GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)

 NR5A2_HUMAN             Reviewed;         541 AA.
O00482; B4E2P3; O95642; Q147U3;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
26-FEB-2020, entry version 199.
RecName: Full=Nuclear receptor subfamily 5 group A member 2;
AltName: Full=Alpha-1-fetoprotein transcription factor;
AltName: Full=B1-binding factor;
Short=hB1F;
AltName: Full=CYP7A promoter-binding factor;
AltName: Full=Hepatocytic transcription factor;
AltName: Full=Liver receptor homolog 1;
Short=LRH-1;
Name=NR5A2; Synonyms=B1F, CPF, FTF;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND ALTERNATIVE SPLICING.
TISSUE=Liver;
PubMed=9786908; DOI=10.1074/jbc.273.44.29022;
Li M., Xie Y.-H., Kong Y.-Y., Wu X., Zhu L., Wang Y.;
"Cloning and characterization of a novel human hepatocyte transcription
factor, hB1F, which binds and activates enhancer II of hepatitis B virus.";
J. Biol. Chem. 273:29022-29031(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Hepatoma;
Li M., Xie Y.-H., Wang Y.;
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
TISSUE=Liver;
PubMed=10359768; DOI=10.1073/pnas.96.12.6660;
Nitta M., Ku S., Brown C., Okamoto A.Y., Shan B.;
"CPF: an orphan nuclear receptor that regulates liver-specific expression
of the human cholesterol 7alpha-hydroxylase gene.";
Proc. Natl. Acad. Sci. U.S.A. 96:6660-6665(1999).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
PubMed=11595170; DOI=10.1016/s0378-1119(01)00586-8;
Zhang C.K., Lin W., Cai Y.N., Xu P.L., Dong H., Li M., Kong Y.Y., Fu G.,
Xie Y.H., Huang G.M., Wang Y.;
"Characterization of the genomic structure and tissue-specific promoter of
the human nuclear receptor NR5A2 (hB1F) gene.";
Gene 273:239-249(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
TISSUE=Trachea;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
NUCLEOTIDE SEQUENCE [MRNA] OF 41-541.
PubMed=9858833; DOI=10.1159/000015116;
Galarneau L., Drouin R., Belanger L.;
"Assignment of the fetoprotein transcription factor gene (FTF) to human
chromosome band 1q32.11 by in situ hybridization.";
Cytogenet. Cell Genet. 82:269-270(1998).
[10]
FUNCTION, INTERACTION WITH GPS2, SUMOYLATION AT LYS-270, AND MUTAGENESIS OF
LYS-270.
PubMed=20159957; DOI=10.1101/gad.545110;
Venteclef N., Jakobsson T., Ehrlund A., Damdimopoulos A., Mikkonen L.,
Ellis E., Nilsson L.M., Parini P., Jaenne O.A., Gustafsson J.A.,
Steffensen K.R., Treuter E.;
"GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions
of LRH-1 and LXRbeta in the hepatic acute phase response.";
Genes Dev. 24:381-395(2010).
[11]
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 300-541 IN COMPLEX WITH NCOA2 AND
PHOSPHOLIPIDS, AND FUNCTION.
PubMed=15707893; DOI=10.1016/j.cell.2005.01.024;
Krylova I.N., Sablin E.P., Moore J., Xu R.X., Waitt G.M., MacKay J.A.,
Juzumiene D., Bynum J.M., Madauss K., Montana V., Lebedeva L., Suzawa M.,
Williams J.D., Williams S.P., Guy R.K., Thornton J.W., Fletterick R.J.,
Willson T.M., Ingraham H.A.;
"Structural analyses reveal phosphatidyl inositols as ligands for the NR5
orphan receptors SF-1 and LRH-1.";
Cell 120:343-355(2005).
[12]
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 79-187 IN COMPLEX WITH DNA,
MUTAGENESIS OF TYR-96; PHE-168; 169-GLY-PRO-170 AND TYR-172, AND FUNCTION.
PubMed=16289203; DOI=10.1016/j.jmb.2005.10.009;
Solomon I.H., Hager J.M., Safi R., McDonnell D.P., Redinbo M.R.,
Ortlund E.A.;
"Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain
positioning is required for receptor activity.";
J. Mol. Biol. 354:1091-1102(2005).
[13]
X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 290-541 IN COMPLEX WITH NR0B2 AND
PHOSPHOLIPID, MUTAGENESIS OF PHE-342 AND ILE-416, AND FUNCTION.
PubMed=15723037; DOI=10.1038/nsmb910;
Ortlund E.A., Lee Y., Solomon I.H., Hager J.M., Safi R., Choi Y., Guan Z.,
Tripathy A., Raetz C.R.H., McDonnell D.P., Moore D.D., Redinbo M.R.;
"Modulation of human nuclear receptor LRH-1 activity by phospholipids and
SHP.";
Nat. Struct. Mol. Biol. 12:357-363(2005).
[14]
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 297-541 IN COMPLEX WITH NCOA2 AND
PHOSPHOLIPID, AND FUNCTION.
PubMed=15897460; DOI=10.1073/pnas.0409482102;
Wang W., Zhang C., Marimuthu A., Krupka H.I., Tabrizizad M., Shelloe R.,
Mehra U., Eng K., Nguyen H., Settachatgul C., Powell B., Milburn M.V.,
West B.L.;
"The crystal structures of human steroidogenic factor-1 and liver receptor
homologue-1.";
Proc. Natl. Acad. Sci. U.S.A. 102:7505-7510(2005).
-!- FUNCTION: Nuclear receptor that acts as a key metabolic sensor by
regulating the expression of genes involved in bile acid synthesis,
cholesterol homeostasis and triglyceride synthesis. Together with the
oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an
essential transcriptional regulator of lipid metabolism. Plays an anti-
inflammatory role during the hepatic acute phase response by acting as
a corepressor: inhibits the hepatic acute phase response by preventing
dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds
to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of
hepatitis B virus genes, a critical cis-element of their expression and
regulation. May be responsible for the liver-specific activity of
enhancer II, probably in combination with other hepatocyte
transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase
gene (CYP7A) expression in liver. May also contribute to the regulation
of pancreas-specific genes and play important roles in embryonic
development. Activates the transcription of CYP2C38 (By similarity).
{ECO:0000250|UniProtKB:P45448, ECO:0000269|PubMed:15707893,
ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:15897460,
ECO:0000269|PubMed:16289203, ECO:0000269|PubMed:20159957}.
-!- SUBUNIT: Binds DNA as a monomer (By similarity). Interacts with GRIP1,
NCOA2 and NR0B2 (PubMed:15707893, PubMed:15723037, PubMed:15897460,
PubMed:16289203). Interacts (when sumoylated) with GPS2; interaction
with GPS2 onto hepatic acute phase protein promoters prevents N-Cor
corepressor complex dissociation (PubMed:20159957). {ECO:0000250,
ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:15723037,
ECO:0000269|PubMed:15897460, ECO:0000269|PubMed:16289203,
ECO:0000269|PubMed:20159957}.
-!- INTERACTION:
P35222:CTNNB1; NbExp=5; IntAct=EBI-15960777, EBI-491549;
O60869:EDF1; NbExp=2; IntAct=EBI-781320, EBI-781301;
Q15596:NCOA2; NbExp=2; IntAct=EBI-15960777, EBI-81236;
Q15466:NR0B2; NbExp=2; IntAct=EBI-15960777, EBI-3910729;
Q92786:PROX1; NbExp=9; IntAct=EBI-9257474, EBI-3912635;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=2; Synonyms=B1F2;
IsoId=O00482-1; Sequence=Displayed;
Name=1;
IsoId=O00482-2; Sequence=VSP_003716;
Name=3;
IsoId=O00482-3; Sequence=VSP_003717;
Name=4;
IsoId=O00482-4; Sequence=VSP_054548;
-!- TISSUE SPECIFICITY: Abundantly expressed in pancreas, less in liver,
very low levels in heart and lung. Expressed in the Hep-G2 cell line.
Isoform 1 and isoform 2 seem to be present in fetal and adult liver and
Hep-G2 cells.
-!- PTM: Sumoylated by SUMO1 at Lys-270 during the hepatic acute phase
response, leading to promote interaction with GPS2 and prevent N-Cor
corepressor complex dissociation. {ECO:0000269|PubMed:20159957}.
-!- MISCELLANEOUS: [Isoform 3]: Does not induce CYP7A promoter activity.
{ECO:0000305}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; U80251; AAC78727.1; -; mRNA.
EMBL; AF146343; AAD37378.1; -; mRNA.
EMBL; AF124247; AAD26565.1; -; mRNA.
EMBL; AF190464; AAG17124.1; -; Genomic_DNA.
EMBL; AF190464; AAG17125.1; -; Genomic_DNA.
EMBL; AK304365; BAG65205.1; -; mRNA.
EMBL; AK316513; BAH14884.1; -; mRNA.
EMBL; AC096633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471067; EAW91306.1; -; Genomic_DNA.
EMBL; BC118571; AAI18572.1; -; mRNA.
EMBL; BC118652; AAI18653.1; -; mRNA.
EMBL; U93553; AAD03155.1; -; mRNA.
CCDS; CCDS1400.1; -. [O00482-2]
CCDS; CCDS1401.1; -. [O00482-1]
CCDS; CCDS60383.1; -. [O00482-4]
RefSeq; NP_001263393.1; NM_001276464.1. [O00482-4]
RefSeq; NP_003813.1; NM_003822.4. [O00482-2]
RefSeq; NP_995582.1; NM_205860.2. [O00482-1]
RefSeq; XP_005245119.1; XM_005245062.3. [O00482-4]
RefSeq; XP_011507684.1; XM_011509382.1. [O00482-4]
PDB; 1YOK; X-ray; 2.50 A; A=300-541.
PDB; 1YUC; X-ray; 1.90 A; A/B=290-541.
PDB; 1ZDU; X-ray; 2.50 A; A=297-541.
PDB; 2A66; X-ray; 2.20 A; A=79-187.
PDB; 3PLZ; X-ray; 1.75 A; A/B=300-541.
PDB; 3TX7; X-ray; 2.76 A; B=191-541.
PDB; 4DOR; X-ray; 1.90 A; A/B=290-541.
PDB; 4DOS; X-ray; 2.00 A; A=299-538.
PDB; 4IS8; X-ray; 2.78 A; A/B=300-538.
PDB; 4ONI; X-ray; 1.80 A; A/B=291-541.
PDB; 4PLD; X-ray; 1.75 A; A=301-541.
PDB; 4PLE; X-ray; 1.75 A; A/C/E/G=301-541.
PDB; 4RWV; X-ray; 1.86 A; A=294-541.
PDB; 5L0M; X-ray; 2.20 A; A=79-187.
PDB; 5L11; X-ray; 1.85 A; A=299-541.
PDB; 5SYZ; X-ray; 1.93 A; A=297-538.
PDB; 5UNJ; X-ray; 1.96 A; A=299-541.
PDB; 6OQX; X-ray; 2.00 A; A=299-541.
PDB; 6OQY; X-ray; 2.23 A; A=299-541.
PDB; 6OR1; X-ray; 2.17 A; A=299-541.
PDBsum; 1YOK; -.
PDBsum; 1YUC; -.
PDBsum; 1ZDU; -.
PDBsum; 2A66; -.
PDBsum; 3PLZ; -.
PDBsum; 3TX7; -.
PDBsum; 4DOR; -.
PDBsum; 4DOS; -.
PDBsum; 4IS8; -.
PDBsum; 4ONI; -.
PDBsum; 4PLD; -.
PDBsum; 4PLE; -.
PDBsum; 4RWV; -.
PDBsum; 5L0M; -.
PDBsum; 5L11; -.
PDBsum; 5SYZ; -.
PDBsum; 5UNJ; -.
PDBsum; 6OQX; -.
PDBsum; 6OQY; -.
PDBsum; 6OR1; -.
SMR; O00482; -.
BioGrid; 108772; 21.
CORUM; O00482; -.
DIP; DIP-37952N; -.
IntAct; O00482; 10.
MINT; O00482; -.
STRING; 9606.ENSP00000356331; -.
BindingDB; O00482; -.
ChEMBL; CHEMBL3544; -.
GuidetoPHARMACOLOGY; 633; -.
SwissLipids; SLP:000001542; -.
TCDB; 9.B.208.1.4; the vitamin d3 receptor (vdr) family.
iPTMnet; O00482; -.
PhosphoSitePlus; O00482; -.
BioMuta; NR5A2; -.
MassIVE; O00482; -.
PaxDb; O00482; -.
PeptideAtlas; O00482; -.
PRIDE; O00482; -.
ProteomicsDB; 47928; -. [O00482-1]
ProteomicsDB; 47929; -. [O00482-2]
ProteomicsDB; 47930; -. [O00482-3]
ProteomicsDB; 5842; -.
Ensembl; ENST00000236914; ENSP00000236914; ENSG00000116833. [O00482-2]
Ensembl; ENST00000367362; ENSP00000356331; ENSG00000116833. [O00482-1]
Ensembl; ENST00000544748; ENSP00000439116; ENSG00000116833. [O00482-4]
GeneID; 2494; -.
KEGG; hsa:2494; -.
UCSC; uc001gvb.5; human. [O00482-1]
CTD; 2494; -.
DisGeNET; 2494; -.
GeneCards; NR5A2; -.
HGNC; HGNC:7984; NR5A2.
HPA; HPA005455; -.
HPA; HPA017067; -.
MIM; 604453; gene.
neXtProt; NX_O00482; -.
OpenTargets; ENSG00000116833; -.
PharmGKB; PA31765; -.
eggNOG; KOG4218; Eukaryota.
eggNOG; ENOG410YWC2; LUCA.
GeneTree; ENSGT00940000153391; -.
HOGENOM; CLU_011437_0_0_1; -.
InParanoid; O00482; -.
KO; K08027; -.
OMA; SAIQNMH; -.
OrthoDB; 619653at2759; -.
PhylomeDB; O00482; -.
TreeFam; TF350737; -.
Reactome; R-HSA-210747; Regulation of gene expression in early pancreatic precursor cells. [O00482-1]
Reactome; R-HSA-383280; Nuclear Receptor transcription pathway.
Reactome; R-HSA-4090294; SUMOylation of intracellular receptors. [O00482-2]
Reactome; R-HSA-9018519; Estrogen-dependent gene expression.
SignaLink; O00482; -.
SIGNOR; O00482; -.
ChiTaRS; NR5A2; human.
EvolutionaryTrace; O00482; -.
GeneWiki; Liver_receptor_homolog-1; -.
GenomeRNAi; 2494; -.
Pharos; O00482; Tchem.
PRO; PR:O00482; -.
Proteomes; UP000005640; Chromosome 1.
RNAct; O00482; protein.
Bgee; ENSG00000116833; Expressed in body of pancreas and 109 other tissues.
ExpressionAtlas; O00482; baseline and differential.
Genevisible; O00482; HS.
GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL.
GO; GO:0000790; C:nuclear chromatin; ISA:NTNU_SB.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; ISS:BHF-UCL.
GO; GO:0003682; F:chromatin binding; ISS:BHF-UCL.
GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
GO; GO:0005543; F:phospholipid binding; IDA:UniProtKB.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:BHF-UCL.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0008206; P:bile acid metabolic process; IEA:Ensembl.
GO; GO:0097720; P:calcineurin-mediated signaling; IEA:Ensembl.
GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; TAS:UniProtKB.
GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
GO; GO:0042592; P:homeostatic process; NAS:UniProtKB.
GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
GO; GO:0061113; P:pancreas morphogenesis; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:BHF-UCL.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:BHF-UCL.
GO; GO:0045070; P:positive regulation of viral genome replication; IDA:BHF-UCL.
GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0009888; P:tissue development; IBA:GO_Central.
GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR-like_dom_sf.
InterPro; IPR016355; NR5_fam.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
PANTHER; PTHR24086; PTHR24086; 1.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PIRSF; PIRSF002530; Nuc_orph_FTZ-F1; 1.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
1: Evidence at protein level;
3D-structure; Activator; Alternative splicing; DNA-binding;
Isopeptide bond; Lipid-binding; Metal-binding; Nucleus; Receptor;
Reference proteome; Transcription; Transcription regulation;
Ubl conjugation; Zinc; Zinc-finger.
CHAIN 1..541
/note="Nuclear receptor subfamily 5 group A member 2"
/id="PRO_0000053735"
DOMAIN 300..539
/note="NR LBD"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
DNA_BIND 83..154
/note="Nuclear receptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 86..106
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 122..146
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
REGION 419..424
/note="Lipid binding"
MOTIF 155..184
/note="FTZ-F1 box"
BINDING 516
/note="Lipid headgroup"
BINDING 520
/note="Lipid headgroup"
CROSSLNK 270
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO1)"
/evidence="ECO:0000269|PubMed:20159957"
VAR_SEQ 1..72
/note="Missing (in isoform 4)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_054548"
VAR_SEQ 22..67
/note="Missing (in isoform 1)"
/evidence="ECO:0000303|PubMed:10359768,
ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:9786908"
/id="VSP_003716"
VAR_SEQ 199..370
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|PubMed:10359768"
/id="VSP_003717"
MUTAGEN 96
/note="Y->A: Slightly reduced DNA binding. Strongly reduced
transactivation; when associated with A-168 and A-172."
/evidence="ECO:0000269|PubMed:16289203"
MUTAGEN 168
/note="F->A: Slightly reduced DNA binding. Strongly reduced
transactivation; when associated with A-96 and A-172."
/evidence="ECO:0000269|PubMed:16289203"
MUTAGEN 169..170
/note="GP->VA: Reduced DNA binding. Loss of
transactivation."
/evidence="ECO:0000269|PubMed:16289203"
MUTAGEN 172
/note="Y->A: Slightly reduced DNA binding. Strongly reduced
transactivation; when associated with A-96 and A-168."
/evidence="ECO:0000269|PubMed:16289203"
MUTAGEN 270
/note="K->R: Impaired ability to act as an anti-
inflammatory role during the hepatic acute phase response."
/evidence="ECO:0000269|PubMed:20159957"
MUTAGEN 342
/note="F->W: Reduced phospholipid binding. Strongly reduced
transactivation; when associated with W-416."
/evidence="ECO:0000269|PubMed:15723037"
MUTAGEN 416
/note="I->W: Reduced phospholipid binding. Strongly reduced
transactivation; when associated with W-342."
/evidence="ECO:0000269|PubMed:15723037"
CONFLICT 250..251
/note="PP -> L (in Ref. 9; AAD03155)"
/evidence="ECO:0000305"
CONFLICT 353
/note="L -> V (in Ref. 9; AAD03155)"
/evidence="ECO:0000305"
TURN 87..89
/evidence="ECO:0000244|PDB:5L0M"
STRAND 95..97
/evidence="ECO:0000244|PDB:5L0M"
STRAND 100..102
/evidence="ECO:0000244|PDB:5L0M"
HELIX 104..115
/evidence="ECO:0000244|PDB:5L0M"
TURN 132..137
/evidence="ECO:0000244|PDB:5L0M"
HELIX 139..148
/evidence="ECO:0000244|PDB:5L0M"
HELIX 153..155
/evidence="ECO:0000244|PDB:5L0M"
TURN 167..170
/evidence="ECO:0000244|PDB:5L0M"
HELIX 171..175
/evidence="ECO:0000244|PDB:5L0M"
HELIX 303..310
/evidence="ECO:0000244|PDB:3PLZ"
HELIX 315..328
/evidence="ECO:0000244|PDB:3PLZ"
HELIX 335..337
/evidence="ECO:0000244|PDB:4PLD"
HELIX 341..362
/evidence="ECO:0000244|PDB:3PLZ"
HELIX 366..368
/evidence="ECO:0000244|PDB:3PLZ"
HELIX 371..397
/evidence="ECO:0000244|PDB:3PLZ"
STRAND 402..404
/evidence="ECO:0000244|PDB:3PLZ"
STRAND 410..412
/evidence="ECO:0000244|PDB:3PLZ"
HELIX 413..417
/evidence="ECO:0000244|PDB:3PLZ"
HELIX 422..440
/evidence="ECO:0000244|PDB:3PLZ"
HELIX 445..456
/evidence="ECO:0000244|PDB:3PLZ"
HELIX 467..488
/evidence="ECO:0000244|PDB:3PLZ"
STRAND 490..492
/evidence="ECO:0000244|PDB:4IS8"
HELIX 495..500
/evidence="ECO:0000244|PDB:3PLZ"
HELIX 502..522
/evidence="ECO:0000244|PDB:3PLZ"
STRAND 528..530
/evidence="ECO:0000244|PDB:6OQX"
HELIX 531..536
/evidence="ECO:0000244|PDB:3PLZ"
SEQUENCE 541 AA; 61331 MW; 7B07170C075490FE CRC64;
MSSNSDTGDL QESLKHGLTP IGAGLPDRHG SPIPARGRLV MLPKVETEAL GLARSHGEQG
QMPENMQVSQ FKMVNYSYDE DLEELCPVCG DKVSGYHYGL LTCESCKGFF KRTVQNNKRY
TCIENQNCQI DKTQRKRCPY CRFQKCLSVG MKLEAVRADR MRGGRNKFGP MYKRDRALKQ
QKKALIRANG LKLEAMSQVI QAMPSDLTIS SAIQNIHSAS KGLPLNHAAL PPTDYDRSPF
VTSPISMTMP PHGSLQGYQT YGHFPSRAIK SEYPDPYTSS PESIMGYSYM DSYQTSSPAS
IPHLILELLK CEPDEPQVQA KIMAYLQQEQ ANRSKHEKLS TFGLMCKMAD QTLFSIVEWA
RSSIFFRELK VDDQMKLLQN CWSELLILDH IYRQVVHGKE GSIFLVTGQQ VDYSIIASQA
GATLNNLMSH AQELVAKLRS LQFDQREFVC LKFLVLFSLD VKNLENFQLV EGVQEQVNAA
LLDYTMCNYP QQTEKFGQLL LRLPEIRAIS MQAEEYLYYK HLNGDVPYNN LLIEMLHAKR
A


Related products :

Catalog number Product name Quantity
18-461-10169 Orphan nuclear receptor NR5A2 - Alpha-1-fetoprotein transcription factor; Hepatocytic transcription factor; B1-binding factor; hB1F; CYP7A promoter-binding factor; Liver receptor homolog 1; LRH-1 Poly 0.05 ml
EIAAB27823 Alpha-1-fetoprotein transcription factor,B1-binding factor,B1F,CPF,CYP7A promoter-binding factor,FTF,hB1F,Hepatocytic transcription factor,Homo sapiens,Human,Liver receptor homolog 1,LRH-1,NR5A2,Nucle
EIAAB40274 Adrenal 4-binding protein,FTZF1,Fushi tarazu factor homolog 1,NR5A1,Nuclear receptor subfamily 5 group A member 1,Pig,SF-1,Steroid hormone receptor Ad4BP,Steroidogenic factor 1,STF-1,Sus scrofa
EIAAB40277 Adrenal 4-binding protein,Ftzf1,Fushi tarazu factor homolog 1,Nr5a1,Nuclear receptor subfamily 5 group A member 1,Rat,Rattus norvegicus,SF-1,Steroid hormone receptor Ad4BP,Steroidogenic factor 1,STF-1
EIAAB40275 AD4BP,Adrenal 4-binding protein,Bos taurus,Bovine,FTZF1,Fushi tarazu factor homolog 1,NR5A1,Nuclear receptor subfamily 5 group A member 1,SF-1,Steroid hormone receptor Ad4BP,Steroidogenic factor 1,STF
EIAAB40276 AD4BP,Adrenal 4-binding protein,FTZF1,Fushi tarazu factor homolog 1,Homo sapiens,Human,NR5A1,Nuclear receptor subfamily 5 group A member 1,SF1,SF-1,Steroid hormone receptor Ad4BP,Steroidogenic factor
EIAAB08690 COUP transcription factor 1,COUP transcription factor I,COUP-TF I,COUP-TF1,EAR-3,Erbal3,Mouse,Mus musculus,Nr2f1,Nuclear receptor subfamily 2 group F member 1,Tfcoup1,V-erbA-related protein 3
EIAAB08695 Apolipoprotein A-I regulatory protein 1,ARP1,ARP-1,COUP transcription factor 2,COUP transcription factor II,COUP-TF II,COUP-TF2,Homo sapiens,Human,NR2F2,Nuclear receptor subfamily 2 group F member 2,T
EIAAB08691 Apolipoprotein A-I regulatory protein 1,Arp1,ARP-1,COUP transcription factor 2,COUP transcription factor II,COUPb,COUP-TF II,COUP-TF2,Nr2f2,Nuclear receptor subfamily 2 group F member 2,Ovalbumin upst
EIAAB08692 Bos taurus,Bovine,COUP transcription factor 2,COUP transcription factor II,COUP-TF II,COUP-TF2,NR2F2,Nuclear receptor subfamily 2 group F member 2,TFCOUP2
EIAAB08689 Bos taurus,Bovine,COUP transcription factor 1,COUP transcription factor I,COUP-TF I,COUP-TF1,NR2F1,Nuclear receptor subfamily 2 group F member 1,TFCOUP1
EIAAB08688 COUP transcription factor 1,COUP transcription factor I,COUP-TF I,COUP-TF1,EAR3,EAR-3,ERBAL3,Homo sapiens,Human,NR2F1,Nuclear receptor subfamily 2 group F member 1,TFCOUP1,V-erbA-related protein 3
18-003-44075 Transcription factor E2-alpha - Immunoglobulin enhancer-binding factor E12_E47; Transcription factor 3; TCF-3; Immunoglobulin transcription factor 1; Transcription factor ITF-1; Kappa-E2-binding facto 0.1 mg Protein A
EIAAB42103 Immunoglobulin enhancer-binding factor E12_E47,Pan,Pancreas specific transcription factor 1c,Ptf1c,Rat,Rattus norvegicus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor E2-alpha,Transcri
EIAAB42104 Alf2,Immunoglobulin enhancer-binding factor E12_E47,Me2,Mouse,Mus musculus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor A1,Transcription factor E2-alpha
EIAAB27106 CAAT box DNA-binding protein subunit A,CBF-B,CCAAT-binding transcription factor subunit B,Nfya,NF-YA,Nuclear transcription factor Y subunit A,Nuclear transcription factor Y subunit alpha,Rat,Rattus no
EIAAB08693 Chicken,COUP transcription factor 2,COUP transcription factor II,COUP-TF II,COUP-TF2,Gallus gallus,NR2F2,Nuclear receptor subfamily 2 group F member 2,TFCOUP2
EIAAB27055 CCAAT-box-binding transcription factor,CTF,Homo sapiens,Human,KIAA1439,NF1-A,NF-I_A,NFIA,NFI-A,Nuclear factor 1 A-type,Nuclear factor 1_A,Nuclear factor I_A,TGGCA-binding protein
EIAAB27075 CCAAT-box-binding transcription factor,CTF,Homo sapiens,Human,NF1-X,NF-I_X,NFIX,NFI-X,Nuclear factor 1 X-type,Nuclear factor 1_X,Nuclear factor I_X,TGGCA-binding protein
EIAAB27061 CCAAT-box-binding transcription factor,CTF,Homo sapiens,Human,NF1-C,NFI,NF-I_C,NFIC,NFI-C,Nuclear factor 1 C-type,Nuclear factor 1_C,Nuclear factor I_C,TGGCA-binding protein
EIAAB27058 CCAAT-box-binding transcription factor,CTF,Homo sapiens,Human,NF1-B,NF-I_B,NFIB,NFI-B,Nuclear factor 1 B-type,Nuclear factor 1_B,Nuclear factor I_B,TGGCA-binding protein
EIAAB27054 CCAAT-box-binding transcription factor,CTF,NF1-A,Nf1l21,NF-I_A,Nfia,NFI-A,Nuclear factor 1 A-type,Nuclear factor 1_A,Nuclear factor I_A,Rat,Rattus norvegicus,TGGCA-binding protein
EIAAB27076 CCAAT-box-binding transcription factor,CTF,Mouse,Mus musculus,NF1-X,NF-I_X,Nfix,NFI-X,Nuclear factor 1 X-type,Nuclear factor 1_X,Nuclear factor I_X,TGGCA-binding protein
EIAAB27052 CCAAT-box-binding transcription factor,CTF,Mouse,Mus musculus,NF1-A,NF-I_A,Nfia,NFI-A,Nuclear factor 1 A-type,Nuclear factor 1_A,Nuclear factor I_A,TGGCA-binding protein
EIAAB27063 CCAAT-box-binding transcription factor,CTF,Mouse,Mus musculus,NF1-C,NF-I_C,Nfic,NFI-C,Nuclear factor 1 C-type,Nuclear factor 1_C,Nuclear factor I_C,TGGCA-binding protein
Pathways :
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP272: Blood Clotting Cascade
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP590: Cardiovascular Signaling
WP2292: Chemokine signaling pathway
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP1963: The effect of Glucocorticoids on target gene expression
WP1531: Vitamin D synthesis
WP566: canonical wnt - zebrafish
WP1284: EPO Receptor Signaling
WP177: Eukaryotic Transcription Initiation
WP2272: Pathogenic Escherichia coli infection
WP425: Eukaryotic Transcription Initiation

Related Genes :
[NR5A2 B1F CPF FTF] Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)
[NR5A1 AD4BP FTZF1 SF1] Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)
[HNF4A HNF4 NR2A1 TCF14] Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
[Hnf4a Hnf-4 Hnf4 Nr2a1 Tcf14] Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
[NR2F2 ARP1 TFCOUP2] COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2)
[Nr2f2 Arp1 Tfcoup2] COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (COUPb) (Nuclear receptor subfamily 2 group F member 2) (Ovalbumin upstream promoter beta nuclear receptor)
[NR1H4 BAR FXR HRR1 RIP14] Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
[Nr1h4 Bar Fxr Rip14] Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
[HNF1A TCF1] Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
[Nr1d1 Ear1] Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)
[Nr1h4 Bar Fxr Rip14] Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
[Hnf4 NR2A4 CG9310] Transcription factor HNF-4 homolog (dHNF4) (Nuclear receptor subfamily 2 group A member 4)
[Nr2f2 Aporp1 Arp-1 Arp1 Tfcoup2] COUP transcription factor 2 (COUP-TF2) (Apolipoprotein AI regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2)
[NR0B1 AHC DAX1] Nuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1)
[NR1H4] Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4)
[NR1D1 EAR1 HREV THRAL] Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)
[Nr2f6 Ear-2 Ear2 Erbal2] Nuclear receptor subfamily 2 group F member 6 (COUP transcription factor 3) (COUP-TF3) (V-erbA-related protein 2) (EAR-2)
[Nr1d1] Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)
[NR1D1] Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)
[ZFHX3 ATBF1] Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)
[NR1D1] Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)
[raraa nr1b1a rara2a zgc:109797] Retinoic acid receptor alpha-A (RAR-alpha-A) (Nuclear receptor subfamily 1 group B member 1-A) (Retinoic acid receptor alpha) (zRAR alpha) (Retinoic acid receptor alpha-2.A) (RAR-alpha-2.A)
[RXRA NR2B1] Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
[Rxra Nr2b1] Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
[Rxra Nr2b1] Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
[Nr1h2 Lxrb] Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR)
[SMARCA2 BAF190B BRM SNF2A SNF2L2] Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2)
[Nr4a1 Hmr Ngfib] Nuclear receptor subfamily 4 group A member 1 (NUR77) (Nerve growth factor-induced protein I-B) (NGFI-B) (Orphan nuclear receptor HMR)
[RARA NR1B1] Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
[Esrra Err1 Estrra Nr3b1] Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)

Bibliography :