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Noggin

 G3T4H3_LOXAF            Unreviewed;       219 AA.
G3T4H3;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
16-JAN-2019, entry version 41.
RecName: Full=Noggin {ECO:0000256|PIRNR:PIRNR008129};
Name=NOG {ECO:0000313|Ensembl:ENSLAFP00000008256};
Loxodonta africana (African elephant).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000008256};
[1] {ECO:0000313|Ensembl:ENSLAFP00000008256}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008256};
Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
Lindblad-Toh K.;
"The Genome Sequence of Loxodonta africana (African elephant).";
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSLAFP00000008256}
IDENTIFICATION.
STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000008256};
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling
which is required for growth and patterning of the neural tube and
somite. {ECO:0000256|PIRNR:PIRNR008129}.
-!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR008129}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR008129}.
-!- SIMILARITY: Belongs to the noggin family.
{ECO:0000256|PIRNR:PIRNR008129}.
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STRING; 9785.ENSLAFP00000008256; -.
Ensembl; ENSLAFT00000009854; ENSLAFP00000008256; ENSLAFG00000009858.
eggNOG; ENOG410IIR6; Eukaryota.
eggNOG; ENOG410Z62S; LUCA.
GeneTree; ENSGT00390000006009; -.
InParanoid; G3T4H3; -.
OMA; ITDCKCS; -.
TreeFam; TF353745; -.
Proteomes; UP000007646; Unassembled WGS sequence.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0048318; P:axial mesoderm development; IEA:Ensembl.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0051216; P:cartilage development; IEA:UniProtKB-UniRule.
GO; GO:0021533; P:cell differentiation in hindbrain; IEA:Ensembl.
GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl.
GO; GO:0001706; P:endoderm formation; IEA:Ensembl.
GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
GO; GO:0060825; P:fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
GO; GO:0061384; P:heart trabecula morphogenesis; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0060425; P:lung morphogenesis; IEA:Ensembl.
GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0061037; P:negative regulation of cartilage development; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0060302; P:negative regulation of cytokine activity; IEA:Ensembl.
GO; GO:1905006; P:negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0001839; P:neural plate morphogenesis; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0048570; P:notochord morphogenesis; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0090193; P:positive regulation of glomerulus development; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl.
GO; GO:2000313; P:regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0061053; P:somite development; IEA:Ensembl.
GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl.
GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR008717; Noggin.
PANTHER; PTHR10494; PTHR10494; 1.
PIRSF; PIRSF008129; Noggin; 1.
SUPFAM; SSF57501; SSF57501; 1.
3: Inferred from homology;
Chondrogenesis {ECO:0000256|PIRNR:PIRNR008129};
Complete proteome {ECO:0000313|Proteomes:UP000007646};
Developmental protein {ECO:0000256|PIRNR:PIRNR008129};
Differentiation {ECO:0000256|PIRNR:PIRNR008129};
Disulfide bond {ECO:0000256|PIRSR:PIRSR008129-1};
Reference proteome {ECO:0000313|Proteomes:UP000007646};
Secreted {ECO:0000256|PIRNR:PIRNR008129};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 27 {ECO:0000256|SAM:SignalP}.
CHAIN 28 219 Noggin. {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003454863.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000256|PIRSR:PIRSR008129-2}.
DISULFID 142 179 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 165 215 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 171 217 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 194 202 {ECO:0000256|PIRSR:PIRSR008129-1}.
SEQUENCE 219 AA; 24732 MW; 1587A8FDAB142DEB CRC64;
MERCPSLGVT LYALVVVLGL RAAPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD
LNETLLRSLL GGHYDPGFMA TSPPEEDLAE LDQLLRQRPS GAMPSEIKGL EFSEGLAPGK
KQRLSKKLRR KLQMWLWSQT FCPVLYAWND LGSRFWPRYV KVGSCFSKRS CSVPEGMVCK
PSKSVHLTVL RWRCQRRGGQ RCGWIPIQYP IISECKCSC


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