GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

NLR family CARD domain-containing protein 4 (Ice protease-activating factor) (Ipaf)

 NLRC4_RAT               Reviewed;        1023 AA.
F1M649;
31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
31-OCT-2012, sequence version 2.
26-FEB-2020, entry version 68.
RecName: Full=NLR family CARD domain-containing protein 4;
AltName: Full=Ice protease-activating factor;
Short=Ipaf;
Name=Nlrc4; Synonyms=Ipaf;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
PubMed=15057822; DOI=10.1038/nature02426;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
Mockrin S., Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into mammalian
evolution.";
Nature 428:493-521(2004).
-!- FUNCTION: Key component of inflammasomes that indirectly senses
specific proteins from pathogenic bacteria and fungi and responds by
assembling an inflammasome complex that promotes caspase-1 activation,
cytokine production and macrophage pyroptosis. The NLRC4 inflammasome
is activated as part of the innate immune response to a range of
intracellular bacteria. {ECO:0000250|UniProtKB:Q3UP24}.
-!- SUBUNIT: Homooligomer; homooligomerizes following activation of Naip
proteins by pathogenic proteins such as S.typhimurium (Salmonella)
flagellin or PrgJ. Component of the NLRC4 inflammasome, at least
composed of NLRC4, caspase-1 (CASP1) and some NAIP family member (By
similarity). Interacts with EIF2AK2/PKR (By similarity).
{ECO:0000250|UniProtKB:Q3UP24, ECO:0000250|UniProtKB:Q9NPP4}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
{ECO:0000250|UniProtKB:Q3UP24}.
-!- DOMAIN: In an autoinhibited form the C-terminal leucine-rich repeat
(LRR) domain is positioned to sterically occlude one side of the NBD
domain and consequently sequester NLRC4 in a monomeric state. An ADP-
mediated interaction between the NBD and the WHD also contributes to
the autoinhibition. {ECO:0000250|UniProtKB:Q3UP24}.
-!- PTM: Phosphorylated at Ser-533 following infection of macrophages with
S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4
inflammasome function to promote caspase-1 activation and pyroptosis.
PRKCD phosphorylates Ser-533 in vitro. {ECO:0000250|UniProtKB:Q3UP24}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
RefSeq; NP_001296361.1; NM_001309432.1.
RefSeq; XP_008762713.1; XM_008764491.2.
SMR; F1M649; -.
STRING; 10116.ENSRNOP00000007655; -.
PaxDb; F1M649; -.
PRIDE; F1M649; -.
Ensembl; ENSRNOT00000007655; ENSRNOP00000007655; ENSRNOG00000005810.
GeneID; 298784; -.
KEGG; rno:298784; -.
UCSC; RGD:1309831; rat.
CTD; 58484; -.
RGD; 1309831; Nlrc4.
eggNOG; ENOG410IHIG; Eukaryota.
eggNOG; ENOG410YI2E; LUCA.
GeneTree; ENSGT00940000161744; -.
HOGENOM; CLU_011683_0_0_1; -.
InParanoid; F1M649; -.
KO; K12805; -.
OMA; MASWEKA; -.
OrthoDB; 137566at2759; -.
PRO; PR:F1M649; -.
Proteomes; UP000002494; Chromosome 6.
Bgee; ENSRNOG00000005810; Expressed in colon and 8 other tissues.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0072557; C:IPAF inflammasome complex; ISS:UniProtKB.
GO; GO:0005524; F:ATP binding; ISO:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IEA:Ensembl.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:RGD.
GO; GO:0002218; P:activation of innate immune response; ISS:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0042742; P:defense response to bacterium; ISS:UniProtKB.
GO; GO:0016045; P:detection of bacterium; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0050702; P:interleukin-1 beta secretion; ISS:UniProtKB.
GO; GO:0050713; P:negative regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:RGD.
GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
GO; GO:0070269; P:pyroptosis; ISS:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
GO; GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:RGD.
Gene3D; 3.80.10.10; -; 2.
InterPro; IPR001315; CARD.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR007111; NACHT_NTPase.
InterPro; IPR042220; NLRC4.
InterPro; IPR040535; NLRC4_HD.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR47688; PTHR47688; 1.
Pfam; PF00619; CARD; 1.
Pfam; PF05729; NACHT; 1.
Pfam; PF17889; NLRC4_HD; 1.
SUPFAM; SSF47986; SSF47986; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50209; CARD; 1.
PROSITE; PS50837; NACHT; 1.
3: Inferred from homology;
Apoptosis; ATP-binding; Cytoplasm; Immunity; Inflammatory response;
Innate immunity; Leucine-rich repeat; Nucleotide-binding; Phosphoprotein;
Reference proteome; Repeat.
CHAIN 1..1023
/note="NLR family CARD domain-containing protein 4"
/id="PRO_0000419976"
DOMAIN 1..88
/note="CARD"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00046"
DOMAIN 163..476
/note="NACHT"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
REPEAT 578..598
/note="LRR 1"
REPEAT 655..678
/note="LRR 2"
REPEAT 734..757
/note="LRR 3"
REPEAT 761..784
/note="LRR 4"
REPEAT 786..811
/note="LRR 5"
REPEAT 823..846
/note="LRR 6"
REPEAT 847..869
/note="LRR 7"
REPEAT 877..901
/note="LRR 8"
REPEAT 910..932
/note="LRR 9"
REPEAT 935..962
/note="LRR 10"
REPEAT 964..984
/note="LRR 11"
REPEAT 998..1020
/note="LRR 12"
NP_BIND 169..176
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
REGION 95..298
/note="Nucleotide-binding domain (NBD)"
/evidence="ECO:0000250"
REGION 356..463
/note="Winged-helix domain (WHD)"
/evidence="ECO:0000250"
MOD_RES 533
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q3UP24"
SEQUENCE 1023 AA; 116142 MW; A91F740D9D78F327 CRC64;
MNFIKENSQA LIQRMGIVVI KQICDDLFAL NVLNGEEVAI ICSHRVEQDA ARDIVHMILK
KGSAACNLFL KSLENWNYPV YQDLTGHSLF HQNLEEDLDV LAQSLKDLYN SPVFKNFFPL
GEDIDIIFNL QITFTEPVLW RKDHRHHRVE QMTLGSLLEA LKSPCLIEGE SGKGKSTLLQ
KIAMLWASGM CPALNQFKLV FFIRLSSARG GLFETLYDQL VNIPDSISKP TFRALLLKLH
KKVLFLLDAY NEFHPQNCPE IEALVKENHR FKNMVIVTTT TECLRHIRHV GALTVEVGDM
TEDSARVLIR EVLINELAEG LLFQMQESRC LRNLMRTPLF VVITCAIQMG SEEFQAHTQT
MLFQTFYDLL IQKNRRRHSG GTSGDFVRSL DYCGDLALEG VFSHKFDFEL EDVCSMNEDV
LVRTGLLCKY TAQRLRPTYK FFHKSFQEYT AGRRLSSLLK SREPEEVSKG NSYLKKMVSI
SDITSLYGNL LLYTCGSSTE ATRAIMRHLA MVCEHGSLQG LSVTKRPLWR QESIQNLRNT
TEQDVLKAIN VNSFVECGIN LFSESISKSE LSQEFEAFFQ GKSLYINSEN IPDYLFDFFK
YLPNCVSALD FVKLDFYGRA TVSQDKTGEN SSGVHTEGPS TYIPSRAVSL FFNWMQKFKT
LEVTLRDISK LNKQDIKYLG KIFSSASNLK LYIKRCAAVA GRLSSVLRTC KNIHSLMVEA
SPLTTEDEQY ITSVTDLQNL SIHDLHTQRL PGGLADSLGN LKNLLKLILD DIRLNEEDAK
SLAEGLRNLK KMRLLHLTRL SDMGEGMDYI VKSLSEEPCD LQEMKLVDCC LTANSLKILA
QNLHNLVKLS VLDMSENYLE KAGSEALQGL IGRLGVLEQL SALMLPWCWD AYISLPNLLK
QLEGTPGLVK LGLKNWRLRD EEIRSFGEFL EMNPLRDLQQ LDLAGHGVSS DGWLSFMDVF
ENLKQLVFFD FGTEEFLPDA ALVRKLGQVL SKLTLLQEAR LTGWELDDYD ISVIKGTFKL
VTA


Related products :

Catalog number Product name Quantity
U1535h CLIA CARD, LRR, and NACHT-containing protein,CARD12,Caspase recruitment domain-containing protein 12,CLAN,Clan protein,CLAN1,Homo sapiens,Human,Ice protease-activating factor,Ipaf,IPAF,NLR family CARD 96T
E1535h ELISA CARD, LRR, and NACHT-containing protein,CARD12,Caspase recruitment domain-containing protein 12,CLAN,Clan protein,CLAN1,Homo sapiens,Human,Ice protease-activating factor,Ipaf,IPAF,NLR family CAR 96T
E1535h ELISA kit CARD, LRR, and NACHT-containing protein,CARD12,Caspase recruitment domain-containing protein 12,CLAN,Clan protein,CLAN1,Homo sapiens,Human,Ice protease-activating factor,Ipaf,IPAF,NLR famil 96T
18-661-15141 Caspase recruitment domain-containing protein 12 - Ice protease-activating factor; Ipaf; CARD. LRR. and NACHT-containing protein; Clan protein Polyclonal 0.1 mg
18-001-30061 Caspase recruitment domain-containing protein 12 - Ice protease-activating factor; Ipaf; CARD. LRR. and NACHT-containing protein; Clan protein Polyclonal 0.1 mg
18-003-42864 Caspase recruitment domain-containing protein 12 - Ice protease-activating factor; Ipaf; CARD. LRR. and NACHT-containing protein; Clan protein Polyclonal 0.05 mg Aff Pur
IPAF11-S Anti-Human Ice Protease-Activating Factor (IPAF) or CARD12 antiserum 100 ul
IPAF11-A Anti-Human Ice Protease-Activating Factor (IPAF) or CARD12 IgG, aff pure 100 ug
IPAF11-P Human ice Protease-Activating Factor (IPAF) or CARD12 Control blocking peptide 100 ug
IPAF11-S Anti-Human Ice Protease-Activating Factor (IPAF) or CARD12 antiserum Species Reactivity: Human 100 ul Product tipe: Antiserum
IPAF11-P Human ice Protease-Activating Factor (IPAF) or CARD12 Control_blocking peptide Species Reactivity: Human 100 ug Product tipe: Peptide
IPAF11-A Anti-Human Ice Protease-Activating Factor (IPAF) or CARD12 IgG, aff pure Species Reactivity: Human 100 ug Product tipe: Antibodies
18-661-15159 Caspase recruitment domain-containing protein 8 - Apoptotic protein NDPP1; DACAR; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; Tumor-up-regulated CARD-containing antagonist of CASP9; TUCA 0.1 mg
27-056 HTRA4 is a member of the HtrA family of proteases. The protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domai 0.05 mg
18-661-15095 Apoptosis-associated speck-like protein containing a CARD - hASC; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1; Caspase recruitment domain-containing protein 5 Pol 0.1 mg
EIAAB27073 Homo sapiens,Human,KIAA1165,N4WBP5A,NDFIP2,NEDD4 family-interacting protein 2,NEDD4 WW domain-binding protein 5A,Putative MAPK-activating protein PM04_PM05_PM06_PM07,Putative NF-kappa-B-activating pro
25-097 PRDM5 is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell 0.05 mg
E0627h ELISA APAF-3,Apoptotic protease Mch-6,Apoptotic protease-activating factor 3,CASP9,CASP-9,Caspase-9,Homo sapiens,Human,ICE-LAP6,ICE-like apoptotic protease 6,MCH6 96T
U0627h CLIA APAF-3,Apoptotic protease Mch-6,Apoptotic protease-activating factor 3,CASP9,CASP-9,Caspase-9,Homo sapiens,Human,ICE-LAP6,ICE-like apoptotic protease 6,MCH6 96T
E0627h ELISA kit APAF-3,Apoptotic protease Mch-6,Apoptotic protease-activating factor 3,CASP9,CASP-9,Caspase-9,Homo sapiens,Human,ICE-LAP6,ICE-like apoptotic protease 6,MCH6 96T
E3911h Human NLR Family, CARD Domain Containing Protein 5 96T
E3098h Human NLR Family, CARD Domain Containing Protein 4 96T
E7680h Human NLR Family, CARD Domain Containing Protein 3 96T
EH1796 NLR family CARD domain-containing protein 4 Elisa Kit 96T
EIAAB34704 ARHGAP27,CAMGAP1,CIN85-associated multi-domain-containing Rho GTPase-activating protein 1,Homo sapiens,Human,PP905,Rho GTPase-activating protein 27,Rho-type GTPase-activating protein 27,SH3 domain-con
Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP2199: Seed Development
WP1909: Signal regulatory protein (SIRP) family interactions
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP931: G Protein Signaling Pathways
WP1032: NLR proteins
WP1676: Non-homologous end-joining
WP2371: Parkinsons Disease Pathway
WP1566: Citrate cycle (TCA cycle)
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1624: Bacterial secretion system
WP1939: Unfolded Protein Response
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP210: Cytoplasmic Ribosomal Proteins
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1693: Purine metabolism
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1650: Fluorobenzoate degradation
WP73: G Protein Signaling Pathways
WP1659: Glycine, serine and threonine metabolism
WP1360: NLR proteins
WP1713: Two-component system
WP1485: Interactions between CFTR and other ion channels
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP810: Signaling of Hepatocyte Growth Factor Receptor

Related Genes :
[NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215] NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (Clan protein) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
[Nlrc4 Card12 Ipaf] NLR family CARD domain-containing protein 4 (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
[Nlrc4 Ipaf] NLR family CARD domain-containing protein 4 (Ice protease-activating factor) (Ipaf)
[NLRC4 IPAF] NLR family CARD domain-containing protein 4 (Ice protease-activating factor) (Ipaf)
[NLRC3 NOD3] NLR family CARD domain-containing protein 3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (NACHT, LRR and CARD domains-containing protein 3) (Nucleotide-binding oligomerization domain protein 3)
[CASP4 ICH2] Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
[CARD16 COP COP1] Caspase recruitment domain-containing protein 16 (Caspase recruitment domain-only protein 1) (CARD-only protein 1) (Caspase-1 inhibitor COP) (Pseudo interleukin-1 beta converting enzyme) (Pseudo-ICE) (Pseudo-IL1B-converting enzyme)
[Pycard Asc] Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein)
[PYCARD ASC CARD5 TMS1] Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
[RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092] Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
[HABP2 HGFAL PHBP] Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
[Masp1 Crarf Masp3] Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
[MASP1 CRARF CRARF1 PRSS5] Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[PPAF1 PPAF-I] Phenoloxidase-activating factor 1 (EC 3.4.21.-) (Prophenoloxidase-activating factor I) (Serine protease PPAF-1) [Cleaved into: Phenoloxidase-activating factor 1 light chain; Phenoloxidase-activating factor 1 heavy chain]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[F10 FX] Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Virus-activating protease) (VAP) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[Masp1 Crarf Masp3] Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
[PPAF2 PPAF-II] Phenoloxidase-activating factor 2 (45 KDa PPAF) (Hd-45) (Prophenoloxidase-activating factor II) (Serine protease-like PPAF-2) [Cleaved into: Phenoloxidase-activating factor 2 light chain; Phenoloxidase-activating factor 2 heavy chain]
[MAVS IPS1 KIAA1271 VISA] Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
[NLRP1 CARD7 DEFCAP KIAA0926 NAC NALP1] NACHT, LRR and PYD domains-containing protein 1 (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain)
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[IFIH1 MDA5 RH116] Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)
[] Coagulation factor X-activating enzyme heavy chain (EC 3.4.24.58) (Coagulation factor X-activating enzyme chain alpha) (Snake venom metalloproteinase) (SVMP) (VL factor X activator) (VLFXA heavy chain) [Cleaved into: Coagulation factor X-activating enzyme heavy chain alternate form]
[Asap1 Ddef1 Kiaa1249 Shag1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[ASAP1 DDEF1 KIAA1249] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[PPBP CTAP3 CXCL7 SCYB7 TGB1 THBGB1] Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
[BCL10 CIPER CLAP] B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10)

Bibliography :
[20085538] Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.