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NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)

 NEMO_PIG                Reviewed;         419 AA.
A9QT41; F1RZ22; K7GSV8;
07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
05-FEB-2008, sequence version 1.
17-JUN-2020, entry version 94.
RecName: Full=NF-kappa-B essential modulator;
Short=NEMO;
AltName: Full=FIP-3;
AltName: Full=IkB kinase-associated protein 1;
Short=IKKAP1;
AltName: Full=Inhibitor of nuclear factor kappa-B kinase subunit gamma;
Short=I-kappa-B kinase subunit gamma;
Short=IKK-gamma;
Short=IKKG;
Short=IkB kinase subunit gamma;
AltName: Full=NF-kappa-B essential modifier;
Name=IKBKG;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Fang Y., Wang D., Li T., Xiao S., Fang L.;
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[3]
CLEAVAGE BY PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS SERINE
PROTEASE NSP4 AT GLU-349 (MICROBIAL INFECTION).
PubMed=25008936; DOI=10.1128/jvi.01396-14;
Huang C., Zhang Q., Guo X.K., Yu Z.B., Xu A.T., Tang J., Feng W.H.;
"Porcine reproductive and respiratory syndrome virus nonstructural protein
4 antagonizes beta interferon expression by targeting the NF-kappaB
essential modulator.";
J. Virol. 88:10934-10945(2014).
-!- FUNCTION: Regulatory subunit of the IKK core complex which
phosphorylates inhibitors of NF-kappa-B thus leading to the
dissociation of the inhibitor/NF-kappa-B complex and ultimately the
degradation of the inhibitor. Its binding to scaffolding polyubiquitin
seems to play a role in IKK activation by multiple signaling receptor
pathways. However, the specific type of polyubiquitin recognized upon
cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and
its functional importance is reported conflictingly. Also considered to
be a mediator for TAX activation of NF-kappa-B. Could be implicated in
NF-kappa-B-mediated protection from cytokine toxicity. Essential for
viral activation of IRF3. Involved in TLR3- and IFIH1-mediated
antiviral innate response; this function requires 'Lys-27'-linked
polyubiquitination. {ECO:0000250|UniProtKB:Q9Y6K9}.
-!- SUBUNIT: Homodimer; disulfide-linked. Component of the I-kappa-B-kinase
(IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four
alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG
subunits. The IKK core complex seems to associate with regulatory or
adapter proteins to form a IKK-signalosome holo-complex. The IKK
complex associates with TERF2IP/RAP1, leading to promote IKK-mediated
phosphorylation of RELA/p65. Part of a complex composed of NCOA2,
NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD,
NALP2, TRPC4AP and PIDD1. Interacts with ATM; the complex is exported
from the nucleus. Interacts with TRAF6. Interacts with IKBKE. Interacts
with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a
ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with
ZFAND5. Interacts with RIPK2. Interacts with TNIP1 and TNFAIP3; TNIP1
facilitates the TNFAIP3-mediated de-ubiquitination of IKBKG. Interacts
with TNFAIP3; the interaction is induced by TNF stimulation and by
polyubiquitin. Binds polyubiquitin; the interaction is mediated by two
domains; reports about the binding to 'Lys-63'-linked and/or linear
polyubiquitin, respective binding affinities and stoichiometry are
conflicting. Interacts with NLRP10. Interacts with TANK; this
interaction increases in response to DNA damage. Interacts with USP10;
this interaction increases in response to DNA damage. Interacts with
ZC3H12A; this interaction increases in response to DNA damage.
Interacts with IFIT5; the interaction synergizes the recruitment of IKK
to MAP3K7 and enhances IKK phosphorylation. Interacts with TRIM29; this
interaction induces IKBKG/NEMO ubiquitination and proteolytic
degradation. Interacts with TRIM13; this interaction leads to
IKBKG/NEMO ubiquitination (By similarity). Interacts with RIPK1 (By
similarity). {ECO:0000250|UniProtKB:O88522,
ECO:0000250|UniProtKB:Q9Y6K9}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y6K9}. Nucleus
{ECO:0000250|UniProtKB:Q9Y6K9}. Note=Sumoylated NEMO accumulates in the
nucleus in response to genotoxic stress.
{ECO:0000250|UniProtKB:Q9Y6K9}.
-!- DOMAIN: The leucine-zipper domain and the CCHC NOA-type zinc-finger are
essential for polyubiquitin binding and for the activation of IRF3.
{ECO:0000250|UniProtKB:Q9Y6K9}.
-!- PTM: Phosphorylation at Ser-68 attenuates aminoterminal
homodimerization. {ECO:0000250|UniProtKB:Q9Y6K9}.
-!- PTM: Polyubiquitinated on Lys-285 through 'Lys-63'; the ubiquitination
is mediated by NOD2 and RIPK2 and probably plays a role in signaling by
facilitating interactions with ubiquitin domain-containing proteins and
activates the NF-kappa-B pathway. Polyubiquitinated on Lys-399 through
'Lys-63'; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and
probably plays a role in signaling by facilitating interactions with
ubiquitin domain-containing proteins and activates the NF-kappa-B
pathway. Monoubiquitinated on Lys-277 and Lys-309; promotes nuclear
export. Polyubiquitinated through 'Lys-27' by TRIM23; involved in
antiviral innate and inflammatory responses. Linear polyubiquitinated
on Lys-111, Lys-143, Lys-226, Lys-246, Lys-264, Lys-277, Lys-285, Lys-
292, Lys-302, Lys-309 and Lys-326; the head-to-tail polyubiquitination
is mediated by the LUBAC complex and plays a key role in NF-kappa-B
activation. Deubiquitinated by USP10 in a TANK-dependent and
-independent manner, leading to the negative regulation of NF-kappa-B
signaling upon DNA damage. {ECO:0000250|UniProtKB:Q9Y6K9}.
-!- PTM: Sumoylated on Lys-277 and Lys-309 with SUMO1; the modification
results in phosphorylation of Ser-85 by ATM leading to a replacement of
the sumoylation by mono-ubiquitination on these residues.
{ECO:0000250|UniProtKB:Q9Y6K9}.
-!- PTM: Neddylated by TRIM40, resulting in stabilization of NFKBIA and
down-regulation of NF-kappa-B activity. {ECO:0000250|UniProtKB:Q9Y6K9}.
-!- PTM: (Microbial infection) Cleaved by porcine reproductive and
respiratory syndrome virus serine protease nsp4 after Glu-349. The
cleavage inhibits NEMO proper function. {ECO:0000269|PubMed:25008936}.
---------------------------------------------------------------------------
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EMBL; AEMK02000122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; EU258760; ABX57883.1; -; mRNA.
RefSeq; NP_001106524.1; NM_001113053.1.
RefSeq; XP_005674095.1; XM_005674038.2.
RefSeq; XP_005674097.1; XM_005674040.2.
RefSeq; XP_013842025.1; XM_013986571.1.
SMR; A9QT41; -.
STRING; 9823.ENSSSCP00000031038; -.
PaxDb; A9QT41; -.
PRIDE; A9QT41; -.
Ensembl; ENSSSCT00000048167; ENSSSCP00000059040; ENSSSCG00000012825.
Ensembl; ENSSSCT00015037010; ENSSSCP00015014717; ENSSSCG00015027234.
Ensembl; ENSSSCT00025017296; ENSSSCP00025006922; ENSSSCG00025012844.
Ensembl; ENSSSCT00030095898; ENSSSCP00030044189; ENSSSCG00030068530.
Ensembl; ENSSSCT00035059651; ENSSSCP00035023987; ENSSSCG00035044882.
Ensembl; ENSSSCT00040068051; ENSSSCP00040028929; ENSSSCG00040050271.
Ensembl; ENSSSCT00045064285; ENSSSCP00045045401; ENSSSCG00045037264.
Ensembl; ENSSSCT00050058363; ENSSSCP00050024992; ENSSSCG00050042920.
Ensembl; ENSSSCT00055014307; ENSSSCP00055011250; ENSSSCG00055007278.
Ensembl; ENSSSCT00060011074; ENSSSCP00060004090; ENSSSCG00060008639.
Ensembl; ENSSSCT00065008059; ENSSSCP00065003382; ENSSSCG00065005991.
GeneID; 100127355; -.
KEGG; ssc:100127355; -.
CTD; 8517; -.
VGNC; VGNC:89072; IKBKG.
eggNOG; ENOG410IJBJ; Eukaryota.
eggNOG; ENOG410Y1FG; LUCA.
GeneTree; ENSGT00530000063808; -.
KO; K07210; -.
OMA; AHPSFHL; -.
TreeFam; TF326608; -.
Proteomes; UP000008227; Chromosome X.
Bgee; ENSSSCG00000012825; Expressed in liver and 5 other tissues.
ExpressionAtlas; A9QT41; baseline and differential.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0008385; C:IkappaB kinase complex; IEA:Ensembl.
GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0000922; C:spindle pole; IEA:Ensembl.
GO; GO:0000151; C:ubiquitin ligase complex; IEA:Ensembl.
GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:InterPro.
GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
GO; GO:1990450; F:linear polyubiquitin binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
GO; GO:0051650; P:establishment of vesicle localization; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
InterPro; IPR032419; CC2-LZ_dom.
InterPro; IPR021063; NEMO_N.
InterPro; IPR034735; NEMO_ZF.
Pfam; PF16516; CC2-LZ; 1.
Pfam; PF11577; NEMO; 1.
PROSITE; PS51801; ZF_CCHC_NOA; 1.
1: Evidence at protein level;
Coiled coil; Cytoplasm; Disulfide bond; DNA damage; Isopeptide bond;
Kinase; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
Transcription; Transcription regulation; Transferase; Ubl conjugation;
Zinc; Zinc-finger.
CHAIN 1..419
/note="NF-kappa-B essential modulator"
/id="PRO_0000445606"
ZN_FING 389..419
/note="CCHC NOA-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01142"
REGION 44..111
/note="Interaction with CHUK/IKBKB"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
REGION 150..257
/note="Interaction with TANK"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
REGION 242..350
/note="Ubiquitin-binding (UBD)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
REGION 246..365
/note="Self-association"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
REGION 251..419
/note="Required for interaction with TNFAIP3"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
REGION 322..343
/note="Leucine-zipper"
/evidence="ECO:0000255"
REGION 382..419
/note="Interaction with CYLD"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
COILED 100..353
/evidence="ECO:0000255"
SITE 349..350
/note="(Microbial infection) Cleavage; by porcine
reproductive and respiratory syndrome virus serine protease
nsp4"
/evidence="ECO:0000269|PubMed:25008936"
MOD_RES 31
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 43
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 68
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 85
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 376
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 387
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
DISULFID 54
/note="Interchain"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
DISULFID 347
/note="Interchain"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 111
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 139
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 143
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 226
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 246
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 264
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 277
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO); alternate"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 277
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin); alternate"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 283
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 285
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 292
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 302
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 309
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO); alternate"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 309
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin); alternate"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 326
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 399
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
SEQUENCE 419 AA; 48637 MW; 12B7AF4B2583B883 CRC64;
MSRTPWKSQP CEMVQPSGGP AGDQDVLGEE SSLGKPTMLH LPSEQGAPET FQRCLEENQE
LRDAIRQSNQ MLRERCEELQ RFQGSQREEK EFLMQKFCEA RRLVERLSLE KLELRRQREQ
ALQEVELLKT CQQQMAEDKA SVKAQVTSLL GELQESQSRL EAATKERQAL ESRVRATSEQ
VRQLENEREA LQQQHSVQVD QLRLQSQSME AALRMERQAA SEEKRKLAQL QVAYHQLFQE
YDNHIKSSVV SSERNRGLQL EDLKQQLQQA EEALVAKQEV IDKLKEEAEQ HKIVMETVPV
LKAQADIYKA DFQAERQARE QLAERKELLQ EQLEQLQREY SRLKTSCQES ARIEDMRKRH
VEVSQPTLPP APAHHSFHPA LPSQRRSPPE EPPNFCCPKC QYQAPDMDTL QIHVMECIE


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Pathways :
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WP2292: Chemokine signaling pathway
WP1224: EBV LMP1 signaling
WP32: Translation Factors
WP866: EBV LMP1 signaling
WP262: EBV LMP1 signaling
WP2152: BDNF
WP1493: Carbon assimilation C4 pathway
WP1654: gamma-Hexachlorocyclohexane degradation
WP2199: Seed Development
WP1571: EBV LMP1 signaling
WP1694: Pyrimidine metabolism
WP1278: EBV LMP1 signaling
WP1701: Starch and sucrose metabolism
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP253: Glycolysis
WP868: estrogen signalling
WP542: Electron Transport Chain
WP1644: DNA replication
WP1722: Th1/Th2
WP1844: MAP kinase cascade
WP1567: Glycolysis and Gluconeogenesis
WP1693: Purine metabolism
WP1243: EBV LMP1 signaling
WP1328: EBV LMP1 signaling

Related Genes :
[IKBKG FIP3 NEMO] NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKG] NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKG NEMO] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[CHUK IKKA TCF16] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
[IKBKB IKKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[Chuk Ikka] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[CHUK IKKA] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (EC 2.7.11.10) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[IKBKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[chuk ikk1 zgc:56539] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[IKBKE IKKE IKKI KIAA0151] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[Ikbke Ikke Ikki] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[NFKBIA IKBA MAD3 NFKBI] NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
[TBK1 NAK] Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
[Rel CG11992] Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
[Nfkb2] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[RELA NFKB3] Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
[Nfkbia Ikba] NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (RL/IF-1)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] (Fragment)
[NFKB2 LYT10] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[Nfkbia Ikba] NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha)
[NFKBIA IKBA] NF-kappa-B inhibitor alpha (ECI-6) (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha)
[TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6] Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
[Rela Nfkb3] Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
[NFKBIB IKBB TRIP9] NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)

Bibliography :
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