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Olfactory receptor 10X1 (Olfactory receptor OR1-14)

 O10X1_HUMAN             Reviewed;         326 AA.
Q8NGY0; Q6IFR8;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
15-JAN-2008, sequence version 2.
13-FEB-2019, entry version 128.
RecName: Full=Olfactory receptor 10X1;
AltName: Full=Olfactory receptor OR1-14;
Name=OR10X1; Synonyms=OR10X1P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[4]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
[5]
POLYMORPHISM.
PubMed=12730696; DOI=10.1038/ng1160;
Menashe I., Man O., Lancet D., Gilad Y.;
"Different noses for different people.";
Nat. Genet. 34:143-144(2003).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- POLYMORPHISM: A stop codon at position Trp-66 in the gene coding
for this protein is responsible for functional diversity thus
producing a pseudogene. The stop codon is more frequent in
African-Americans than in non-Africans.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- SEQUENCE CAUTION:
Sequence=BAC05862.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10X1";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AB065636; BAC05862.1; ALT_INIT; Genomic_DNA.
EMBL; AL160283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BK004194; DAA04592.1; -; Genomic_DNA.
RefSeq; NP_001004477.1; NM_001004477.1.
UniGene; Hs.553589; -.
ProteinModelPortal; Q8NGY0; -.
STRING; 9606.ENSP00000357132; -.
iPTMnet; Q8NGY0; -.
PhosphoSitePlus; Q8NGY0; -.
BioMuta; OR10X1; -.
DMDM; 166214962; -.
PaxDb; Q8NGY0; -.
PeptideAtlas; Q8NGY0; -.
PRIDE; Q8NGY0; -.
ProteomicsDB; 73621; -.
DNASU; 128367; -.
Ensembl; ENST00000623167; ENSP00000485609; ENSG00000279111.
GeneID; 128367; -.
KEGG; hsa:128367; -.
UCSC; uc010pin.2; human.
CTD; 128367; -.
EuPathDB; HostDB:ENSG00000186400.3; -.
EuPathDB; HostDB:ENSG00000279111.1; -.
GeneCards; OR10X1; -.
HGNC; HGNC:14995; OR10X1.
neXtProt; NX_Q8NGY0; -.
PharmGKB; PA32007; -.
eggNOG; ENOG410IKKE; Eukaryota.
eggNOG; ENOG41115SF; LUCA.
GeneTree; ENSGT00940000161831; -.
HOGENOM; HOG000041365; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8NGY0; -.
KO; K04257; -.
OMA; FRRMMGN; -.
OrthoDB; 1029633at2759; -.
PhylomeDB; Q8NGY0; -.
TreeFam; TF337925; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR10X1; -.
GenomeRNAi; 128367; -.
PRO; PR:Q8NGY0; -.
Proteomes; UP000005640; Chromosome 1.
ExpressionAtlas; Q8NGY0; baseline and differential.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 326 Olfactory receptor 10X1.
/FTId=PRO_0000150720.
TOPO_DOM 1 41 Extracellular. {ECO:0000255}.
TRANSMEM 42 62 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 63 70 Cytoplasmic. {ECO:0000255}.
TRANSMEM 71 91 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 92 115 Extracellular. {ECO:0000255}.
TRANSMEM 116 136 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 137 155 Cytoplasmic. {ECO:0000255}.
TRANSMEM 156 176 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 177 213 Extracellular. {ECO:0000255}.
TRANSMEM 214 233 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 234 253 Cytoplasmic. {ECO:0000255}.
TRANSMEM 254 274 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 275 284 Extracellular. {ECO:0000255}.
TRANSMEM 285 305 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 306 326 Cytoplasmic. {ECO:0000255}.
CARBOHYD 21 21 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 209 209 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 113 205 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 60 60 I -> T (in dbSNP:rs863363).
/FTId=VAR_053290.
VARIANT 81 81 A -> S (in dbSNP:rs950164).
/FTId=VAR_053291.
VARIANT 172 172 S -> P (in dbSNP:rs7550131).
/FTId=VAR_053292.
VARIANT 180 180 F -> L (in dbSNP:rs16840360).
/FTId=VAR_053293.
SEQUENCE 326 AA; 36446 MW; BFB0BB8E958C15E4 CRC64;
MVLNVYCCFF QISDIQTMKI NQTILKEFIL VGFSVYPHVQ TFLFVVFFCL YLLTLAGNLI
IMGLTWVDRS LHTPMYLFLS ALSFSETCYT LTIVPKMLED LLAKDRSISV TGCSLQMCFF
LGLGGTNCII LTLMGYDRFL AICNPLRYPL LMTNIVCGQL VASACTAGFF ISLTETALIF
RDSFCRPNLV KHFFCHMLAV IRLSCIDSNH TEFIITLISV SGLLGTLLLI ILTDVFIIST
VLRIPSAEGK QKAFTTCASH LTVVIIHFGF ASIVYLKPEA SGDDTLIAVP YTVITPFLSP
IIFSLRNKDM KNAFRRMMGN TVALKK


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Pathways :
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1067: Toll-like receptor signaling pathway
WP1112: EPO Receptor Signaling
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1144: B Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1183: Toll-like receptor signaling pathway
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1249: EPO Receptor Signaling
WP1271: Toll-like receptor signaling pathway
WP1284: EPO Receptor Signaling
WP1309: Toll-like receptor signaling pathway
WP1336: EPO Receptor Signaling
WP1341: Kit Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway

Related Genes :
[OR10X1 OR10X1P] Olfactory receptor 10X1 (Olfactory receptor OR1-14)
[OR1F1 OLFMF OR1F10 OR1F4 OR1F5 OR1F6 OR1F7 OR1F8 OR1F9] Olfactory receptor 1F1 (Olfactory receptor 16-35) (OR16-35) (Olfactory receptor 1F10) (Olfactory receptor 1F4) (Olfactory receptor 1F5) (Olfactory receptor 1F6) (Olfactory receptor 1F7) (Olfactory receptor 1F8) (Olfactory receptor 1F9) (Olfactory receptor OR16-4)
[OR1D2 OLFR1] Olfactory receptor 1D2 (Olfactory receptor 17-4) (OR17-4) (Olfactory receptor OR17-6) (Olfactory receptor-like protein HGMP07E)
[ppnP OR1_03385] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[OR1E1 OR1E5 OR1E6 OR1E9P] Olfactory receptor 1E1 (Olfactory receptor 13-66) (OR13-66) (Olfactory receptor 17-2/17-32) (OR17-2) (OR17-32) (Olfactory receptor 1E5) (Olfactory receptor 1E6) (Olfactory receptor 5-85) (OR5-85) (Olfactory receptor OR17-18) (Olfactory receptor-like protein HGMP07I)
[glmU OR1_01412] Bifunctional protein GlmU [Includes: Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase)]
[nnr nnrD nnrE OR1_02963] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[OR1Q1 OR1Q2 OR1Q3] Olfactory receptor 1Q1 (OST226) (Olfactory receptor 1Q2) (Olfactory receptor 1Q3) (Olfactory receptor 9-A) (OR9-A) (Olfactory receptor OR9-25) (Olfactory receptor TPCR106)
[ribBA OR1_02316] Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]
[murE OR1_01796] UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase)
[OR1J2 OR1J3 OR1J5] Olfactory receptor 1J2 (HSA5) (HTPCRX15) (OST044) (Olfactory receptor 1J3) (Olfactory receptor 1J5) (Olfactory receptor OR9-19)
[OR1E2 OR1E4] Olfactory receptor 1E2 (Olfactory receptor 17-93/17-135/17-136) (OR17-135) (OR17-136) (OR17-93) (Olfactory receptor 1E4)
[OR1L1 OR1L2] Olfactory receptor 1L1 (Olfactory receptor 1L2) (Olfactory receptor 9-C) (OR9-C) (Olfactory receptor OR9-27)
[prs OR1_02395] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[rlmN OR1_00217] Dual-specificity RNA methyltransferase RlmN (EC 2.1.1.192) (23S rRNA (adenine(2503)-C(2))-methyltransferase) (23S rRNA m2A2503 methyltransferase) (Ribosomal RNA large subunit methyltransferase N) (tRNA (adenine(37)-C(2))-methyltransferase) (tRNA m2A37 methyltransferase)
[OR1L6 OR1L7] Olfactory receptor 1L6 (Olfactory receptor 1L7) (Olfactory receptor OR9-30)
[OR1N1 OR1N3] Olfactory receptor 1N1 (Olfactory receptor 1-26) (OR1-26) (Olfactory receptor 1N3) (Olfactory receptor OR9-22)
[pfkA2 pfkA OR1_02331] ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)
[asd OR1_03295] Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase)
[asd OR1_03294] Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase)
[pyrG OR1_01074] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)
[OR1B1] Olfactory receptor 1B1 (Olfactory receptor 9-B) (OR9-B) (Olfactory receptor OR9-26)
[fdhD mobA OR1_01893] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[OR1G1 OR1G2] Olfactory receptor 1G1 (Olfactory receptor 17-209) (OR17-209) (Olfactory receptor 1G2) (Olfactory receptor OR17-8)
[OR1_03036] dITP/XTP pyrophosphatase (EC 3.6.1.66) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[serS OR1_03230] Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)
[ackA OR1_02968] Acetate kinase (EC 2.7.2.1) (Acetokinase)
[ilvC OR1_03722] Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase)
[OR1L4 OR1L5] Olfactory receptor 1L4 (OST046) (Olfactory receptor 1L5) (Olfactory receptor 9-E) (OR9-E) (Olfactory receptor OR9-29)
[pfkA OR1_00174] ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)

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