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 U3FU84_CALJA            Unreviewed;       232 AA.
13-NOV-2013, integrated into UniProtKB/TrEMBL.
13-NOV-2013, sequence version 1.
31-JUL-2019, entry version 38.
RecName: Full=Noggin {ECO:0000256|PIRNR:PIRNR008129};
Name=NOG {ECO:0000313|EMBL:JAB51746.1,
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB51746.1};
[1] {ECO:0000313|Ensembl:ENSCJAP00000053661}
Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:JAB51746.1}
TISSUE=Cerebellum {ECO:0000313|EMBL:JAB51746.1},
Cerebral cortex {ECO:0000313|EMBL:JAB24031.1}, and
Hippocampus {ECO:0000313|EMBL:JAB13845.1};
PubMed=25243066; DOI=10.1186/2047-217X-3-14;
Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
Moriyama E.N., French J.A., Norgren R.B.Jr.;
"De novo assembly of the common marmoset transcriptome from NextGen
mRNA sequences.";
Gigascience 3:14-14(2014).
[3] {ECO:0000313|Ensembl:ENSCJAP00000053661}
Submitted (APR-2018) to UniProtKB.
-!- FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling
which is required for growth and patterning of the neural tube and
somite. {ECO:0000256|PIRNR:PIRNR008129}.
-!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR008129}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR008129}.
-!- SIMILARITY: Belongs to the noggin family.
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; GAMS01009291; JAB13845.1; -; mRNA.
EMBL; GAMR01009901; JAB24031.1; -; mRNA.
EMBL; GAMP01001010; JAB51745.1; -; mRNA.
EMBL; GAMP01001009; JAB51746.1; -; mRNA.
RefSeq; XP_002748445.1; XM_002748399.3.
Ensembl; ENSCJAT00000026991; ENSCJAP00000053661; ENSCJAG00000013903.
GeneID; 100395820; -.
KEGG; cjc:100395820; -.
CTD; 9241; -.
GeneTree; ENSGT00390000006009; -.
KO; K04658; -.
OrthoDB; 1391421at2759; -.
Proteomes; UP000008225; Unplaced.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0048318; P:axial mesoderm development; IEA:Ensembl.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0051216; P:cartilage development; IEA:UniProtKB-UniRule.
GO; GO:0021533; P:cell differentiation in hindbrain; IEA:Ensembl.
GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl.
GO; GO:0001706; P:endoderm formation; IEA:Ensembl.
GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
GO; GO:0060825; P:fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
GO; GO:0061384; P:heart trabecula morphogenesis; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0060425; P:lung morphogenesis; IEA:Ensembl.
GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0061037; P:negative regulation of cartilage development; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0060302; P:negative regulation of cytokine activity; IEA:Ensembl.
GO; GO:1905006; P:negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0001839; P:neural plate morphogenesis; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0048570; P:notochord morphogenesis; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0090193; P:positive regulation of glomerulus development; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl.
GO; GO:2000313; P:regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0061053; P:somite development; IEA:Ensembl.
GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl.
GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
Gene3D;; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR008717; Noggin.
PANTHER; PTHR10494; PTHR10494; 1.
PIRSF; PIRSF008129; Noggin; 1.
SUPFAM; SSF57501; SSF57501; 1.
2: Evidence at transcript level;
Chondrogenesis {ECO:0000256|PIRNR:PIRNR008129};
Complete proteome {ECO:0000313|Proteomes:UP000008225};
Developmental protein {ECO:0000256|PIRNR:PIRNR008129};
Differentiation {ECO:0000256|PIRNR:PIRNR008129};
Disulfide bond {ECO:0000256|PIRSR:PIRSR008129-1};
Reference proteome {ECO:0000313|Proteomes:UP000008225};
Secreted {ECO:0000256|PIRNR:PIRNR008129};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 27 {ECO:0000256|SAM:SignalP}.
CHAIN 28 232 Noggin. {ECO:0000256|SAM:SignalP}.
REGION 77 96 Disordered. {ECO:0000256|SAM:MobiDB-
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
DISULFID 155 192 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 178 228 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 184 230 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 207 215 {ECO:0000256|PIRSR:PIRSR008129-1}.
SEQUENCE 232 AA; 25774 MW; FCA0D8E1E2098580 CRC64;

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Pathways :
WP211: BMP signaling pathway

Related Genes :
[NOG] Noggin
[Nog] Noggin
[Nog] Noggin (Fragment)
[NOG] Noggin
[NOG] Noggin
[NOG CK820_G0020947] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG CR201_G0012164] Noggin
[NOG] Noggin
[NOG] Noggin
[Nog] Noggin
[Nog] Noggin
[Nog rCG_34836] Noggin
[Nog] Noggin
[CgPICR_003326] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
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Bibliography :
[31428484] A Start Codon Variant in Underlies Symphalangism and Ossicular Chain Malformations Affecting Both the Incus and the Stapes.
[31323019] Novel protective and risk loci in hip dysplasia in German Shepherds.
[31317663] Isoflavones rich cowpea and vitamin D induces the proliferation and differentiation of human osteoblasts via BMP-2/Smad pathway activation: Mechanistic approach.
[31309000] CRISPR/Cas9-mediated knockout plays an essential role in the growth of dermal papilla cells through enhanced relative genes.
[31296009] Nanotopographical Cues Mediate Osteogenesis of Stem Cells on Virus Substrates through BMP-2 Intermediate.
[31249412] Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells.
[31240991] Mesenchymal Wnt/β-catenin signaling induces Wnt and BMP antagonists in dental epithelium.
[31239677] Comparison of osteogenic differentiation induced by and delivered by lipopolysaccharide-amine nanopolymersomes and underlying molecular mechanisms.
[31228951] YAP promotes neural crest emigration through interactions with BMP and Wnt activities.
[31222004] FOXF2 reprograms breast cancer cells into bone metastasis seeds.