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Olfactory receptor 7D4 (OR19-B) (Odorant receptor family subfamily D member 4RT) (Olfactory receptor OR19-7)

 OR7D4_HUMAN             Reviewed;         312 AA.
Q8NG98; A8CAH8; A8CAH9; A8CAI0; A8CAI1; B9EH79;
19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
13-FEB-2019, entry version 128.
RecName: Full=Olfactory receptor 7D4;
AltName: Full=OR19-B;
AltName: Full=Odorant receptor family subfamily D member 4RT;
AltName: Full=Olfactory receptor OR19-7;
Name=OR7D4; Synonyms=OR7D4P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-52; CYS-75;
LEU-79; ASN-84; TRP-88; GLN-131; MET-133; ILE-136; ARG-139; TYR-139;
PRO-162; ASP-279 AND MET-292.
PubMed=17873857; DOI=10.1038/nature06162;
Keller A., Zhuang H., Chi Q., Vosshall L.B., Matsunami H.;
"Genetic variation in a human odorant receptor alters odour
perception.";
Nature 449:468-472(2007).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[6]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
[7]
TISSUE SPECIFICITY.
PubMed=17509148; DOI=10.1186/gb-2007-8-5-r86;
Zhang X., De la Cruz O., Pinto J.M., Nicolae D., Firestein S.,
Gilad Y.;
"Characterizing the expression of the human olfactory receptor gene
family using a novel DNA microarray.";
Genome Biol. 8:R86.1-R86.10(2007).
-!- FUNCTION: Odorant receptor. Selectively activated by androstenone
and the related odorous steroid androstadienone.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Nasal olfactory epithelium.
{ECO:0000269|PubMed:17509148}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7D4";
-!- WEB RESOURCE: Name=Protein Spotlight; Note=The selfish smell
- Issue 94 of May 2008;
URL="https://web.expasy.org/spotlight/back_issues/094";
-----------------------------------------------------------------------
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EMBL; EU049291; ABV66282.1; -; Genomic_DNA.
EMBL; EU049292; ABV66283.1; -; Genomic_DNA.
EMBL; EU049293; ABV66284.1; -; Genomic_DNA.
EMBL; EU049294; ABV66285.1; -; Genomic_DNA.
EMBL; AB065929; BAC06144.1; -; Genomic_DNA.
EMBL; CH471106; EAW84021.1; -; Genomic_DNA.
EMBL; BC137147; AAI37148.1; -; mRNA.
EMBL; BC137162; AAI37163.1; -; mRNA.
EMBL; BK004226; DAA04624.1; -; Genomic_DNA.
CCDS; CCDS32901.1; -.
RefSeq; NP_001005191.1; NM_001005191.2.
UniGene; Hs.446910; -.
ProteinModelPortal; Q8NG98; -.
IntAct; Q8NG98; 3.
STRING; 9606.ENSP00000310488; -.
BioMuta; OR7D4; -.
DMDM; 71153032; -.
PaxDb; Q8NG98; -.
PRIDE; Q8NG98; -.
ProteomicsDB; 73456; -.
Ensembl; ENST00000308682; ENSP00000310488; ENSG00000174667.
Ensembl; ENST00000641244; ENSP00000493404; ENSG00000174667.
Ensembl; ENST00000641669; ENSP00000493383; ENSG00000174667.
GeneID; 125958; -.
KEGG; hsa:125958; -.
UCSC; uc002mla.2; human.
CTD; 125958; -.
DisGeNET; 125958; -.
EuPathDB; HostDB:ENSG00000174667.3; -.
GeneCards; OR7D4; -.
HGNC; HGNC:8380; OR7D4.
MIM; 611538; gene.
neXtProt; NX_Q8NG98; -.
OpenTargets; ENSG00000174667; -.
PharmGKB; PA32628; -.
eggNOG; ENOG410IVB1; Eukaryota.
eggNOG; ENOG410YBQN; LUCA.
GeneTree; ENSGT00940000153686; -.
HOGENOM; HOG000041365; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8NG98; -.
KO; K04257; -.
OMA; FFCEPAQ; -.
OrthoDB; 995191at2759; -.
PhylomeDB; Q8NG98; -.
TreeFam; TF337210; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR7D4; -.
GenomeRNAi; 125958; -.
PRO; PR:Q8NG98; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000174667; Expressed in 1 organ(s), highest expression level in left testis.
ExpressionAtlas; Q8NG98; baseline and differential.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 312 Olfactory receptor 7D4.
/FTId=PRO_0000150649.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 46 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 47 54 Cytoplasmic. {ECO:0000255}.
TRANSMEM 55 75 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 76 99 Extracellular. {ECO:0000255}.
TRANSMEM 100 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 160 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 161 197 Extracellular. {ECO:0000255}.
TRANSMEM 198 217 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 218 237 Cytoplasmic. {ECO:0000255}.
TRANSMEM 238 258 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 259 271 Extracellular. {ECO:0000255}.
TRANSMEM 272 292 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 293 312 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 17 17 L -> F (in dbSNP:rs57568862).
/FTId=VAR_062056.
VARIANT 52 52 D -> G (in dbSNP:rs144165121).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037778.
VARIANT 75 75 S -> C (in dbSNP:rs778417216).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037779.
VARIANT 79 79 P -> L (impaired response to androstenone
and androstadienone; dbSNP:rs61732668).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037780.
VARIANT 84 84 S -> N (high sensitivity to androstenone
and androstadienone; dbSNP:rs5020280).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037781.
VARIANT 88 88 R -> W (impaired response to androstenone
and androstadienone; when associated with
M-133; dbSNP:rs61729907).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037782.
VARIANT 131 131 H -> Q (in dbSNP:rs748899150).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037783.
VARIANT 133 133 T -> M (impaired response to androstenone
and androstadienone; when associated with
W-88; dbSNP:rs5020278).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037784.
VARIANT 136 136 M -> I (in dbSNP:rs5020277).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037785.
VARIANT 139 139 C -> R (in dbSNP:rs1310684516).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037786.
VARIANT 139 139 C -> Y (in dbSNP:rs1205320769).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037787.
VARIANT 162 162 L -> P (in dbSNP:rs1321662937).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037788.
VARIANT 279 279 A -> D (in dbSNP:rs138510982).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037789.
VARIANT 292 292 L -> M (in dbSNP:rs4564704).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037790.
SEQUENCE 312 AA; 34448 MW; FD97DD41B890B085 CRC64;
MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS SDSHLHTPMY
FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ VYFLMMFAGM DTFLLAVMAY
DRFVAICHPL HYTVIMNPCL CGLLVLASWF IIFWFSLVHI LLMKRLTFST GTEIPHFFCE
PAQVLKVACS NTLLNNIVLY VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST
CGSHLCVVSL FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA
LERLLSRADS CP


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Pathways :
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1067: Toll-like receptor signaling pathway
WP1112: EPO Receptor Signaling
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1144: B Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1183: Toll-like receptor signaling pathway
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1249: EPO Receptor Signaling
WP1271: Toll-like receptor signaling pathway
WP1284: EPO Receptor Signaling
WP1309: Toll-like receptor signaling pathway
WP1336: EPO Receptor Signaling
WP1341: Kit Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway

Related Genes :
[OR7D4 OR7D4P] Olfactory receptor 7D4 (OR19-B) (Odorant receptor family subfamily D member 4RT) (Olfactory receptor OR19-7)
[OR7G1 OR7G1P] Olfactory receptor 7G1 (Olfactory receptor 19-15) (OR19-15) (Olfactory receptor OR19-8)
[OR7C2 OR7C3] Olfactory receptor 7C2 (Olfactory receptor 19-18) (OR19-18) (Olfactory receptor 7C3) (Olfactory receptor OR19-22)
[OR7C1 OR7C4] Olfactory receptor 7C1 (Olfactory receptor 7C4) (Olfactory receptor OR19-16) (Olfactory receptor TPCR86)
[OR1D2 OLFR1] Olfactory receptor 1D2 (Olfactory receptor 17-4) (OR17-4) (Olfactory receptor OR17-6) (Olfactory receptor-like protein HGMP07E)
[OR7D2] Olfactory receptor 7D2 (HTPCRH03) (Olfactory receptor 19-4) (OR19-4) (Olfactory receptor OR19-10)
[OR1F1 OLFMF OR1F10 OR1F4 OR1F5 OR1F6 OR1F7 OR1F8 OR1F9] Olfactory receptor 1F1 (Olfactory receptor 16-35) (OR16-35) (Olfactory receptor 1F10) (Olfactory receptor 1F4) (Olfactory receptor 1F5) (Olfactory receptor 1F6) (Olfactory receptor 1F7) (Olfactory receptor 1F8) (Olfactory receptor 1F9) (Olfactory receptor OR16-4)
[OR7G2] Olfactory receptor 7G2 (OST260) (Olfactory receptor 19-13) (OR19-13) (Olfactory receptor OR19-6)
[OR10H5] Olfactory receptor 10H5 (Olfactory receptor OR19-25) (Olfactory receptor OR19-26)
[Or22b AN12 DOR22A.2 dor67 Or22A.2 CG4231] Odorant receptor 22b
[Or19a CG18859] Odorant receptor 19a
[Orco A45 Or83b CG10609] Odorant receptor coreceptor (Odorant receptor 83b)
[OR3A3 OR3A6 OR3A7 OR3A8P] Olfactory receptor 3A3 (Olfactory receptor 17-201) (OR17-201) (Olfactory receptor 3A6) (Olfactory receptor 3A7) (Olfactory receptor 3A8) (Olfactory receptor OR17-22)
[OR10H3] Olfactory receptor 10H3 (Olfactory receptor OR19-24)
[OR10H4] Olfactory receptor 10H4 (Olfactory receptor OR19-28)
[OR10H1] Olfactory receptor 10H1 (Olfactory receptor OR19-27)
[OR10H2] Olfactory receptor 10H2 (Olfactory receptor OR19-23)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[OR1M1] Olfactory receptor 1M1 (Olfactory receptor 19-6) (OR19-6) (Olfactory receptor OR19-5)
[Or51e2 Mol2.3 Olfr78 Psgr] Olfactory receptor 51E2 (Olfactory receptor 78)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[OR7A10] Olfactory receptor 7A10 (OST027) (Olfactory receptor OR19-18)
[OR7E24 OR7E24P] Olfactory receptor 7E24 (Olfactory receptor OR19-14)
[Olfr15 Mor256-17] Olfactory receptor 15 (Odorant receptor OR3) (Olfactory receptor 256-17)
[Or22a AN11 DOR22A.1 dor53 Or22A.1 CG12193] Odorant receptor 22a
[OR2A4 OR2A10] Olfactory receptor 2A4 (Olfactory receptor 2A10) (Olfactory receptor OR6-37)
[odr-7 T18D3.2] Nuclear hormone receptor family member odr-7 (Odorant response abnormal protein 7)
[OR8D1 OR8D3] Olfactory receptor 8D1 (OST004) (Olfactory receptor 8D3) (Olfactory receptor OR11-301) (Olfactory receptor-like protein JCG9)
[OR7A5] Olfactory receptor 7A5 (Olfactory receptor OR19-17) (Olfactory receptor TPCR92)
[OR1E1 OR1E5 OR1E6 OR1E9P] Olfactory receptor 1E1 (Olfactory receptor 13-66) (OR13-66) (Olfactory receptor 17-2/17-32) (OR17-2) (OR17-32) (Olfactory receptor 1E5) (Olfactory receptor 1E6) (Olfactory receptor 5-85) (OR5-85) (Olfactory receptor OR17-18) (Olfactory receptor-like protein HGMP07I)

Bibliography :