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Olfactory receptor 1F1 (Olfactory receptor 16-35) (OR16-35) (Olfactory receptor 1F10) (Olfactory receptor 1F4) (Olfactory receptor 1F5) (Olfactory receptor 1F6) (Olfactory receptor 1F7) (Olfactory receptor 1F8) (Olfactory receptor 1F9) (Olfactory receptor OR16-4)

 OR1F1_HUMAN             Reviewed;         312 AA.
O43749; O15246; Q6IFL5;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
08-MAY-2019, entry version 161.
RecName: Full=Olfactory receptor 1F1;
AltName: Full=Olfactory receptor 16-35;
Short=OR16-35;
AltName: Full=Olfactory receptor 1F10;
AltName: Full=Olfactory receptor 1F4;
AltName: Full=Olfactory receptor 1F5;
AltName: Full=Olfactory receptor 1F6;
AltName: Full=Olfactory receptor 1F7;
AltName: Full=Olfactory receptor 1F8;
AltName: Full=Olfactory receptor 1F9;
AltName: Full=Olfactory receptor OR16-4;
Name=OR1F1;
Synonyms=OLFMF, OR1F10, OR1F4, OR1F5, OR1F6, OR1F7, OR1F8, OR1F9;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9288094; DOI=10.1038/ng0997-25;
Bernot A., Clepet C., Dasilva C., Devaud C., Petit J.-L.,
Caloustian C., Cruaud C., Samson D., Pulcini F., Weissenbach J.,
Heilig R., Notanicola C., Domingo C., Rozenbaum M., Benchetrit E.,
Topaloglu R., Dewalle M., Dross C., Hadjari P., Dupont M.,
Demaille J.G., Touitou I., Smaoui N., Nedelec B., Mery J.-P.,
Chaabouni H., Delpech M., Grateau G.;
"A candidate gene for familial Mediterranean fever.";
Nat. Genet. 17:25-31(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9653642; DOI=10.1006/geno.1998.5313;
Bernot A., Heilig R., Clepet C., Smaoui N., Da Silva C., Petit J.-L.,
Devaud C., Chiannilkulchai N., Fizames C., Samson D., Cruaud C.,
Caloustian C., Gyapay G., Delpech M., Weissenbach J.;
"A transcriptional map of the FMF region.";
Genomics 50:147-160(1998).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
PubMed=9500546; DOI=10.1038/ng0398-243;
Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
Demaille J.G., Giorgi D.;
"Distribution of olfactory receptor genes in the human genome.";
Nat. Genet. 18:243-250(1998).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
[7]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[8]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1F1";
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; Y14442; CAA74794.1; -; mRNA.
EMBL; AJ003147; CAA05903.1; -; Genomic_DNA.
EMBL; AB065907; BAC06122.1; -; Genomic_DNA.
EMBL; BC069335; AAH69335.1; -; mRNA.
EMBL; U86234; AAC39614.1; -; Genomic_DNA.
EMBL; AF399559; AAK95044.1; -; Genomic_DNA.
EMBL; BK004247; DAA04645.1; -; Genomic_DNA.
CCDS; CCDS10496.1; -.
RefSeq; NP_036492.1; NM_012360.1.
RefSeq; XP_011520809.1; XM_011522507.2.
STRING; 9606.ENSP00000305424; -.
PhosphoSitePlus; O43749; -.
BioMuta; OR1F1; -.
PaxDb; O43749; -.
PeptideAtlas; O43749; -.
PRIDE; O43749; -.
ProteomicsDB; 49148; -.
Ensembl; ENST00000304646; ENSP00000305424; ENSG00000168124.
GeneID; 4992; -.
KEGG; hsa:4992; -.
UCSC; uc010uwu.3; human.
CTD; 4992; -.
GeneCards; OR1F1; -.
H-InvDB; HIX0202335; -.
HGNC; HGNC:8194; OR1F1.
MIM; 603232; gene.
neXtProt; NX_O43749; -.
OpenTargets; ENSG00000168124; -.
PharmGKB; PA32070; -.
eggNOG; ENOG410IVEZ; Eukaryota.
eggNOG; ENOG41113FS; LUCA.
GeneTree; ENSGT00940000153683; -.
HOGENOM; HOG000041364; -.
InParanoid; O43749; -.
KO; K04257; -.
OMA; TAKMTHQ; -.
OrthoDB; 902247at2759; -.
PhylomeDB; O43749; -.
TreeFam; TF337210; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
ChiTaRS; OR1F1; human.
GeneWiki; OR1F1; -.
GenomeRNAi; 4992; -.
PRO; PR:O43749; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000168124; Expressed in 56 organ(s), highest expression level in right hemisphere of cerebellum.
Genevisible; O43749; HS.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; NAS:ProtInc.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 312 Olfactory receptor 1F1.
/FTId=PRO_0000150431.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 49 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 50 57 Cytoplasmic. {ECO:0000255}.
TRANSMEM 58 79 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 80 100 Extracellular. {ECO:0000255}.
TRANSMEM 101 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 158 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 159 196 Extracellular. {ECO:0000255}.
TRANSMEM 197 219 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 220 236 Cytoplasmic. {ECO:0000255}.
TRANSMEM 237 259 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 260 272 Extracellular. {ECO:0000255}.
TRANSMEM 273 292 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 293 312 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 75 75 F -> S (in dbSNP:rs1834026).
/FTId=VAR_024086.
VARIANT 126 126 V -> M (in dbSNP:rs8045183).
/FTId=VAR_053121.
CONFLICT 191 191 D -> N (in Ref. 1; CAA74794).
{ECO:0000305}.
CONFLICT 305 305 V -> I (in Ref. 1; CAA74794).
{ECO:0000305}.
SEQUENCE 312 AA; 34866 MW; 5C1E1708A18B10E4 CRC64;
MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS IDSCLHTPMY
FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ MYFVFMFVDM DNFLLAVMAY
DHFVAVCHPL HYTAKMTHQL CALLVAGLWV VANLNVLLHT LLMAPLSFCA DNAITHFFCD
VTPLLKLSCS DTHLNEVIIL SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST
CGSHLAVVLL FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA
LKKVVGRVVF SV


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