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NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)

 NEMO_RAT                Reviewed;         412 AA.
Q6TMG5;
12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
17-JUN-2020, entry version 121.
RecName: Full=NF-kappa-B essential modulator;
Short=NEMO;
AltName: Full=IkB kinase-associated protein 1;
Short=IKKAP1;
AltName: Full=Inhibitor of nuclear factor kappa-B kinase subunit gamma;
Short=I-kappa-B kinase subunit gamma;
Short=IKK-gamma;
Short=IKKG;
Short=IkB kinase subunit gamma;
AltName: Full=NF-kappa-B essential modifier;
Name=Ikbkg; Synonyms=Nemo;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer 344;
PubMed=12968033; DOI=10.1074/jbc.m302549200;
Saito N., Courtois G., Chiba A., Yamamoto N., Nitta T., Hironaka N.,
Rowe M., Yamamoto N., Yamaoka S.;
"Two carboxyl-terminal activation regions of Epstein-Barr virus latent
membrane protein 1 activate NF-kappaB through distinct signaling pathways
in fibroblast cell lines.";
J. Biol. Chem. 278:46565-46575(2003).
-!- FUNCTION: Regulatory subunit of the IKK core complex which
phosphorylates inhibitors of NF-kappa-B thus leading to the
dissociation of the inhibitor/NF-kappa-B complex and ultimately the
degradation of the inhibitor. Its binding to scaffolding polyubiquitin
seems to play a role in IKK activation by multiple signaling receptor
pathways. Also considered to be a mediator for TAX activation of NF-
kappa-B. Could be implicated in NF-kappa-B-mediated protection from
cytokine toxicity. Essential for viral activation of IRF3. Involved in
TLR3- and IFIH1-mediated antiviral innate response; this function
requires 'Lys-27'-linked polyubiquitination (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Homodimer; disulfide-linked. Component of the I-kappa-B-kinase
(IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four
alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG
subunits. The IKK core complex seems to associate with regulatory or
adapter proteins to form a IKK-signalosome holo-complex. The IKK
complex associates with TERF2IP/RAP1, leading to promote IKK-mediated
phosphorylation of RELA/p65. Part of a complex composed of NCOA2,
NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD,
NALP2, TRPC4AP and PIDD1. Interacts with ATM; the complex is exported
from the nucleus. Interacts with TRAF6. Interacts with IKBKE. Interacts
with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a
ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with
ZFAND5. Interacts with TNIP1 and TNFAIP3; TNIP1 facilitates the
TNFAIP3-mediated de-ubiquitination of IKBKG. Interacts with TNFAIP3;
the interaction is induced by TNF stimulation and by polyubiquitin.
Interacts with NLRP10. Interacts with TANK; this interaction increases
in response to DNA damage (By similarity). Interacts with USP10; this
interaction increases in response to DNA damage (By similarity).
Interacts with ZC3H12A; this interaction increases in response to DNA
damage (By similarity). Interacts with TRIM29; this interaction induces
IKBKG/NEMO ubiquitination and proteolytic degradation (By similarity).
Interacts with TRIM13; this interaction leads to IKBKG/NEMO
ubiquitination (By similarity). Interacts with ARFIP2 (By similarity).
Interacts with RIPK1 (By similarity). {ECO:0000250|UniProtKB:O88522,
ECO:0000250|UniProtKB:Q9Y6K9}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
-!- DOMAIN: The leucine-zipper domain and the CCHC NOA-type zinc-finger are
essential for polyubiquitin binding and for the activation of IRF3.
{ECO:0000250}.
-!- PTM: Phosphorylation at Ser-68 attenuates aminoterminal
homodimerization. {ECO:0000250}.
-!- PTM: Polyubiquitinated on Lys-278 through 'Lys-63'; the ubiquitination
is mediated by NOD2 and RIPK2 and probably plays a role in signaling by
facilitating interactions with ubiquitin domain-containing proteins and
activates the NF-kappa-B pathway. Polyubiquitinated on Lys-392 through
'Lys-63'; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and
probably plays a role in signaling by facilitating interactions with
ubiquitin domain-containing proteins and activates the NF-kappa-B
pathway. Monoubiquitinated on Lys-270 and Lys-302; promotes nuclear
export. Polyubiquitinated through 'Lys-27' by TRIM23; involved in
antiviral innate and inflammatory responses. Linear polyubiquitinated
on Lys-111, Lys-143, Lys-226, Lys-246, Lys-270, Lys-278, Lys-285, Lys-
295, Lys-302 and Lys-319; the head-to-tail polyubiquitination is
mediated by the LUBAC complex and plays a key role in NF-kappa-B
activation. Deubiquitinated by USP10 in a TANK-dependent and
-independent manner, leading to the negative regulation of NF-kappa-B
signaling upon DNA damage (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:Q9Y6K9}.
-!- PTM: Sumoylated on Lys-270 and Lys-302 with SUMO1; the modification
results in phosphorylation of Ser-85 by ATM leading to a replacement of
the sumoylation by mono-ubiquitination on these residues.
{ECO:0000250}.
-!- PTM: Neddylated by TRIM40, resulting in stabilization of NFKBIA and
down-regulation of NF-kappa-B activity. {ECO:0000250}.
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EMBL; AY392762; AAQ94056.1; -; mRNA.
RefSeq; NP_954534.1; NM_199103.1.
RefSeq; XP_006229646.1; XM_006229584.3.
RefSeq; XP_006229647.1; XM_006229585.3.
SMR; Q6TMG5; -.
BioGRID; 259339; 1.
CORUM; Q6TMG5; -.
STRING; 10116.ENSRNOP00000053114; -.
PhosphoSitePlus; Q6TMG5; -.
PaxDb; Q6TMG5; -.
PRIDE; Q6TMG5; -.
Ensembl; ENSRNOT00000078438; ENSRNOP00000075158; ENSRNOG00000060936.
GeneID; 309295; -.
KEGG; rno:309295; -.
CTD; 8517; -.
RGD; 735223; Ikbkg.
eggNOG; ENOG410IJBJ; Eukaryota.
eggNOG; ENOG410Y1FG; LUCA.
GeneTree; ENSGT00530000063808; -.
HOGENOM; CLU_034097_0_0_1; -.
InParanoid; Q6TMG5; -.
KO; K07210; -.
OMA; AHPSFHL; -.
OrthoDB; 745047at2759; -.
PhylomeDB; Q6TMG5; -.
Reactome; R-RNO-1169091; Activation of NF-kappaB in B cells.
Reactome; R-RNO-168638; NOD1/2 Signaling Pathway.
Reactome; R-RNO-1810476; RIP-mediated NFkB activation via ZBP1.
Reactome; R-RNO-202424; Downstream TCR signaling.
Reactome; R-RNO-2871837; FCERI mediated NF-kB activation.
Reactome; R-RNO-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
Reactome; R-RNO-450302; activated TAK1 mediates p38 MAPK activation.
Reactome; R-RNO-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
Reactome; R-RNO-4755510; SUMOylation of immune response proteins.
Reactome; R-RNO-5357905; Regulation of TNFR1 signaling.
Reactome; R-RNO-5357956; TNFR1-induced NFkappaB signaling pathway.
Reactome; R-RNO-5607764; CLEC7A (Dectin-1) signaling.
Reactome; R-RNO-5684264; MAP3K8 (TPL2)-dependent MAPK1/3 activation.
Reactome; R-RNO-5689880; Ub-specific processing proteases.
Reactome; R-RNO-5689896; Ovarian tumor domain proteases.
Reactome; R-RNO-9020702; Interleukin-1 signaling.
Reactome; R-RNO-933542; TRAF6 mediated NF-kB activation.
Reactome; R-RNO-937039; IRAK1 recruits IKK complex.
Reactome; R-RNO-975144; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
PRO; PR:Q6TMG5; -.
Proteomes; UP000002494; Chromosome X.
Bgee; ENSRNOG00000060936; Expressed in liver and 8 other tissues.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0008385; C:IkappaB kinase complex; IDA:RGD.
GO; GO:0072686; C:mitotic spindle; ISO:RGD.
GO; GO:0005634; C:nucleus; ISO:RGD.
GO; GO:0032991; C:protein-containing complex; ISO:RGD.
GO; GO:0000922; C:spindle pole; ISO:RGD.
GO; GO:0000151; C:ubiquitin ligase complex; ISO:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; ISO:RGD.
GO; GO:1990450; F:linear polyubiquitin binding; ISO:RGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0042975; F:peroxisome proliferator activated receptor binding; IPI:RGD.
GO; GO:0019904; F:protein domain specific binding; ISO:RGD.
GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0044877; F:protein-containing complex binding; IPI:RGD.
GO; GO:1990459; F:transferrin receptor binding; ISO:RGD.
GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:RGD.
GO; GO:0007250; P:activation of NF-kappaB-inducing kinase activity; ISO:RGD.
GO; GO:0043276; P:anoikis; ISO:RGD.
GO; GO:0001782; P:B cell homeostasis; ISO:RGD.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
GO; GO:0051650; P:establishment of vesicle localization; ISO:RGD.
GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISO:RGD.
GO; GO:0016239; P:positive regulation of macroautophagy; ISO:RGD.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0065003; P:protein-containing complex assembly; ISO:RGD.
GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
InterPro; IPR032419; CC2-LZ_dom.
InterPro; IPR021063; NEMO_N.
InterPro; IPR034735; NEMO_ZF.
Pfam; PF16516; CC2-LZ; 1.
Pfam; PF11577; NEMO; 1.
PROSITE; PS51801; ZF_CCHC_NOA; 1.
2: Evidence at transcript level;
Coiled coil; Cytoplasm; Disulfide bond; DNA damage; Isopeptide bond;
Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
CHAIN 1..412
/note="NF-kappa-B essential modulator"
/id="PRO_0000269197"
ZN_FING 382..412
/note="CCHC NOA-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01142"
REGION 44..111
/note="Interaction with CHUK/IKBKB"
/evidence="ECO:0000250"
REGION 150..250
/note="Interaction with TANK"
/evidence="ECO:0000250"
REGION 242..343
/note="Ubiquitin-binding (UBD)"
REGION 246..358
/note="Self-association"
/evidence="ECO:0000250"
REGION 249..412
/note="Required for interaction with TNFAIP3"
/evidence="ECO:0000250"
REGION 315..336
/note="Leucine-zipper"
/evidence="ECO:0000255"
REGION 375..412
/note="Interaction with CYLD"
/evidence="ECO:0000250"
COILED 49..343
/evidence="ECO:0000255"
MOD_RES 31
/note="Phosphoserine; by IKKB"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 43
/note="Phosphoserine; by IKKB"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 68
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 85
/note="Phosphoserine; by ATM"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 369
/note="Phosphoserine; by IKKB"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
MOD_RES 380
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
DISULFID 54
/note="Interchain"
/evidence="ECO:0000250"
DISULFID 340
/note="Interchain"
/evidence="ECO:0000250"
CROSSLNK 111
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 139
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 143
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 226
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 246
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 270
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO); alternate"
/evidence="ECO:0000250"
CROSSLNK 270
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin); alternate"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 276
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 278
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 285
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 295
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 302
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO); alternate"
/evidence="ECO:0000250"
CROSSLNK 302
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin); alternate"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 314
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 319
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
CROSSLNK 392
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q9Y6K9"
SEQUENCE 412 AA; 48066 MW; 6D5D96B08A4CCEC2 CRC64;
MSRHLWKNQL SEMVQPSGGP AEDQDMLGEE SSLGKPAMLH LPSEQGTPET LQRCLEENQE
LRDAIRQSNQ MLRERCEELL HFQVSQREEK EFLMCKFQEA RKLVERLSLE KLDLRRQREQ
ALEDLEHLKK CQQQMAEDKA SVKAQVTSLL GELQESQSRL EAATKERQTL EGRIRAVSEQ
VRQLESEREV LQQQHSVQVD QLRMQNQSVE AALRMERQAA SEEKRKLAQL QAAYHQLFQD
YDSHIKSSKG MQLEDLRQQL QQAEEALVAK QELIDKLKEE AEQHKIVMET VPVLKAQADI
YKADFQAERH AREKLVERKE LLQEQLEQLQ REFNKLKVGC HESARIEDMR KRHVETSQPP
LLPAPAHHSF HLALSNQRRS PPEEPPDFCC PKCQYQAPDM DTLQIHVMEC IE


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Catalog number Product name Quantity
18-661-15103 NF-kappa-B essential modulator - NEMO; NF-kappa-B essential modifier; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IkB kinase subunit gamma; I-kappa-B kinase gamma; IKK-gamma; IKKG; IkB k 0.1 mg
EIAAB26935 I-kappa-B kinase subunit gamma,IkB kinase subunit gamma,IkB kinase-associated protein 1,Ikbkg,IKKAP1,IKKG,IKK-gamma,Inhibitor of nuclear factor kappa-B kinase subunit gamma,NEMO,Nemo,NF-kappa-B essent
EIAAB26933 Bos taurus,Bovine,I-kappa-B kinase subunit gamma,IkB kinase subunit gamma,IkB kinase-associated protein 1,IKBKG,IKKAP1,IKKG,IKK-gamma,Inhibitor of nuclear factor kappa-B kinase subunit gamma,NEMO,NEMO
EIAAB26932 I-kappa-B kinase subunit gamma,IkB kinase subunit gamma,IkB kinase-associated protein 1,Ikbkg,IKKAP1,IKKG,IKK-gamma,Inhibitor of nuclear factor kappa-B kinase subunit gamma,mFIP-3,Mouse,Mus musculus,N
EIAAB26934 FIP3,FIP-3,Homo sapiens,Human,I-kappa-B kinase subunit gamma,IkB kinase subunit gamma,IkB kinase-associated protein 1,IKBKG,IKKAP1,IKKG,IKK-gamma,Inhibitor of nuclear factor kappa-B kinase subunit gam
U1953h CLIA Homo sapiens,Human,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKKB,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibito 96T
E1953h ELISA Homo sapiens,Human,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKKB,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibit 96T
U1953m CLIA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,Mouse,Mus musculus,NFKBIKB,Nuclear factor NF-kappa-B inhibito 96T
U1953h CLIA kit Homo sapiens,Human,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKKB,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inh 96T
E1953h ELISA kit Homo sapiens,Human,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKKB,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B in 96T
E1953m ELISA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,Mouse,Mus musculus,NFKBIKB,Nuclear factor NF-kappa-B inhibit 96T
15-288-21170 Inhibitor of nuclear factor kappa-B kinase alpha subunit - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitou 0.05 mg
18-661-15055 Inhibitor of nuclear factor kappa-B kinase alpha subunit - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitou 0.1 mg
18-661-15038 Inhibitor of nuclear factor kappa-B kinase alpha subunit - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitou 0.1 mg
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U1953m CLIA kit I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,Mouse,Mus musculus,NFKBIKB,Nuclear factor NF-kappa-B inh 96T
E1953m ELISA kit I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,Mouse,Mus musculus,NFKBIKB,Nuclear factor NF-kappa-B in 96T
U1953b CLIA Bos taurus,Bovine,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kina 96T
18-661-15102 Inhibitor of nuclear factor kappa-B kinase epsilon subunit - EC 2.7.11.1; I kappa-B kinase epsilon; IkBKE; IKK-epsilon; IKK-E; Inducible I kappa-B kinase; IKK-i Polyclonal 0.1 mg
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U1953b CLIA kit Bos taurus,Bovine,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor 96T
U1953r CLIA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta,Rat,R 96T
E1953r ELISA kit I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta 96T
Pathways :
WP758: EBV LMP1 signaling
WP2292: Chemokine signaling pathway
WP1224: EBV LMP1 signaling
WP32: Translation Factors
WP866: EBV LMP1 signaling
WP262: EBV LMP1 signaling
WP2152: BDNF
WP1493: Carbon assimilation C4 pathway
WP1654: gamma-Hexachlorocyclohexane degradation
WP2199: Seed Development
WP1278: EBV LMP1 signaling
WP1571: EBV LMP1 signaling
WP1694: Pyrimidine metabolism
WP1701: Starch and sucrose metabolism
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1644: DNA replication
WP1722: Th1/Th2
WP253: Glycolysis
WP868: estrogen signalling
WP542: Electron Transport Chain
WP1844: MAP kinase cascade
WP1243: EBV LMP1 signaling
WP1567: Glycolysis and Gluconeogenesis
WP1693: Purine metabolism
WP2272: Pathogenic Escherichia coli infection

Related Genes :
[IKBKG FIP3 NEMO] NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKG] NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IKBKG NEMO] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[CHUK IKKA TCF16] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
[IKBKB IKKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[Chuk Ikka] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[CHUK IKKA] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (EC 2.7.11.10) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[IKBKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[chuk ikk1 zgc:56539] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[IKBKE IKKE IKKI KIAA0151] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[Ikbke Ikke Ikki] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[TBK1 NAK] Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
[NFKBIA IKBA MAD3 NFKBI] NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
[Rel CG11992] Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
[Nfkb2] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[Nfkbia Ikba] NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (RL/IF-1)
[RELA NFKB3] Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] (Fragment)
[NFKB2 LYT10] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[Nfkbia Ikba] NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha)
[NFKBIA IKBA] NF-kappa-B inhibitor alpha (ECI-6) (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha)
[NFKBIB IKBB TRIP9] NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
[chuk ikka TEgg047h13.1] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[Nfkbid Ikbns] NF-kappa-B inhibitor delta (I-kappa-B-delta) (IkB-delta) (IkappaBdelta) (IkappaBNS)

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