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Osteopontin (Bone sialoprotein 1) (Secreted phosphoprotein 1) (SPP-1)

 OSTP_CHICK              Reviewed;         264 AA.
P23498;
01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 3.
26-FEB-2020, entry version 105.
RecName: Full=Osteopontin;
AltName: Full=Bone sialoprotein 1;
AltName: Full=Secreted phosphoprotein 1;
Short=SPP-1;
Flags: Precursor;
Name=SPP1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2033080;
Castagnola P., Bet P., Quarto R., Gennari M., Migliaccio G., Cancedda R.;
"cDNA cloning and gene expression of chicken osteopontin. Expression of
osteopontin mRNA in chondrocytes is enhanced by trypsin treatment of
cells.";
J. Biol. Chem. 266:9944-9949(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2001376; DOI=10.1021/bi00223a029;
Moore M.A., Gotoh Y., Rafidi K., Gerstenfeld L.C.;
"Characterization of a cDNA for chicken osteopontin: expression during bone
development, osteoblast differentiation, and tissue distribution.";
Biochemistry 30:2501-2508(1991).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8144023; DOI=10.1016/0378-1119(94)90540-1;
Rafidi K., Simikina I., Johnson E., Moore M.A., Gerstenfeld L.C.;
"Characterization of the chicken osteopontin-encoding gene.";
Gene 140:163-169(1994).
-!- FUNCTION: Binds tightly to hydroxyapatite. Appears to form an integral
part of the mineralized matrix. Probably important to cell-matrix
interaction.
-!- FUNCTION: Acts as a cytokine involved in enhancing production of
interferon-gamma and interleukin-12 and reducing production of
interleukin-10 and is essential in the pathway that leads to type I
immunity. {ECO:0000250}.
-!- SUBUNIT: Ligand for integrin alpha-V/beta-3.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Extensively phosphorylated on serine residues.
-!- PTM: N-glycosylated.
-!- SIMILARITY: Belongs to the osteopontin family. {ECO:0000305}.
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EMBL; X56772; CAA40091.1; -; mRNA.
EMBL; M59182; AAA62729.1; -; mRNA.
EMBL; U01844; AAA18584.1; -; Genomic_DNA.
PIR; I51384; A40019.
RefSeq; NP_989866.1; NM_204535.4.
STRING; 9031.ENSGALP00000017754; -.
PaxDb; P23498; -.
GeneID; 395210; -.
KEGG; gga:395210; -.
CTD; 6696; -.
eggNOG; ENOG410IVP1; Eukaryota.
eggNOG; ENOG41116B5; LUCA.
InParanoid; P23498; -.
KO; K06250; -.
OrthoDB; 1280650at2759; -.
PhylomeDB; P23498; -.
PRO; PR:P23498; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005623; C:cell; IDA:AgBase.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0050840; F:extracellular matrix binding; IBA:GO_Central.
GO; GO:0008201; F:heparin binding; ISS:AgBase.
GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
GO; GO:0001649; P:osteoblast differentiation; IBA:GO_Central.
GO; GO:0045780; P:positive regulation of bone resorption; IBA:GO_Central.
InterPro; IPR002038; Osteopontin.
InterPro; IPR019841; Osteopontin_CS.
PANTHER; PTHR10607; PTHR10607; 1.
Pfam; PF00865; Osteopontin; 1.
SMART; SM00017; OSTEO; 1.
PROSITE; PS00884; OSTEOPONTIN; 1.
2: Evidence at transcript level;
Biomineralization; Cell adhesion; Cytokine; Glycoprotein; Phosphoprotein;
Reference proteome; Secreted; Sialic acid; Signal.
SIGNAL 1..16
CHAIN 17..264
/note="Osteopontin"
/id="PRO_0000020327"
MOTIF 132..134
/note="Cell attachment site"
CARBOHYD 106
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 109
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 204
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 242
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CONFLICT 104
/note="D -> G (in Ref. 2; AAA62729)"
/evidence="ECO:0000305"
CONFLICT 216
/note="G -> D (in Ref. 1; CAA40091)"
/evidence="ECO:0000305"
CONFLICT 235
/note="R -> A (in Ref. 1; CAA40091)"
/evidence="ECO:0000305"
CONFLICT 240
/note="T -> A (in Ref. 1; CAA40091)"
/evidence="ECO:0000305"
SEQUENCE 264 AA; 29162 MW; CA2F17DB70A92591 CRC64;
MKLAFLCLCF ISIAAAWPVS KSRQHAISAS SEEKYDPRSH HTHRYHQDHV DSQSQEHLQQ
TQNDLASLQQ THYSSEENAD VPEQPDFPDI PSKSQEAVDD DDDDDNDSND TDESDEVVTD
FPTEAPVTPF NRGDNAGRGD SVAYGFRAKA HVVKASKLRK AARKLIEDDA TAEVGDSQLA
GLWLPKESRE QDSRELAQHQ SVENDSRPRF DSPEVGGGDS KASAGVDSRE SLASRSAVDT
SNQTLESAED AEDRHSIENN EVTR


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A 4228AG.1 Osteopontin Secreted Phosphoprotein 1 antigen: human Osteopontin 10
Pathways :
WP1383: Endochondral Ossification
WP828: Endochondral Ossification
WP474: Endochondral Ossification
WP1434: Osteopontin Signaling

Related Genes :
[SPP1 BNSP OPN PSEC0156] Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)
[IBSP BNSP] Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)
[Dspp Dmp3] Dentin sialophosphoprotein (Dentin matrix protein 3) (DMP-3) [Cleaved into: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)]
[DSPP] Dentin sialophosphoprotein [Cleaved into: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)]
[Ibsp] Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)
[IBSP] Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)
[Ibsp] Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)
[RUNX2 AML3 CBFA1 OSF2 PEBP2A] Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)
[SPP2 SPP24] Secreted phosphoprotein 24 (Spp-24) (Secreted phosphoprotein 2)
[IBSP] Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)
[IBSP] Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)
[IMPG1 SPACR] Interphotoreceptor matrix proteoglycan 1 (Sialoprotein associated with cones and rods) (SPACR)
[ACP5] Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase)
[cat-1 NCU08791] Catalase-1 (EC 1.11.1.6)
[Enpp1 Npps Pc1 Pdnp1] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Lymphocyte antigen 41) (Ly-41) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
[ENPP1 M6S1 NPPS PC1 PDNP1] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[Enpp1 Npps Pc1 Pdnp1] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
[GOLM1 C9orf155 GOLPH2 PSEC0242 UNQ686/PRO1326] Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2)
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10-Pol (NC-pol); Protease (PR) (EC 3.4.23.-) (p14); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p80); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p46)]
[Crmp1 Dpysl1 Ulip3] Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3)
[BGN SLRR1A] Biglycan (Bone/cartilage proteoglycan I) (PG-S1)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[SGPP1 SPP1] Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1)
[STMN1 C1orf215 LAP18 OP18] Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)
[ALPL] Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)
[al-3 B8P8.010 NCU01427] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Albino-3 protein) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)

Bibliography :
[28830685] Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma.
[26796295] Exposure to cypermethrin and mancozeb alters the expression profile of THBS1, SPP1, FEZ1 and GPNMB in human peripheral blood mononuclear cells.
[25035397] Osteopontin shapes immunosuppression in the metastatic niche.
[24853141] HCC development is associated to peripheral insulin resistance in a mouse model of NASH.
[21696062] Prognostic and predictive potential molecular biomarkers in colon cancer.
[16844665] The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: a potential biomarker.
[8015545] DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor.
[1665202] DNA binding properties of the vitamin D3 receptor zinc finger region.
[1938474] Immunohistochemical localization of bone sialoprotein in foetal porcine bone tissues: comparisons with secreted phosphoprotein 1 (SPP-1, osteopontin) and SPARC (osteonectin).
[1863811] Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter.