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Odorant receptor 22b

 OR22B_DROME             Reviewed;         397 AA.
P81910; B7VC06; B7VC10; B7VC50; B7VC52; B7VC62; B7VC68; B7VC76;
B7VC81; B7VC83; B7VC85; B7VC86; B7VC87; B7VC91; B7VC99; B7VCA1;
B7VCA6; Q9U6X6; Q9VQ19;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
20-JAN-2009, sequence version 3.
16-JAN-2019, entry version 142.
RecName: Full=Odorant receptor 22b;
Name=Or22b; Synonyms=AN12, DOR22A.2, dor67, Or22A.2; ORFNames=CG4231;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=Oregon-R; TISSUE=Antenna;
PubMed=10089887; DOI=10.1016/S0092-8674(00)80582-6;
Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.;
"A spatial map of olfactory receptor expression in the Drosophila
antenna.";
Cell 96:725-736(1999).
[2]
SEQUENCE REVISION TO 58.
Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.;
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10458908; DOI=10.1006/geno.1999.5894;
Gao Q., Chess A.;
"Identification of candidate Drosophila olfactory receptors from
genomic DNA sequence.";
Genomics 60:31-39(1999).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-3; LYS-4; ILE-25;
LEU-30; GLU-38; ILE-45; PRO-47; ALA-69; LEU-87; GLU-88; ASP-92;
VAL-93; CYS-101; PHE-102; GLU-111; ARG-126; ALA-140; LEU-150; PHE-156;
THR-157; VAL-167; MET-194; LEU-196; ALA-201; LEU-213; MET-214;
SER-220; MET-235; THR-245; ASN-256; ARG-267; VAL-278; GLU-309;
SER-313; SER-341; ILE-354 AND MET-387.
STRAIN=CN1, CN13, CN14, CN18, CN21, CN28, CN29, CN3, CN43, CN45, CN46,
CN51, LA108, LA116, LA120, LA128, LA13, LA15, LA25, LA3, LA32, LA34,
LA35, LA4, LA9, MA13, MA18, MA21, MA24, MA43, MA45, MA48, MA50, MA7,
MA74, MA8, MW25, MW27, MW29, MW3, MW32, MW37, MW44, MW46, MW56, MW6,
MW7, MW9, NC100b, NC10b, NC16a, NC1b, NC21a, NC37a, NC52a, NC62a,
NC73a, NC79b, NC84a, NC88a, NC89a, and NC97a;
PubMed=18922763; DOI=10.1093/molbev/msn227;
Aguade M.;
"Nucleotide and copy-number polymorphism at the odorant receptor genes
Or22a and Or22b in Drosophila melanogaster.";
Mol. Biol. Evol. 26:61-70(2009).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[6]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[7]
IDENTIFICATION, AND TISSUE SPECIFICITY.
TISSUE=Antenna;
PubMed=10069338; DOI=10.1016/S0896-6273(00)81093-4;
Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R.;
"A novel family of divergent seven-transmembrane proteins: candidate
odorant receptors in Drosophila.";
Neuron 22:327-338(1999).
[8]
TISSUE SPECIFICITY.
PubMed=10943836; DOI=10.1016/S0092-8674(00)00021-0;
Vosshall L.B., Wong A.M., Axel R.;
"An olfactory sensory map in the fly brain.";
Cell 102:147-159(2000).
[9]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=12628173; DOI=10.1016/S0896-6273(03)00094-1;
Dobritsa A.A., van der Goes van Naters W., Warr C.G.,
Steinbrecht R.A., Carlson J.R.;
"Integrating the molecular and cellular basis of odor coding in the
Drosophila antenna.";
Neuron 37:827-841(2003).
[10]
FUNCTION, INTERACTION WITH ORCO, AND TISSUE SPECIFICITY.
PubMed=16402857; DOI=10.1371/journal.pbio.0040020;
Benton R., Sachse S., Michnick S.W., Vosshall L.B.;
"Atypical membrane topology and heteromeric function of Drosophila
odorant receptors in vivo.";
PLoS Biol. 4:E20-E20(2006).
[11]
FUNCTION.
PubMed=22038943; DOI=10.1093/chemse/bjr097;
Richgels P.K., Rollmann S.M.;
"Genetic variation in odorant receptors contributes to variation in
olfactory behavior in a natural population of Drosophila
melanogaster.";
Chem. Senses 37:229-240(2012).
-!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
behavior, depending on its substrates. The odorant receptor
repertoire encodes a large collection of odor stimuli that vary
widely in identity, intensity, and duration. Involved in the
behavioral responses to esters. Complexes with Orco to form
odorant-sensing units, providing sensitive and prolonged odorant
signaling and calcium permeability. They are necessary and
sufficient to promote functional reconstitution of odor-evoked
signaling in sensory neurons that normally respond only to carbon
dioxide. {ECO:0000269|PubMed:12628173,
ECO:0000269|PubMed:16402857, ECO:0000269|PubMed:22038943}.
-!- SUBUNIT: Interacts with Orco, via conserved C-terminal cytoplasmic
loops. Complexes exist early in the endomembrane system in
olfactory sensory neurons (OSNs), coupling these complexes to the
conserved ciliary trafficking pathway.
{ECO:0000269|PubMed:16402857}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed with Orco in 20-22 sensory neurons
on the medial-proximal edge of the antenna. This expression
pattern matches the distribution of the large sensilla basiconica.
Expression is first seen at 60 hours APF in a subset of cells
restricted to a subregion of the developing antenna. Expression
continues throughout antennal development. Expressed in the ab3A
neuron which responds to ethyl butyrate.
{ECO:0000269|PubMed:10069338, ECO:0000269|PubMed:10089887,
ECO:0000269|PubMed:10943836, ECO:0000269|PubMed:12628173,
ECO:0000269|PubMed:16402857}.
-!- MISCELLANEOUS: The atypical heteromeric and topological design of
the odorant receptors appears to be an insect-specific solution
for odor recognition, making the OR/Orco complex an attractive
target for the development of highly selective insect repellents
to disrupt olfactory-mediated host-seeking behaviors of insect
disease vectors. Odor-evoked OR currents are independent of known
G-protein-coupled second messenger pathways.
-!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a
subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAR79088.1; Type=Miscellaneous discrepancy; Note=Intron retention and rearrangement of DNA.; Evidence={ECO:0000305};
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EMBL; AF127924; AAD26359.2; -; mRNA.
EMBL; FM212142; CAR79042.1; -; Genomic_DNA.
EMBL; FM212143; CAR79044.1; -; Genomic_DNA.
EMBL; FM212144; CAR79046.1; -; Genomic_DNA.
EMBL; FM212145; CAR79048.1; -; Genomic_DNA.
EMBL; FM212146; CAR79050.1; -; Genomic_DNA.
EMBL; FM212147; CAR79052.1; -; Genomic_DNA.
EMBL; FM212148; CAR79054.1; -; Genomic_DNA.
EMBL; FM212149; CAR79056.1; -; Genomic_DNA.
EMBL; FM212150; CAR79058.1; -; Genomic_DNA.
EMBL; FM212151; CAR79060.1; -; Genomic_DNA.
EMBL; FM212152; CAR79062.1; -; Genomic_DNA.
EMBL; FM212153; CAR79064.1; -; Genomic_DNA.
EMBL; FM212154; CAR79066.1; -; Genomic_DNA.
EMBL; FM212155; CAR79068.1; -; Genomic_DNA.
EMBL; FM212156; CAR79070.1; -; Genomic_DNA.
EMBL; FM212157; CAR79072.1; -; Genomic_DNA.
EMBL; FM212158; CAR79074.1; -; Genomic_DNA.
EMBL; FM212159; CAR79076.1; -; Genomic_DNA.
EMBL; FM212160; CAR79078.1; -; Genomic_DNA.
EMBL; FM212161; CAR79080.1; -; Genomic_DNA.
EMBL; FM212162; CAR79082.1; -; Genomic_DNA.
EMBL; FM212163; CAR79084.1; -; Genomic_DNA.
EMBL; FM212164; CAR79086.1; -; Genomic_DNA.
EMBL; FM212165; CAR79088.1; ALT_SEQ; Genomic_DNA.
EMBL; FM212166; CAR79090.1; -; Genomic_DNA.
EMBL; FM212167; CAR79092.1; -; Genomic_DNA.
EMBL; FM212168; CAR79094.1; -; Genomic_DNA.
EMBL; FM212169; CAR79096.1; -; Genomic_DNA.
EMBL; FM212170; CAR79098.1; -; Genomic_DNA.
EMBL; FM212171; CAR79100.1; -; Genomic_DNA.
EMBL; FM212172; CAR79102.1; -; Genomic_DNA.
EMBL; FM212173; CAR79104.1; -; Genomic_DNA.
EMBL; FM212174; CAR79106.1; -; Genomic_DNA.
EMBL; FM212175; CAR79108.1; -; Genomic_DNA.
EMBL; FM212176; CAR79110.1; -; Genomic_DNA.
EMBL; FM212177; CAR79112.1; -; Genomic_DNA.
EMBL; FM212178; CAR79114.1; -; Genomic_DNA.
EMBL; FM212180; CAR79340.1; -; Genomic_DNA.
EMBL; FM212181; CAR79341.1; -; Genomic_DNA.
EMBL; FM212182; CAR79342.1; -; Genomic_DNA.
EMBL; FM212183; CAR79343.1; -; Genomic_DNA.
EMBL; FM212184; CAR79344.1; -; Genomic_DNA.
EMBL; FM212185; CAR79345.1; -; Genomic_DNA.
EMBL; FM212186; CAR79346.1; -; Genomic_DNA.
EMBL; FM212187; CAR79347.1; -; Genomic_DNA.
EMBL; FM212188; CAR79348.1; -; Genomic_DNA.
EMBL; FM212189; CAR79349.1; -; Genomic_DNA.
EMBL; FM212190; CAR79350.1; -; Genomic_DNA.
EMBL; FM212191; CAR79351.1; -; Genomic_DNA.
EMBL; FM212192; CAR79352.1; -; Genomic_DNA.
EMBL; FM212193; CAR79353.1; -; Genomic_DNA.
EMBL; FM212194; CAR79354.1; -; Genomic_DNA.
EMBL; FM212195; CAR79355.1; -; Genomic_DNA.
EMBL; FM212196; CAR79356.1; -; Genomic_DNA.
EMBL; FM212197; CAR79357.1; -; Genomic_DNA.
EMBL; FM212198; CAR79358.1; -; Genomic_DNA.
EMBL; FM212199; CAR79359.1; -; Genomic_DNA.
EMBL; FM212200; CAR79360.1; -; Genomic_DNA.
EMBL; FM212201; CAR79361.1; -; Genomic_DNA.
EMBL; FM212202; CAR79362.1; -; Genomic_DNA.
EMBL; FM212203; CAR79363.1; -; Genomic_DNA.
EMBL; FM212205; CAR79365.1; -; Genomic_DNA.
EMBL; AE014134; AAF51363.1; -; Genomic_DNA.
RefSeq; NP_477425.1; NM_058077.3.
UniGene; Dm.4820; -.
BioGrid; 59580; 1.
IntAct; P81910; 1.
STRING; 7227.FBpp0077542; -.
TCDB; 1.A.69.1.1; the heteromeric odorant receptor channel (horc) family.
PaxDb; P81910; -.
PRIDE; P81910; -.
EnsemblMetazoa; FBtr0077874; FBpp0077542; FBgn0026397.
GeneID; 33336; -.
KEGG; dme:Dmel_CG4231; -.
CTD; 33336; -.
FlyBase; FBgn0026397; Or22b.
eggNOG; ENOG410JQH3; Eukaryota.
eggNOG; ENOG410ZQEW; LUCA.
GeneTree; ENSGT00540000073151; -.
InParanoid; P81910; -.
KO; K22984; -.
OMA; IHAWRMY; -.
OrthoDB; 745330at2759; -.
PhylomeDB; P81910; -.
GenomeRNAi; 33336; -.
PRO; PR:P81910; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0026397; Expressed in 4 organ(s), highest expression level in antenna.
ExpressionAtlas; P81910; differential.
Genevisible; P81910; DM.
GO; GO:0030425; C:dendrite; IDA:FlyBase.
GO; GO:0032590; C:dendrite membrane; IDA:FlyBase.
GO; GO:0016021; C:integral component of membrane; ISM:FlyBase.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005549; F:odorant binding; ISS:FlyBase.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0004888; F:transmembrane signaling receptor activity; ISM:FlyBase.
GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
GO; GO:0007608; P:sensory perception of smell; IEP:FlyBase.
GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
InterPro; IPR004117; 7tm6_olfct_rcpt.
PANTHER; PTHR21137; PTHR21137; 1.
Pfam; PF02949; 7tm_6; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Membrane; Olfaction; Polymorphism;
Receptor; Reference proteome; Sensory transduction; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 397 Odorant receptor 22b.
/FTId=PRO_0000174233.
TOPO_DOM 1 49 Cytoplasmic. {ECO:0000255}.
TRANSMEM 50 70 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 71 85 Extracellular. {ECO:0000255}.
TRANSMEM 86 105 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 106 143 Cytoplasmic. {ECO:0000255}.
TRANSMEM 144 164 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 165 194 Extracellular. {ECO:0000255}.
TRANSMEM 195 215 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 216 268 Cytoplasmic. {ECO:0000255}.
TRANSMEM 269 289 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 290 295 Extracellular. {ECO:0000255}.
TRANSMEM 296 316 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 317 347 Cytoplasmic. {ECO:0000255}.
TRANSMEM 348 368 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 369 397 Extracellular. {ECO:0000255}.
VARIANT 3 3 S -> G (in strain: MA7).
{ECO:0000269|PubMed:18922763}.
VARIANT 4 4 Q -> K (in strain: LA116, MA18, MA45,
MA48, MA50, MA7, MA8, MW25, MW29, MW3,
MW32, MW37, MW44, MW46, MW56, MW6, MW7,
MW9, NC21a, NC52a, NC62a, NC73a and
NC79b). {ECO:0000269|PubMed:18922763}.
VARIANT 25 25 V -> I (in strain: LA116, MA13, MA18,
MA43, MA45, MA48, MA50, MA7, MA74, MA8,
MW25, MW27, MW29, MW3, MW32, MW37, MW44,
MW46, MW56, MW6, MW7, MW9, NC21a, NC52a,
NC62a, NC73a and NC79b).
{ECO:0000269|PubMed:18922763}.
VARIANT 30 30 V -> L (in strain: NC52a and NC73a).
{ECO:0000269|PubMed:18922763}.
VARIANT 38 38 V -> E (in strain: NC21a, NC52a, NC62a,
NC73a and NC79b).
{ECO:0000269|PubMed:18922763}.
VARIANT 45 45 D -> I (in strain: LA116, MA45, MA50,
MW37, MW6 and MW9).
{ECO:0000269|PubMed:18922763}.
VARIANT 47 47 H -> P (in strain: LA116).
{ECO:0000269|PubMed:18922763}.
VARIANT 69 69 V -> A (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 87 87 I -> L (in strain: LA116).
{ECO:0000269|PubMed:18922763}.
VARIANT 88 88 Q -> E (in strain: LA116).
{ECO:0000269|PubMed:18922763}.
VARIANT 92 92 N -> D (in strain: NC21a, NC52a, NC62a,
NC73a and NC79b).
{ECO:0000269|PubMed:18922763}.
VARIANT 93 93 M -> V (in strain: LA116).
{ECO:0000269|PubMed:18922763}.
VARIANT 101 101 Y -> C (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 102 102 L -> F (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 111 111 Q -> E (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 126 126 C -> R (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 140 140 G -> A (in strain: LA9).
{ECO:0000269|PubMed:18922763}.
VARIANT 150 150 A -> L (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 156 156 I -> F (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 157 157 S -> T (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 167 167 I -> V (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 194 194 R -> M (in strain: LA116, MA13, MA18,
MA43, MA45, MA48, MA50, MA7, MA74, MA8,
MW25, MW27, MW29, MW3, MW32, MW37, MW44,
MW46, MW56, MW6, MW7, MW9, NC21a, NC52a,
NC62a, NC73a and NC79b).
{ECO:0000269|PubMed:18922763}.
VARIANT 196 196 W -> L (in strain: LA116).
{ECO:0000269|PubMed:18922763}.
VARIANT 201 201 D -> A (in strain: NC21a, NC52a, NC62a,
NC73a and NC79b).
{ECO:0000269|PubMed:18922763}.
VARIANT 213 213 V -> L (in strain: LA116, MA45, MA50,
MW37, MW6, MW9, NC52a and NC73a).
{ECO:0000269|PubMed:18922763}.
VARIANT 214 214 I -> M (in strain: LA116, MA45, MA50,
MW37, MW6 and MW9).
{ECO:0000269|PubMed:18922763}.
VARIANT 220 220 T -> S (in strain: LA116, MA45, MA50,
MW37, MW6 and MW9).
{ECO:0000269|PubMed:18922763}.
VARIANT 235 235 R -> M (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 245 245 A -> T (in strain: LA116, MA45, MA50,
MW37, MW6 and MW9).
{ECO:0000269|PubMed:18922763}.
VARIANT 256 256 D -> N (in strain: MW44).
{ECO:0000269|PubMed:18922763}.
VARIANT 267 267 G -> R (in strain: MA45, MA50, MW37, MW6
and MW9). {ECO:0000269|PubMed:18922763}.
VARIANT 278 278 I -> V (in strain: LA108 and LA120).
{ECO:0000269|PubMed:18922763}.
VARIANT 309 309 Q -> E (in strain: LA116, LA25, LA4,
MA24, MA45, MA50, MW37, MW6 and MW9).
{ECO:0000269|PubMed:18922763}.
VARIANT 313 313 F -> S (in strain: NC16a).
{ECO:0000269|PubMed:18922763}.
VARIANT 341 341 R -> S (in strain: LA116).
{ECO:0000269|PubMed:18922763}.
VARIANT 354 354 L -> I (in strain: NC52a, NC73a and
NC79b). {ECO:0000269|PubMed:18922763}.
VARIANT 387 387 V -> M (in strain: LA9).
{ECO:0000269|PubMed:18922763}.
CONFLICT 52 60 STFVTLLIF -> LAFVNIVML (in Ref. 4;
CAR79365). {ECO:0000305}.
CONFLICT 58 58 L -> V (in Ref. 1; AAD26359).
{ECO:0000305}.
CONFLICT 67 73 VSVEYIQ -> ISIEYLH (in Ref. 4; CAR79365).
{ECO:0000305}.
CONFLICT 129 133 ERTIV -> DRSII (in Ref. 4; CAR79363/
CAR79362/CAR79361/CAR79351/CAR79350).
{ECO:0000305}.
CONFLICT 256 256 D -> TICFDKFFYLPYFFS (in Ref. 3).
{ECO:0000305}.
CONFLICT 376 397 MVKLAFTVVTIVKQFNLAEKFQ -> VSINQYEL (in
Ref. 3). {ECO:0000305}.
SEQUENCE 397 AA; 46402 MW; CE0CDA1C5EFE11DA CRC64;
MLSQFFPHIK EKPLSERVKS RDAFVYLDRV MWSFGWTVPE NKRWDLHYKL WSTFVTLLIF
ILLPISVSVE YIQRFKTFSA GEFLSSIQIG VNMYGSSFKS YLTMMGYKKR QEAKMSLDEL
DKRCVCDEER TIVHRHVALG NFCYIFYHIA YTSFLISNFL SFIMKRIHAW RMYFPYVDPE
KQFYISSIAE VILRGWAVFM DLCTDVCPLI SMVIARCHIT LLKQRLRNLR SEPGRTEDEY
LKELADCVRD HRLILDYVDA LRSVFSGTIF VQFLLIGIVL GLSMINIMFF STLSTGVAVV
LFMSCVSMQT FPFCYLCNMI MDDCQEMADS LFQSDWTSAD RRYKSTLVYF LHNLQQPIIL
TAGGVFPISM QTNLNMVKLA FTVVTIVKQF NLAEKFQ


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Kits Elisa; taq POLYMERASE

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Gentaur; yes we can

Pathways :
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1067: Toll-like receptor signaling pathway
WP1112: EPO Receptor Signaling
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1144: B Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1183: Toll-like receptor signaling pathway
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1249: EPO Receptor Signaling
WP1271: Toll-like receptor signaling pathway
WP1284: EPO Receptor Signaling
WP1309: Toll-like receptor signaling pathway
WP1336: EPO Receptor Signaling
WP1341: Kit Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway

Related Genes :
[Or22b AN12 DOR22A.2 dor67 Or22A.2 CG4231] Odorant receptor 22b
[Sec22b Sec22l1] Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) (mSec22b)
[TBC1D22B C6orf197] TBC1 domain family member 22B
[SEC22B SEC22L1] Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
[Sec22b Sec22l1] Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
[RAB31 RAB22B] Ras-related protein Rab-31 (Ras-related protein Rab-22B)
[TSSK2 DGSG SPOGA2 STK22B] Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B)
[Tssk2 Stk22b] Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (Serine/threonine-protein kinase 22B)
[egl-13 cog-2 T22B7.1] Transcription factor egl-13 (Protein egg laying defective 13)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[evl-20 arl-2 F22B5.1] ADP-ribosylation factor-like protein 2 (Abnormal eversion of vulva protein 20)
[zyg-9 F22B5.7] Zygote defective protein 9
[his-1 T10C6.14; his-5 F45F2.3; his-10 ZK131.4; his-14 ZK131.8; his-18 K06C4.10; his-26 ZK131.1; his-28 K06C4.2; his-31 F17E9.12; his-37 C50F4.7; his-38 K03A1.6; his-46 B0035.9; his-50 F07B7.9; his-56 F54E12.3; his-60 F55G1.11; his-64 F22B3.1; his-67 T23D8.5] Histone H4
[ZBTB43 KIAA0414 ZBTB22B ZNF297B] Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x)
[Cd22 Lyb-8 Siglec2] B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
[NA] Neuraminidase (EC 3.2.1.18)
[his-2 T10C6.13; his-6 F45F2.13; his-9 ZK131.3; his-13 ZK131.7; his-17 K06C4.5; his-25 ZK131.2; his-27 K06C4.13; his-32 F17E9.10; his-42 F08G2.3; his-45 B0035.10; his-49 F07B7.5; his-55 F54E12.1; his-59 F55G1.2; his-63 F22B3.2] Histone H3

Bibliography :
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