GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen)

 OCAD1_HUMAN             Reviewed;         245 AA.
Q9NX40; C9K030; G8JLN7; Q9BZE8;
11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
29-SEP-2021, entry version 161.
RecName: Full=OCIA domain-containing protein 1;
AltName: Full=Ovarian cancer immunoreactive antigen domain containing 1 {ECO:0000303|PubMed:20515946};
AltName: Full=Ovarian carcinoma immunoreactive antigen;
Name=OCIAD1 {ECO:0000312|HGNC:HGNC:16074};
Synonyms=ASRIJ {ECO:0000250|UniProtKB:Q9CRD0}, OCIA;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
TISSUE=Ovarian carcinoma;
PubMed=11162530; DOI=10.1006/bbrc.2000.4126;
Luo L.Y., Soosaipillai A., Diamandis E.P.;
"Molecular cloning of a novel human gene on chromosome 4p11 by
immunoscreening of an ovarian carcinoma cDNA library.";
Biochem. Biophys. Res. Commun. 280:401-406(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Pituitary tumor;
Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
TISSUE=Fetal brain;
Li W.B., Gruber C., Jessee J., Polayes D.;
"Full-length cDNA libraries and normalization.";
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and
4.";
Nature 434:724-731(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108 AND SER-191, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling
networks.";
Cell 127:635-648(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the
kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19608861; DOI=10.1126/science.1175371;
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
Olsen J.V., Mann M.;
"Lysine acetylation targets protein complexes and co-regulates major
cellular functions.";
Science 325:834-840(2009).
[13]
FUNCTION.
PubMed=20515946; DOI=10.1158/1535-7163.mct-09-1024;
Wang C., Michener C.M., Belinson J.L., Vaziri S., Ganapathi R.,
Sengupta S.;
"Role of the 18:1 lysophosphatidic acid-ovarian cancer immunoreactive
antigen domain containing 1 (OCIAD1)-integrin axis in generating late-stage
ovarian cancer.";
Mol. Cancer Ther. 9:1709-1718(2010).
[14]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
"Quantitative phosphoproteomics reveals widespread full phosphorylation
site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[15]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108; SER-123 AND SER-191, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
"System-wide temporal characterization of the proteome and phosphoproteome
of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
[17]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108; SER-116 AND SER-123, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[18]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123 AND SER-191, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
phosphoproteome.";
J. Proteomics 96:253-262(2014).
[19]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
-!- FUNCTION: Maintains stem cell potency (By similarity). Increases STAT3
phosphorylation and controls ERK phosphorylation (By similarity). May
act as a scaffold, increasing STAT3 recruitment onto endosomes (By
similarity). Involved in integrin-mediated cancer cell adhesion and
colony formation in ovarian cancer (PubMed:20515946).
{ECO:0000250|UniProtKB:Q9CRD0, ECO:0000269|PubMed:20515946}.
-!- SUBUNIT: Interacts with STAT3. {ECO:0000250|UniProtKB:Q9CRD0}.
-!- INTERACTION:
Q9NX40; Q12797-6: ASPH; NbExp=3; IntAct=EBI-2683029, EBI-12092171;
Q9NX40; P17544: ATF7; NbExp=2; IntAct=EBI-2683029, EBI-765623;
Q9NX40; P49069: CAMLG; NbExp=3; IntAct=EBI-2683029, EBI-1748958;
Q9NX40; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-2683029, EBI-3918971;
Q9NX40; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-2683029, EBI-713304;
Q9NX40; Q15546: MMD; NbExp=3; IntAct=EBI-2683029, EBI-17873222;
Q9NX40; Q99726: SLC30A3; NbExp=3; IntAct=EBI-2683029, EBI-10294651;
Q9NX40; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-2683029, EBI-11528917;
-!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q9CRD0}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1; Synonyms=A;
IsoId=Q9NX40-1; Sequence=Displayed;
Name=2; Synonyms=B;
IsoId=Q9NX40-2; Sequence=VSP_027621, VSP_027622;
Name=3;
IsoId=Q9NX40-3; Sequence=VSP_027622;
Name=4;
IsoId=Q9NX40-4; Sequence=VSP_046212;
-!- TISSUE SPECIFICITY: Isoform 1 is highly expressed in many tissues,
including testis, brain, placenta, ovary, prostate and mammary gland.
Isoform 2 expression is restricted to the central nervous system
including brain, cerebellum and spinal cord.
{ECO:0000269|PubMed:11162530}.
-!- DOMAIN: The OCIA domain is necessary and sufficient for endosomal
localization. {ECO:0000250|UniProtKB:Q9CRD0}.
-!- MISCELLANEOUS: 'Asrij' stands for 'blood' in Sanskrit as this protein
is strongly expressed in blood vessels.
-!- SIMILARITY: Belongs to the OCIAD1 family. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AF323665; AAG45220.1; -; mRNA.
EMBL; AF324350; AAK12121.1; -; mRNA.
EMBL; AF251296; AAG44596.1; -; mRNA.
EMBL; AL539411; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AK000462; BAA91181.1; -; mRNA.
EMBL; AC079927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471069; EAW93070.1; -; Genomic_DNA.
EMBL; BC003409; AAH03409.1; -; mRNA.
EMBL; BC088361; AAH88361.1; -; mRNA.
CCDS; CCDS3484.1; -. [Q9NX40-1]
CCDS; CCDS43228.1; -. [Q9NX40-2]
CCDS; CCDS47052.1; -. [Q9NX40-4]
PIR; JC7586; JC7586.
RefSeq; NP_001073308.1; NM_001079839.2. [Q9NX40-1]
RefSeq; NP_001073309.1; NM_001079840.2. [Q9NX40-4]
RefSeq; NP_001073310.1; NM_001079841.2. [Q9NX40-2]
RefSeq; NP_001073311.2; NM_001079842.2. [Q9NX40-4]
RefSeq; NP_060300.1; NM_017830.3. [Q9NX40-1]
RefSeq; XP_016863818.1; XM_017008329.1. [Q9NX40-2]
BioGRID; 120280; 290.
IntAct; Q9NX40; 107.
MINT; Q9NX40; -.
STRING; 9606.ENSP00000370882; -.
GlyGen; Q9NX40; 1 site, 1 O-linked glycan (1 site).
iPTMnet; Q9NX40; -.
PhosphoSitePlus; Q9NX40; -.
SwissPalm; Q9NX40; -.
BioMuta; OCIAD1; -.
DMDM; 74734685; -.
EPD; Q9NX40; -.
jPOST; Q9NX40; -.
MassIVE; Q9NX40; -.
MaxQB; Q9NX40; -.
PaxDb; Q9NX40; -.
PeptideAtlas; Q9NX40; -.
PRIDE; Q9NX40; -.
ProteomicsDB; 34288; -.
ProteomicsDB; 83031; -. [Q9NX40-1]
ProteomicsDB; 83032; -. [Q9NX40-2]
ProteomicsDB; 83033; -. [Q9NX40-3]
TopDownProteomics; Q9NX40-1; -. [Q9NX40-1]
TopDownProteomics; Q9NX40-2; -. [Q9NX40-2]
TopDownProteomics; Q9NX40-3; -. [Q9NX40-3]
Antibodypedia; 23858; 228 antibodies.
DNASU; 54940; -.
Ensembl; ENST00000264312; ENSP00000264312; ENSG00000109180. [Q9NX40-1]
Ensembl; ENST00000381473; ENSP00000370882; ENSG00000109180. [Q9NX40-1]
Ensembl; ENST00000396448; ENSP00000379725; ENSG00000109180. [Q9NX40-2]
Ensembl; ENST00000425583; ENSP00000416943; ENSG00000109180. [Q9NX40-4]
Ensembl; ENST00000444354; ENSP00000399656; ENSG00000109180. [Q9NX40-4]
Ensembl; ENST00000508293; ENSP00000423002; ENSG00000109180. [Q9NX40-1]
Ensembl; ENST00000513391; ENSP00000423909; ENSG00000109180. [Q9NX40-1]
GeneID; 54940; -.
KEGG; hsa:54940; -.
UCSC; uc003gyo.4; human. [Q9NX40-1]
CTD; 54940; -.
DisGeNET; 54940; -.
GeneCards; OCIAD1; -.
HGNC; HGNC:16074; OCIAD1.
HPA; ENSG00000109180; Low tissue specificity.
neXtProt; NX_Q9NX40; -.
OpenTargets; ENSG00000109180; -.
PharmGKB; PA134898158; -.
VEuPathDB; HostDB:ENSG00000109180; -.
eggNOG; ENOG502RXQR; Eukaryota.
GeneTree; ENSGT00530000063690; -.
HOGENOM; CLU_083038_0_0_1; -.
InParanoid; Q9NX40; -.
OMA; CNQESFF; -.
OrthoDB; 1322104at2759; -.
PhylomeDB; Q9NX40; -.
TreeFam; TF327106; -.
PathwayCommons; Q9NX40; -.
BioGRID-ORCS; 54940; 33 hits in 1018 CRISPR screens.
ChiTaRS; OCIAD1; human.
GenomeRNAi; 54940; -.
Pharos; Q9NX40; Tbio.
PRO; PR:Q9NX40; -.
Proteomes; UP000005640; Chromosome 4.
RNAct; Q9NX40; protein.
Bgee; ENSG00000109180; Expressed in caudate nucleus and 225 other tissues.
ExpressionAtlas; Q9NX40; baseline and differential.
Genevisible; Q9NX40; HS.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; ISS:FlyBase.
GO; GO:0005764; C:lysosome; ISS:FlyBase.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0006897; P:endocytosis; ISS:FlyBase.
GO; GO:0061484; P:hematopoietic stem cell homeostasis; ISS:FlyBase.
GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISS:FlyBase.
GO; GO:2000736; P:regulation of stem cell differentiation; ISS:UniProtKB.
InterPro; IPR040187; OCAD1/2.
InterPro; IPR009764; OCIA_dom.
PANTHER; PTHR13336; PTHR13336; 1.
Pfam; PF07051; OCIA; 1.
1: Evidence at protein level;
Alternative splicing; Endosome; Phosphoprotein; Reference proteome.
CHAIN 1..245
/note="OCIA domain-containing protein 1"
/id="PRO_0000299382"
DOMAIN 1..112
/note="OCIA"
REGION 111..141
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 169..245
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 123..141
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 188..212
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 221..245
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOD_RES 108
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:17081983,
ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332,
ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
ECO:0007744|PubMed:23186163"
MOD_RES 116
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:23186163"
MOD_RES 123
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21406692,
ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569"
MOD_RES 191
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:17081983,
ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569"
VAR_SEQ 183..233
/note="Missing (in isoform 4)"
/evidence="ECO:0000303|Ref.3"
/id="VSP_046212"
VAR_SEQ 184..187
/note="PDPN -> RNFS (in isoform 2)"
/evidence="ECO:0000303|PubMed:11162530"
/id="VSP_027621"
VAR_SEQ 188..245
/note="Missing (in isoform 2 and isoform 3)"
/evidence="ECO:0000303|PubMed:11162530"
/id="VSP_027622"
SEQUENCE 245 AA; 27626 MW; B4CD4F4B5483884D CRC64;
MNGRADFREP NAEVPRPIPH IGPDYIPTEE ERRVFAECND ESFWFRSVPL AATSMLITQG
LISKGILSSH PKYGSIPKLI LACIMGYFAG KLSYVKTCQE KFKKLENSPL GEALRSGQAR
RSSPPGHYYQ KSKYDSSVSG QSSFVTSPAA DNIEMLPHYE PIPFSSSMNE SAPTGITDHI
VQGPDPNLEE SPKRKNITYE ELRNKNRESY EVSLTQKTDP SVRPMHERVP KKEVKVNKYG
DTWDE


Related products :

Catalog number Product name Quantity
EIAAB28606 Homo sapiens,Human,OCIA,OCIA domain-containing protein 1,OCIAD1,Ovarian carcinoma immunoreactive antigen
EIAAB28610 Homo sapiens,Human,OCIA domain-containing protein 2,OCIAD2,Ovarian carcinoma immunoreactive antigen-like protein
5465 Ovarian cancer immuno-reactive antigen domain-containing protein 2 0.5 mg
5461 Ovarian cancer immuno-reactive antigen domain-containing protein 1 0.1 mg
5461 Ovarian cancer immuno-reactive antigen domain-containing protein 1 0.5 mg
5465 Ovarian cancer immuno-reactive antigen domain-containing protein 2 0.1 mg
5463 Ovarian cancer immuno-reactive antigen domain-containing protein 2 0.1 mg
5463 Ovarian cancer immuno-reactive antigen domain-containing protein 2 0.5 mg
E0154h ELISA CA125,CA-125,Homo sapiens,Human,MUC16,MUC-16,Mucin-16,Ovarian cancer-related tumor marker CA125,Ovarian carcinoma antigen CA125 96T
E0154h ELISA kit CA125,CA-125,Homo sapiens,Human,MUC16,MUC-16,Mucin-16,Ovarian cancer-related tumor marker CA125,Ovarian carcinoma antigen CA125 96T
U0154h CLIA CA125,CA-125,Homo sapiens,Human,MUC16,MUC-16,Mucin-16,Ovarian cancer-related tumor marker CA125,Ovarian carcinoma antigen CA125 96T
SER870Hu ELISA Kit for Ovarian Cancer Immuno Reactive Antigen Domain Containing Protein 2 (OCIAD2) Homo sapiens (Human) 96T
E04O0338 Rabbit Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125 96 Tests/kit
E11O0338 Bovine Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125 96 Tests/kit
E08O0338 Canine Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125
E11O0338 Bovine Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125
E09O0338 Monkey Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125 96 Tests/kit
E12O0338 Chicken Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125 96 Tests/kit
E05O0338 Guinea pig Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125
E06O0338 Goat Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125
E12O0338 Chicken Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125
E07O0338 Porcine Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125 96 Tests/kit
E03O0338 Mouse Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125
E06O0338 Goat Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125 96 Tests/kit
E14O0338 Sheep Ovarian cancer marker_Carbohydrate antigen 125 ELISA, Ovarian cancer marker-CA125 96 Tests/kit
Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP1003: Ovarian Infertility Genes
WP1424: Globo Sphingolipid Metabolism
WP273: Ovarian Infertility Genes
WP2328: Allograft rejection
WP885: Ovarian Infertility Genes
WP1120: Ovarian Infertility Genes
WP263: Ovarian Infertility Genes
WP1340: Ovarian Infertility Genes
WP34: Ovarian Infertility Genes
WP773: Ovarian Infertility Genes
WP1690: Propanoate metabolism
WP2367: Private Pancreatic Cancer
WP1625: Base excision repair
WP2107: pathways in human cancer
WP931: G Protein Signaling Pathways
WP1654: gamma-Hexachlorocyclohexane degradation
WP2203: TSLP Signaling Pathway
WP1165: G Protein Signaling Pathways
WP1694: Pyrimidine metabolism
WP2411: Cancer prevention Q
WP1714: Tyrosine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP2263: Prostate Cancer
WP1672: Mismatch repair

Related Genes :
[MUC16 CA125] Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125)
[ENOX2 COVA1] Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]
[MUC1 PUM] Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
[FOLR1 FOLR] Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)
[TFDP3 DP4 HCA661] Transcription factor Dp family member 3 (Cancer/testis antigen 30) (CT30) (Hepatocellular carcinoma-associated antigen 661)
[ARID4B BRCAA1 RBBP1L1 RBP1L1 SAP180] AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)
[MAGEC2 HCA587 MAGEE1] Melanoma-associated antigen C2 (Cancer/testis antigen 10) (CT10) (Hepatocellular carcinoma-associated antigen 587) (MAGE-C2 antigen) (MAGE-E1 antigen)
[GPR68 OGR1] Ovarian cancer G-protein coupled receptor 1 (OGR-1) (G-protein coupled receptor 68) (GPR12A) (Sphingosylphosphorylcholine receptor)
[STK11 LKB1 PJS] Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)
[YTHDF2 HGRG8] YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2)
[PLAAT3 HRASLS3 HREV107 PLA2G16] Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (H-REV107) (HREV107-1) (HRAS-like suppressor 1) (HRAS-like suppressor 3) (HRSL3) (HREV107-3) (Renal carcinoma antigen NY-REN-65)
[LMNA LMN1] Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
[SLC35C2 C20orf5 OVCOV1 CGI-15] Solute carrier family 35 member C2 (Ovarian cancer-overexpressed gene 1 protein)
[CTNNA1] Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)
[DPH1 DPH2L DPH2L1 OVCA1] 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)
[DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[GCC2 KIAA0336 RANBP2L4] GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53)
[LIMS1 PINCH PINCH1] LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48)
[TRMT10C MRPP1 RG9MTD1] tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221)
[EBAG9 RCAS1] Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein)
[KLHDC2 HCA33] Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)
[ECI2 DRS1 HCA88 PECI] Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)
[CTAG1A CTAG CTAG1 ESO1 LAGE2 LAGE2A; CTAG1B LAGE2B] Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2)
[Gpr68 Ogr1] Ovarian cancer G-protein coupled receptor 1 (G-protein coupled receptor 68) (Sphingosylphosphorylcholine receptor)
[USH1C AIE75] Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein)
[MAGEA1 MAGE1 MAGE1A] Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen)
[SEPTIN9 KIAA0991 MSF SEPT9] Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1)
[NSMCE3 HCA4 MAGEG1 NDNL2] Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2)
[KDM5B JARID1B PLU1 RBBP2H1] Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B)
[MAGEA3 MAGE3] Melanoma-associated antigen 3 (Antigen MZ2-D) (Cancer/testis antigen 1.3) (CT1.3) (MAGE-3 antigen)

Bibliography :
No related Items