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Non-classical export protein 102

 NCE2_CANAL              Reviewed;         170 AA.
Q5ANE3; A0A1D8PK31;
01-APR-2015, integrated into UniProtKB/Swiss-Prot.
26-APR-2005, sequence version 1.
13-FEB-2019, entry version 71.
RecName: Full=Non-classical export protein 102 {ECO:0000305};
Name=NCE102 {ECO:0000303|PubMed:24281718};
OrderedLocusNames=CAALFM_C304910CA; ORFNames=CaO19.13381, CaO19.5960;
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Candida/Lodderomyces clade; Candida.
NCBI_TaxID=237561;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=15123810; DOI=10.1073/pnas.0401648101;
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
[2]
GENOME REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
Chibana H., Nantel A., Magee P.T.;
"Assembly of the Candida albicans genome into sixteen supercontigs
aligned on the eight chromosomes.";
Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
"Assembly of a phased diploid Candida albicans genome facilitates
allele-specific measurements and provides a simple model for repeat
and indel structure.";
Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
[4]
IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
PubMed=19824013; DOI=10.1002/pmic.200800988;
Cabezon V., Llama-Palacios A., Nombela C., Monteoliva L., Gil C.;
"Analysis of Candida albicans plasma membrane proteome.";
Proteomics 9:4770-4786(2009).
[5]
DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=24281718; DOI=10.1128/mBio.00723-13;
Douglas L.M., Wang H.X., Konopka J.B.;
"The MARVEL domain protein Nce102 regulates actin organization and
invasive growth of Candida albicans.";
MBio 4:E00723-E00723(2013).
-!- FUNCTION: Involved in membrane organization. Involved in a novel
pathway of export of proteins that lack a cleavable signal
sequence. Non-classical export pathway functions also as an
alternative clearance/detoxification pathway to eliminate damaged
material, when the basic repair pathway is not sufficient (By
similarity). Regulates actin organization and subsequent
morphogenesis and pathogenesis. {ECO:0000250|UniProtKB:Q12207,
ECO:0000269|PubMed:24281718}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19824013};
Multi-pass membrane protein {ECO:0000255}. Note=Accumulates in
membrane domains at eisosomes. {ECO:0000250|UniProtKB:Q12207}.
-!- DISRUPTION PHENOTYPE: Leads to decreased virulence and forms
abnormal hyphae in mice. Shows defects in forming hyphae and
invading low concentrations of agar but can invade well in higher
agar concentrations. {ECO:0000269|PubMed:24281718}.
-!- SIMILARITY: Belongs to the NCE102 family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; CP017625; AOW28507.1; -; Genomic_DNA.
RefSeq; XP_723171.1; XM_718078.1.
EnsemblFungi; KHC79033; KHC79033; W5Q_03000.
EnsemblFungi; KHC87257; KHC87257; I503_02994.
GeneID; 3635267; -.
KEGG; cal:CAALFM_C304910CA; -.
CGD; CAL0000190917; NCE102.
EuPathDB; FungiDB:C3_04910C_A; -.
HOGENOM; HOG000185206; -.
InParanoid; Q5ANE3; -.
OMA; QASTAFM; -.
OrthoDB; 1421517at2759; -.
PRO; PR:Q5ANE3; -.
Proteomes; UP000000559; Chromosome 3.
GO; GO:0032126; C:eisosome; IDA:CGD.
GO; GO:0035838; C:growing cell tip; IEA:EnsemblFungi.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0045121; C:membrane raft; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IDA:CGD.
GO; GO:0030036; P:actin cytoskeleton organization; IMP:CGD.
GO; GO:0007015; P:actin filament organization; IMP:CACAO.
GO; GO:0070941; P:eisosome assembly; IBA:GO_Central.
GO; GO:0009405; P:pathogenesis; IMP:CGD.
GO; GO:0007009; P:plasma membrane organization; IEA:EnsemblFungi.
GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
InterPro; IPR008253; Marvel.
Pfam; PF01284; MARVEL; 1.
PROSITE; PS51225; MARVEL; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Membrane; Protein transport;
Reference proteome; Transmembrane; Transmembrane helix; Transport;
Virulence.
CHAIN 1 170 Non-classical export protein 102.
/FTId=PRO_0000431765.
TOPO_DOM 1 11 Cytoplasmic. {ECO:0000305}.
TRANSMEM 12 32 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 33 38 Extracellular. {ECO:0000305}.
TRANSMEM 39 61 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 62 76 Cytoplasmic. {ECO:0000305}.
TRANSMEM 77 97 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 98 125 Extracellular. {ECO:0000305}.
TRANSMEM 126 146 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 147 170 Cytoplasmic. {ECO:0000305}.
DOMAIN 6 141 MARVEL. {ECO:0000255|PROSITE-
ProRule:PRU00581}.
SEQUENCE 170 AA; 18123 MW; CB8AC9D732D08858 CRC64;
MLAIGDVILR AFNFVFLVIA LGLTGSLAAT TITQHNPQIN FAVFAAAFGL LTSSFYGVFA
YFVAAFAWPV ILFVFDFLNF VFTFAAATAI AAGIRAHSCS NQDYLDDNNI AQGSSGRCRK
AQASTAFLYF STFIFIASAI FSAISLSKGG LFGHSSRPAP RTGVPTMSQV


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Pathways :
WP1692: Protein export
WP1049: G Protein Signaling Pathways
WP1095: Complement Activation, Classical Pathway
WP1165: G Protein Signaling Pathways
WP1355: One Carbon Metabolism
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation

Related Genes :
[NCE102 NCE2 RTG2S2 YPR149W P9659.2] Non-classical export protein 2
[NCE102 CAALFM_C304910CA CaO19.13381 CaO19.5960] Non-classical export protein 102
[] Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); Capsid protein C (Core protein); E(rns) glycoprotein (gp44/48); Envelope glycoprotein E1 (gp33); Envelope glycoprotein E2 (gp55); p7; Non-structural protein 2-3 (NS2-3); Cysteine protease NS2 (EC 3.4.22.-) (Non-structural protein 2); Serine protease NS3 (EC 3.4.21.113) (EC 3.6.1.15) (EC 3.6.4.13) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); Non-structural protein 5A (NS5A); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B)]
[NCE103 NCE3 YNL036W N2695] Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) (Non-classical export protein 3)
[] Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); Capsid protein C; E(rns) glycoprotein (gp44/48); Envelope glycoprotein E1 (gp33); Envelope glycoprotein E2 (gp55); p7; Non-structural protein 2-3 (NS2-3); Cysteine protease NS2 (EC 3.4.22.-) (Non-structural protein 2); Serine protease NS3 (EC 3.4.21.113) (EC 3.6.1.15) (EC 3.6.4.13) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); Non-structural protein 5A (NS5A); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B)]
[fhn1 SPBC1685.13] Non-classical export protein 2 homolog
[FHN1 YGR131W] Non-classical export protein 2 homolog 1 (Functional homolog of NCE102)
[nhaD VC0395_0225 VC395_A1039] Na(+)/H(+) antiporter NhaD (Sodium/proton antiporter NhaD)
[nqrF VC0395_A1879 VC395_2406] Na(+)-translocating NADH-quinone reductase subunit F (Na(+)-NQR subunit F) (Na(+)-translocating NQR subunit F) (EC 7.2.1.1) (NQR complex subunit F) (NQR-1 subunit F)
[NCE103 CAALFM_C301300CA CaO19.1721 CaO19.9289] Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) (Non-classical export protein 103)
[AGP31 At1g28290 F3H9.6] Non-classical arabinogalactan protein 31 (Hydroxyproline-rich arabinogalactan protein 31)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[nqrB VC0395_A1883 VC395_2410] Na(+)-translocating NADH-quinone reductase subunit B (Na(+)-NQR subunit B) (Na(+)-translocating NQR subunit B) (EC 7.2.1.1) (NQR complex subunit B) (NQR-1 subunit B)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[nqrC VC0395_A1882 VC395_2409] Na(+)-translocating NADH-quinone reductase subunit C (Na(+)-NQR subunit C) (Na(+)-translocating NQR subunit C) (EC 7.2.1.1) (NQR complex subunit C) (NQR-1 subunit C)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[vgrG1 vgrG-1 VC0395_A1026] Actin cross-linking toxin VgrG1 (EC 6.3.2.-)
[NXF1 TAP] Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP)
[esxA esaT6 Rv3875 MTV027.10] 6 kDa early secretory antigenic target (ESAT-6)
[ctxA toxA VC_1457] Cholera enterotoxin subunit A (Cholera enterotoxin, A chain) [Cleaved into: Cholera enterotoxin subunit A1 (EC 2.4.2.-) (Cholera enterotoxin A1 chain) (Cholera enterotoxin alpha chain) (NAD(+)--diphthamide ADP-ribosyltransferase); Cholera enterotoxin subunit A2 (Cholera enterotoxin A2 chain) (Cholera enterotoxin gamma chain)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[cyp102A1 cyp102 BG04_163] Bifunctional cytochrome P450/NADPH--P450 reductase (Cytochrome P450(BM-3)) (Cytochrome P450BM-3) (Fatty acid monooxygenase) (Flavocytochrome P450 BM3) [Includes: Cytochrome P450 102A1 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[rep 1a-1b] Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.19.12) (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); Serine protease nsp4 (3CLSP) (EC 3.4.21.-) (3C-like serine proteinase) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase nsp10 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Non-structural protein 11 (Nsp11); Non-structural protein 12 (Nsp12)]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

Bibliography :
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