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Noggin

 U3FU84_CALJA            Unreviewed;       232 AA.
U3FU84;
13-NOV-2013, integrated into UniProtKB/TrEMBL.
13-NOV-2013, sequence version 1.
31-JUL-2019, entry version 38.
RecName: Full=Noggin {ECO:0000256|PIRNR:PIRNR008129};
Name=NOG {ECO:0000313|EMBL:JAB51746.1,
ECO:0000313|Ensembl:ENSCJAP00000053661};
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB51746.1};
[1] {ECO:0000313|Ensembl:ENSCJAP00000053661}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:JAB51746.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Cerebellum {ECO:0000313|EMBL:JAB51746.1},
Cerebral cortex {ECO:0000313|EMBL:JAB24031.1}, and
Hippocampus {ECO:0000313|EMBL:JAB13845.1};
PubMed=25243066; DOI=10.1186/2047-217X-3-14;
Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
Moriyama E.N., French J.A., Norgren R.B.Jr.;
"De novo assembly of the common marmoset transcriptome from NextGen
mRNA sequences.";
Gigascience 3:14-14(2014).
[3] {ECO:0000313|Ensembl:ENSCJAP00000053661}
IDENTIFICATION.
Ensembl;
Submitted (APR-2018) to UniProtKB.
-!- FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling
which is required for growth and patterning of the neural tube and
somite. {ECO:0000256|PIRNR:PIRNR008129}.
-!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR008129}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR008129}.
-!- SIMILARITY: Belongs to the noggin family.
{ECO:0000256|PIRNR:PIRNR008129}.
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EMBL; GAMS01009291; JAB13845.1; -; mRNA.
EMBL; GAMR01009901; JAB24031.1; -; mRNA.
EMBL; GAMP01001010; JAB51745.1; -; mRNA.
EMBL; GAMP01001009; JAB51746.1; -; mRNA.
RefSeq; XP_002748445.1; XM_002748399.3.
Ensembl; ENSCJAT00000026991; ENSCJAP00000053661; ENSCJAG00000013903.
GeneID; 100395820; -.
KEGG; cjc:100395820; -.
CTD; 9241; -.
GeneTree; ENSGT00390000006009; -.
KO; K04658; -.
OrthoDB; 1391421at2759; -.
Proteomes; UP000008225; Unplaced.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0048318; P:axial mesoderm development; IEA:Ensembl.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0051216; P:cartilage development; IEA:UniProtKB-UniRule.
GO; GO:0021533; P:cell differentiation in hindbrain; IEA:Ensembl.
GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl.
GO; GO:0001706; P:endoderm formation; IEA:Ensembl.
GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
GO; GO:0060825; P:fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
GO; GO:0061384; P:heart trabecula morphogenesis; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0060425; P:lung morphogenesis; IEA:Ensembl.
GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0061037; P:negative regulation of cartilage development; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0060302; P:negative regulation of cytokine activity; IEA:Ensembl.
GO; GO:1905006; P:negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0001839; P:neural plate morphogenesis; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0048570; P:notochord morphogenesis; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0090193; P:positive regulation of glomerulus development; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl.
GO; GO:2000313; P:regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0061053; P:somite development; IEA:Ensembl.
GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl.
GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR008717; Noggin.
PANTHER; PTHR10494; PTHR10494; 1.
PIRSF; PIRSF008129; Noggin; 1.
SUPFAM; SSF57501; SSF57501; 1.
2: Evidence at transcript level;
Chondrogenesis {ECO:0000256|PIRNR:PIRNR008129};
Complete proteome {ECO:0000313|Proteomes:UP000008225};
Developmental protein {ECO:0000256|PIRNR:PIRNR008129};
Differentiation {ECO:0000256|PIRNR:PIRNR008129};
Disulfide bond {ECO:0000256|PIRSR:PIRSR008129-1};
Reference proteome {ECO:0000313|Proteomes:UP000008225};
Secreted {ECO:0000256|PIRNR:PIRNR008129};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 27 {ECO:0000256|SAM:SignalP}.
CHAIN 28 232 Noggin. {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5015101563.
REGION 77 96 Disordered. {ECO:0000256|SAM:MobiDB-
lite}.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000256|PIRSR:PIRSR008129-2}.
DISULFID 155 192 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 178 228 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 184 230 {ECO:0000256|PIRSR:PIRSR008129-1}.
DISULFID 207 215 {ECO:0000256|PIRSR:PIRSR008129-1}.
SEQUENCE 232 AA; 25774 MW; FCA0D8E1E2098580 CRC64;
MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD
LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI
KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS
KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC


Related products :

Catalog number Product name Quantity
cyt-475 Recombinant Human Noggin Noggin 20
cyt-475 Recombinant Human Noggin Noggin 1mg
cyt-475 Recombinant Human Noggin Noggin 5
orb82812 Mouse Noggin protein Recombinant Mouse NOGGIN (NOG) belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to sig 1 mg
LF-PA0092 anti-Noggin, Rabbit polyclonal to Noggin, Isotype IgG, Host Rabbit 100 ul
orb82756 Human Noggin protein Recombinant Human Noggin is a non-glycosylated, non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains, having a total molecular mass of approximately 1 mg
orb80093 Mouse Noggin protein Noggin Mouse Recombinant produced in E.coli is non-glycosylated, non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains, having total molecular mass of 5
orb80092 Human Noggin protein Noggin Human Recombinant produced in E.coli is non-glycosylated, non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains, having total molecular mass of 5
orb83085 Human Noggin Fc tag protein Recombinant Human Noggin Fc tag protein. For research use only. 100
orb83669 Human Noggin His tag protein Recombinant Human Noggin His tag protein. For research use only. 50
orb92582 Mouse Noggin gene Mouse Noggin gene is a cDNA gene. For research use only. 10
orb90858 Human Noggin gene Human Noggin gene is a cDNA gene. For research use only. 10
CYT-475 Noggin 5µg
PA285X Noggin 20 µg
PA285 Noggin 5 µg
NOGN15-R-5 Noggin 5 µg
NOGN15-R-20 Noggin 20 µg
NOGN12-A Noggin 0.1 ml
GT15159-100 Noggin 0.1 mg
AR01020PU-S Noggin 5 µg
AR01020PU-N Noggin 20 µg
GTX100861 Noggin 100 µl
30117 IgG,Noggin 0.1 mg
RP17660060001 Noggin 1 mg
90256-2 Noggin 50
Pathways :
WP211: BMP signaling pathway

Related Genes :
[NOG] Noggin
[Nog] Noggin
[Nog] Noggin (Fragment)
[NOG] Noggin
[NOG] Noggin
[NOG CK820_G0020947] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG CR201_G0012164] Noggin
[NOG] Noggin
[NOG] Noggin
[Nog] Noggin
[Nog] Noggin
[Nog rCG_34836] Noggin
[Nog] Noggin
[CgPICR_003326] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin
[NOG] Noggin

Bibliography :
[31428484] A Start Codon Variant in Underlies Symphalangism and Ossicular Chain Malformations Affecting Both the Incus and the Stapes.
[31323019] Novel protective and risk loci in hip dysplasia in German Shepherds.
[31317663] Isoflavones rich cowpea and vitamin D induces the proliferation and differentiation of human osteoblasts via BMP-2/Smad pathway activation: Mechanistic approach.
[31309000] CRISPR/Cas9-mediated knockout plays an essential role in the growth of dermal papilla cells through enhanced relative genes.
[31296009] Nanotopographical Cues Mediate Osteogenesis of Stem Cells on Virus Substrates through BMP-2 Intermediate.
[31249412] Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells.
[31240991] Mesenchymal Wnt/β-catenin signaling induces Wnt and BMP antagonists in dental epithelium.
[31239677] Comparison of osteogenic differentiation induced by and delivered by lipopolysaccharide-amine nanopolymersomes and underlying molecular mechanisms.
[31228951] YAP promotes neural crest emigration through interactions with BMP and Wnt activities.
[31222004] FOXF2 reprograms breast cancer cells into bone metastasis seeds.