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Nephrin (Renal glomerulus-specific cell adhesion receptor)

 NPHN_MOUSE              Reviewed;        1256 AA.
Q9QZS7; D2KXA7; Q811S5; Q925S5; Q9ESC6; Q9ET59; Q9JIX1;
16-APR-2002, integrated into UniProtKB/Swiss-Prot.
08-MAR-2011, sequence version 2.
13-FEB-2019, entry version 154.
RecName: Full=Nephrin;
AltName: Full=Renal glomerulus-specific cell adhesion receptor;
Flags: Precursor;
Name=Nphs1; Synonyms=Nphn;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND SUBCELLULAR LOCATION.
PubMed=10504499; DOI=10.1046/j.1523-1755.1999.00719.x;
Holzman L.B., St John P.L., Kovari I.A., Verma R., Holthoefer H.,
Abrahamson D.R.;
"Nephrin localizes to the slit pore of the glomerular epithelial
cell.";
Kidney Int. 56:1481-1491(1999).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND TISSUE
SPECIFICITY.
TISSUE=Kidney;
PubMed=10820162;
Putaala H., Sainio K., Sariola H., Tryggvason K.;
"Primary structure of mouse and rat nephrin cDNA and structure and
expression of the mouse gene.";
J. Am. Soc. Nephrol. 11:991-1001(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC
DNA] OF 1-494 (ISOFORM 1), FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=129/SvEv, and C57BL/6J;
PubMed=12039968; DOI=10.1074/jbc.M204806200;
Hamano Y., Grunkemeyer J.A., Sudhakar A., Zeisberg M., Cosgrove D.,
Morello R., Lee B., Sugimoto H., Kalluri R.;
"Determinants of vascular permeability in the kidney glomerulus.";
J. Biol. Chem. 277:31154-31162(2002).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SELF-ASSOCIATION, INTERACTION
WITH KIRREL2, AND TISSUE SPECIFICITY.
PubMed=19887377; DOI=10.1074/jbc.M109.060657;
Nishida K., Hoshino M., Kawaguchi Y., Murakami F.;
"Ptf1a directly controls expression of immunoglobulin superfamily
molecules Nephrin and Neph3 in the developing central nervous
system.";
J. Biol. Chem. 285:373-380(2010).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19 (ISOFORM 2), TISSUE
SPECIFICITY, AND ALTERNATIVE SPLICING.
STRAIN=129/Sv;
PubMed=12538735; DOI=10.1097/01.ASN.0000043081.65110.C4;
Beltcheva O., Kontusaari S., Fetissov S., Putaala H., Kilpelainen P.,
Hokfelt T., Tryggvason K.;
"Alternatively used promoters and distinct elements direct tissue-
specific expression of nephrin.";
J. Am. Soc. Nephrol. 14:352-358(2003).
[7]
INTERACTION WITH CD2AP.
PubMed=11733379; DOI=10.1016/S0002-9440(10)63080-5;
Shih N.Y., Li J., Cotran R., Mundel P., Miner J.H., Shaw A.S.;
"CD2AP localizes to the slit diaphragm and binds to nephrin via a
novel C-terminal domain.";
Am. J. Pathol. 159:2303-2308(2001).
[8]
FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=11136707; DOI=10.1093/hmg/10.1.1;
Putaala H., Soininen R., Kilpelainen P., Wartiovaara J.,
Tryggvason K.;
"The murine nephrin gene is specifically expressed in kidney, brain
and pancreas: inactivation of the gene leads to massive proteinuria
and neonatal death.";
Hum. Mol. Genet. 10:1-8(2001).
[9]
INTERACTION WITH CD2AP AND NPHS2.
PubMed=11733557; DOI=10.1172/JCI200112849;
Schwarz K., Simons M., Reiser J., Saleem M.A., Faul C., Kriz W.,
Shaw A.S., Holzman L.B., Mundel P.;
"Podocin, a raft-associated component of the glomerular slit
diaphragm, interacts with CD2AP and nephrin.";
J. Clin. Invest. 108:1621-1629(2001).
[10]
INTERACTION WITH KIRREL1.
STRAIN=Swiss Webster; TISSUE=Brain;
PubMed=12424224; DOI=10.1096/fj.02-0242fje;
Sellin L., Huber T.B., Gerke P., Quack I., Pavenstaedt H., Walz G.;
"NEPH1 defines a novel family of podocin interacting proteins.";
FASEB J. 17:115-117(2003).
[11]
SELF-ASSOCIATION, AND INTERACTION WITH KIRREL1.
PubMed=12660326; DOI=10.1097/01.ASN.0000057853.05686.89;
Gerke P., Huber T.B., Sellin L., Benzing T., Walz G.;
"Homodimerization and heterodimerization of the glomerular podocyte
proteins nephrin and NEPH1.";
J. Am. Soc. Nephrol. 14:918-926(2003).
[12]
INTERACTION WITH KIRREL3.
PubMed=15843475; DOI=10.1681/ASN.2004060439;
Gerke P., Sellin L., Kretz O., Petraschka D., Zentgraf H., Benzing T.,
Walz G.;
"NEPH2 is located at the glomerular slit diaphragm, interacts with
nephrin and is cleaved from podocytes by metalloproteinases.";
J. Am. Soc. Nephrol. 16:1693-1702(2005).
[13]
INTERACTION WITH DDN.
PubMed=17537921; DOI=10.1073/pnas.0700917104;
Asanuma K., Campbell K.N., Kim K., Faul C., Mundel P.;
"Nuclear relocation of the nephrin and CD2AP-binding protein dendrin
promotes apoptosis of podocytes.";
Proc. Natl. Acad. Sci. U.S.A. 104:10134-10139(2007).
[14]
INTERACTION WITH KIRREL3.
PubMed=18752272; DOI=10.1002/cne.21838;
Komori T., Gyobu H., Ueno H., Kitamura T., Senba E., Morikawa Y.;
"Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive
neurons of the dorsal root ganglia and its interaction with nephrin in
muscle spindles.";
J. Comp. Neurol. 511:92-108(2008).
[15]
FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=19470472; DOI=10.1073/pnas.0904398106;
Sohn R.L., Huang P., Kawahara G., Mitchell M., Guyon J., Kalluri R.,
Kunkel L.M., Gussoni E.;
"A role for nephrin, a renal protein, in vertebrate skeletal muscle
cell fusion.";
Proc. Natl. Acad. Sci. U.S.A. 106:9274-9279(2009).
[16]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Seems to play a role in the development or function of
the kidney glomerular filtration barrier. Regulates glomerular
vascular permeability. May anchor the podocyte slit diaphragm to
the actin cytoskeleton. Plays a role in skeletal muscle formation
through regulation of myoblast fusion.
{ECO:0000269|PubMed:11136707, ECO:0000269|PubMed:12039968,
ECO:0000269|PubMed:19470472}.
-!- SUBUNIT: Interacts with NPHS2 and with CD2AP (via C-terminal
domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a
tripartite complex with IGSF5/JAM4. Forms a complex with ACTN4,
CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1 (By similarity). Interacts
with DDN; the interaction is direct. Self-associates (via the Ig-
like domains). Also interacts (via the Ig-like domains) with
KIRREL1 and KIRREL2; the interaction with KIRREL1 is dependent on
KIRREL1 glycosylation. Interacts with KIRREL3 (PubMed:15843475,
PubMed:18752272). {ECO:0000250|UniProtKB:Q9R044,
ECO:0000269|PubMed:11733379, ECO:0000269|PubMed:11733557,
ECO:0000269|PubMed:12424224, ECO:0000269|PubMed:12660326,
ECO:0000269|PubMed:15843475, ECO:0000269|PubMed:17537921,
ECO:0000269|PubMed:18752272, ECO:0000269|PubMed:19887377}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass
type I membrane protein {ECO:0000305}. Note=Located at podocyte
slit diaphragm between podocyte foot processes.
{ECO:0000269|PubMed:10504499}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=NephrinA;
IsoId=Q9QZS7-1; Sequence=Displayed;
Name=2; Synonyms=NephrinB;
IsoId=Q9QZS7-2; Sequence=VSP_040676;
-!- TISSUE SPECIFICITY: Expressed in kidney glomeruli. In the embryo,
expressed in the mesonephric kidney at E11 with strong expression
in cranial tubules with podocyte-like structures. Expression is
observed in the podocytes of the developing kidney from E13. High
expression is also detected in the developing cerebellum,
hindbrain, spinal cord, retina and hypothalamus. Expressed in
skeletal muscle during myoblast fusion such as in the adult
following acute injury and in the embryo but not detected in
uninjured adult skeletal muscle. Isoform 1 and isoform 2 are
expressed in the newborn brain and developing cerebellum. Isoform
1 is the predominant isoform in adult kidney.
{ECO:0000269|PubMed:10820162, ECO:0000269|PubMed:11136707,
ECO:0000269|PubMed:12538735, ECO:0000269|PubMed:19470472,
ECO:0000269|PubMed:19887377}.
-!- PTM: Phosphorylated at Tyr-1208 by FYN, leading to the recruitment
and activation of phospholipase C-gamma-1/PLCG1. {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Death by postnatal day 2 associated with
proteinuria, edema and massive glomerular vascular leak. Kidneys
display enlarged Bowman's spaces, dilated tubuli, effacement of
podocyte foot processes and an absence of the glomerular
epithelial slit diaphragm. Impaired skeletal muscle development
characterized by incomplete myoblast fusion.
{ECO:0000269|PubMed:11136707, ECO:0000269|PubMed:12039968,
ECO:0000269|PubMed:19470472}.
-!- SIMILARITY: Belongs to the immunoglobulin superfamily.
{ECO:0000305}.
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EMBL; AF168466; AAF03368.1; -; mRNA.
EMBL; AF172254; AAF91085.1; -; Genomic_DNA.
EMBL; AF172247; AAF91085.1; JOINED; Genomic_DNA.
EMBL; AF172248; AAF91085.1; JOINED; Genomic_DNA.
EMBL; AF172249; AAF91085.1; JOINED; Genomic_DNA.
EMBL; AF172250; AAF91085.1; JOINED; Genomic_DNA.
EMBL; AF172251; AAF91085.1; JOINED; Genomic_DNA.
EMBL; AF172252; AAF91085.1; JOINED; Genomic_DNA.
EMBL; AF172253; AAF91085.1; JOINED; Genomic_DNA.
EMBL; AF172256; AAF91087.1; -; mRNA.
EMBL; AF190638; AAG17142.1; -; Genomic_DNA.
EMBL; AF191090; AAK38483.1; -; mRNA.
EMBL; AB513652; BAI63574.1; -; mRNA.
EMBL; AC167970; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AY183460; AAO22850.1; -; Genomic_DNA.
CCDS; CCDS39884.1; -. [Q9QZS7-1]
RefSeq; NP_062332.2; NM_019459.2. [Q9QZS7-1]
RefSeq; XP_011248949.1; XM_011250647.1. [Q9QZS7-2]
UniGene; Mm.437830; -.
ProteinModelPortal; Q9QZS7; -.
BioGrid; 207694; 2.
DIP; DIP-61265N; -.
IntAct; Q9QZS7; 3.
STRING; 10090.ENSMUSP00000006825; -.
iPTMnet; Q9QZS7; -.
PhosphoSitePlus; Q9QZS7; -.
jPOST; Q9QZS7; -.
PaxDb; Q9QZS7; -.
PRIDE; Q9QZS7; -.
DNASU; 54631; -.
Ensembl; ENSMUST00000006825; ENSMUSP00000006825; ENSMUSG00000006649. [Q9QZS7-1]
Ensembl; ENSMUST00000126297; ENSMUSP00000116500; ENSMUSG00000006649. [Q9QZS7-2]
GeneID; 54631; -.
KEGG; mmu:54631; -.
UCSC; uc009gem.1; mouse. [Q9QZS7-2]
UCSC; uc009gen.1; mouse. [Q9QZS7-1]
CTD; 4868; -.
MGI; MGI:1859637; Nphs1.
eggNOG; KOG3515; Eukaryota.
eggNOG; ENOG410XRJN; LUCA.
GeneTree; ENSGT00940000159510; -.
HOVERGEN; HBG031752; -.
InParanoid; Q9QZS7; -.
OMA; YSVGLEW; -.
OrthoDB; 269917at2759; -.
PhylomeDB; Q9QZS7; -.
TreeFam; TF327139; -.
Reactome; R-MMU-373753; Nephrin family interactions.
PRO; PR:Q9QZS7; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000006649; Expressed in 42 organ(s), highest expression level in glomerular tuft.
ExpressionAtlas; Q9QZS7; baseline and differential.
Genevisible; Q9QZS7; MM.
GO; GO:0042995; C:cell projection; IDA:UniProtKB.
GO; GO:0016021; C:integral component of membrane; TAS:MGI.
GO; GO:0005887; C:integral component of plasma membrane; TAS:MGI.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0045121; C:membrane raft; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0036057; C:slit diaphragm; ISS:UniProtKB.
GO; GO:0051393; F:alpha-actinin binding; ISO:MGI.
GO; GO:0017022; F:myosin binding; ISO:MGI.
GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
GO; GO:0030507; F:spectrin binding; ISO:MGI.
GO; GO:0007155; P:cell adhesion; IGI:MGI.
GO; GO:0032836; P:glomerular basement membrane development; IEA:Ensembl.
GO; GO:0072015; P:glomerular visceral epithelial cell development; IEA:Ensembl.
GO; GO:0007254; P:JNK cascade; IDA:MGI.
GO; GO:0000165; P:MAPK cascade; IDA:MGI.
GO; GO:0007520; P:myoblast fusion; IMP:UniProtKB.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IGI:MGI.
GO; GO:0035418; P:protein localization to synapse; ISO:MGI.
GO; GO:0044062; P:regulation of excretion; IMP:UniProtKB.
GO; GO:0007519; P:skeletal muscle tissue development; IMP:UniProtKB.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 10.
InterPro; IPR013162; CD80_C2-set.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
Pfam; PF08205; C2-set_2; 5.
Pfam; PF00041; fn3; 1.
SMART; SM00060; FN3; 1.
SMART; SM00409; IG; 8.
SMART; SM00408; IGc2; 6.
SUPFAM; SSF48726; SSF48726; 9.
SUPFAM; SSF49265; SSF49265; 1.
PROSITE; PS50853; FN3; 1.
PROSITE; PS50835; IG_LIKE; 8.
1: Evidence at protein level;
Alternative splicing; Cell adhesion; Cell membrane; Complete proteome;
Developmental protein; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Myogenesis; Phosphoprotein;
Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 35 {ECO:0000255}.
CHAIN 36 1256 Nephrin.
/FTId=PRO_0000015053.
TOPO_DOM 36 1078 Extracellular. {ECO:0000255}.
TRANSMEM 1079 1099 Helical. {ECO:0000255}.
TOPO_DOM 1100 1256 Cytoplasmic. {ECO:0000255}.
DOMAIN 39 144 Ig-like C2-type 1.
DOMAIN 149 247 Ig-like C2-type 2.
DOMAIN 256 347 Ig-like C2-type 3.
DOMAIN 354 448 Ig-like C2-type 4.
DOMAIN 454 554 Ig-like C2-type 5.
DOMAIN 558 649 Ig-like C2-type 6.
DOMAIN 754 846 Ig-like C2-type 7.
DOMAIN 852 953 Ig-like C2-type 8.
DOMAIN 957 1051 Fibronectin type-III.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
MOD_RES 446 446 Phosphoserine.
{ECO:0000250|UniProtKB:O60500}.
MOD_RES 1112 1112 Phosphoserine.
{ECO:0000250|UniProtKB:Q9R044}.
MOD_RES 1115 1115 Phosphothreonine.
{ECO:0000250|UniProtKB:Q9R044}.
MOD_RES 1119 1119 Phosphoserine.
{ECO:0000250|UniProtKB:Q9R044}.
MOD_RES 1208 1208 Phosphotyrosine; by FYN.
{ECO:0000250|UniProtKB:Q9R044}.
CARBOHYD 54 54 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 370 370 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 415 415 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 561 561 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 578 578 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 591 591 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 722 722 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 67 125 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 174 231 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 279 331 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 375 431 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 479 542 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 581 637 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 775 830 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 877 934 {ECO:0000255|PROSITE-ProRule:PRU00114}.
VAR_SEQ 1 33 MGAKEATVRGPGASPVHRTCHLIPLLLAGMLTT -> MEKW
RAWDPQSIQRRKTAK (in isoform 2).
{ECO:0000303|PubMed:19887377}.
/FTId=VSP_040676.
CONFLICT 1 24 MGAKEATVRGPGASPVHRTCHLIP -> MALGTTLRAS
(in Ref. 1; AAF03368). {ECO:0000305}.
CONFLICT 6 6 A -> V (in Ref. 2; AAF91087).
{ECO:0000305}.
CONFLICT 21 21 H -> R (in Ref. 2; AAF91087).
{ECO:0000305}.
CONFLICT 43 43 S -> P (in Ref. 2; AAF91085, 3; AAG17142/
AAK38483 and 4; BAI63574). {ECO:0000305}.
CONFLICT 63 63 V -> I (in Ref. 1; AAF03368 and 2;
AAF91087). {ECO:0000305}.
CONFLICT 140 140 S -> R (in Ref. 1; AAF03368 and 2;
AAF91087). {ECO:0000305}.
CONFLICT 145 145 I -> V (in Ref. 1; AAF03368 and 2;
AAF91087). {ECO:0000305}.
CONFLICT 148 148 S -> P (in Ref. 1; AAF03368 and 2;
AAF91087). {ECO:0000305}.
CONFLICT 178 178 D -> G (in Ref. 1; AAF03368 and 2;
AAF91087). {ECO:0000305}.
CONFLICT 763 763 T -> A (in Ref. 1; AAF03368).
{ECO:0000305}.
CONFLICT 996 996 S -> T (in Ref. 1; AAF03368 and 2;
AAF91087). {ECO:0000305}.
CONFLICT 1076 1076 L -> Q (in Ref. 1; AAF03368).
{ECO:0000305}.
SEQUENCE 1256 AA; 136336 MW; 339A670F2AF000A2 CRC64;
MGAKEATVRG PGASPVHRTC HLIPLLLAGM LTTGLAQSPV PTSAPRGFWA LSENLTVVEG
STVKLWCGVR APGSVVQWAK DGLLLGPNPK IPGFPRYSLE GDSAKGEFHL LIEACDLSDD
AEYECQVGRS ELGPELVSPS VILSILVSPK VLQLTPEAGS TVTWVAGQEY VVTCVSGDAK
PAPDIIFIQG GRTVEDVSSS VNEGSEEKLF FTEAEARVTP QSSDNGQLLV CEGSNPALAT
PIKASFTMNI LFPPGPPVID WPGLNEGHVR AGENLELPCI ARGGNPPATL QWLKNGKPVS
IAWGTEHAQA VAHSVLVMTV RPEDHGARLS CQSYNSVSAE TQERSITLQV TFPPSAVTIL
GSTSQSENKN VTLCCLTKSS RPRVLLRWWL GGRQLLPTDE TVMDGLHGGH ISMSNLTLLV
KREDNGLSLT CEAFSDAFSK ETFKKSLTLN VKYPAQKLWI EGPPEGQSIR TGTRVRLVCL
AIGGNPEPSL TWLKDSRPVN DPRQSQEPRR VQLGSVEKSG STFSRELVLI IGPPDNLAKF
SCKAGQLSAS TQLVVQFPPT NLTILANSSA LRPGDALNLT CVSISSNPPV NLSLDKEGER
LDDVAAKPQS APFKGSAASR SVFLRVSSRD HGHRVTCRAH SEALRETVSS FYRLNVLYPP
EFLGEQVRAV TVVEQGQALL PVSVSANPAP EAFNWTFRGY RLSPAGGPRH RILSGGALQL
WNVTRADDGF YQLHCQNSEG TAEALLKLDV HYAPTIRALK DPTEVNVGGS VDIVCTVDAN
PILPEMFSWE RLGEDEEELN LDDMEKMSKG STGRLRIRQA KLSQAGAYQC IVDNGVAPAA
RGLVRLVVRF APQVDHPTPL TKVAAAGDST SSATLHCRAR GVPNIDFTWT KNGVPLDLQD
PRYTEHKYHQ GVVHSSLLTI ANVSAAQDYA LFKCTATNAL GSDHTNIQLV SISRPDPPLG
LKVVSVSPHS VGLEWKPGFD GGLPQRFQIR YEALESPGFL YMDVLPAQAT TFTLTGLKPS
TRYRIWLLAS NALGDSGLTD KGIQVSITTP GLDQAPEDTD QPLPTEQPPG PPRLPLLPVL
FAVGGLLLLS NASCVGGLLW RRRLRRLAEE ISEKTEAGSE EDRIRNEYEE SQWTGDRDTR
SSTVSTAEVD PHYYSMRDFS PQLPPTLEEV SYRQAFTGIE DEDMAFPGHL YDEVERVYGP
PGVWGPLYDE VQMDPYDLRW PEVKYEDPRG IYDQVAADMD AGEPGSLPFE LRGHLV


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E0937m ELISA kit Mouse,Mus musculus,Nephrin,Nphn,Nphs1,Renal glomerulus-specific cell adhesion receptor 96T
E0937r ELISA kit Nephrin,Nphn,Nphs1,Rat,Rattus norvegicus,Renal glomerulus-specific cell adhesion receptor 96T
E0937h ELISA kit Homo sapiens,Human,Nephrin,NPHN,NPHS1,Renal glomerulus-specific cell adhesion receptor 96T
E0937h ELISA Homo sapiens,Human,Nephrin,NPHN,NPHS1,Renal glomerulus-specific cell adhesion receptor 96T
U0937h CLIA Homo sapiens,Human,Nephrin,NPHN,NPHS1,Renal glomerulus-specific cell adhesion receptor 96T
gen13319 NPHN_HUMAN Renal glomerulus-specific cell adhesion receptor ELISA tesk kit 1
gen13323 NPHN_MOUSE Renal glomerulus-specific cell adhesion receptor ELISA tesk kit 1
gen13327 NPHN_RAT Renal glomerulus-specific cell adhesion receptor ELISA tesk kit 1
2265 Kidney glomerulus-specific cell adhesion receptor 0.1 mg
2265 Kidney glomerulus-specific cell adhesion receptor 0.5 mg
AA0040 T-Cell Receptor Signaling Phospho-Specific Array includes 188 highly specific and well-characterized phosphorylation antibodies in the T-cell receptor signaling pathway. 2 Pieces/Box
5-81031 Human renal epithelial cell (normal), male, 53, renal cancer vial
MEDCLA319-1 Renal Cell Carcinoma Marker, Proximal Nephrogenic Renal Ag.,Carb. dom. of a 200kD gp200, Cl 66.4.C2,Mab anti_Hu; prfn 1 ml.
MEDCLA319-01 Renal Cell Carcinoma Marker, Proximal Nephrogenic Renal Ag.,Carb. dom. of a 200kD gp200, Cl 66.4.C2,Mab anti_Hu; prfn 0.1 ml.
20-783-73630 MOUSE ANTI HUMAN RENAL CELL CARCINOMA - Translocation-associated; Papillary renal cell carcinoma (Translocation-associated). isoform CRA_b Monoclonal 0.2 mg
EIAAB05126 Brain immunoglobulin receptor,CADM3,Cell adhesion molecule 3,Homo sapiens,Human,IgSF4B,IGSF4B,Immunoglobulin superfamily member 4B,NECL1,NECL-1,Nectin-like protein 1,Synaptic cell adhesion molecule 3,
TS1068 Human renal clear cell carcinoma (90 cases) and normal renal (10 cases) Tissue Section 1 slide
TA1036 Human renal clear cell carcinoma (70 cases) and normal renal (10 cases) tissues array
TS1109 Human renal clear cell carcinoma (70 cases) and normal renal (10 cases) Tissue Section 1 slide
E1513m ELISA kit B-cell receptor CD22,BL-CAM,B-lymphocyte cell adhesion molecule,Cd22,Lyb-8,Mouse,Mus musculus,Sialic acid-binding Ig-like lectin 2,Siglec2,Siglec-2,T-cell surface antigen Leu-14 96T
U1513m CLIA B-cell receptor CD22,BL-CAM,B-lymphocyte cell adhesion molecule,Cd22,Lyb-8,Mouse,Mus musculus,Sialic acid-binding Ig-like lectin 2,Siglec2,Siglec-2,T-cell surface antigen Leu-14 96T

Kits Elisa; taq POLYMERASE

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Pathways :
WP2328: Allograft rejection
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1069: Integrin-mediated cell adhesion
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1185: Integrin-mediated cell adhesion
WP1345: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1386: Integrin-mediated cell adhesion
WP185: Integrin-mediated cell adhesion
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP1963: The effect of Glucocorticoids on target gene expression
WP23: B Cell Receptor Signaling Pathway
WP274: B Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP352: T Cell Receptor Signaling Pathway
WP480: T Cell Receptor Signaling Pathway
WP6: Integrin-mediated cell adhesion
WP74: Integrin-mediated cell adhesion
WP780: T Cell Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway
WP832: Integrin-mediated cell adhesion
WP894: T Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway

Related Genes :
[Nphs1 Nphn] Nephrin (Renal glomerulus-specific cell adhesion receptor)
[NPHS1 NPHN] Nephrin (Renal glomerulus-specific cell adhesion receptor)
[Nphs1 Nphn] Nephrin (Renal glomerulus-specific cell adhesion receptor)
[NEDD9 CASL CASS2] Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
[TEK TIE2 VMCM VMCM1] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
[Ptk2b Fak2 Pyk2 Raftk] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[RET CDHF12 CDHR16 PTC RET51] Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
[PTK2B FAK2 PYK2 RAFTK] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[Ptk2b Fak2 Pyk2] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2)
[ITGAM CD11B CR3A] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
[Nectin2 Mph Pvr Pvrl2 Pvs] Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Murine herpes virus entry protein B) (mHveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor homolog) (Poliovirus receptor-related protein 2) (CD antigen CD112)
[Tek Hyk Tie-2 Tie2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[NECTIN1 HVEC PRR1 PVRL1] Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111)
[Sell Lnhr Ly-22 Ly22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[ADGRG2 GPR64 HE6 TM7LN2] Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6)
[NECTIN4 LNIR PRR4 PVRL4] Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4]
[EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5] Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
[ITGB2 CD18 MFI7] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[ADGRB1 BAI1] Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)]
[CADM3 IGSF4B NECL1 SYNCAM3 TSLL1 UNQ225/PRO258] Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1)
[NECTIN2 HVEB PRR2 PVRL2] Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
[LIMS1 PINCH PINCH1] LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48)
[Adgrl1 Cirl Cirl1 Cl1 Lphn1] Adhesion G protein-coupled receptor L1 (Calcium-independent alpha-latrotoxin receptor 1) (CIRL-1) (Latrophilin-1)
[Ceacam2 Bgp2] Carcinoembryonic antigen-related cell adhesion molecule 2 (CEA-related cell adhesion molecule 2) (Biliary glycoprotein 2) (BGP-2)
[SELL LNHR LYAM1] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
[Itgb2] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Adrm1 Gp110] Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Rpn13 homolog)

Bibliography :
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