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Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)

 NR2C2_MOUSE             Reviewed;         596 AA.
P49117; P55093;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
12-AUG-2020, entry version 175.
RecName: Full=Nuclear receptor subfamily 2 group C member 2;
AltName: Full=Orphan nuclear receptor TAK1;
AltName: Full=Orphan nuclear receptor TR4;
AltName: Full=Testicular receptor 4;
Name=Nr2c2; Synonyms=Mtr2r1, Tak1, Tr4;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=CD-1;
PubMed=7590273; DOI=10.1016/0378-1119(95)00414-2;
Hirose T., O'Brien D.A., Jetten A.M.;
"Cloning of the gene encoding the murine orphan receptor TAK1 and cell-
type-specific expression in testis.";
Gene 163:239-242(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7841789;
Law S.W., Conneely O.M., O'Malley B.W.;
"Molecular cloning of a novel member of the nuclear receptor superfamily
related to the orphan receptor, TR2.";
Gene Expr. 4:77-84(1994).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Testis;
Young W.J., Smith S., Chang C.;
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
[4]
TISSUE SPECIFICITY.
PubMed=10347174; DOI=10.1074/jbc.274.23.16198;
Lee Y.F., Young W.J., Lin W.J., Shyr C.R., Chang C.;
"Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4
thyroid hormone signaling pathways by the human TR4 orphan receptor.";
J. Biol. Chem. 274:16198-16205(1999).
[5]
IDENTIFICATION BY MASS SPECTROMETRY AS A COMPONENT OF THE DRED COMPLEX,
FUNCTION, SUBCELLULAR LOCATION, HETERODIMERIZATION, AND DEVELOPMENTAL
STAGE.
PubMed=12093744; DOI=10.1093/emboj/cdf340;
Tanabe O., Katsuoka F., Campbell A.D., Song W., Yamamoto M., Tanimoto K.,
Engel J.D.;
"An embryonic/fetal beta-type globin gene repressor contains a nuclear
receptor TR2/TR4 heterodimer.";
EMBO J. 21:3434-3442(2002).
[6]
DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
FUNCTION.
PubMed=15199144; DOI=10.1128/mcb.24.13.5887-5899.2004;
Mu X., Lee Y.F., Liu N.C., Chen Y.T., Kim E., Shyr C.R., Chang C.;
"Targeted inactivation of testicular nuclear orphan receptor 4 delays and
disrupts late meiotic prophase and subsequent meiotic divisions of
spermatogenesis.";
Mol. Cell. Biol. 24:5887-5899(2004).
[7]
PHOSPHORYLATION AT SER-19; SER-55 AND SER-68, FUNCTION, IDENTIFICATION BY
MASS SPECTROMETRY, INTERACTION WITH NRIP1 AND PCAF, AND MUTAGENESIS OF
SER-19; SER-55 AND SER-68.
PubMed=16887930; DOI=10.1074/mcp.m600180-mcp200;
Huq M.D., Gupta P., Tsai N.P., Wei L.N.;
"Modulation of testicular receptor 4 activity by mitogen-activated protein
kinase-mediated phosphorylation.";
Mol. Cell. Proteomics 5:2072-2082(2006).
[8]
DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND FUNCTION.
PubMed=17706948; DOI=10.1016/j.brainres.2007.06.069;
Chen Y.T., Collins L.L., Uno H., Chou S.M., Meshul C.K., Chang S.S.,
Chang C.;
"Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in
adult mice lacking TR4 orphan nuclear receptor.";
Brain Res. 1168:72-82(2007).
[9]
HETERODIMERIZATION, AND FUNCTION.
PubMed=17974920; DOI=10.1101/gad.1593307;
Tanabe O., Shen Y., Liu Q., Campbell A.D., Kuroha T., Yamamoto M.,
Engel J.D.;
"The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription.";
Genes Dev. 21:2832-2844(2007).
[10]
DISRUPTION PHENOTYPE, INDUCTION, AND FUNCTION.
PubMed=19131575; DOI=10.1210/en.2008-1165;
Shyr C.R., Kang H.Y., Tsai M.Y., Liu N.C., Ku P.Y., Huang K.E., Chang C.;
"Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic
development and embryonic stem cells.";
Endocrinology 150:2454-2462(2009).
[11]
DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=20393820; DOI=10.1007/s12311-010-0163-z;
Kim Y.S., Harry G.J., Kang H.S., Goulding D., Wine R.N., Kissling G.E.,
Liao G., Jetten A.M.;
"Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is
associated with deficits in GLAST(+) glia, alterations in social behavior,
motor learning, startle reactivity, and microglia.";
Cerebellum 9:310-323(2010).
[12]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-231, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic
pathways.";
Mol. Cell 50:919-930(2013).
-!- FUNCTION: Orphan nuclear receptor that can act as a repressor or
activator of transcription. An important repressor of nuclear receptor
signaling pathways such as retinoic acid receptor, retinoid X, vitamin
D3 receptor, thyroid hormone receptor and estrogen receptor pathways.
May regulate gene expression during the late phase of spermatogenesis.
Activates transcriptional activity of LHCG and is antagonist of PPARA-
mediated transactivation (By similarity). Together with NR2C1, forms
the core of the DRED (direct repeat erythroid-definitive) complex that
represses embryonic and fetal globin transcription including that of
GATA1. Binds to hormone response elements (HREs) consisting of two 5'-
AGGTCA-3' half site direct repeat consensus sequences. Plays a
fundamental role in early embryonic development and embryonic stem
cells. Required for normal spermatogenesis and cerebellum development.
Appears to be important for neurodevelopmentally regulated behavior.
{ECO:0000250, ECO:0000269|PubMed:12093744, ECO:0000269|PubMed:15199144,
ECO:0000269|PubMed:16887930, ECO:0000269|PubMed:17706948,
ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:19131575,
ECO:0000269|PubMed:20393820}.
-!- SUBUNIT: Homodimer; can bind DNA as homodimer (By similarity).
Heterodimer; binds DNA as a heterodimer with NR2C1 required for
chromatin remodeling and for binding to promoter regions such as globin
DR1 repeats. Interacts with NR2C2AP; the interaction represses
selective NR2C2-mediated transcriptional activity (By similarity).
Interacts with PCAF; the interaction preferentially occurs on the non-
phosphorylated form and induces NR2C2-mediated transactivation activity
and does not require the ligand-binding domain (PubMed:16887930).
Interacts (MAPK-mediated phosphorylated form) with NRIP1; the
interaction promotes repression of NR2C2-mediated activity
(PubMed:16887930). Interacts with NLRP10. Interacts (via ligand-binding
region) with transcriptional corepressor JAZF1; the interaction
promotes NR2C2-mediated transcriptional repression (By similarity).
{ECO:0000250|UniProtKB:P49116, ECO:0000269|PubMed:16887930}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
-!- TISSUE SPECIFICITY: Expressed, during embryogenesis, in perichondrium,
developing glomeruli structures and tubules of kidney, as well as in
intestiinal villi. Also expressed in lung and hair follicles.
{ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:15199144,
ECO:0000269|PubMed:17706948}.
-!- INDUCTION: Induced by retinoic acid. {ECO:0000269|PubMed:19131575}.
-!- PTM: Phosphorylation on Ser-19 and Ser-68 is an important regulator of
NR2C2-mediated transcriptional activity. Phosphorylation on these
residues recruits the corepressor, NRIP1, leading to transcripional
repression, whereas the non-phosphorylated form preferentially recruits
the coactivator, PCAF. {ECO:0000269|PubMed:16887930}.
-!- DISRUPTION PHENOTYPE: Impaired spermatogenesis. Mutant animals have
smaller cerebellums with disruption of lobes VI-VII. They exhibit a
delay in monolayer maturation of dysmorphic calbindin 28K-positive
Purkinje cells 7 days after birth. Deficiencies in acoustic startle
response, prepulse startle inhibition, and social interactions were
observed. Also responses to novel environmental situations are
inhibited. NR2C1 and NR2C2 double knockout results in embryonic
lethality around 7.5 dpc and increased apoptosis.
{ECO:0000269|PubMed:15199144, ECO:0000269|PubMed:17706948,
ECO:0000269|PubMed:19131575, ECO:0000269|PubMed:20393820}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAB33314.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Sequence=AAC18408.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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EMBL; U11688; AAA93150.1; -; mRNA.
EMBL; S75970; AAB33314.1; ALT_INIT; mRNA.
EMBL; U32939; AAC18408.1; ALT_INIT; mRNA.
CCDS; CCDS20372.1; -.
PIR; I54075; I54075.
PIR; JC4299; JC4299.
RefSeq; NP_001334271.1; NM_001347342.1.
RefSeq; NP_035760.1; NM_011630.3.
RefSeq; XP_006505967.1; XM_006505904.3.
RefSeq; XP_006505968.1; XM_006505905.3.
RefSeq; XP_006505969.1; XM_006505906.3.
BioGRID; 204300; 4.
IntAct; P49117; 1.
MINT; P49117; -.
STRING; 10090.ENSMUSP00000109087; -.
ChEMBL; CHEMBL4295769; -.
iPTMnet; P49117; -.
PhosphoSitePlus; P49117; -.
EPD; P49117; -.
jPOST; P49117; -.
PaxDb; P49117; -.
PRIDE; P49117; -.
Antibodypedia; 1697; 471 antibodies.
Ensembl; ENSMUST00000113460; ENSMUSP00000109087; ENSMUSG00000005893.
GeneID; 22026; -.
KEGG; mmu:22026; -.
UCSC; uc009cyp.2; mouse.
CTD; 7182; -.
MGI; MGI:1352466; Nr2c2.
eggNOG; KOG3575; Eukaryota.
GeneTree; ENSGT00940000158393; -.
HOGENOM; CLU_007368_16_2_1; -.
InParanoid; P49117; -.
KO; K08544; -.
OMA; GAWPALM; -.
PhylomeDB; P49117; -.
TreeFam; TF316650; -.
Reactome; R-MMU-383280; Nuclear Receptor transcription pathway.
BioGRID-ORCS; 22026; 1 hit in 18 CRISPR screens.
ChiTaRS; Nr2c2; mouse.
PRO; PR:P49117; -.
Proteomes; UP000000589; Chromosome 6.
RNAct; P49117; protein.
Bgee; ENSMUSG00000005893; Expressed in rostral migratory stream and 291 other tissues.
ExpressionAtlas; P49117; baseline and differential.
Genevisible; P49117; MM.
GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0021549; P:cerebellum development; IMP:UniProtKB.
GO; GO:0051321; P:meiotic cell cycle; IMP:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0038066; P:p38MAPK cascade; IEP:CACAO.
GO; GO:0048520; P:positive regulation of behavior; IMP:UniProtKB.
GO; GO:0040019; P:positive regulation of embryonic development; IMP:UniProtKB.
GO; GO:0045663; P:positive regulation of myoblast differentiation; IDA:CACAO.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0007283; P:spermatogenesis; IMP:MGI.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR-like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
1: Evidence at protein level;
Acetylation; Activator; Differentiation; DNA-binding; Isopeptide bond;
Metal-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome;
Repressor; Spermatogenesis; Transcription; Transcription regulation;
Ubl conjugation; Zinc; Zinc-finger.
CHAIN 1..596
/note="Nuclear receptor subfamily 2 group C member 2"
/id="PRO_0000053589"
DOMAIN 341..583
/note="NR LBD"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
DNA_BIND 114..189
/note="Nuclear receptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 117..137
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 153..177
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
MOD_RES 19
/note="Phosphoserine; by MAPK"
/evidence="ECO:0000269|PubMed:16887930"
MOD_RES 46
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P49116"
MOD_RES 55
/note="Phosphoserine; by MAPK"
/evidence="ECO:0000269|PubMed:16887930"
MOD_RES 68
/note="Phosphoserine; by MAPK"
/evidence="ECO:0000269|PubMed:16887930"
MOD_RES 98
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P49116"
MOD_RES 219
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P49116"
MOD_RES 231
/note="N6-acetyllysine"
/evidence="ECO:0000244|PubMed:23806337"
CROSSLNK 192
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2)"
/evidence="ECO:0000250|UniProtKB:P49116"
MUTAGEN 15
/note="S->A: Enhanced transcriptional activation; Greatly
enhanced transcriptional activation; when associated with
A-68."
MUTAGEN 19
/note="S->E: Some repression of transcriptional activation;
Repressed transcriptional activity by about 10-fold; when
associated with E-68."
/evidence="ECO:0000269|PubMed:16887930"
MUTAGEN 55
/note="S->A: No effect on transcriptional activation."
/evidence="ECO:0000269|PubMed:16887930"
MUTAGEN 68
/note="S->A: Enhanced transcriptional activation; Greatly
enhanced transcriptional activation; when associated with
A-15."
/evidence="ECO:0000269|PubMed:16887930"
MUTAGEN 68
/note="S->E: Some repression of transcriptional activation;
Repressed transcriptional activity by about 10-fold; when
associated with E-19."
/evidence="ECO:0000269|PubMed:16887930"
CONFLICT 60
/note="G -> E (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
CONFLICT 106
/note="A -> Q (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
CONFLICT 122
/note="D -> V (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
CONFLICT 247
/note="N -> K (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
CONFLICT 263
/note="A -> T (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
CONFLICT 323
/note="T -> I (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
CONFLICT 327..328
/note="SP -> CF (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
CONFLICT 337
/note="A -> T (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
CONFLICT 484..485
/note="KL -> NW (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
CONFLICT 510
/note="G -> S (in Ref. 2; AAC18408)"
/evidence="ECO:0000305"
SEQUENCE 596 AA; 65239 MW; DE93C438A9CF1ED7 CRC64;
MTSPSPRIQI ISTDSAVASP QRIQIVTDQQ TGQKIQIVTA VDASGSSKQQ FILTSPDGAG
TGKVILASPE TSSAKQLIFT TSDNLVPGRI QIVTDSASVE RLLGKADVQR PQVVEYCVVC
GDKASGRHYG AVSCEGCKGF FKRSVRKNLT YSCRSSQDCI INKHHRNRCQ FCRLKKCLEM
GMKMESVQSE RKPFDVQREK PSNCAASTEK IYIRKDLRSP LIATPTFVAD KDGARQTGLL
DPGMLVNIQQ PLIREDGTVL LAADSKAETS QGALGTLANV VTSLANLSES LNNGDASEMQ
PEDQSASEIT RAFDTLAKAL NTTDSASPPS LADGIDASGG GSIHVISRDQ STPIIEVEGP
LLSDTHVTFK LTMPSPMPEY LNVHYICESA SRLLFLSMHW ARSIPAFQAL GQDCNTSLVR
ACWNELFTLG LAQCAQVMSL STILAAIVNH LQNSIQEDKL SGDRIKQVME HIWKLQEFCN
SMAKLDIDGY EYAYLKAIVL FSPDHPGLTG TSQIEKFQEK AQMELQDYVQ KTYSEDTYRL
ARILVRLPAL RLMSSNITEE LFFTGLIGNV SIDSIIPYIL KMETAEYNGQ ITGASL


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WP996: EPO Receptor Signaling
WP1025: B Cell Receptor Signaling Pathway
WP68: Androgen Receptor Signaling Pathway
WP1067: Toll-like receptor signaling pathway
WP1284: EPO Receptor Signaling
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP886: Kit Receptor Signaling Pathway
WP1336: EPO Receptor Signaling
WP733: Serotonin Receptor 2 and STAT3 Signaling
WP1112: EPO Receptor Signaling

Related Genes :
[Nr2c2 Mtr2r1 Tak1 Tr4] Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
[NR2C2 TAK1 TR4] Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
[Nr2c2 Tr4] Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TR4) (Testicular receptor 4)
[Nr2c1 Tr2 Tr2-11] Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2) (mTR2)
[NR4A1 GFRP1 HMR NAK1] Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)
[Rorc Nr1f3 Rorg Thor] Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) (Thymus orphan receptor) (TOR)
[RORC NR1F3 RORG RZRG] Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
[Nr1d2] Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear receptor RVR) (Rev-erb-beta)
[Rora Nr1f1 Rzra] Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)
[NR1D2] Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
[Nr4a1 Gfrp Hmr N10 Nur77] Nuclear receptor subfamily 4 group A member 1 (Nuclear hormone receptor NUR/77) (Nuclear protein N10) (Orphan nuclear receptor HMR)
[RORA NR1F1 RZRA] Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)
[Nr1h2 Lxrb] Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR)
[Nr4a1 Hmr Ngfib] Nuclear receptor subfamily 4 group A member 1 (NUR77) (Nerve growth factor-induced protein I-B) (NGFI-B) (Orphan nuclear receptor HMR)
[RORB NR1F2 RZRB] Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)
[nhr-6 cnr-8 nr4a5 C48D5.1] Nuclear hormone receptor family member nhr-6 (Nuclear receptor subfamily 4 group A member 5) (Steroid hormone receptor family member cnr8)
[NR4A1 HMR] Nuclear receptor subfamily 4 group A member 1 (Orphan nuclear receptor HMR) (Orphan nuclear receptor NGFI-B)
[NR0B1 AHC DAX1] Nuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1)
[Esrrb Err-2 Err2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[Nr2e3 Pnr Rnr] Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor)
[NR2E3 PNR RNR] Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor)
[AR DHTR NR3C4] Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
[Nr1d1 Ear1] Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)
[Nr2f6 Ear-2 Ear2 Erbal2] Nuclear receptor subfamily 2 group F member 6 (COUP transcription factor 3) (COUP-TF3) (V-erbA-related protein 2) (EAR-2)
[NR5A1 AD4BP FTZF1 SF1] Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)
[NR5A2 B1F CPF FTF] Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)
[Thrb Erba2 Nr1a2] Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
[Nr3c2 Mlr] Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2)
[Nr1h4 Bar Fxr Rip14] Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
[NRIP1] Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140)

Bibliography :
[31633027] Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway.
[30571995] The planarian Schmidtea mediterranea is a new model to study host-pathogen interactions during fungal infections.
[30473219] Role and mechanism of miR-4778-3p and its targets NR2C2 and Med19 in cervical cancer radioresistance.
[30248360] Molecular identification and expression analysis of TAB1 from orange-spotted grouper (Epinephelus coioides).
[29973687] TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals.
[29018082] The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation.
[28974699] NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis.
[28623141] Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
[28527578] TR2 and TR4 Orphan Nuclear Receptors: An Overview.
[28210900] False responses of Renilla luciferase reporter control to nuclear receptor TR4.