_15060 GJG25_15325 GJG26_16315 GJG28_16415 GJG29_14235 GJG30_16180 GJG35_16225 GJG37_15715 GJG38_18655 GJG39_18260 GJG40_14820 GJG45_19440 GJG48_17440 GJG49_18945 GJG51_19455 GJG54_21345 GJG57_19125 GJG58_19175 GJG60_18005 GJG63_17960 GJG66_18105 GJG70_17990 GJG71_16195 GJG76_18470 GJG77_18995 GJG81_16360 GJG84_18715 GNA67_003852 GNA68_003740 GNA89_003109 GNA90_003610 GNA94_003248 GNA95_003605 GNB01_003578 GNB24_003575 GNB30_003635 GNB32_003570 GNB39_003909 GNB51_003077 GNB52_003552 GNB53_003749 GNB87_003935 GNB90_003879 GYI57_002966 GYK12_04750 GYK13_17425 OB33_18235 R841_07660 ZQ07_09565 ZR89_19430 ZW25_11665] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)]
[yjeF nnr nnrD nnrE A6V01_16625 A9X72_22835 AC789_1c45800 ACN002_4392 AW106_17115 AWB10_23600 BB545_04070 BN17_41441 BOH76_10905 BON72_19710 BON76_04155 BON95_14955 BTQ06_07255 BVL39_04290 C5F73_05795 C5N07_07145 C6669_06565 C7235_22665 C7B02_22745 C9306_16010 C9Z28_08925 C9Z37_19300 C9Z89_19770 CA593_04975 CO706_20770 COD30_21525 CR538_23135 CRD98_04165 CRM83_17370 D0X26_12915 D2184_07750 D4628_06615 D4636_22485 D5H35_20705 D6004_16440 D6T60_21965 D6T98_03825 D6X36_01235 D7Z75_22435 D9610_19255 D9F87_11835 D9G95_09255 D9J44_09440 D9K48_15185 D9S45_09270 DAH18_07435 DBQ99_23525 DEO20_13735 DIV22_15595 DL479_09745 DL530_20050 DL705_08080 DL800_29085 DLU50_02155 DLU67_01070 DM155_20490 DM267_22125 DM296_19440 DM820_22760 DMZ30_14180 DN660_14005 DN700_22785 DN808_26000 DND79_22955 DOY67_18795 DP277_02605 DQF36_19900 DQF57_15735 DQF72_18940 DQP61_08520 DRW19_23395 DS143_20990 DS732_02620 DVB38_20810 E4K51_09050 E4K53_08625 E4K55_08625 E5S38_10420 EAM59_16370 EAN77_04060 EAX79_02935 EB476_05880 EB525_RS07260 EBM08_18815 ED600_08260 EG075_07990 EG599_16930 EG796_08825 EH412_13985 EHD79_20055 EHH55_18965 EHJ36_13975 EI028_05185 EJ366_20605 EJC75_20595 EKI52_12685 EYD11_20595 EYV18_13035 EYY78_08665 F7D02_20255 F7F23_18595 F7F26_20125 F7F56_08475 FQ915_09945 FQZ46_21935 G5668_17825 G5680_17200 G5686_17280 GNZ05_12065 GP662_06490 GP664_20690 GP666_16320 GP698_02295 GP935_18145 GP945_15635 GP946_15695 GQN16_16290 GQN24_16710 GRW12_08105 GUB85_10740 GUB91_12710 GUB95_12420 GUC01_09020 GUC12_13450 HV022_21340 HV156_11280 HV159_13410 HVZ12_22090 HZT35_15135] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)]
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BMA87_25350 BMT91_24760 BON76_21885 BON98_16880 BvCmsC61A_00149 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C7B08_25495 CR538_10415 D3Y67_22910 D4023_08350 D9G42_11130 D9I97_22010 D9J11_25195 D9J52_16665 DJ503_24045 DLX40_18195 DM267_05215 DN627_18690 DP258_02540 DQE91_25240 EC3234A_36c00010 EC382_21100 ECTO6_01955 EHH55_07135 F9B07_15220 FORC82_1921 FV293_07100 GKE15_01795 GKE22_01795 GKE24_01795 GKE26_01795 GKE29_19015 GKE31_01795 GKE39_01795 GKE46_01795 GKE58_00235 GKE60_01795 GKE64_01795 GKE69_17580 GKE77_01800 GKE79_01795 GKE87_19180 GKE93_04790 GKF39_23615 GKF74_23075 GKF86_23585 GKF89_24720 GKG12_21690 GP650_12530 GP662_07780 GP700_02420 GP720_02430 GP727_01495 GP912_03195 GP954_23930 GQE36_20530 HV109_09045 HVX75_09660 HVZ53_09665 HX136_09920 HXS78_09430 NCTC8500_02249 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[nnr nnrD nnrE BHS81_24940 BMA87_06210 BON75_25135 BUE81_24185 BW690_00535 C5F72_23675 C5P01_11605 C9114_00800 C9160_20005 C9201_17640 C9Z03_11025 CG692_00180 CI641_014360 CI693_12780 COD46_22200 CWS33_03515 D2185_07770 D3821_07085 D3O91_01535 D3Y67_00680 D4011_02210 D6W00_07670 D6X63_00505 D7W70_13040 D8Y65_09515 D9D20_08295 D9D44_05795 D9H68_15720 D9H94_06330 D9I18_04405 D9J11_13510 D9J52_05810 DAH30_09295 DAH34_17710 DAH37_06235 DEN89_23315 DEO04_15015 DK132_00975 DL292_04305 DL326_12595 DLU82_19955 DM973_03315 DMC44_08050 DMY83_06260 DNW42_15620 DOY22_05310 DOY61_22135 DQE91_09055 DT034_15395 E0I42_01095 E2119_06500 E5S42_20000 E5S56_11810 EA213_12050 EAI42_08035 EAI42_19730 EAI46_08330 ED307_02425 EEP23_07485 EH186_16255 EI021_09655 EI041_04975 EL75_3998 EL79_4176 EL80_4091 EPT01_09990 EXX24_09350 F0L67_00935 F1E19_03510 FNW97_22675 FQ022_21765 FRV13_14670 FV293_00830 G5632_13635 GII66_00800 GKF89_03420 GNZ03_04915 GP654_08840 GP678_11365 GP689_08305 GQA63_14675 GQE30_17865 GQE33_09220 GQE34_01730 GQE51_12505 GQE64_09140 GQF59_13930 GQM10_00800 GRW05_08900 GRW57_11930 GRW80_01300 GRW81_08375 HVY77_23140 HVY93_21430 HX136_22720 HXS78_20595 RK56_012375] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)]
[cobB A8C65_17980 A9R57_10780 ACU57_04380 AM464_23635 BJJ90_15625 BMT91_12645 BN17_09831 BON75_05285 BON98_05145 BvCms12BK_01118 BvCmsHHP001_00979 BvCmsHHP019_01023 BvCmsHHP056_02943 BvCmsKSP011_05316 BvCmsKSP024_01940 BvCmsKSP026_03162 BvCmsSINP011_02951 BW690_23120 BZL31_08405 C2U48_03300 C5F72_15645 CG692_05810 CI693_26075 CI694_24500 D2185_03810 D3821_20670 D3O91_24920 D3Y67_15945 D4718_04355 D9D20_13915 D9G69_05205 D9H68_09100 D9I18_08715 D9I97_05705 D9J11_10470 D9J52_06705 D9Z28_16645 DAH34_08040 DL326_11095 DT034_08485 DTL43_16110 DXT71_17790 DXT73_16565 E2119_09590 E2127_07825 E2128_06715 E2134_02425 E2135_09110 E4K61_12600 EA213_13010 EAI52_08920 EC1094V2_2712 ECTO6_02838 ED307_19155 EI021_06925 EI032_10515 EIZ93_12995 EL75_2625 EL79_2659 EL80_2637 EPT01_12255 ERS150873_02733 EXX71_16955 F1E19_06620 F9040_05140 F9X20_14590 FNW97_05865 FRV13_07595 FV293_24135 G5632_08605 G5688_05235 GII66_19990 GJD95_14640 GJD96_14830 GKG12_11215 GP689_02460 GQE22_15660 GQE33_15650 GQE34_18495 GQE42_09405 GQE64_00790 GQE87_03440 GRW42_04440 GRW80_14965 GRW81_06920 HmCms184_02367 HV065_03675 HV109_14455 HVY77_15610 HVY93_14150 NCTC10429_05327 NCTC10963_03027 NCTC11126_00878 NCTC13216_03723 NCTC8500_03291 NCTC9058_03967 NCTC9062_05323 NCTC9073_01936 NCTC9117_03803 NCTC9706_00381 PGD_02175 RK56_003010 SAMEA3472044_03465 SAMEA3472047_01525 SAMEA3472080_03059 SAMEA3484427_03765 SAMEA3484429_03683 SAMEA3752557_01586 SAMEA3752559_02085 SAMEA3753097_03388 SAMEA3753300_01432 SK85_01186 WP7S17E04_26220 WR15_24010] NAD-dependent protein deacylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog)
[ppnP yaiE yaiE_1 yaiE_2 A6581_06820 A6592_08565 A6V01_02400 A8C65_08910 A9819_01890 A9P13_20020 A9R57_08485 A9X72_19070 AC067_13660 AC789_1c03900 ACN002_0406 ACN68_10320 ACN81_25005 ACU57_12035 ACU90_20960 AM270_02350 AM446_21575 AM464_18935 AM465_24670 AMK83_08820 AML35_16935 APT94_15240 APU18_24510 APZ14_19390 ARC77_21605 AU473_24575 AUQ13_18550 AUS26_08265 AW059_14025 AW106_10290 AWB10_19430 AWE53_023695 AWF59_002255 AWG78_005920 AWG90_003705 AZZ83_000156 B6V57_02070 B7C53_19905 B9N33_08655 B9T59_05995 BANRA_00817 BANRA_00925 BANRA_02015 BANRA_03594 BB545_15535 BE963_16095 BEN53_04105 BER14_23410 BFD68_18150 BHF03_17705 BHS81_02405 BHS87_02130 BIQ87_02175 BIU72_03345 BIZ41_26355 BJJ90_20310 BK248_04610 BK292_14635 BK373_01320 BK375_26975 BK383_14985 BMA87_04900 BMT91_05310 BN17_01951 BOH76_16090 BON63_11530 BON65_18745 BON66_09075 BON69_11595 BON72_15085 BON75_11450 BON76_23825 BON83_20655 BON86_03800 BON87_15370 BON91_23895 BON92_15465 BON94_14845 BON95_06500 BON96_22295 BON98_18895 BTQ04_02855 BTQ06_17790 BUE81_15520 BvCms12BK_04795 BvCms2454_01767 BvCms28BK_00703 BvCms35BK_00554 BvCmsC61A_02990 BvCmsHHP001_01952 BvCmsHHP019_02594 BvCmsHHP019_02735 BvCmsHHP056_01410 BvCmsKKP036_04281 BvCmsKKP061_04019 BvCmsKSNP073_05624 BvCmsKSNP081_00030 BvCmsKSNP120_04274 BvCmsKSP011_04945 BvCmsKSP024_04930 BvCmsKSP045_04772 BvCmsKSP058_04860 BvCmsKSP067_05191 BvCmsKSP076_04759 BvCmsNSP006_01281 BvCmsNSP007_00849 BvCmsNSP047_03416 BvCmsNSP072_00997 BvCmsOUP014_01108 BvCmsSINP011_02573 BvCmsSINP022_02885 BvCmsSIP019_03625 BvCmsSIP024_01003 BvCmsSIP044_01545 BVL39_00880 BW690_06575 BWI89_12535 BWP17_02145 BXT93_00165 BZL31_10725 BZL69_16805 C2M16_02670 C2U48_08110 C4K41_08090 C4M78_16865 C5715_13595 C5F72_20070 C5F73_09375 C5N07_12740 C5P01_16305 C5P44_19530 C6669_02755 C7235_18880 C7B02_04545 C7B06_13385 C7B07_15195 C7B08_06180 C7B18_00985 C9114_16640 C9160_00550 C9201_03800 C9306_02820 C9E25_04580 C9E67_23765 C9Z03_06575 C9Z23_12315 C9Z28_08265 C9Z37_04640 C9Z68_20485 C9Z70_09610 C9Z78_08360 C9Z89_10690 CA593_01185 CCZ14_02440 CCZ17_04120 CDC27_00860 CDL37_09465 CG692_05055 CI641_017850 CI693_15730 CI694_14320 CJU63_02125 CJU64_02110 CO706_24355 COD30_16055 COD46_04855 CQP61_20925 CR538_19495 CR539_06140 CRD98_01665 CRE06_07890 CRM83_13790 CRT43_02180 CRX46_25985 CT146_15735 CUB99_06570 CV83915_01183 CVH05_20630 CWS33_22875 D0X26_07420 D1912_23295 D2184_11515 D2185_12065 D2188_07740 D3821_12900 D3822_22465 D3C88_28950 D3M98_10990 D3O91_15305 D3Y67_14350 D4011_06560 D4023_06905 D4074_04630 D4628_13540 D4636_05645 D4660_05035 D4718_02350 D4L91_04625 D4M06_05545 D4M76_11590 D4U49_03050 D4U85_07085 D4V08_07680 D5H35_11765 D5I97_03520 D6004_10480 D6C36_05740 D6D43_08420 D6T60_09300 D6T98_08110 D6W00_11135 D6X36_16585 D6X63_13510 D6X76_06760 D7K33_06120 D7K63_09055 D7K66_05505 D7W70_07505 D7Y10_05925 D7Z75_05315 D8Y65_05290 D9610_20040 D9C99_17255 D9D20_11505 D9D31_21970 D9D33_06060 D9D43_14830 D9D94_14580 D9E13_00125 D9E34_09525 D9E49_06955 D9E73_13115 D9F32_03890 D9F87_10325 D9G11_17940 D9G42_13940 D9G48_15840 D9G69_10950 D9G95_10030 D9H10_13930 D9H53_17415 D9H68_03320 D9H70_06445 D9H94_24405 D9I18_05395 D9I20_07245 D9I37_10805 D9I87_03310 D9I88_07660 D9I97_02265 D9J03_17400 D9J11_02150 D9J44_05830 D9J46_05500 D9J52_12125 D9J58_08695 D9J61_02635 D9K02_04260 D9K48_11575 D9K54_20845 D9L89_06360 D9L99_04375 D9S45_05535 D9X77_04435 D9X97_05410 D9Z28_01965 DAH18_14975 DAH26_10405 DAH30_15925 DAH34_21345 DAH37_05240 DBQ99_19625 DD762_07680 DEN86_05080 DEN89_14495 DEO04_04545 DEO20_14385 DIV22_26285 DJ503_01820 DK132_06010 DL257_08620 DL292_11525 DL326_11415 DL455_04445 DL479_02175 DL530_07575 DL545_19130 DL705_16435 DL800_03885 DL979_15710 DLT82_12465 DLU50_08285 DLU82_01595 DLX40_16565 DLY41_06340 DLY44_14080 DM102_12740 DM129_06110 DM155_09525 DM267_00880 DM296_09365 DM382_20220 DM820_05775 DM962_06005 DM973_16495 DMC44_03035 DMI04_05340 DMI53_06710 DMO02_05340 DMY83_21365 DMZ30_04890 DMZ50_06340 DN627_04525 DN660_05650 DN700_06730 DN703_04290 DN808_18120 DNB37_05440 DNC98_06510 DND16_02325 DND79_04070 DNI21_04080 DNJ62_06830 DNK12_05040 DNQ45_00335 DNR35_00475 DNR41_17405 DNW42_09070 DNX19_03125 DOE35_04920 DOS18_04715 DOT81_06465 DOU81_04760 DOY22_07805 DOY56_05925 DOY61_02085 DOY67_05265 DP258_05110 DP265_04025 DP277_07535 DQE91_06675 DQF36_00830 DQF57_07675 DQF72_03865 DQG35_06310 DQO13_05500 DQP61_12090 DRP48_07670 DRW19_06400 DS143_21555 DS721_06100 DS732_06920 DS966_18475 DT034_10500 DTL43_07415 DTL90_10740 DTM10_06080 DTM45_10960 DTZ20_03380 DU321_19460 DU333_14985 DVB38_10440 DW236_15815 DWB25_19225 DXT69_08115 DXT71_02970 DXT73_01860 DXX80_018650 E0I42_07410 E0L04_02150 E0L12_02445 E2114_20640 E2115_06350 E2119_01725 E2126_014065 E2127_09375 E2128_04435 E2129_13975 E2134_12225 E2135_01410 E2855_00540 E2863_00426 E4K51_12070 E4K53_09880 E4K55_09545 E4K61_11255 E5P24_15620 E5P28_11315 E5S38_06765 E5S42_13060 E5S56_05125 E5S58_11035 E5S61_09810 E5S62_19990 EA159_14475 EA164_19085 EA167_08615 EA174_09235 EA184_12770 EA191_05310 EA198_18085 EA200_17785 EA203_10735 EA213_08335 EA214_19270 EA225_09190 EA231_12680 EA232_03760 EA233_12800 EA239_15730 EA242_16550 EA245_15610 EA250_12110 EA429_16040 EA433_19520 EA434_07105 EA435_05820 EA834_11650 EAI42_35435 EAI46_25725 EAI46_25840 EAI52_02950 EAM59_14455 EAN70_14905 EAN77_07940 EAX79_06830 EB476_03650 EB509_06855 EB510_01625 EB515_09345 EB525_RS00545 EBA46_13990 EBJ06_07125 EBM08_07705 EBP16_12520 EC1094V2_3464 EC3234A_4c00610 EC382_12595 EC95NR1_04612 ECs0441 ECTO124_03817 ECTO6_03708 ED225_07600 ED307_07160 ED600_06320 ED611_06650 ED648_16775 ED903_13725 ED944_09580 EEA45_02855 EEP23_01045 EF082_13590 EF173_10565 EG075_09120 EG599_13105 EG796_02110 EG808_04255 EGC26_06115 EGT48_21390 EGU87_05200 EH186_21735 EH412_12630 EHD63_07610 EHD79_03470 EHH55_15815 EHJ36_08465 EHJ66_07060 EHV81_03360 EHV90_10850 EHW09_13270 EHX09_04730 EI021_16245 EI028_11795 EI032_07550 EI041_08145 EIA21_11810 EIZ93_00830 EJ366_17220 EJC75_24145 EKI52_09170 EL75_3359 EL79_3454 EL80_3408 ELT17_22260 ELT22_04045 ELT23_00125 ELT31_00280 ELT33_03015 ELT48_00735 ELT49_21480 ELT58_21305 ELU82_03335 ELU85_08960 ELU96_05805 ELV00_13055 ELV08_00785 ELV13_00555 ELV15_22680 ELV22_01630 ELV24_16525 ELV28_08410 ELX56_03900 ELX61_20790 ELX68_02065 ELX69_19550 ELX70_07125 ELX76_05850 ELX79_24270 ELX83_01445 ELY05_09885 ELY23_04665 ELY24_07180 ELY32_22740 ELY41_15435 ELY48_07355 ELY50_04295 EO241_13835 EPS76_10515 EPS91_09770 EPT01_06355 EQ820_00745 EQ823_11615 EQ825_18070 EQ830_03660 EQO00_19840 ERS085365_01840 ERS085366_04179 ERS085374_02377 ERS085379_01215 ERS085383_01024 ERS085386_01096 ERS085404_01742 ERS085406_02227 ERS085416_01968 ERS139211_01252 ERS150873_01858 EST51_18990 EVY14_00050 EWK56_10245 EXM29_24150 ExPECSC038_04895 ExPECSC065_04439 EXX06_12400 EXX13_09665 EXX23_09965 EXX24_01870 EXX53_07630 EXX55_11875 EXX71_12170 EXX87_11565 EYD11_17450 EYV18_10135 EYX82_01145 EYY27_15550 EYY34_27625 EYY78_10095 F0L67_19465 F1E19_02455 F7D02_16780 F7D05_04595 F7D06_00920 F7F11_06850 F7F23_13355 F7F26_08530 F7F56_11190 F7G03_09695 F9040_18980 F9050_11410 F9059_11725 F9B07_11235 F9X20_10705 F9Z74_08605 FAF34_030290 FE846_08235 FKO60_24460 FNJ67_20330 FNJ69_23475 FNW97_01845 FORC82_3666 FPI65_02250 FQ021_04720 FQ022_05995 FQ915_14565 FQU83_20855 FQZ46_13785 FRV13_03860 FTV90_10360 FTV92_11870 FTV93_12360 FV293_06120 FV295_17245 FV438_20585 FWK02_29295 FZC17_02065 FZN26_02330 FZN30_08825 G3565_02860 G5616_16275 G5668_11855 G5670_13140 G5675_09500 G5680_11755 G5686_06920 G5688_07395 G5696_10795 G6Z99_23355 GFU40_10345 GFU45_05185 GFU47_21615 GII66_02490 GII67_08760 GIJ01_19765 GIY13_13165 GIY19_15475 GJ11_02375 GJ638_13910 GJD95_18350 GJD97_21645 GKE15_12960 GKE22_07290 GKE24_12270 GKE26_09485 GKE29_12130 GKE31_10420 GKE39_07870 GKE46_05810 GKE58_10855 GKE60_09410 GKE64_05810 GKE69_07380 GKE77_09145 GKE79_09230 GKE87_01825 GKE92_20460 GKE93_01170 GKE98_12210 GKF34_16490 GKF39_01885 GKF52_17565 GKF74_01460 GKF86_04910 GKF89_04055 GKG12_02940 GNZ00_09900 GNZ02_03615 GNZ03_09955 GNZ05_01665 GP650_16700 GP654_09510 GP661_19290 GP662_13045 GP664_11395 GP666_10645 GP678_21450 GP689_14645 GP698_13660 GP700_10180 GP711_02810 GP712_12955 GP720_05730 GP727_13245 GP912_14540 GP935_14810 GP945_18805 GP946_18990 GP954_12950 GP979_17585 GQA63_00790 GQE22_09325 GQE30_08115 GQE33_07115 GQE34_00765 GQE36_18000 GQE42_04900 GQE47_13225 GQE51_10750 GQE58_13505 GQE64_07505 GQE68_24505 GQE87_15550 GQE88_10390 GQE93_05310 GQF59_00790 GQM04_16295 GQM06_17115 GQM09_10135 GQM10_05275 GQM13_16755 GQM17_10365 GQM18_17190 GQM28_05335 GQN16_05995 GQN24_05490 GQN33_00860 GQS26_04035 GRW05_15575 GRW12_15215 GRW30_07965 GRW42_03295 GRW57_16360 GRW80_21245 GRW81_04110 GUB08_22335 GUB85_11880 GUB91_14510 GUB95_14180 GUC01_07480 GUC12_15000 GUI33_03675 HHJ41_01370 HmCms169_03669 HmCms184_01874 HmCmsJML074_04353 HmCmsJML079_00649 HmCmsJML146_03132 HmCmsJML204_02343 HMPREF3040_03387 HPE49_20435 HPE52_15660 HR075_18950 HV022_17950 HV023_08705 HV065_00215 HV098_18955 HV109_18115 HV156_07825 HV159_09785 HV160_09785 HV168_09465 HV260_09930 HV303_20415 HVV39_18775 HVW22_00965 HVW93_05045 HVW95_10270 HVX17_19490 HVX75_18690 HVY01_17550 HVY77_19945 HVY93_17995 HVZ12_18920 HVZ21_18085 HVZ47_04860 HVZ53_18680 HW43_05570 HX136_19525 HXS78_17140 HZT35_11660 MJ49_04490 MS8345_00396 NCTC10082_01078 NCTC10089_03910 NCTC10418_05682 NCTC10429_03762 NCTC10764_05371 NCTC10767_04209 NCTC10865_04787 NCTC10963_03206 NCTC11022_05137 NCTC11126_00022 NCTC11181_01145 NCTC11341_03896 NCTC12950_04180 NCTC13127_05156 NCTC13216_02895 NCTC13846_03688 NCTC7922_06246 NCTC7927_04270 NCTC8009_07014 NCTC8179_01642 NCTC8450_01367 NCTC8500_04283 NCTC8621_03984 NCTC8622_02997 NCTC8959_05017 NCTC8960_01314 NCTC8985_02798 NCTC9001_00537 NCTC9007_00270 NCTC9036_03840 NCTC9044_03501 NCTC9045_04434 NCTC9050_01764 NCTC9055_00703 NCTC9058_03120 NCTC9062_04466 NCTC9075_05103 NCTC9077_04792 NCTC9081_02496 NCTC9111_03977 NCTC9117_04804 NCTC9119_03997 NCTC9434_02812 NCTC9701_04128 NCTC9702_04480 NCTC9703_03222 NCTC9706_01114 NCTC9777_00174 NCTC9969_04032 PGD_02920 PU06_02955 RG28_02910 RK56_026705 RX35_02064 SAMEA3472043_02682 SAMEA3472044_00466 SAMEA3472047_02102 SAMEA3472055_02163 SAMEA3472056_03633 SAMEA3472070_02281 SAMEA3472080_01810 SAMEA3472090_01813 SAMEA3472108_01855 SAMEA3472110_00729 SAMEA3472112_02965 SAMEA3472114_01257 SAMEA3472147_04902 SAMEA3484427_03543 SAMEA3484429_01888 SAMEA3484434_01710 SAMEA3485101_03989 SAMEA3752372_02749 SAMEA3752553_00287 SAMEA3752557_00215 SAMEA3752559_02897 SAMEA3752620_00785 SAMEA3753064_01236 SAMEA3753097_00513 SAMEA3753164_00218 SAMEA3753290_01725 SAMEA3753300_00458 SK85_00418 SY51_02060 TUM18780_32860 U14A_00395 UC41_24265 UN86_08900 UN91_18725 WP2S18E08_35360 WP4S18E07_34480 WP7S17E01_36800 WP7S17E04_33320 WP7S18E09_37190 WQ89_01420 WR15_04360 YDC107_3656] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[cobB sir2 TM_0490] NAD-dependent protein deacetylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) (Sir2Tm)
[yjeF nnrD nnrE t4406 CAJ76_18910 CAJ80_12025 CAJ85_16745 CAL67_12535 CB224_17630 CC884_15170 CC907_13160 CC972_16855 D4Z37_21030 D6Q30_10805 DKA88_18575 DNM71_17840 DNV09_18940 DS261_21470 DUQ91_20925 DUV11_20235 DVG36_19690 EBC38_19550 EID90_19210 ELQ62_17220 EU445_18025 EVI00_20515 F9R11_18640 F9Y21_18425 FI137_14765 G2227_18665 G2244_16605 G3982_001993 G3V49_001017 G4I71_002410 G4L28_002401 G4P30_002128 G4Y41_000643 G4Y55_003260 G9264_002081 G9C68_003422 G9X37_001256 GDI29_20050 GND71_003613 ZZ17_16425] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)]
[nnr nnrD nnrE AM465_02020 B9N33_15780 CCZ14_19830 CCZ17_16420 CRT43_25115 CUB99_10555 D3M98_16440 D4M76_01520 DMZ50_17425 E0L04_15155 EA159_10695 EA164_20565 EA167_13135 EA191_15140 EA203_13015 EA232_12620 EA435_16485 EA834_13380 EGT48_17755 ELT48_15265 ELU82_07770 ELU96_21535 ELV00_12020 ELV13_19730 ELV22_09140 ELV24_17300 ELX56_19295 ELX68_09020 ELX79_17045 ELX83_07080 ELY23_03690 ELY24_03230 ELY50_08410 EPS76_03600 FNJ67_23970 G3565_21820 GJ638_00690 GQE47_08805 GQS26_11015 GUI33_10830 HR075_15410 HV303_16910] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)]
[hchA A8C65_13880 A9R57_25255 AMK83_16550 AWB10_10580 AWG90_013200 B7C53_22525 B9T59_01945 BJJ90_15205 BMT49_12710 BON65_01250 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5F73_18020 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9Z23_21970 C9Z37_00915 C9Z43_06360 C9Z78_05610 CDC27_10055 CDL37_00765 CI693_17820 CI694_25210 COD46_23180 CQP61_17160 CRD98_26150 D2188_01360 D4628_09465 D6T98_10515 D6X36_17295 D9D20_21030 D9D43_06110 D9G69_01560 D9H68_20750 D9H70_25730 D9I87_15275 D9J58_04360 D9S45_22925 DEN89_24995 DEO04_05510 DL705_18425 DL800_09215 DLU50_17670 DLW88_16170 DLY44_04800 DND16_20085 DNR35_16895 DQP61_11280 DTL43_21780 DTZ20_09315 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E4K53_17755 E4K55_17625 E4K61_03800 E5P24_13240 E5S62_15980 EA174_20215 EA213_19000 EA225_13320 EAX79_27320 EB525_RS22125 EBP16_01985 EC95NR1_00961 ED648_25045 EG796_17135 EHD79_18540 EI028_00085 ELV08_24970 ELX69_01215 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ExPECSC038_01920 EXX71_02385 EYD11_09165 F7D02_06115 F7D05_14270 F7D06_10605 F7F11_20115 F7F56_19940 F9050_12760 FQ915_04255 FQZ46_21375 FWK02_18105 FZN26_21485 G5688_24190 G5696_13480 GII66_08310 GIJ01_07415 GIY13_02485 GJD96_10575 GNZ00_15670 GNZ02_11235 GNZ03_00440 GP712_09450 GQE64_12165 GQE87_19550 GQM04_17335 GQM10_10435 GQM17_02800 GRW05_22880 GRW57_10520 GUB08_10670 GUB85_01360 GUB91_04210 GUB95_01360 GUC01_04925 GUC12_01360 HmCmsJML079_02678 HMPREF3040_01583 HV022_08990 HV160_01080 HVX17_09450 HVY77_10520 HVY93_09295 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WP4S18E07_18560 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)

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