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NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)

 NKG2D_MOUSE             Reviewed;         232 AA.
O54709;
24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 2.
11-DEC-2019, entry version 155.
RecName: Full=NKG2-D type II integral membrane protein;
AltName: Full=Killer cell lectin-like receptor subfamily K member 1;
AltName: Full=NK cell receptor D;
AltName: Full=NKG2-D-activating NK receptor;
AltName: CD_antigen=CD314;
Name=Klrk1; Synonyms=Nkg2d;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=C57BL/6J;
PubMed=9600963; DOI=10.1073/pnas.95.11.6320;
Ho E.L., Heusel J.W., Brown M.G., Matsumoto K., Scalzo A.A., Yokoyama W.M.;
"Murine Nkg2d and Cd94 are clustered within the natural killer complex and
are expressed independently in natural killer cells.";
Proc. Natl. Acad. Sci. U.S.A. 95:6320-6325(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Spleen;
Butcher S., Cottage A., Cook G.P.;
"Mouse natural killer cell receptors homologous to human CD94 and NKG2-D.";
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=NMRI; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
STRAIN=C57BL/6J;
PubMed=9464811; DOI=10.1002/eji.1830271222;
Vance R.E., Tanamachi D.M., Hanke T., Raulet D.H.;
"Cloning of a mouse homolog of CD94 extends the family of C-type lectins on
murine natural killer cells.";
Eur. J. Immunol. 27:3236-3241(1997).
[5]
FUNCTION IN CYTOTOXICITY ACTIVATION, AND FUNCTION AS A RECEPTOR FOR RAET1A;
RAET1B; RAET1C; RAET1D AND H60.
PubMed=10894171; DOI=10.1016/s1074-7613(00)80222-8;
Cerwenka A., Bakker A.B., McClanahan T., Wagner J., Wu J., Phillips J.H.,
Lanier L.L.;
"Retinoic acid early inducible genes define a ligand family for the
activating NKG2D receptor in mice.";
Immunity 12:721-727(2000).
[6]
FUNCTION IN CYTOTOXICITY ACTIVATION, FUNCTION AS A RECEPTOR FOR RAET1B AND
H60, AND TISSUE SPECIFICITY.
PubMed=11248803; DOI=10.1038/77793;
Diefenbach A., Jamieson A.M., Liu S.D., Shastri N., Raulet D.H.;
"Ligands for the murine NKG2D receptor: expression by tumor cells and
activation of NK cells and macrophages.";
Nat. Immunol. 1:119-126(2000).
[7]
FUNCTION IN CYTOTOXICITY ACTIVATION, AND FUNCTION AS A RECEPTOR FOR RAET1B
AND H60.
PubMed=11557981; DOI=10.1038/35093109;
Diefenbach A., Jensen E.R., Jamieson A.M., Raulet D.H.;
"Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity.";
Nature 413:165-171(2001).
[8]
FUNCTION IN CYTOTOXICITY ACTIVATION, FUNCTION AS A RECEPTOR FOR RAET1E, AND
TISSUE SPECIFICITY.
PubMed=11567106; DOI=10.1126/science.1063916;
Girardi M., Oppenheim D.E., Steele C.R., Lewis J.M., Glusac E., Filler R.,
Hobby P., Sutton B., Tigelaar R.E., Hayday A.C.;
"Regulation of cutaneous malignancy by gammadelta T cells.";
Science 294:605-609(2001).
[9]
FUNCTION IN CYTOTOXICITY ACTIVATION, INDUCTION, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
PubMed=12150888; DOI=10.1016/s1074-7613(02)00333-3;
Jamieson A.M., Diefenbach A., McMahon C.W., Xiong N., Carlyle J.R.,
Raulet D.H.;
"The role of the NKG2D immunoreceptor in immune cell activation and natural
killing.";
Immunity 17:19-29(2002).
[10]
FUNCTION AS A RECEPTOR FOR MULT1.
PubMed=12370332; DOI=10.4049/jimmunol.169.8.4079;
Carayannopoulos L.N., Naidenko O.V., Fremont D.H., Yokoyama W.M.;
"Murine UL16-binding protein-like transcript 1: a newly described
transcript encoding a high-affinity ligand for murine NKG2D.";
J. Immunol. 169:4079-4083(2002).
[11]
REVIEW, AND ALTERNATIVE SPLICING.
PubMed=11973127; DOI=10.1016/s0952-7915(02)00337-0;
Vivier E., Tomasello E., Paul P.;
"Lymphocyte activation via NKG2D: towards a new paradigm in immune
recognition?";
Curr. Opin. Immunol. 14:306-311(2002).
[12]
FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION,
AND INTERACTION WITH HCST AND TYROBP.
PubMed=12426565; DOI=10.1038/ni858;
Diefenbach A., Tomasello E., Lucas M., Jamieson A.M., Hsia J.K., Vivier E.,
Raulet D.H.;
"Selective associations with signaling proteins determine stimulatory
versus costimulatory activity of NKG2D.";
Nat. Immunol. 3:1142-1149(2002).
[13]
FUNCTION IN CYTOTOXICITY ACTIVATION, AND INTERACTION WITH TYROBP.
PubMed=12426564; DOI=10.1038/ni857;
Gilfillan S., Ho E.L., Cella M., Yokoyama W.M., Colonna M.;
"NKG2D recruits two distinct adapters to trigger NK cell activation and
costimulation.";
Nat. Immunol. 3:1150-1155(2002).
[14]
TISSUE SPECIFICITY.
PubMed=15048723; DOI=10.1002/eji.200324793;
Alli R., Savithri B., Das S., Varalakshmi C., Rangaraj N., Khar A.;
"Involvement of NKR-P2/NKG2D in DC-mediated killing of tumor targets:
indicative of a common, innate, target-recognition paradigm?";
Eur. J. Immunol. 34:1119-1126(2004).
[15]
FUNCTION, INVOLVEMENT IN AUTOIMMUNE DIABETES, AND INDUCTION.
PubMed=15189740; DOI=10.1016/j.immuni.2004.05.008;
Ogasawara K., Hamerman J.A., Ehrlich L.R., Bour-Jordan H., Santamaria P.,
Bluestone J.A., Lanier L.L.;
"NKG2D blockade prevents autoimmune diabetes in NOD mice.";
Immunity 20:757-767(2004).
[16]
ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), INTERACTION WITH HCST AND TYROBP,
AND SUBCELLULAR LOCATION.
PubMed=15294961; DOI=10.4049/jimmunol.173.4.2470;
Rosen D.B., Araki M., Hamerman J.A., Chen T., Yamamura T., Lanier L.L.;
"A Structural basis for the association of DAP12 with mouse, but not human,
NKG2D.";
J. Immunol. 173:2470-2478(2004).
[17]
FUNCTION IN IMMUNITY AND ALLOGRAFT REJECTION, AND FUNCTION AS A RECEPTOR
FOR RAET1E.
PubMed=16086018; DOI=10.1038/ni1236;
Ogasawara K., Benjamin J., Takaki R., Phillips J.H., Lanier L.L.;
"Function of NKG2D in natural killer cell-mediated rejection of mouse bone
marrow grafts.";
Nat. Immunol. 6:938-945(2005).
[18]
FUNCTION IN TUMOR SURVEILLANCE, AND DISRUPTION PHENOTYPE.
PubMed=18394936; DOI=10.1016/j.immuni.2008.02.016;
Guerra N., Tan Y.X., Joncker N.T., Choy A., Gallardo F., Xiong N.,
Knoblaugh S., Cado D., Greenberg N.M., Greenberg N.R., Raulet D.H.;
"NKG2D-deficient mice are defective in tumor surveillance in models of
spontaneous malignancy.";
Immunity 28:571-580(2008).
[19]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[20]
FUNCTION IN NK CELL DIFFERENTIATION, AND DISRUPTION PHENOTYPE.
PubMed=19631564; DOI=10.1016/j.immuni.2009.06.017;
Zafirova B., Mandaric S., Antulov R., Krmpotic A., Jonsson H.,
Yokoyama W.M., Jonjic S., Polic B.;
"Altered NK cell development and enhanced NK cell-mediated resistance to
mouse cytomegalovirus in NKG2D-deficient mice.";
Immunity 31:270-282(2009).
[21]
REVIEW, AND FUNCTION.
PubMed=21898152; DOI=10.1007/s00018-011-0797-0;
Zafirova B., Wensveen F.M., Gulin M., Polic B.;
"Regulation of immune cell function and differentiation by the NKG2D
receptor.";
Cell. Mol. Life Sci. 68:3519-3529(2011).
[22]
REVIEW, AND FUNCTION AS A RECEPTOR FOR MHC CLASS I-RELATED GLYCOPROTEINS.
PubMed=23298206; DOI=10.1146/annurev-immunol-032712-095951;
Raulet D.H., Gasser S., Gowen B.G., Deng W., Jung H.;
"Regulation of ligands for the NKG2D activating receptor.";
Annu. Rev. Immunol. 31:413-441(2013).
[23]
X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 110-232.
PubMed=11224525; DOI=10.1038/85311;
Wolan D.W., Teyton L., Rudolph M.G., Villmow B., Bauer S., Busch D.H.,
Wilson I.A.;
"Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95
A.";
Nat. Immunol. 2:248-254(2001).
[24]
X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 110-232 IN COMPLEX WITH RAET1B.
PubMed=11825567; DOI=10.1016/s1074-7613(02)00258-3;
Li P., McDermott G., Strong R.K.;
"Crystal structures of RAE-1beta and its complex with the activating
immunoreceptor NKG2D.";
Immunity 16:77-86(2002).
-!- FUNCTION: Function as an activating and costimulatory receptor involved
in immunosurveillance upon binding to various cellular stress-inducible
ligands displayed at the surface of autologous tumor cells and virus-
infected cells. Provides both stimulatory and costimulatory innate
immune responses on activated killer (NK) cells, leading to cytotoxic
activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in
CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell
activation. Stimulates perforin-mediated elimination of ligand-
expressing tumor cells. Signaling involves calcium influx, culminating
in the expression of TNF-alpha. Participates in NK cell-mediated bone
marrow graft rejection. May play a regulatory role in differentiation
and survival of NK cells. Binds to ligands belonging to various
subfamilies of MHC class I-related glycoproteins including RAET1A,
RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1.
{ECO:0000269|PubMed:10894171, ECO:0000269|PubMed:11248803,
ECO:0000269|PubMed:11557981, ECO:0000269|PubMed:11567106,
ECO:0000269|PubMed:12150888, ECO:0000269|PubMed:12370332,
ECO:0000269|PubMed:12426564, ECO:0000269|PubMed:12426565,
ECO:0000269|PubMed:15189740, ECO:0000269|PubMed:16086018,
ECO:0000269|PubMed:18394936, ECO:0000269|PubMed:19631564,
ECO:0000269|PubMed:21898152, ECO:0000269|PubMed:23298206}.
-!- SUBUNIT: Homodimer; disulfide-linked. Heterohexamer composed of two
subunits of KLRK1 and four subunits of HCST/DAP10 (By similarity).
Isoform 1 (via transmembrane domain) interacts with HCST/DAP10; the
interaction is required for KLRK1 cell surface expression on activated
CD8(+) T-cells, but is dispensable on activated TYROBP-expressing NK
cells. Isoform 2 (via transmembrane domain) interacts with HCST/DAP10
(via transmembrane domain); the interaction is required for KLRK1 NK
cell surface expression and induces NK cell-mediated cytotoxicity.
Isoform 2 (via transmembrane domain) interacts with TYROBP (via
transmembrane domain); the interaction is required for KLRK1 NK cell
surface expression and induce NK cell-mediated cytotoxicity and
cytokine secretion. Isoform 1 does not interact with TYROBP. Interacts
with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (By
similarity). {ECO:0000250, ECO:0000250|UniProtKB:P26718,
ECO:0000269|PubMed:11825567, ECO:0000269|PubMed:12426564,
ECO:0000269|PubMed:12426565, ECO:0000269|PubMed:15294961}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12426565,
ECO:0000269|PubMed:15294961}; Single-pass type II membrane protein
{ECO:0000269|PubMed:12426565, ECO:0000269|PubMed:15294961}.
Note=Colocalized with HCST and TYROBP on the cell surface.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Comment=A number of isoforms are produced.;
Name=1; Synonyms=NKG2D long, NKG2D-L;
IsoId=O54709-1; Sequence=Displayed;
Name=2; Synonyms=NKG2D short, NKG2D-S;
IsoId=O54709-2; Sequence=VSP_053945;
-!- TISSUE SPECIFICITY: Expressed in natural killer (NK) cells, activated
CD8(+) alpha-beta and gamma-delta T-cells and natural killer T (NKT)
cells (at protein level). May be expressed on dendritic cell (DC).
Isoform 1 is strongly expressed in natural killer (NK) cells. Isoform 2
is weakly expressed in natural killer (NK) cells. Isoform 1 and isoform
2 are expressed in stimulated, but not in unstimulated, CD8(+) T-cells
and macrophages. {ECO:0000269|PubMed:11248803,
ECO:0000269|PubMed:11567106, ECO:0000269|PubMed:12150888,
ECO:0000269|PubMed:15048723}.
-!- DEVELOPMENTAL STAGE: Expressed in NK cells from the thymus at 15 dpc
(at protein level). {ECO:0000269|PubMed:12150888}.
-!- INDUCTION: Up-regulated in activated CD8(+) T-cells. Up-regulated upon
lipopolysaccharide (LPS) and interferon treatments in macrophages. Up-
regulated in CD8(+) T-cell infiltring pancreatic islets of prediabetic
nonobese diabetic (NOD) mice (at protein level). Isoform 1 and isoform
2 are up-regulated upon T-cell receptor (TCR) stimulation in CD8(+) T-
cells. Isoform 1 is modestly up-regulated upon lipopolysaccharide (LPS)
in macrophages. Isoform 2 is up-regulated upon lipopolysaccharide (LPS)
in macrophages. Isoform 2 is up-regulated upon poly(I:C) and
interleukin IL2 in natural killer (NK) cells.
{ECO:0000269|PubMed:12150888, ECO:0000269|PubMed:15189740}.
-!- DISEASE: Note=Involved in autoreactive CD8(+) T-cell-mediated
development of autoimmune diabetes. {ECO:0000269|PubMed:15189740}.
-!- DISRUPTION PHENOTYPE: Mice display no visible phenotype. According to
PubMed:18394936, show normal development of NK cells, B and T cells but
display enhanced formation of aggressive tumors. According to
PubMed:19631564, exhibit developmental perturbation in size of NK cell
subpopulations, increased proliferation, faster maturation and
increased sensitivity to apoptosis of immature NK cells, and lower
cytolytic response to KLRK1-sensitive tumor targets.
{ECO:0000269|PubMed:18394936, ECO:0000269|PubMed:19631564}.
-!- MISCELLANEOUS: Is not capable of signal transduction by itself; isoform
1 operates either through the signaling adapter protein HCST and
isoform 2 through both HCST and TYROBP signaling adapter proteins
(PubMed:12426564). Some families of ligands for mouse and human KLRK1
receptors have been characterized being very similar in structure and
highly likely to be orthologs. In humans, an additional distinct
subfamily of ligands (MICA and MICB) differs structurally, having an
extra MHC alpha 3-like domain (PubMed:23298206).
{ECO:0000305|PubMed:12426564, ECO:0000305|PubMed:23298206}.
-!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
Note=NKG2 D;
URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_286";
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EMBL; AF054819; AAC24356.1; -; mRNA.
EMBL; AF039026; AAD02117.1; -; mRNA.
EMBL; BC057147; AAH57147.1; -; mRNA.
EMBL; AF030313; AAC28245.1; -; mRNA.
CCDS; CCDS39660.1; -. [O54709-1]
CCDS; CCDS39661.1; -. [O54709-2]
RefSeq; NP_001076791.1; NM_001083322.2. [O54709-2]
RefSeq; NP_149069.1; NM_033078.4. [O54709-1]
PDB; 1HQ8; X-ray; 1.95 A; A=110-232.
PDB; 4PP8; X-ray; 1.95 A; A/B=109-232.
PDBsum; 1HQ8; -.
PDBsum; 4PP8; -.
SMR; O54709; -.
BioGrid; 205095; 3.
IntAct; O54709; 1.
STRING; 10090.ENSMUSP00000032252; -.
iPTMnet; O54709; -.
PhosphoSitePlus; O54709; -.
PaxDb; O54709; -.
PRIDE; O54709; -.
Ensembl; ENSMUST00000032252; ENSMUSP00000032252; ENSMUSG00000030149. [O54709-1]
Ensembl; ENSMUST00000095412; ENSMUSP00000093061; ENSMUSG00000030149. [O54709-2]
GeneID; 27007; -.
KEGG; mmu:27007; -.
UCSC; uc009egf.2; mouse. [O54709-1]
CTD; 22914; -.
MGI; MGI:1196250; Klrk1.
eggNOG; KOG4297; Eukaryota.
eggNOG; ENOG410XPJ1; LUCA.
GeneTree; ENSGT00940000154558; -.
HOGENOM; HOG000220925; -.
InParanoid; O54709; -.
KO; K06728; -.
OrthoDB; 1201127at2759; -.
PhylomeDB; O54709; -.
TreeFam; TF336674; -.
Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-MMU-2424491; DAP12 signaling.
ChiTaRS; Klrk1; mouse.
EvolutionaryTrace; O54709; -.
PRO; PR:O54709; -.
Proteomes; UP000000589; Chromosome 6.
RNAct; O54709; protein.
Bgee; ENSMUSG00000030149; Expressed in 91 organ(s), highest expression level in frontal cortex.
ExpressionAtlas; O54709; baseline and differential.
Genevisible; O54709; MM.
GO; GO:0009986; C:cell surface; IDA:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0019900; F:kinase binding; IPI:UniProtKB.
GO; GO:0042288; F:MHC class I protein binding; IPI:MGI.
GO; GO:0032394; F:MHC class Ib receptor activity; IMP:MGI.
GO; GO:0042803; F:protein homodimerization activity; IDA:MGI.
GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IDA:MGI.
GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:MGI.
GO; GO:0030101; P:natural killer cell activation; IMP:MGI.
GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
GO; GO:0034260; P:negative regulation of GTPase activity; IEA:Ensembl.
GO; GO:2000502; P:negative regulation of natural killer cell chemotaxis; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:MGI.
GO; GO:0030887; P:positive regulation of myeloid dendritic cell activation; ISO:MGI.
GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IDA:UniProtKB.
GO; GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; ISO:MGI.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IDA:MGI.
GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; IMP:MGI.
CDD; cd03593; CLECT_NK_receptors_like; 1.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR042169; NKG2D.
InterPro; IPR033992; NKR-like_CTLD.
PANTHER; PTHR47494; PTHR47494; 1.
Pfam; PF00059; Lectin_C; 1.
SMART; SM00034; CLECT; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
1: Evidence at protein level;
3D-structure; Adaptive immunity; Alternative splicing; Cell membrane;
Differentiation; Disulfide bond; Glycoprotein; Immunity; Innate immunity;
Lectin; Membrane; Receptor; Reference proteome; Signal-anchor;
Transmembrane; Transmembrane helix.
CHAIN 1..232
/note="NKG2-D type II integral membrane protein"
/id="PRO_0000046668"
TOPO_DOM 1..66
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 67..89
/note="Helical; Signal-anchor for type II membrane protein"
/evidence="ECO:0000255"
TOPO_DOM 90..232
/note="Extracellular"
/evidence="ECO:0000255"
DOMAIN 122..228
/note="C-type lectin"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
CARBOHYD 137
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 147
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 179
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 112..121
DISULFID 115..126
DISULFID 143..227
DISULFID 205..219
VAR_SEQ 1..13
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:9464811"
/id="VSP_053945"
STRAND 110..112
/evidence="ECO:0000244|PDB:4PP8"
STRAND 120..122
/evidence="ECO:0000244|PDB:1HQ8"
STRAND 125..134
/evidence="ECO:0000244|PDB:1HQ8"
HELIX 136..144
/evidence="ECO:0000244|PDB:1HQ8"
TURN 145..147
/evidence="ECO:0000244|PDB:1HQ8"
TURN 156..159
/evidence="ECO:0000244|PDB:1HQ8"
HELIX 160..164
/evidence="ECO:0000244|PDB:1HQ8"
STRAND 169..175
/evidence="ECO:0000244|PDB:1HQ8"
TURN 177..179
/evidence="ECO:0000244|PDB:1HQ8"
STRAND 182..184
/evidence="ECO:0000244|PDB:1HQ8"
TURN 192..194
/evidence="ECO:0000244|PDB:1HQ8"
STRAND 196..198
/evidence="ECO:0000244|PDB:1HQ8"
STRAND 205..208
/evidence="ECO:0000244|PDB:1HQ8"
STRAND 213..217
/evidence="ECO:0000244|PDB:1HQ8"
STRAND 223..229
/evidence="ECO:0000244|PDB:1HQ8"
SEQUENCE 232 AA; 26710 MW; 050536EF8C23088A CRC64;
MALIRDRKSH HSEMSKCHNY DLKPAKWDTS QEQQKQRLAL TTSQPGENGI IRGRYPIEKL
KISPMFVVRV LAIALAIRFT LNTLMWLAIF KETFQPVLCN KEVPVSSREG YCGPCPNNWI
CHRNNCYQFF NEEKTWNQSQ ASCLSQNSSL LKIYSKEEQD FLKLVKSYHW MGLVQIPANG
SWQWEDGSSL SYNQLTLVEI PKGSCAVYGS SFKAYTEDCA NLNTYICMKR AV


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EIAAB27284 Killer cell lectin-like receptor subfamily K member 1,Klrk1,NK cell receptor D,NK lectin-like receptor,Nkg2d,NKG2-D type II integral membrane protein,NKG2-D-activating NK receptor,NKLLR,Nkrp2,NKR-P2,R
EIAAB27287 Killer cell lectin-like receptor subfamily K member 1,KLRK1,NK cell receptor D,NKG2D,NKG2-D type II integral membrane protein,NKG2-D-activating NK receptor,Pig,Sus scrofa
EIAAB27286 Killer cell lectin-like receptor subfamily K member 1,Klrk1,Mouse,Mus musculus,NK cell receptor D,Nkg2d,NKG2-D type II integral membrane protein,NKG2-D-activating NK receptor
EIAAB27285 D12S2489E,Homo sapiens,Human,Killer cell lectin-like receptor subfamily K member 1,KLRK1,NK cell receptor D,NKG2D,NKG2-D type II integral membrane protein,NKG2-D-activating NK receptor
20-783-74234 MOUSE ANTI HUMAN CD314 FITC - NKG2-D-activating NK receptor; NK cell receptor D; Killer cell lectin-like receptor subfamily K member 1; CD314 antigen Monoclonal 0.1 mg
20-783-74230 MOUSE ANTI HUMAN CD314 Low Endotoxin - NKG2-D-activating NK receptor; NK cell receptor D; Killer cell lectin-like receptor subfamily K member 1; CD314 antigen Monoclonal 0.5 mg
EIAAB27283 CD159 antigen-like family member C,Homo sapiens,Human,KLRC2,NK cell receptor C,NKG2C,NKG2-C type II integral membrane protein,NKG2-C-activating NK receptor
EIAAB27282 CD159 antigen-like family member A,Homo sapiens,Human,KLRC1,NK cell receptor A,NKG2A,NKG2-A_B-activating NK receptor,NKG2-A_NKG2-B type II integral membrane protein
EIAAB27289 Homo sapiens,Human,KLRC4,NK cell receptor F,NKG2F,NKG2-F type II integral membrane protein,NKG2-F-activating NK receptor
EIAAB27288 Homo sapiens,Human,KLRC3,NK cell receptor E,NKG2E,NKG2-E type II integral membrane protein,NKG2-E-activating NK receptor
20-783-74030 RAT ANTI MOUSE NKG2A_C_E RPE - NKG2-A_B-activating NK receptor; NK cell receptor A; CD159a antigen Monoclonal 100 TESTS
4993 Killer cell lectin-like receptor subfamily A member 3 0.1 mg
4999 (IN) Killer cell lectin-like receptor subfamily A member 1 0.1 mg
4989 (CT) Killer cell lectin-like receptor subfamily A member 1 0.1 mg
5017 Killer cell lectin-like receptor subfamily A member 2 0.1 mg
5017 Killer cell lectin-like receptor subfamily A member 2 0.5 mg
4989 (CT) Killer cell lectin-like receptor subfamily A member 1 0.5 mg
4999 (IN) Killer cell lectin-like receptor subfamily A member 1 0.5 mg
4993 Killer cell lectin-like receptor subfamily A member 3 0.5 mg
CSB-EL012470DO Dog killer cell lectin-like receptor subfamily D, member 1 (KLRD1) ELISA kit, Species Dog, Sample Type serum, plasma 96T
CSB-EL012470RA Rat killer cell lectin-like receptor subfamily D, member 1 (KLRD1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL012472RA Rat killer cell lectin-like receptor subfamily G, member 1 (KLRG1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL012474RA Rat killer cell lectin-like receptor subfamily K, member 1 (KLRK1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL012474PI Pig killer cell lectin-like receptor subfamily K, member 1 (KLRK1) ELISA kit, Species Pig, Sample Type serum, plasma 96T
20-272-191893 CD94 - Mouse monoclonal [HP-3B1] to CD94; NK cell receptor; Killer cell lectin-like receptor subfamily D member 1; KP43 Monoclonal 0.1 mg
Pathways :
WP2328: Allograft rejection
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP1130: T Cell Receptor Signaling Pathway
WP480: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP780: T Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway
WP894: T Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP2272: Pathogenic Escherichia coli infection
WP23: B Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP352: T Cell Receptor Signaling Pathway
WP274: B Cell Receptor Signaling Pathway
WP2292: Chemokine signaling pathway
WP734: Serotonin Receptor 4/6/7 and NR3C Signaling
WP1133: Androgen receptor signaling pathway
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1004: Kit Receptor Signaling Pathway
WP1284: EPO Receptor Signaling
WP926: TGF-beta Receptor Signaling Pathway

Related Genes :
[Klrk1 Nkg2d Nkrp2] NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NK lectin-like receptor) (NKLLR) (NKG2-D-activating NK receptor) (NKR-P2) (CD antigen CD314)
[Klre1 NKG2I] Killer cell lectin-like receptor subfamily E member 1
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[KIR2DS2 CD158J NKAT5] Killer cell immunoglobulin-like receptor 2DS2 (CD158 antigen-like family member J) (MHC class I NK cell receptor) (NK receptor 183 ActI) (Natural killer-associated transcript 5) (NKAT-5) (p58 natural killer cell receptor clone CL-49) (p58 NK receptor CL-49) (CD antigen CD158j)
[Cd244 2b4 Nmrk] Natural killer cell receptor 2B4 (NK cell type I receptor protein 2B4) (NKR2B4) (Non-MHC restricted killing associated) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[CD244 2B4] Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[KIR2DS5 CD158G NKAT9] Killer cell immunoglobulin-like receptor 2DS5 (CD158 antigen-like family member G) (MHC class I NK cell receptor) (Natural killer-associated transcript 9) (NKAT-9) (CD antigen CD158g)
[Klrg1 Mafa] Killer cell lectin-like receptor subfamily G member 1 (Mast cell function-associated antigen 2F1)
[KIR2DS1 CD158H] Killer cell immunoglobulin-like receptor 2DS1 (CD158 antigen-like family member H) (MHC class I NK cell receptor Eb6 ActI) (CD antigen CD158h)
[Tyrobp Dap12 Karap] TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)
[TYROBP DAP12 KARAP] TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)
[SLAMF6 KALI UNQ6123/PRO20080] SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)
[CEACAM1 BGP BGP1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
[KIR3DS1 NKAT10] Killer cell immunoglobulin-like receptor 3DS1 (MHC class I NK cell receptor) (Natural killer-associated transcript 10) (NKAT-10)
[Clec9a Dngr-1] C-type lectin domain family 9 member A (Dendritic cell natural killer lectin group receptor 1) (CD antigen CD370)
[LILRB2 ILT4 LIR2 MIR10] Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
[CD300A CMRF35H IGSF12 HSPC083] CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)
[CD160 BY55] CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]
[Cd160 By55] CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]
[HLA-E HLA-6.2 HLAE] HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]
[LILRB1 ILT2 LIR1 MIR7] Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
[Klre1] Killer cell lectin-like receptor subfamily E member 1
[HCST DAP10 KAP10 PIK3AP UNQ587/PRO1157] Hematopoietic cell signal transducer (DNAX-activation protein 10) (Membrane protein DAP10) (Transmembrane adapter protein KAP10)
[CD69 CLEC2C] Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)
[LILRA2 ILT1 LIR7] Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h)
[CLEC7A BGR CLECSF12 DECTIN1 UNQ539/PRO1082] C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)
[LILRA5 ILT11 LILRB7 LIR9] Leukocyte immunoglobulin-like receptor subfamily A member 5 (CD85 antigen-like family member F) (Immunoglobulin-like transcript 11) (ILT-11) (Leukocyte immunoglobulin-like receptor 9) (LIR-9) (CD antigen CD85f)
[SLAMF7 CS1 UNQ576/PRO1138] SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319)
[MRC1 CLEC13D CLEC13DL MRC1L1] Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)
[MICA PERB11.1] MHC class I polypeptide-related sequence A (MIC-A)

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