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Negative elongation factor C/D (NELF-C/D) (TH1-like protein)

 NELFD_HUMAN             Reviewed;         590 AA.
Q8IXH7; B4DE06; Q9BYL2; Q9H405; Q9H888; Q9H8T3; Q9NVX5; Q9P029; Q9UGN1;
Q9UGN2; Q9UGN3;
14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
14-NOV-2003, sequence version 2.
02-JUN-2021, entry version 175.
RecName: Full=Negative elongation factor C/D;
Short=NELF-C/D;
AltName: Full=TH1-like protein;
Name=NELFCD; Synonyms=NELFD, TH1, TH1L; ORFNames=HSPC130;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE (ISOFORM NELF-C), AND TISSUE SPECIFICITY.
PubMed=11030415; DOI=10.1007/s004390000344;
Bonthron D.T., Hayward B.E., Moran V., Strain L.;
"Characterization of TH1 and CTSZ, two non-imprinted genes downstream of
GNAS1 in chromosome 20q13.";
Hum. Genet. 107:165-175(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM NELF-C).
TISSUE=Umbilical cord blood;
PubMed=11042152; DOI=10.1101/gr.140200;
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
"Cloning and functional analysis of cDNAs with open reading frames for 300
previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
cells.";
Genome Res. 10:1546-1560(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS NELF-C AND 3).
TISSUE=Ovarian carcinoma, Teratocarcinoma, and Thyroid;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM NELF-C).
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PROTEIN SEQUENCE OF 126-139; 223-230; 303-315 AND 476-491, IDENTIFICATION
IN A NELF COMPLEX, ALTERNATIVE INITIATION, FUNCTION, AND TISSUE
SPECIFICITY.
PubMed=12612062; DOI=10.1128/mcb.23.6.1863-1873.2003;
Narita T., Yamaguchi Y., Yano K., Sugimoto S., Chanarat S., Wada T.,
Kim D.-K., Hasegawa J., Omori M., Inukai N., Endoh M., Yamada T., Handa H.;
"Human transcription elongation factor NELF: identification of novel
subunits and reconstitution of the functionally active complex.";
Mol. Cell. Biol. 23:1863-1873(2003).
[7]
INTERACTION WITH ARAF.
PubMed=11952167; DOI=10.1023/a:1014437024129;
Yin X.L., Chen S., Gu J.X.;
"Identification of TH1 as an interaction partner of A-Raf kinase.";
Mol. Cell. Biochem. 231:69-74(2002).
[8]
FUNCTION OF THE NELF COMPLEX.
PubMed=10199401; DOI=10.1016/s0092-8674(00)80713-8;
Yamaguchi Y., Takagi T., Wada T., Yano K., Furuya A., Sugimoto S.,
Hasegawa J., Handa H.;
"NELF, a multisubunit complex containing RD, cooperates with DSIF to
repress RNA polymerase II elongation.";
Cell 97:41-51(1999).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[10]
FUNCTION OF THE NELF COMPLEX IN HIV-1 LATENCY (MICROBIAL INFECTION), AND
INTERACTION WITH PCF11.
PubMed=23884411; DOI=10.1074/jbc.m113.496489;
Natarajan M., Schiralli Lester G.M., Lee C., Missra A., Wasserman G.A.,
Steffen M., Gilmour D.S., Henderson A.J.;
"Negative elongation factor (NELF) coordinates RNA polymerase II pausing,
premature termination, and chromatin remodeling to regulate HIV
transcription.";
J. Biol. Chem. 288:25995-26003(2013).
[11]
X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 186-590 IN COMPLEX WITH NELFA,
RECONSTITUTION OF THE NELF COMPLEX, RNA BINDING, AND MUTAGENESIS OF
ARG-291; LYS-315; LYS-371; LYS-372; LYS-374; LYS-384; ARG-419 AND ARG-506.
PubMed=27282391; DOI=10.7554/elife.14981;
Vos S.M., Pollmann D., Caizzi L., Hofmann K.B., Rombaut P., Zimniak T.,
Herzog F., Cramer P.;
"Architecture and RNA binding of the human negative elongation factor.";
Elife 5:0-0(2016).
-!- FUNCTION: Essential component of the NELF complex, a complex that
negatively regulates the elongation of transcription by RNA polymerase
II (PubMed:12612062). The NELF complex, which acts via an association
with the DSIF complex and causes transcriptional pausing, is
counteracted by the P-TEFb kinase complex (PubMed:10199401).
{ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12612062}.
-!- FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1
latency possibly involving recruitment of PCF11 to paused RNA
polymerase II. {ECO:0000269|PubMed:23884411}.
-!- SUBUNIT: The NELF complex is composed of NELFA, NELFB, NELFCD (isoform
NELF-C or isoform NELF-D) and NELFE; NELFA and NELFCD form a stable
subcomplex that binds primarily through NELFCD to the N-terminus of
NELFB (PubMed:27282391, PubMed:12612062). Binds RNA which may help to
stabilize the NELF complex on nucleic acid (PubMed:27282391). In vitro,
the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and
structure-dependent manner (PubMed:27282391). Interacts with ARAF
(PubMed:11952167). Interacts with PCF11 (PubMed:23884411). Interacts
with KAT8 (By similarity). {ECO:0000250|UniProtKB:Q922L6,
ECO:0000269|PubMed:11952167, ECO:0000269|PubMed:12612062,
ECO:0000269|PubMed:23884411, ECO:0000269|PubMed:27282391}.
-!- INTERACTION:
Q8IXH7; P10398: ARAF; NbExp=5; IntAct=EBI-536725, EBI-365961;
Q8IXH7; O14901: KLF11; NbExp=3; IntAct=EBI-536725, EBI-948266;
Q8IXH7; Q9H3P2: NELFA; NbExp=12; IntAct=EBI-536725, EBI-5461341;
Q8IXH7; Q8WX92-2: NELFB; NbExp=3; IntAct=EBI-536725, EBI-22734860;
Q8IXH7; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-536725, EBI-2811583;
Q8IXH7; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-536725, EBI-5235340;
Q8IXH7; A0A1U9X8X8; NbExp=3; IntAct=EBI-536725, EBI-17234977;
Q8IXH7-4; Q9H3P2: NELFA; NbExp=5; IntAct=EBI-6109710, EBI-5461341;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing, Alternative initiation; Named isoforms=3;
Name=NELF-C;
IsoId=Q8IXH7-1; Sequence=Displayed;
Name=3;
IsoId=Q8IXH7-3; Sequence=VSP_008950, VSP_008951;
Name=NELF-D;
IsoId=Q8IXH7-4; Sequence=VSP_018769;
-!- TISSUE SPECIFICITY: Widely expressed. Expressed in heart, brain, lung,
placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney
and pancreas. {ECO:0000269|PubMed:11030415,
ECO:0000269|PubMed:12612062}.
-!- MISCELLANEOUS: [Isoform NELF-D]: Produced by alternative initiation at
Met-10 of isoform NELF-C. {ECO:0000305}.
-!- SIMILARITY: Belongs to the NELF-D family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAF29094.1; Type=Frameshift; Evidence={ECO:0000305};
Sequence=BAA91618.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAB14519.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=CAB64339.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AJ238374; CAB64337.1; -; mRNA.
EMBL; AJ238375; CAB64373.1; -; mRNA.
EMBL; AJ238379; CAB64339.1; ALT_INIT; mRNA.
EMBL; AF161479; AAF29094.1; ALT_FRAME; mRNA.
EMBL; AK001316; BAA91618.1; ALT_INIT; mRNA.
EMBL; AK023310; BAB14519.1; ALT_INIT; mRNA.
EMBL; AK023927; BAB14729.1; -; mRNA.
EMBL; AK293410; BAG56917.1; -; mRNA.
EMBL; AL109840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC014952; AAH14952.1; -; mRNA.
CCDS; CCDS13473.2; -. [Q8IXH7-4]
RefSeq; NP_945327.2; NM_198976.2. [Q8IXH7-4]
PDB; 5L3X; X-ray; 2.75 A; B=186-590.
PDB; 6GML; EM; 3.20 A; W=10-590.
PDBsum; 5L3X; -.
PDBsum; 6GML; -.
SMR; Q8IXH7; -.
BioGRID; 119572; 56.
CORUM; Q8IXH7; -.
DIP; DIP-34061N; -.
IntAct; Q8IXH7; 44.
MINT; Q8IXH7; -.
STRING; 9606.ENSP00000473290; -.
iPTMnet; Q8IXH7; -.
MetOSite; Q8IXH7; -.
PhosphoSitePlus; Q8IXH7; -.
BioMuta; NELFCD; -.
DMDM; 38372376; -.
EPD; Q8IXH7; -.
jPOST; Q8IXH7; -.
MassIVE; Q8IXH7; -.
MaxQB; Q8IXH7; -.
PaxDb; Q8IXH7; -.
PeptideAtlas; Q8IXH7; -.
PRIDE; Q8IXH7; -.
ProteomicsDB; 70993; -. [Q8IXH7-1]
ProteomicsDB; 70994; -. [Q8IXH7-3]
ProteomicsDB; 70995; -. [Q8IXH7-4]
Antibodypedia; 29232; 174 antibodies.
DNASU; 51497; -.
Ensembl; ENST00000652272; ENSP00000499018; ENSG00000101158. [Q8IXH7-4]
GeneID; 51497; -.
KEGG; hsa:51497; -.
UCSC; uc061ydt.1; human. [Q8IXH7-1]
CTD; 51497; -.
DisGeNET; 51497; -.
GeneCards; NELFCD; -.
HGNC; HGNC:15934; NELFCD.
MIM; 605297; gene.
neXtProt; NX_Q8IXH7; -.
OpenTargets; ENSG00000101158; -.
PharmGKB; PA38055; -.
VEuPathDB; HostDB:ENSG00000101158.12; -.
eggNOG; ENOG502QPUE; Eukaryota.
GeneTree; ENSGT00390000001799; -.
InParanoid; Q8IXH7; -.
OrthoDB; 1288184at2759; -.
PhylomeDB; Q8IXH7; -.
TreeFam; TF324118; -.
PathwayCommons; Q8IXH7; -.
Reactome; R-HSA-112382; Formation of RNA Pol II elongation complex.
Reactome; R-HSA-113418; Formation of the Early Elongation Complex.
Reactome; R-HSA-167152; Formation of HIV elongation complex in the absence of HIV Tat.
Reactome; R-HSA-167158; Formation of the HIV-1 Early Elongation Complex.
Reactome; R-HSA-167200; Formation of HIV-1 elongation complex containing HIV-1 Tat.
Reactome; R-HSA-167238; Pausing and recovery of Tat-mediated HIV elongation.
Reactome; R-HSA-167242; Abortive elongation of HIV-1 transcript in the absence of Tat.
Reactome; R-HSA-167243; Tat-mediated HIV elongation arrest and recovery.
Reactome; R-HSA-167246; Tat-mediated elongation of the HIV-1 transcript.
Reactome; R-HSA-167287; HIV elongation arrest and recovery.
Reactome; R-HSA-167290; Pausing and recovery of HIV elongation.
Reactome; R-HSA-674695; RNA Polymerase II Pre-transcription Events.
Reactome; R-HSA-6796648; TP53 Regulates Transcription of DNA Repair Genes.
Reactome; R-HSA-75955; RNA Polymerase II Transcription Elongation.
BioGRID-ORCS; 51497; 513 hits in 1003 CRISPR screens.
ChiTaRS; NELFCD; human.
GeneWiki; TH1L; -.
GenomeRNAi; 51497; -.
Pharos; Q8IXH7; Tbio.
PRO; PR:Q8IXH7; -.
Proteomes; UP000005640; Chromosome 20.
RNAct; Q8IXH7; protein.
Bgee; ENSG00000101158; Expressed in adenohypophysis and 235 other tissues.
ExpressionAtlas; Q8IXH7; baseline and differential.
Genevisible; Q8IXH7; HS.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0032021; C:NELF complex; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0003723; F:RNA binding; IBA:GO_Central.
GO; GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0050434; P:positive regulation of viral transcription; TAS:Reactome.
GO; GO:0006366; P:transcription by RNA polymerase II; TAS:Reactome.
GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
InterPro; IPR006942; TH1.
PANTHER; PTHR12144; PTHR12144; 1.
Pfam; PF04858; TH1; 1.
1: Evidence at protein level;
3D-structure; Alternative initiation; Alternative splicing;
Direct protein sequencing; Nucleus; Reference proteome; Repressor;
RNA-binding; Transcription; Transcription regulation.
CHAIN 1..590
/note="Negative elongation factor C/D"
/id="PRO_0000019456"
REGION 16..43
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 25..41
/note="Acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
VAR_SEQ 1..9
/note="Missing (in isoform NELF-D)"
/evidence="ECO:0000305"
/id="VSP_018769"
VAR_SEQ 178..201
/note="LISDAGYQGEITSVSTACQQLEVF -> VGRVLELRRKVFMNVYFWLLVCFL
(in isoform 3)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_008950"
VAR_SEQ 202..590
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_008951"
MUTAGEN 291
/note="R->Q: Reduces RNA binding; when associated with M-
315, M-371, M-372, M-374, M-384, M-388, Q-419 and Q-506."
/evidence="ECO:0000269|PubMed:27282391"
MUTAGEN 315
/note="K->M: Reduces RNA binding; when associated with Q-
291, M-371, M-372, M-374, M-384, M-388, Q-419 and Q-506."
/evidence="ECO:0000269|PubMed:27282391"
MUTAGEN 371
/note="K->M: Reduces RNA binding; when associated with Q-
291, M-315, M-372, M-374, M-384, M-388, Q-419 and Q-506."
/evidence="ECO:0000269|PubMed:27282391"
MUTAGEN 372
/note="K->M: Reduces RNA binding; when associated with Q-
291, M-315, M-371, M-374, M-384, M-388, Q-419 and Q-506."
/evidence="ECO:0000269|PubMed:27282391"
MUTAGEN 374
/note="K->M: Reduces RNA binding; when associated with Q-
291, M-315, M-371, M-372, M-384, M-388, Q-419 and Q-506."
/evidence="ECO:0000269|PubMed:27282391"
MUTAGEN 384
/note="K->M: Reduces RNA binding; when associated with Q-
291, M-315, M-371, M-372, M-374, M-388, Q-419 and Q-506."
/evidence="ECO:0000269|PubMed:27282391"
MUTAGEN 388
/note="K->M: Reduces RNA binding; when associated with Q-
291, M-315, M-371, M-372, M-374, M-384, Q-419 and Q-506."
/evidence="ECO:0000269|PubMed:27282391"
MUTAGEN 419
/note="R->Q: Reduces RNA binding; when associated with Q-
291, M-315, M-371, M-372, M-374, M-384, M-388 and Q-506."
/evidence="ECO:0000269|PubMed:27282391"
MUTAGEN 506
/note="R->Q: Reduces RNA binding; when associated with Q-
291, M-315, M-371, M-372, M-374, M-384, M-388 and Q-419."
/evidence="ECO:0000269|PubMed:27282391"
CONFLICT 117
/note="N -> D (in Ref. 3; BAA91618)"
/evidence="ECO:0000305"
CONFLICT 306
/note="N -> S (in Ref. 3; BAB14729)"
/evidence="ECO:0000305"
CONFLICT 430
/note="W -> R (in Ref. 3; BAA91618)"
/evidence="ECO:0000305"
CONFLICT 497
/note="L -> P (in Ref. 3; BAA91618)"
/evidence="ECO:0000305"
CONFLICT 573
/note="D -> V (in Ref. 3; BAA91618)"
/evidence="ECO:0000305"
HELIX 58..61
/evidence="ECO:0007829|PDB:6GML"
HELIX 62..70
/evidence="ECO:0007829|PDB:6GML"
HELIX 77..83
/evidence="ECO:0007829|PDB:6GML"
HELIX 91..104
/evidence="ECO:0007829|PDB:6GML"
HELIX 111..126
/evidence="ECO:0007829|PDB:6GML"
HELIX 133..139
/evidence="ECO:0007829|PDB:6GML"
HELIX 144..151
/evidence="ECO:0007829|PDB:6GML"
TURN 153..155
/evidence="ECO:0007829|PDB:6GML"
HELIX 156..163
/evidence="ECO:0007829|PDB:6GML"
HELIX 169..181
/evidence="ECO:0007829|PDB:6GML"
HELIX 191..196
/evidence="ECO:0007829|PDB:5L3X"
HELIX 198..215
/evidence="ECO:0007829|PDB:5L3X"
TURN 216..219
/evidence="ECO:0007829|PDB:5L3X"
HELIX 220..231
/evidence="ECO:0007829|PDB:5L3X"
HELIX 235..248
/evidence="ECO:0007829|PDB:5L3X"
TURN 252..255
/evidence="ECO:0007829|PDB:5L3X"
HELIX 256..271
/evidence="ECO:0007829|PDB:5L3X"
HELIX 277..283
/evidence="ECO:0007829|PDB:5L3X"
HELIX 285..288
/evidence="ECO:0007829|PDB:5L3X"
HELIX 290..302
/evidence="ECO:0007829|PDB:5L3X"
HELIX 307..316
/evidence="ECO:0007829|PDB:5L3X"
STRAND 319..321
/evidence="ECO:0007829|PDB:5L3X"
HELIX 325..327
/evidence="ECO:0007829|PDB:5L3X"
HELIX 331..341
/evidence="ECO:0007829|PDB:5L3X"
STRAND 342..345
/evidence="ECO:0007829|PDB:5L3X"
TURN 350..352
/evidence="ECO:0007829|PDB:5L3X"
HELIX 353..365
/evidence="ECO:0007829|PDB:5L3X"
STRAND 367..373
/evidence="ECO:0007829|PDB:5L3X"
STRAND 375..379
/evidence="ECO:0007829|PDB:5L3X"
HELIX 383..399
/evidence="ECO:0007829|PDB:5L3X"
TURN 407..410
/evidence="ECO:0007829|PDB:5L3X"
HELIX 411..418
/evidence="ECO:0007829|PDB:5L3X"
HELIX 421..436
/evidence="ECO:0007829|PDB:5L3X"
STRAND 437..439
/evidence="ECO:0007829|PDB:5L3X"
STRAND 445..448
/evidence="ECO:0007829|PDB:6GML"
HELIX 450..461
/evidence="ECO:0007829|PDB:5L3X"
HELIX 463..465
/evidence="ECO:0007829|PDB:5L3X"
HELIX 466..477
/evidence="ECO:0007829|PDB:5L3X"
STRAND 482..484
/evidence="ECO:0007829|PDB:5L3X"
HELIX 486..504
/evidence="ECO:0007829|PDB:5L3X"
TURN 505..507
/evidence="ECO:0007829|PDB:5L3X"
HELIX 509..521
/evidence="ECO:0007829|PDB:5L3X"
HELIX 527..538
/evidence="ECO:0007829|PDB:5L3X"
STRAND 541..543
/evidence="ECO:0007829|PDB:5L3X"
HELIX 547..557
/evidence="ECO:0007829|PDB:5L3X"
STRAND 558..560
/evidence="ECO:0007829|PDB:5L3X"
HELIX 563..565
/evidence="ECO:0007829|PDB:6GML"
HELIX 574..585
/evidence="ECO:0007829|PDB:5L3X"
SEQUENCE 590 AA; 66247 MW; 425437DC46DAF953 CRC64;
MAGAVPGAIM DEDYYGSAAE WGDEADGGQQ EDDSGEGEDD AEVQQECLHK FSTRDYIMEP
SIFNTLKRYF QAGGSPENVI QLLSENYTAV AQTVNLLAEW LIQTGVEPVQ VQETVENHLK
SLLIKHFDPR KADSIFTEEG ETPAWLEQMI AHTTWRDLFY KLAEAHPDCL MLNFTVKLIS
DAGYQGEITS VSTACQQLEV FSRVLRTSLA TILDGGEENL EKNLPEFAKM VCHGEHTYLF
AQAMMSVLAQ EEQGGSAVRR IAQEVQRFAQ EKGHDASQIT LALGTAASYP RACQALGAML
SKGALNPADI TVLFKMFTSM DPPPVELIRV PAFLDLFMQS LFKPGARINQ DHKHKYIHIL
AYAASVVETW KKNKRVSINK DELKSTSKAV ETVHNLCCNE NKGASELVAE LSTLYQCIRF
PVVAMGVLKW VDWTVSEPRY FQLQTDHTPV HLALLDEIST CHQLLHPQVL QLLVKLFETE
HSQLDVMEQL ELKKTLLDRM VHLLSRGYVL PVVSYIRKCL EKLDTDISLI RYFVTEVLDV
IAPPYTSDFV QLFLPILEND SIAGTIKTEG EHDPVTEFIA HCKSNFIMVN


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EIAAB26914 Mouse,Mus musculus,mWHSC2,Negative elongation factor A,Nelfa,NELF-A,Whsc2,Whsc2h,Wolf-Hirschhorn syndrome candidate 2 homolog
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EIAAB41690 Mouse,Mus musculus,Tcea3,Tfiish,Transcription elongation factor A protein 3,Transcription elongation factor S-II protein 3,Transcription elongation factor TFIIS.h
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Pathways :
WP1625: Base excision repair
WP2032: TSH signaling pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1690: Propanoate metabolism
WP380: Fatty Acid Elongation, Saturated
WP1165: G Protein Signaling Pathways
WP1694: Pyrimidine metabolism
WP73: G Protein Signaling Pathways
WP1654: gamma-Hexachlorocyclohexane degradation
WP2148: Brain derived neurotrophic factor
WP1661: Glyoxylate and dicarboxylate metabolism
WP2218: sGC
WP1371: G Protein Signaling Pathways
WP1714: Tyrosine metabolism
WP813: G Protein Signaling Pathways
WP1502: Mitochondrial biogenesis
WP1888: Post-translational protein modification
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1672: Mismatch repair
WP232: G Protein Signaling Pathways
WP1676: Non-homologous end-joining
WP272: Blood Clotting Cascade
WP16: Fatty Acid Elongation, Unsaturated
WP1909: Signal regulatory protein (SIRP) family interactions
WP1624: Bacterial secretion system

Related Genes :
[NELFCD NELFD TH1 TH1L HSPC130] Negative elongation factor C/D (NELF-C/D) (TH1-like protein)
[NELFE RD RDBP] Negative elongation factor E (NELF-E) (RNA-binding protein RD)
[NELFA WHSC2 P/OKcl.15] Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)
[NELFB COBRA1 KIAA1182] Negative elongation factor B (NELF-B) (Cofactor of BRCA1)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[hchA A8C65_13880 A9R57_25255 AM375_13680 AMK83_16550 AWB10_10580 B7C53_22525 B9T59_01945 BJJ90_15205 BMT49_12710 BON65_01250 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C3F40_00665 C5715_19445 C5F73_18020 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9Z23_21970 C9Z37_00915 C9Z43_06360 C9Z78_05610 CDC27_10055 CDL37_00765 CI694_25210 COD46_23180 CQP61_17160 CRD98_26150 CY655_12940 D2188_01360 D9D20_21030 D9D43_06110 D9G69_01560 D9H68_20750 D9H70_25730 D9I87_15275 DEN89_24995 DEO04_05510 DL705_18425 DL800_09215 DLW88_16170 DND16_20085 DOT59_17110 DQP61_11280 DSZ60_17620 DTL43_21780 DTM25_06080 DTZ20_09315 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E4K53_17755 E4K55_17625 E4K61_03800 E5P24_13240 E5S34_18005 E5S44_02160 E5S62_15980 EA174_20215 EA211_24400 EA213_19000 EA225_13320 EAX79_27320 EB525_RS22125 EBP16_01985 EC95NR1_00961 ED648_25045 EHD79_18540 ELV08_24970 ELX69_01215 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ETECE1373_01878 ExPECSC038_01920 EXX71_02385 EYD11_09165 F7F11_20115 F7F56_19940 FQ915_04255 FV250_16615 FWK02_18105 FZN26_21485 G5688_24190 G5696_13480 G9P49_08995 G9P50_08450 GHD50_23505 GIJ01_07415 GIY13_02485 GNZ02_11235 GQE64_12165 GQE87_19550 GQM04_17335 GQM10_10435 GQM17_02800 GRW05_22880 GRW57_10520 GUB08_10670 GUB91_04210 GUB95_01360 GUC01_04925 GUC12_01360 HCR07_00070 HF527_10000 HGT58_05770 HHH97_001315 HHJ51_20570 HI055_003004 HIO61_003732 HIT56_001988 HIZ62_000351 HJ359_004479 HJ802_000049 HJN45_004744 HJT90_000222 HJV81_004710 HKA45_004050 HKA57_002195 HKC58_002136 HLU13_00065 HLU98_00030 HmCmsJML079_02678 HMPREF3040_01583 HMT01_17675 HNC80_01240 HNC88_02365 HNC94_16450 HNN81_20520 HNO08_12550 HNV91_17010 HNY58_01965 HS093_00775 HV022_08990 HV188_14570 HV244_08615 HVV53_06790 HVV73_09455 HVV78_13690 HVV92_10545 HVW09_14035 HVW11_20930 HVW43_01085 HVW60_13960 HVX17_09450 HVY77_10520 HVY93_09295 HVZ24_08880 HVZ33_09830 HVZ44_08660 HVZ62_01335 HWQ66_14480 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WP4S18E07_18560 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[Cdk9] Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9)
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[soxA] L-cysteine S-thiosulfotransferase subunit SoxA (EC 2.8.5.2) (Cytochrome c551 subunit monoheme) (Protein SoxA) (SoxAX cytochrome complex subunit A) (Sulfur oxidizing protein A) (Thiosulfate-oxidizing multienzyme system protein SoxA) (TOMES protein SoxA)
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[yaiE ppnP yaiE_1 yaiE_2 A6581_06820 A6592_08565 A6V01_02400 A8C65_08910 A9819_01890 A9P13_20020 A9R57_08485 A9X72_19070 AC067_13660 AC789_1c03900 ACN002_0406 ACN68_10320 ACN81_25005 ACU57_12035 ACU90_20960 AM270_02350 AM333_11080 AM340_00170 AM375_22275 AM446_21575 AM464_18935 AM465_24670 AMK83_08820 AML35_16935 APT94_15240 APU18_24510 APX88_10995 ARC77_21605 AU473_24575 AUQ13_18550 AUS26_08265 AW059_14025 AWB10_19430 AWE53_023695 AWF06_05110 AWF59_002255 AZZ83_000156 B6V57_02070 B7C53_19905 B9N33_08655 B9T59_05995 BANRA_00817 BANRA_00925 BANRA_02015 BANRA_03594 BB545_15535 BE963_16095 BEN53_04105 BER14_23410 BFD68_18150 BFL24_02350 BHF03_17705 BHS81_02405 BHS87_02130 BIQ87_02175 BIU72_03345 BIZ41_26355 BJJ90_20310 BK248_04610 BK292_14635 BK296_16405 BK373_01320 BK375_26975 BK383_14985 BMA87_04900 BMT91_05310 BN17_01951 BOH76_16090 BON63_11530 BON65_18745 BON66_09075 BON69_11595 BON72_15085 BON75_11450 BON76_23825 BON83_20655 BON86_03800 BON87_15370 BON91_23895 BON92_15465 BON94_14845 BON95_06500 BON96_22295 BON98_18895 BTQ04_02855 BTQ06_17790 BUE81_15520 BvCms12BK_04795 BvCms2454_01767 BvCms28BK_00703 BvCms35BK_00554 BvCmsC61A_02990 BvCmsHHP001_01952 BvCmsHHP019_02594 BvCmsHHP019_02735 BvCmsHHP056_01410 BvCmsKKP036_04281 BvCmsKKP061_04019 BvCmsKSNP073_05624 BvCmsKSNP081_00030 BvCmsKSNP120_04274 BvCmsKSP011_04945 BvCmsKSP024_04930 BvCmsKSP045_04772 BvCmsKSP058_04860 BvCmsKSP067_05191 BvCmsKSP076_04759 BvCmsNSP006_01281 BvCmsNSP007_00849 BvCmsNSP047_03416 BvCmsNSP072_00997 BvCmsOUP014_01108 BvCmsSINP011_02573 BvCmsSINP022_02885 BvCmsSIP019_03625 BvCmsSIP024_01003 BvCmsSIP044_01545 BVL39_00880 BW690_06575 BWI89_12535 BWP17_02145 BXT93_00165 BZL31_10725 BZL69_16805 C2M16_02670 C2U48_08110 C3F40_10585 C4K41_08090 C4M78_16865 C5715_13595 C5F72_20070 C5F73_09375 C5N07_12740 C5P01_16305 C5P44_19530 C6669_02755 C6984_01965 C7235_18880 C7B02_04545 C7B06_13385 C7B07_15195 C7B08_06180 C7B18_00985 C9114_16640 C9160_00550 C9162_12650 C9201_03800 C9306_02820 C9E25_04580 C9E63_22465 C9E67_23765 C9Z03_06575 C9Z23_12315 C9Z28_08265 C9Z37_04640 C9Z68_20485 C9Z70_09610 C9Z78_08360 CA593_01185 CCZ17_04120 CDC27_00860 CDL37_09465 CG692_05055 CI641_017850 CI694_14320 CJU64_02110 CO706_24355 COD30_16055 COD46_04855 CQP61_20925 CR538_19495 CR539_06140 CRD98_01665 CRE06_07890 CRM83_13790 CT144_18010 CT146_15735 CUB99_06570 CV83915_01183 CVH05_20630 CWS33_22875 CY655_02075 D0X26_07420 D1912_23295 D2184_11515 D2185_12065 D2188_07740 D3821_12900 D3822_22465 D3C88_28950 D3O91_15305 D3Y67_14350 D4023_06905 D4M06_05545 D4M76_11590 D4U49_03050 D4V08_07680 D5H35_11765 D6004_10480 D6C57_04065 D6D43_08420 D6T60_09300 D6X76_06760 D7K63_09055 D7K66_05505 D7Y10_05925 D7Z75_05315 D8Y65_05290 D9610_20040 D9C99_17255 D9D20_11505 D9D31_21970 D9D43_14830 D9D94_14580 D9E34_09525 D9E49_06955 D9E73_13115 D9E88_02060 D9F32_03890 D9F87_10325 D9G11_17940 D9G42_13940 D9G48_15840 D9G69_10950 D9G95_10030 D9H53_17415 D9H68_03320 D9H70_06445 D9H94_24405 D9I18_05395 D9I20_07245 D9I87_03310 D9I88_07660 D9I97_02265 D9J03_17400 D9J11_02150 D9J44_05830 D9J52_12125 D9J60_08565 D9J61_02635 D9K02_04260 D9K48_11575 D9K54_20845 D9L89_06360 D9X97_05410 D9Z28_01965 DAH18_14975 DAH23_10455 DAH30_15925 DAH34_21345 DAH37_05240 DD762_07680 DEN86_05080 DEN89_14495 DEO04_04545 DEO20_14385 DIV22_26285 DJ503_01820 DL455_04445 DL473_20145 DL530_07575 DL545_19130 DL637_11475 DL705_16435 DL800_03885 DL979_15710 DLU82_01595 DLX40_16565 DM102_12740 DM129_06110 DM155_09525 DM962_06005 DMZ30_04890 DMZ50_06340 DN627_04525 DN660_05650 DN808_18120 DNC98_06510 DND16_02325 DND79_04070 DNI21_04080 DNQ45_00335 DNR41_17405 DOT59_02705 DOY61_02085 DOY67_05265 DP258_05110 DP277_07535 DQF57_07675 DQO13_05500 DQP61_12090 DRW19_06400 DS143_21555 DS732_06920 DS966_18475 DSZ60_03875 DT034_10500 DTL43_07415 DTL90_10740 DTM10_06080 DTM25_13935 DTM45_10960 DTZ20_03380 DU321_19460 DU333_14985 DW236_15815 DWB25_19225 DXT69_08115 DXT71_02970 DXT73_01860 DXX80_018650 E0I42_07410 E0L04_02150 E0L12_02445 E2115_06350 E2119_01725 E2123_04610 E2127_09375 E2128_04435 E2129_13975 E2134_12225 E2135_01410 E2855_00540 E2863_00426 E4K51_12070 E4K53_09880 E4K55_09545 E4K61_11255 E5P24_15620 E5P28_11315 E5S34_07545 E5S38_06765 E5S43_12135 E5S44_09845 E5S56_05125 E5S58_11035 E5S61_09810 E5S62_19990 E8P32_20890 EA174_09235 EA184_12770 EA191_05310 EA206_10815 EA211_00925 EA213_08335 EA214_19270 EA219_17055 EA225_09190 EA233_12800 EA239_15730 EA250_12110 EA433_19520 EA435_05820 EA834_11650 EAI42_35435 EAI46_25725 EAI46_25840 EAI52_02950 EAM59_14455 EAN77_07940 EAX79_06830 EB510_01625 EB515_09345 EB525_RS00545 EBM08_07705 EBP16_12520 EC1094V2_3464 EC3234A_4c00610 EC382_12595 EC95NR1_04612 ECs0441 ECTO124_03817 ECTO6_03708 ED225_07600 ED600_06320 ED611_06650 ED648_16775 ED903_13725 ED944_09580 EEA45_02855 EEP23_01045 EF082_13590 EF173_10565 EG599_13105 EG808_04255 EGT48_21390 EH412_12630 EHD79_03470 EHH55_15815 EHJ36_08465 EI021_16245 EI032_07550 EI041_08145 EIA21_11810 EIZ93_00830 EJC75_24145 EKI52_09170 EL75_3359 EL79_3454 EL80_3408 ELT17_22260 ELT22_04045 ELT23_00125 ELT31_00280 ELT33_03015 ELT48_00735 ELT49_21480 ELT58_21305 ELU82_03335 ELU85_08960 ELU96_05805 ELV00_13055 ELV08_00785 ELV13_00555 ELV15_22680 ELV22_01630 ELV24_16525 ELV28_08410 ELX56_03900 ELX61_20790 ELX68_02065 ELX69_19550 ELX70_07125 ELX76_05850 ELX79_24270 ELX83_01445 ELX96_14305 ELY05_09885 ELY23_04665 ELY24_07180 ELY32_22740 ELY41_15435 ELY48_07355 ELY50_04295 EO241_13835 EPS70_14865 EPS76_10515 EPS91_09770 EPS94_16700 EPT01_06355 EQ820_00745 EQ823_11615 EQ825_18070 EQ830_03660 EQO00_19840 ERS085362_02676 ERS085366_04179 ERS085379_01215 ERS085386_01096 ERS085404_01742 ERS085406_02227 ERS150873_01858 EST51_18990 ETECE1373_03601 ETECE1441_03612 ETECE1649_03506 ETECE1779_04258 ETECE36_04584 ETECE925_03600 EVY14_00050 EWK56_10245 EXM29_24150 ExPECSC038_04895 ExPECSC065_04439 EXX06_12400 EXX13_09665 EXX23_09965 EXX24_01870 EXX53_07630 EXX55_11875 EXX71_12170 EXX87_11565 EYD11_17450 EYV18_10135 EYX82_01145 EYY27_15550 EYY34_27625 EYY78_10095 F0L67_19465 F1E19_02455 F6T45_22350 F6T51_06360 F6V70_05450 F7F11_06850 F7F23_13355 F7F26_08530 F7F56_11190 F7F79_08660 F7G03_09695 F7G05_12635 F7O57_06490 F9B07_11235 F9X20_010625 F9X20_10705 FAF34_030290 FKC84_04690 FKO60_24460 FNJ67_20330 FNJ69_23475 FORC82_3666 FPI65_02250 FQ021_04720 FQ915_14565 FQU83_20855 FRV13_03860 FTV90_10360 FTV92_11870 FTV93_12360 FV250_14320 FV293_06120 FV295_17245 FV438_20585 FVA71_19985 FWK02_29295 FZC17_02065 FZN26_02330 FZN30_08825 G3565_02860 G4276_18370 G4280_18620 G5606_10990 G5668_11855 G5670_13140 G5680_11755 G5688_07395 G5696_10795 G5697_16390 G5V60_18285 G6Z99_23355 G9448_08700 G9P49_16830 G9P50_16250 GE057_12200 GE087_02515 GE096_15955 GE400_02540 GE558_09695 GFU47_21615 GFY48_03475 GHD50_02110 GIJ01_19765 GIY13_13165 GJ11_02375 GKE29_12130 GKE58_10855 GKE60_09410 GKE79_09230 GKE87_01825 GKF34_16490 GKF52_17565 GKF86_04910 GKF89_04055 GKG12_02940 GNZ02_03615 GNZ05_01665 GP650_16700 GP662_13045 GP666_10645 GP698_13660 GP711_02810 GP720_05730 GP935_14810 GP945_18805 GP946_18990 GP954_12950 GP979_17585 GQE22_09325 GQE33_07115 GQE34_00765 GQE36_18000 GQE42_04900 GQE64_07505 GQE67_02555 GQE87_15550 GQF59_00790 GQM04_16295 GQM06_17115 GQM09_10135 GQM10_05275 GQM13_16755 GQM17_10365 GQM18_17190 GQM28_05335 GQN24_05490 GRC73_12510 GRW02_05020 GRW05_15575 GRW30_07965 GRW57_16360 GRW80_21245 GRW81_04110 GUB08_22335 GUB91_14510 GUB95_14180 GUC01_07480 GUC12_15000 GUC40_07390 GUI16_08025 GUI33_03675 GXC14_20220 H4P50_19265 H4P51_19115 H5C68_16910 H5C80_22515 HAP53_09400 HCR07_11915 HF065_000755 HF523_01165 HF527_18375 HFD31_001236 HFD39_002504 HFD59_003103 HFD69_003066 HFU80_001346 HGR17_22385 HGR87_01460 HGR88_06440 HGS97_11820 HGT58_04135 HH117_07870 HH456_002645 HH707_000108 HH814_000579 HH830_001792 HHA77_001423 HHG54_000763 HHH24_000946 HHH97_002377 HHJ41_01370 HHJ44_22155 HHJ51_05025 HI055_001796 HI083_000480 HIB31_002797 HIF87_003470 HIN76_001080 HIO03_001580 HIO61_000590 HIQ74_001213 HIQ82_002038 HIR91_000876 HIT56_001577 HIZ44_002483 HIZ62_001433 HJ359_001771 HJ411_000554 HJ802_001358 HJI79_003357 HJL93_002730 HJM41_000592 HJM89_001896 HJN45_001169 HJO02_002671 HJO44_000019 HJO53_003212 HJP34_000144 HJQ03_003089 HJR58_002219 HJR60_001095 HJR92_002545 HJS12_001242 HJS53_002270 HJT66_002048 HJT90_002082 HJU54_001570 HJV81_000744 HK427_001468 HKA14_002869 HKA45_002554 HKA57_001676 HKC58_001279 HL152_08835 HL186_02490 HL563_20960 HLI97_000112 HLQ75_07955 HLQ92_12990 HLT96_03035 HLU13_05400 HLU98_04605 HLY53_21035 HLZ85_06695 HmCms169_03669 HmCms184_01874 HmCmsJML074_04353 HmCmsJML079_00649 HmCmsJML146_03132 HmCmsJML204_02343 HMG20_09930 HMG24_12660 HMG27_12270 HMG35_19725 HMP86_22290 HMPREF3040_03387 HMQ05_07470 HMT01_08840 HMT08_08320 HMT08_28135 HMW26_10275 HMW26_27920 HNC38_21355 HNC40_07205 HNC59_10160 HNC73_14325 HNC73_28105 HNC75_03340 HNC80_02630 HNC88_10750 HNC94_01805 HNC99_09055 HND23_10890 HNN86_05540 HNO03_09675 HNO08_21040 HNV44_01815 HNV91_05205 HNX16_02485 HNX34_02410 HNY58_07155 HP431_07725 HPE39_05435 HPE49_20435 HPE52_15660 HPM96_04240 HR075_18950 HS093_08480 HV005_16510 HV021_17015 HV022_17950 HV055_18220 HV065_00215 HV068_18270 HV098_18955 HV108_19500 HV109_18115 HV131_23750 HV149_18435 HV152_17755 HV156_07825 HV159_09785 HV168_09465 HV188_05655 HV226_23340 HV244_16550 HV297_16755 HV303_20415 HV348_18230 HVV37_09655 HVV39_18775 HVV53_22620 HVV73_17755 HVV78_05095 HVV92_19015 HVW09_04615 HVW11_04845 HVW22_00965 HVW33_09625 HVW37_18825 HVW43_10265 HVW44_14930 HVW45_17890 HVW59_08530 HVW60_17400 HVW76_17030 HVW90_08090 HVW93_05045 HVW95_10270 HVW98_04760 HVX00_17970 HVX17_19490 HVX22_17445 HVX24_17055 HVX28_17275 HVX30_05390 HVX33_08680 HVX51_18435 HVX60_09555 HVX73_17865 HVX96_09065 HVY01_17550 HVY77_19945 HVY79_05095 HVY93_17995 HVZ20_05415 HVZ21_18085 HVZ24_17385 HVZ33_18480 HVZ42_18115 HVZ44_17970 HVZ47_04860 HVZ53_18680 HVZ62_09000 HVZ71_18990 HWQ66_23340 HX136_19525 HZT35_11660 IB283_04800 IEM32_07330 IMQ59_17410 JE86ST02C_04160 JE86ST05C_04220 MJ49_04490 MS8345_00396 NCTC10082_01078 NCTC10089_03910 NCTC10418_05682 NCTC10429_03762 NCTC10764_05371 NCTC10767_04209 NCTC10865_04787 NCTC11022_05137 NCTC11126_00022 NCTC11181_01145 NCTC11341_03896 NCTC12950_04180 NCTC13127_05156 NCTC13216_02895 NCTC13846_03688 NCTC7922_06246 NCTC7927_04270 NCTC8009_07014 NCTC8179_01642 NCTC8450_01367 NCTC8500_04283 NCTC8621_03984 NCTC8622_02997 NCTC8959_05017 NCTC8960_01314 NCTC8985_02798 NCTC9001_00537 NCTC9007_00270 NCTC9036_03840 NCTC9044_03501 NCTC9045_04434 NCTC9050_01764 NCTC9055_00703 NCTC9058_03120 NCTC9062_04466 NCTC9075_05103 NCTC9077_04792 NCTC9081_02496 NCTC9111_03977 NCTC9117_04804 NCTC9119_03997 NCTC9434_02812 NCTC9701_04128 NCTC9702_04480 NCTC9703_03222 NCTC9706_01114 NCTC9777_00174 NCTC9969_04032 PGD_02920 PU06_02955 RG28_02910 RG36_04960 RK56_026705 RM34_04980 RX35_02064 SAMEA3472043_02682 SAMEA3472044_00466 SAMEA3472047_02102 SAMEA3472055_02163 SAMEA3472056_03633 SAMEA3472070_02281 SAMEA3472080_01810 SAMEA3472090_01813 SAMEA3472108_01855 SAMEA3472110_00729 SAMEA3472112_02965 SAMEA3472114_01257 SAMEA3472147_04902 SAMEA3484427_03543 SAMEA3484429_01888 SAMEA3484434_01710 SAMEA3485101_03989 SAMEA3751407_02141 SAMEA3752372_02749 SAMEA3752553_00287 SAMEA3752557_00215 SAMEA3752559_02897 SAMEA3752620_00785 SAMEA3753064_01236 SAMEA3753097_00513 SAMEA3753164_00218 SAMEA3753290_01725 SAMEA3753300_00458 SK85_00418 SY51_02060 TUM18780_32860 UC41_24265 UN86_08900 UN91_18725 WP2S18E08_35360 WP4S17E03_35290 WP4S17E08_35200 WP4S18E07_34480 WP4S18E08_34230 WP5S18E09_34520 WP7S17E01_36800 WP7S17E04_33320 WP7S18E09_37190 WQ89_01420 WR15_04360 YDC107_3656] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[ORF1ab ORF1a orf1ab] 3C-like proteinase (EC 3.4.19.12) (EC 3.4.22.69) (Growth factor-like peptide) (Leader protein) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (Papain-like proteinase) (p65 homolog)
[] Capsid protein VP0 (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Capsid protein VP1) (Capsid protein VP3) (Capsid protein VP4) (Genome polyprotein) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1A) (P1B) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2A) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (VP4-VP2) (Virion protein 1) (Virion protein 2) (Virion protein 3) (Virion protein 4) (protein 2B)
[] Capsid protein VP0 (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Capsid protein VP1) (Capsid protein VP3) (Capsid protein VP4) (Genome polyprotein) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1A) (P1B) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2A) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (VP4-VP2) (Virion protein 1) (Virion protein 2) (Virion protein 3) (Virion protein 4) (protein 2B)
[] Capsid protein VP0 (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Capsid protein VP1) (Capsid protein VP3) (Capsid protein VP4) (Genome polyprotein) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1A) (P1B) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2A) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (VP4-VP2) (Virion protein 1) (Virion protein 2) (Virion protein 3) (Virion protein 4) (protein 2B)
[] Capsid protein VP0 (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Capsid protein VP1) (Capsid protein VP3) (Capsid protein VP4) (Genome polyprotein) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1A) (P1B) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2A) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (VP4-VP2) (Virion protein 1) (Virion protein 2) (Virion protein 3) (Virion protein 4) (protein 2B)
[] Capsid protein VP0 (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Capsid protein VP1) (Capsid protein VP3) (Capsid protein VP4) (Genome polyprotein) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1A) (P1B) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2A) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (VP4-VP2) (Virion protein 1) (Virion protein 2) (Virion protein 3) (Virion protein 4) (protein 2B)
[] Capsid protein VP0 (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Capsid protein VP1) (Capsid protein VP3) (Genome polyprotein) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (Virion protein 1) (Virion protein 3) (protein 2B)
[] Capsid protein VP0 (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Capsid protein VP1) (Capsid protein VP3) (Genome polyprotein) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (Virion protein 1) (Virion protein 3) (protein 2B)
[] Capsid protein VP0 (EC 2.7.7.48) (EC 3.4.22.28) (EC 3.4.22.46) (EC 3.6.1.15) (Capsid protein VP1) (Capsid protein VP3) (Genome polyprotein) (Genome-linked protein VPg1) (Genome-linked protein VPg2) (Genome-linked protein VPg3) (Leader protease) (P1C) (P1D) (P52) (P56A) (Picornain 3C) (Protease 3C) (Protease P20B) (Protein 2C) (Protein 3A) (Protein 3B-1) (Protein 3B-2) (Protein 3B-3) (RNA-directed RNA polymerase 3D-POL) (Virion protein 1) (Virion protein 3) (protein 2B)

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