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Odorant receptor 22a

 OR22A_DROME             Reviewed;         397 AA.
P81909; B7VC05; B7VC07; B7VC09; B7VC11; B7VC21; B7VC27; B7VC29; B7VC75;
B7VC77; B7VCA5; Q9U6X7;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-AUG-1999, sequence version 1.
11-DEC-2019, entry version 151.
RecName: Full=Odorant receptor 22a;
Name=Or22a; Synonyms=AN11, DOR22A.1, dor53, Or22A.1; ORFNames=CG12193;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
STRAIN=Berkeley;
PubMed=10458908; DOI=10.1006/geno.1999.5894;
Gao Q., Chess A.;
"Identification of candidate Drosophila olfactory receptors from genomic
DNA sequence.";
Genomics 60:31-39(1999).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS TYR-8; ILE-59; MET-67;
VAL-93; SER-100; LEU-102; ALA-196; GLU-201; ASN-220; SER-292; ALA-328;
ASP-329; SER-330; ILE-359; ASN-375; THR-382; ALA-385; ILE-386; VAL-387 AND
LYS-395.
STRAIN=CN1, CN13, CN14, CN18, CN21, CN28, CN29, CN3, CN43, CN45, CN46,
CN51, LA108, LA120, LA128, LA13, LA15, LA25, LA3, LA32, LA34, LA35, LA4,
LA6, LA9, MA21, MA24, MA43, MA74, NC100b, NC10b, NC16a, NC1b, NC37a, NC84a,
NC88a, NC89a, and NC97a;
PubMed=18922763; DOI=10.1093/molbev/msn227;
Aguade M.;
"Nucleotide and copy-number polymorphism at the odorant receptor genes
Or22a and Or22b in Drosophila melanogaster.";
Mol. Biol. Evol. 26:61-70(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic
review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 5-397, AND TISSUE SPECIFICITY.
STRAIN=Oregon-R; TISSUE=Antenna;
PubMed=10089887; DOI=10.1016/s0092-8674(00)80582-6;
Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.;
"A spatial map of olfactory receptor expression in the Drosophila
antenna.";
Cell 96:725-736(1999).
[6]
IDENTIFICATION, AND TISSUE SPECIFICITY.
TISSUE=Antenna;
PubMed=10069338; DOI=10.1016/s0896-6273(00)81093-4;
Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R.;
"A novel family of divergent seven-transmembrane proteins: candidate
odorant receptors in Drosophila.";
Neuron 22:327-338(1999).
[7]
TISSUE SPECIFICITY.
PubMed=10943836; DOI=10.1016/s0092-8674(00)00021-0;
Vosshall L.B., Wong A.M., Axel R.;
"An olfactory sensory map in the fly brain.";
Cell 102:147-159(2000).
[8]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=12628173; DOI=10.1016/s0896-6273(03)00094-1;
Dobritsa A.A., van der Goes van Naters W., Warr C.G., Steinbrecht R.A.,
Carlson J.R.;
"Integrating the molecular and cellular basis of odor coding in the
Drosophila antenna.";
Neuron 37:827-841(2003).
[9]
FUNCTION, INTERACTION WITH ORCO, AND TISSUE SPECIFICITY.
PubMed=15592462; DOI=10.1038/nn1371;
Neuhaus E.M., Gisselmann G., Zhang W., Dooley R., Stortkuhl K., Hatt H.;
"Odorant receptor heterodimerization in the olfactory system of Drosophila
melanogaster.";
Nat. Neurosci. 8:15-17(2005).
[10]
FUNCTION.
PubMed=16615896; DOI=10.1016/j.cell.2006.01.050;
Hallem E.A., Carlson J.R.;
"Coding of odors by a receptor repertoire.";
Cell 125:143-160(2006).
[11]
FUNCTION.
PubMed=17103386; DOI=10.1002/neu.20333;
Pelz D., Roeske T., Syed Z., de Bruyne M., Galizia C.G.;
"The molecular receptive range of an olfactory receptor in vivo (Drosophila
melanogaster Or22a).";
J. Neurobiol. 66:1544-1563(2006).
[12]
FUNCTION, INTERACTION WITH ORCO, AND TISSUE SPECIFICITY.
PubMed=16402857; DOI=10.1371/journal.pbio.0040020;
Benton R., Sachse S., Michnick S.W., Vosshall L.B.;
"Atypical membrane topology and heteromeric function of Drosophila odorant
receptors in vivo.";
PLoS Biol. 4:E20-E20(2006).
[13]
FUNCTION.
PubMed=16919756; DOI=10.1016/j.jneumeth.2006.07.005;
Kiely A., Authier A., Kralicek A.V., Warr C.G., Newcomb R.D.;
"Functional analysis of a Drosophila melanogaster olfactory receptor
expressed in Sf9 cells.";
J. Neurosci. Methods 159:189-194(2007).
[14]
FUNCTION, AND INTERACTION WITH ORCO.
PubMed=18408711; DOI=10.1038/nature06861;
Wicher D., Schaefer R., Bauernfeind R., Stensmyr M.C., Heller R.,
Heinemann S.H., Hansson B.S.;
"Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-
activated cation channels.";
Nature 452:1007-1011(2008).
[15]
FUNCTION.
PubMed=22038943; DOI=10.1093/chemse/bjr097;
Richgels P.K., Rollmann S.M.;
"Genetic variation in odorant receptors contributes to variation in
olfactory behavior in a natural population of Drosophila melanogaster.";
Chem. Senses 37:229-240(2012).
[16]
FUNCTION.
PubMed=23315042; DOI=10.1093/chemse/bjs138;
Munch D., Schmeichel B., Silbering A.F., Galizia C.G.;
"Weaker ligands can dominate an odor blend due to syntopic interactions.";
Chem. Senses 38:293-304(2013).
[17]
INTERACTION WITH ORCO AND SNMP1, AND SUBCELLULAR LOCATION.
PubMed=23196131; DOI=10.1016/j.ibmb.2012.11.002;
German P.F., van der Poel S., Carraher C., Kralicek A.V., Newcomb R.D.;
"Insights into subunit interactions within the insect olfactory receptor
complex using FRET.";
Insect Biochem. Mol. Biol. 43:138-145(2013).
-!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
behavior, depending on its substrates. The odorant receptor repertoire
encodes a large collection of odor stimuli that vary widely in
identity, intensity, and duration. Involved in the behavioral responses
ethyl butyrate and to esters in more general. Complexes with Orco to
form odorant-sensing units, providing sensitive and prolonged odorant
signaling and calcium permeability. They are necessary and sufficient
to promote functional reconstitution of odor-evoked signaling in
sensory neurons that normally respond only to carbon dioxide.
{ECO:0000269|PubMed:12628173, ECO:0000269|PubMed:15592462,
ECO:0000269|PubMed:16402857, ECO:0000269|PubMed:16615896,
ECO:0000269|PubMed:16919756, ECO:0000269|PubMed:17103386,
ECO:0000269|PubMed:18408711, ECO:0000269|PubMed:22038943,
ECO:0000269|PubMed:23315042}.
-!- SUBUNIT: Interacts with Orco, via conserved C-terminal cytoplasmic
loops. Complexes exist early in the endomembrane system in olfactory
sensory neurons (OSNs), coupling these complexes to the conserved
ciliary trafficking pathway. Interacts with snmp1.
{ECO:0000269|PubMed:15592462, ECO:0000269|PubMed:16402857,
ECO:0000269|PubMed:18408711, ECO:0000269|PubMed:23196131}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23196131};
Multi-pass membrane protein {ECO:0000269|PubMed:23196131}.
-!- TISSUE SPECIFICITY: Expressed with Orco in 17-20 sensory neurons on the
medial-proximal edge of the antenna. Expressed in the ab3A neuron which
responds to ethyl butyrate. {ECO:0000269|PubMed:10069338,
ECO:0000269|PubMed:10089887, ECO:0000269|PubMed:10458908,
ECO:0000269|PubMed:10943836, ECO:0000269|PubMed:12628173,
ECO:0000269|PubMed:15592462, ECO:0000269|PubMed:16402857}.
-!- MISCELLANEOUS: The atypical heteromeric and topological design of the
odorant receptors appears to be an insect-specific solution for odor
recognition, making the OR/Orco complex an attractive target for the
development of highly selective insect repellents to disrupt olfactory-
mediated host-seeking behaviors of insect disease vectors. Odor-evoked
OR currents are independent of known G-protein-coupled second messenger
pathways.
-!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a
subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; FM212142; CAR79041.1; -; Genomic_DNA.
EMBL; FM212143; CAR79043.1; -; Genomic_DNA.
EMBL; FM212144; CAR79045.1; -; Genomic_DNA.
EMBL; FM212145; CAR79047.1; -; Genomic_DNA.
EMBL; FM212146; CAR79049.1; -; Genomic_DNA.
EMBL; FM212147; CAR79051.1; -; Genomic_DNA.
EMBL; FM212148; CAR79053.1; -; Genomic_DNA.
EMBL; FM212149; CAR79055.1; -; Genomic_DNA.
EMBL; FM212150; CAR79057.1; -; Genomic_DNA.
EMBL; FM212151; CAR79059.1; -; Genomic_DNA.
EMBL; FM212152; CAR79061.1; -; Genomic_DNA.
EMBL; FM212153; CAR79063.1; -; Genomic_DNA.
EMBL; FM212154; CAR79065.1; -; Genomic_DNA.
EMBL; FM212155; CAR79067.1; -; Genomic_DNA.
EMBL; FM212156; CAR79069.1; -; Genomic_DNA.
EMBL; FM212157; CAR79071.1; -; Genomic_DNA.
EMBL; FM212158; CAR79073.1; -; Genomic_DNA.
EMBL; FM212159; CAR79075.1; -; Genomic_DNA.
EMBL; FM212160; CAR79077.1; -; Genomic_DNA.
EMBL; FM212161; CAR79079.1; -; Genomic_DNA.
EMBL; FM212162; CAR79081.1; -; Genomic_DNA.
EMBL; FM212163; CAR79083.1; -; Genomic_DNA.
EMBL; FM212164; CAR79085.1; -; Genomic_DNA.
EMBL; FM212165; CAR79087.1; -; Genomic_DNA.
EMBL; FM212166; CAR79089.1; -; Genomic_DNA.
EMBL; FM212167; CAR79091.1; -; Genomic_DNA.
EMBL; FM212168; CAR79093.1; -; Genomic_DNA.
EMBL; FM212169; CAR79095.1; -; Genomic_DNA.
EMBL; FM212170; CAR79097.1; -; Genomic_DNA.
EMBL; FM212171; CAR79099.1; -; Genomic_DNA.
EMBL; FM212172; CAR79101.1; -; Genomic_DNA.
EMBL; FM212173; CAR79103.1; -; Genomic_DNA.
EMBL; FM212174; CAR79105.1; -; Genomic_DNA.
EMBL; FM212175; CAR79107.1; -; Genomic_DNA.
EMBL; FM212176; CAR79109.1; -; Genomic_DNA.
EMBL; FM212177; CAR79111.1; -; Genomic_DNA.
EMBL; FM212178; CAR79113.1; -; Genomic_DNA.
EMBL; FM212204; CAR79364.1; -; Genomic_DNA.
EMBL; AE014134; AAF51364.1; -; Genomic_DNA.
EMBL; AF127923; AAD26358.2; -; mRNA.
RefSeq; NP_523453.1; NM_078729.3.
BioGrid; 59579; 5.
DIP; DIP-20484N; -.
IntAct; P81909; 3.
STRING; 7227.FBpp0077541; -.
TCDB; 1.A.69.1.1; the heteromeric odorant receptor channel (horc) family.
PaxDb; P81909; -.
PRIDE; P81909; -.
EnsemblMetazoa; FBtr0077873; FBpp0077541; FBgn0026398.
GeneID; 33335; -.
KEGG; dme:Dmel_CG12193; -.
CTD; 33335; -.
FlyBase; FBgn0026398; Or22a.
eggNOG; ENOG410JQH3; Eukaryota.
eggNOG; ENOG410ZQEW; LUCA.
GeneTree; ENSGT00540000073151; -.
InParanoid; P81909; -.
KO; K22984; -.
OMA; MARCHIC; -.
OrthoDB; 745380at2759; -.
PhylomeDB; P81909; -.
GenomeRNAi; 33335; -.
PRO; PR:P81909; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0026398; Expressed in 5 organ(s), highest expression level in antenna.
ExpressionAtlas; P81909; baseline and differential.
Genevisible; P81909; DM.
GO; GO:0030425; C:dendrite; IDA:FlyBase.
GO; GO:0032590; C:dendrite membrane; IDA:FlyBase.
GO; GO:0016021; C:integral component of membrane; HDA:FlyBase.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0071683; C:sensory dendrite; IDA:FlyBase.
GO; GO:0005549; F:odorant binding; ISS:FlyBase.
GO; GO:0004984; F:olfactory receptor activity; IDA:FlyBase.
GO; GO:0004888; F:transmembrane signaling receptor activity; ISM:FlyBase.
GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; HDA:FlyBase.
GO; GO:0042048; P:olfactory behavior; IMP:FlyBase.
GO; GO:0007608; P:sensory perception of smell; IMP:FlyBase.
GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
InterPro; IPR004117; 7tm6_olfct_rcpt.
PANTHER; PTHR21137; PTHR21137; 1.
Pfam; PF02949; 7tm_6; 1.
1: Evidence at protein level;
Cell membrane; Membrane; Olfaction; Polymorphism; Receptor;
Reference proteome; Sensory transduction; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1..397
/note="Odorant receptor 22a"
/id="PRO_0000174232"
TOPO_DOM 1..49
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 50..70
/note="Helical; Name=1"
/evidence="ECO:0000255"
TOPO_DOM 71..86
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 87..107
/note="Helical; Name=2"
/evidence="ECO:0000255"
TOPO_DOM 108..136
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 137..157
/note="Helical; Name=3"
/evidence="ECO:0000255"
TOPO_DOM 158..182
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 183..203
/note="Helical; Name=4"
/evidence="ECO:0000255"
TOPO_DOM 204..263
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 264..280
/note="Helical; Name=5"
/evidence="ECO:0000255"
TOPO_DOM 281..286
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 287..304
/note="Helical; Name=6"
/evidence="ECO:0000255"
TOPO_DOM 305..356
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 357..377
/note="Helical; Name=7"
/evidence="ECO:0000255"
TOPO_DOM 378..397
/note="Extracellular"
/evidence="ECO:0000255"
VARIANT 8
/note="H -> Y (in strain: MA74)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 59
/note="M -> I (in strain: NC1b)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 67
/note="I -> M (in strain: MA43 and MA74)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 93
/note="M -> V (in strain: NC1b and NC97a)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 100
/note="C -> S (in strain: CN1, CN13, CN18, CN21, CN29,
CN45, CN51, LA128, LA13, LA15, LA25, LA3, LA32, LA34, LA35,
LA4, MA21, MA24, NC1b, NC100b, NC37a, NC84a, NC89a and
NC97a)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 102
/note="F -> L (in strain: NC97a)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 196
/note="E -> A (in strain: CN1, CN13, CN18, CN21, CN28,
CN29, CN45, CN51, LA120, LA128, LA13, LA15, LA25, LA3,
LA32, LA34, LA35, LA4, LA6, LA9, MA21, MA24, NC1b, NC100b,
NC16a, NC37a, NC84a, NC89a and NC97a)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 201
/note="D -> E (in strain: NC1b and NC97a)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 220
/note="S -> N (in strain: CN14)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 292
/note="T -> S (in strain: CN13)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 328
/note="S -> A (in strain: LA6)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 329
/note="N -> D (in strain: LA6)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 330
/note="C -> S (in strain: LA6)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 359
/note="T -> I (in strain: LA6)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 375
/note="A -> N (in strain: LA6)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 382
/note="S -> T (in strain: LA6)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 385
/note="T -> A (in strain: NC1b and NC97a)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 386
/note="V -> I (in strain: LA6)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 387
/note="I -> V (in strain: LA6)"
/evidence="ECO:0000269|PubMed:18922763"
VARIANT 395
/note="R -> K (in strain: LA6)"
/evidence="ECO:0000269|PubMed:18922763"
CONFLICT 256
/note="D -> SIPFLFINGLFLFLS (in Ref. 1)"
/evidence="ECO:0000305"
CONFLICT 376..397
/note="MVKLAFSVVTVIKQFNLAERFQ -> VGVNILDISLILHLF (in Ref.
1)"
/evidence="ECO:0000305"
SEQUENCE 397 AA; 46754 MW; E9D20EF06E69E883 CRC64;
MLSKFFPHIK EKPLSERVKS RDAFIYLDRV MWSFGWTEPE NKRWILPYKL WLAFVNIVML
ILLPISISIE YLHRFKTFSA GEFLSSLEIG VNMYGSSFKC AFTLIGFKKR QEAKVLLDQL
DKRCLSDKER STVHRYVAMG NFFDILYHIF YSTFVVMNFP YFLLERRHAW RMYFPYIDSD
EQFYISSIAE CFLMTEAIYM DLCTDVCPLI SMLMARCHIS LLKQRLRNLR SKPGRTEDEY
LEELTECIRD HRLLLDYVDA LRPVFSGTIF VQFLLIGTVL GLSMINLMFF STFWTGVATC
LFMFDVSMET FPFCYLCNMI IDDCQEMSNC LFQSDWTSAD RRYKSTLVYF LHNLQQPITL
TAGGVFPISM QTNLAMVKLA FSVVTVIKQF NLAERFQ


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EIAAB28793 Mouse,Mus musculus,Odorant receptor M76,Olfactory receptor 12,Olfr12
EIAAB28791 Mouse,Mus musculus,Odorant receptor L45,Olfactory receptor 10,Olfr10
EIAAB28509 Homo sapiens,Human,Odorant receptor HOR3'beta1,Olfactory receptor 51A12,Olfactory receptor 51V1,Olfactory receptor OR11-36,OR51A12,OR51V1
EIAAB28489 Homo sapiens,Human,Odorant receptor HOR5'beta1,Olfactory receptor 51B4,OR51B4
EIAAB28491 Homo sapiens,Human,Odorant receptor HOR5'beta6,Olfactory receptor 51B6,OR51B6
EIAAB28512 Homo sapiens,Human,Odorant receptor HOR3'beta5,Olfactory receptor 52A5,Olfactory receptor OR11-33,OR52A5
EIAAB28516 Homo sapiens,Human,Odorant receptor HOR5'beta14,Olfactory receptor 52D1,Olfactory receptor OR11-43,OR52D1
EIAAB28502 Homo sapiens,Human,Odorant receptor HOR5'beta12,Olfactory receptor 51I2,Olfactory receptor OR11-38,OR51I2
EIAAB28505 Homo sapiens,Human,Odorant receptor HOR5'beta7,Olfactory receptor 51M1,Olfactory receptor OR11-40,OR51M1
EIAAB28490 Homo sapiens,Human,Odorant receptor HOR5'beta5,Olfactory receptor 51B5,Olfactory receptor OR11-37,OR51B5
EIAAB28501 Homo sapiens,Human,Odorant receptor HOR5'beta11,Olfactory receptor 51I1,Olfactory receptor OR11-39,OR51I1
EIAAB28510 Homo sapiens,HPFH1OR,Human,Odorant receptor HOR3'beta4,Olfactory receptor 52A1,Olfactory receptor OR11-319,OR52A1
EIAAB28488 Homo sapiens,Human,Odorant receptor HOR5'beta3,Olfactory receptor 51B1,Olfactory receptor 51B2,OR51B1P,OR51B2
EIAAB28503 Homo sapiens,Human,Odorant receptor HOR5'beta8,Olfactory receptor 51J1,Olfactory receptor 51J2,OR51J1,OR51J1P,OR51J2
EIAAB28730 Mor255-2,Mouse,Mus musculus,Odorant receptor M5,Olfactory receptor 1,Olfactory receptor 139,Olfactory receptor 255-2,Olfr1,Olfr139
EIAAB28742 Mor171-2,Mouse,Mus musculus,Odorant receptor M71,Olfactory receptor 151,Olfactory receptor 171-2,Olfactory receptor 7H,Olfr151,Olfr7
EIAAB28740 Mor224-8,Mouse,Mus musculus,Odorant receptor M31,Olfactory receptor 149,Olfactory receptor 224-8,Olfactory receptor 7G,Olfr149,Olfr7
EIAAB28741 Mor171-18,Mouse,Mus musculus,Odorant receptor M93,Olfactory receptor 150,Olfactory receptor 171-18,Olfactory receptor 7I,Olfr150,Olfr7
EIAAB28734 Mor170-6,Mouse,Mus musculus,Odorant receptor K18,Olfactory receptor 143,Olfactory receptor 170-6,Olfactory receptor 7A,Olfr143,Olfr7
EIAAB28736 Mor161-6,Mouse,Mus musculus,Odorant receptor K21,Olfactory receptor 145,Olfactory receptor 161-6,Olfactory receptor 7C,Olfr145,Olfr7
EIAAB28737 Mor171-10,Mouse,Mus musculus,Odorant receptor M15,Olfactory receptor 146,Olfactory receptor 171-10,Olfactory receptor 7D,Olfr146,Olfr7
EIAAB28731 Mor235-1,Mouse,Mus musculus,Odorant receptor A16,Olfactory receptor 140,Olfactory receptor 235-1,Olfactory receptor 4A,Olfr140,Olfr4
Pathways :
WP2355: Corticotropin-releasing hormone
WP88: Toll Like Receptor signaling
WP1004: Kit Receptor Signaling Pathway
WP147: Kit Receptor Signaling Pathway
WP581: EPO Receptor Signaling
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP732: Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP1284: EPO Receptor Signaling
WP26: Signal Transduction of S1P Receptor
WP897: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1913: Signaling by Insulin receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1067: Toll-like receptor signaling pathway
WP1963: The effect of Glucocorticoids on target gene expression
WP75: Toll-like receptor signaling pathway
WP1341: Kit Receptor Signaling Pathway
WP304: Kit receptor signaling pathway
WP1354: B Cell Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP996: EPO Receptor Signaling
WP1130: T Cell Receptor Signaling Pathway
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP780: T Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway

Related Genes :
[Or22a AN11 DOR22A.1 dor53 Or22A.1 CG12193] Odorant receptor 22a
[Or22b AN12 DOR22A.2 dor67 Or22A.2 CG4231] Odorant receptor 22b
[UL22A UL20A] Glycoprotein UL22A
[nnrE nnrD Maq22A_c01815] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[glmU Maq22A_c08835] Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]
[glmU ClosIBUN22A_CONTIG168g03433] Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]
[nnrD nnrE ClosIBUN22A_CONTIG141g02859] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[TBC1D22A C22orf4] TBC1 domain family member 22A
[ribBA ClosIBUN22A_CONTIG94g01967] Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[murE Maq22A_c02210] UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase)
[SLC22A17 BOCT BOIT] Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR)
[murE ClosIBUN22A_CONTIG187g03754] UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase)
[prsA prs Maq22A_c05445] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[sboA sbo BSU37350] Subtilosin-A (Antilisterial bacteriocin subtilosin)
[pfkA pfp Maq22A_c04320] Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (EC 2.7.1.90) (6-phosphofructokinase, pyrophosphate dependent) (PPi-dependent phosphofructokinase) (PPi-PFK) (Pyrophosphate-dependent 6-phosphofructose-1-kinase)
[Orco A45 Or83b CG10609] Odorant receptor coreceptor (Odorant receptor 83b)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[hflB ftsH Maq22A_c07085] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[rlmN Maq22A_c20645] Dual-specificity RNA methyltransferase RlmN (EC 2.1.1.192) (23S rRNA (adenine(2503)-C(2))-methyltransferase) (23S rRNA m2A2503 methyltransferase) (Ribosomal RNA large subunit methyltransferase N) (tRNA (adenine(37)-C(2))-methyltransferase) (tRNA m2A37 methyltransferase)
[RAB22A RAB22] Ras-related protein Rab-22A (Rab-22)

Bibliography :