GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

PH domain leucine-rich repeat protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein)

 PHLP1_RAT               Reviewed;        1696 AA.
Q9WTR8;
07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
16-JAN-2019, entry version 129.
RecName: Full=PH domain leucine-rich repeat protein phosphatase 1;
EC=3.1.3.16;
AltName: Full=Pleckstrin homology domain-containing family E member 1;
Short=PH domain-containing family E member 1;
AltName: Full=Suprachiasmatic nucleus circadian oscillatory protein;
Name=Phlpp1; Synonyms=Phlpp, Plekhe1, Scop;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
TISSUE=Brain;
PubMed=10570941; DOI=10.1016/S0014-5793(99)01190-4;
Shimizu K., Okada M., Takano A., Nagai K.;
"SCOP, a novel gene product expressed in a circadian manner in rat
suprachiasmatic nucleus.";
FEBS Lett. 458:363-369(1999).
[2]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH KRAS.
PubMed=12594205; DOI=10.1074/jbc.M213214200;
Shimizu K., Okada M., Nagai K., Fukada Y.;
"Suprachiasmatic nucleus circadian oscillatory protein, a novel
binding partner of K-Ras in the membrane rafts, negatively regulates
MAPK pathway.";
J. Biol. Chem. 278:14920-14925(2003).
[3]
FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY (ISOFORMS 1 AND 2),
AND INDUCTION BY INSULIN.
PubMed=20089132; DOI=10.1111/j.1471-4159.2010.06609.x;
Kanan Y., Matsumoto H., Song H., Sokolov M., Anderson R.E.,
Rajala R.V.;
"Serine/threonine kinase akt activation regulates the activity of
retinal serine/threonine phosphatases, PHLPP and PHLPPL.";
J. Neurochem. 113:477-488(2010).
[4]
ALTERNATIVE SPLICING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND
FUNCTION.
PubMed=20819118; DOI=10.1111/j.1471-4159.2010.06984.x;
Jackson T.C., Verrier J.D., Semple-Rowland S., Kumar A., Foster T.C.;
"PHLPP1 splice variants differentially regulate AKT and PKCalpha
signaling in hippocampal neurons: characterization of PHLPP proteins
in the adult hippocampus.";
J. Neurochem. 115:941-955(2010).
-!- FUNCTION: Protein phosphatase involved in regulation of Akt and
PKC signaling. Mediates dephosphorylation in the C-terminal domain
hydrophobic motif of members of the AGC Ser/Thr protein kinase
family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660'
of PRKCB and 'Ser-657' of PRKCA (PubMed:20819118). Isoform 2 seems
to have a major role in regulating Akt signaling in hippocampal
neurons while isoform 1 may promote Akt and PKC activation and
inhibit ERK signaling (PubMed:20819118). Akt regulates the balance
between cell survival and apoptosis through a cascade that
primarily alters the function of transcription factors that
regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-
473' of Akt triggers apoptosis and suppression of tumor growth.
Dephosphorylation of PRKCA and PRKCB leads to their
destabilization and degradation. Dephosphorylates STK4 on 'Thr-
387' leading to STK4 activation and apoptosis (By similarity).
Dephosphorylates RPS6KB1 and is involved in regulation of cap-
dependent translation (By similarity). Inhibits cancer cell
proliferation and may act as a tumor suppressor (By similarity).
Dephosphorylates RAF1 inhibiting its kinase activity (By
similarity). May act as a negative regulator of K-Ras signaling in
membrane rafts (PubMed:12594205). Involved in the hippocampus-
dependent long-term memory formation (By similarity). Involved in
circadian control by regulating the consolidation of circadian
periodicity after resetting (By similarity). Involved in
development and function of regulatory T-cells (By similarity).
{ECO:0000250|UniProtKB:O60346, ECO:0000250|UniProtKB:Q8CHE4,
ECO:0000269|PubMed:12594205, ECO:0000269|PubMed:20819118}.
-!- CATALYTIC ACTIVITY:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999,
ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;
-!- CATALYTIC ACTIVITY:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-
[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-
COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377,
ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977;
EC=3.1.3.16;
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Note=Binds 2 manganese ions per subunit. {ECO:0000250};
-!- ACTIVITY REGULATION: Insensitive to okadaic acid. Deubiquitination
by WDR48-USP12 complex positively regulates PHLPP1 stability.
{ECO:0000250|UniProtKB:O60346}.
-!- SUBUNIT: Interacts with the nucleotide free form of K-Ras (KRAS)
via its LRR repeats (PubMed:12594205). Interacts with AKT2, AKT3
and PRKCB isoform beta-II. Interacts with WDR48 and USP12 (By
similarity). {ECO:0000250|UniProtKB:O60346,
ECO:0000269|PubMed:12594205}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12594205}.
Membrane {ECO:0000269|PubMed:12594205}; Peripheral membrane
protein {ECO:0000269|PubMed:12594205}.
-!- SUBCELLULAR LOCATION: Isoform 1: Cytoplasm
{ECO:0000269|PubMed:20819118}. Cell membrane
{ECO:0000269|PubMed:20819118}.
-!- SUBCELLULAR LOCATION: Isoform 2: Nucleus, nucleoplasm
{ECO:0000269|PubMed:20819118}. Nucleus membrane
{ECO:0000269|PubMed:20819118}. Cytoplasm
{ECO:0000269|PubMed:20819118}. Cell membrane
{ECO:0000269|PubMed:20819118}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=beta;
IsoId=Q9WTR8-1; Sequence=Displayed;
Name=2; Synonyms=alpha;
IsoId=Q9WTR8-2; Sequence=VSP_057811;
-!- TISSUE SPECIFICITY: Mainly present in brain (at protein level)
(PubMed:10570941). Isoform 2 is more abundant in adult brain
neurons than isoform 1 in (PubMed:20819118). Isoforms 1 and 2 are
expressed in the retina but not found in rod outer segments
(PubMed:20089132). {ECO:0000269|PubMed:10570941,
ECO:0000269|PubMed:20089132, ECO:0000269|PubMed:20819118}.
-!- DEVELOPMENTAL STAGE: In the suprachiasmatic nucleus, it increases
during subjective night with a peak at midnight under constant
dark conditions. Expressed at a constant level in neurons
throughout the brain (at protein level) (PubMed:10570941). Isoform
2 expression increases over development and maturation in the
hippocampus. Isoform 1 expression is low in embryonic stages,
increases during postnatal development and is falling back to low
embryonic levels in adulthood (PubMed:20819118).
{ECO:0000269|PubMed:10570941, ECO:0000269|PubMed:20819118}.
-!- INDUCTION: Inhibited by insulin in a PI3K-dependent manner.
{ECO:0000269|PubMed:20089132}.
-!- DOMAIN: The PH domain is required for interaction with PRKCB and
its dephosphorylation. {ECO:0000250}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AB023624; BAA77767.1; -; mRNA.
RefSeq; NP_067689.1; NM_021657.1. [Q9WTR8-1]
UniGene; Rn.163214; -.
ProteinModelPortal; Q9WTR8; -.
BioGrid; 248740; 1.
IntAct; Q9WTR8; 1.
STRING; 10116.ENSRNOP00000003840; -.
PaxDb; Q9WTR8; -.
PRIDE; Q9WTR8; -.
GeneID; 59265; -.
KEGG; rno:59265; -.
UCSC; RGD:621308; rat. [Q9WTR8-1]
CTD; 23239; -.
RGD; 621308; Phlpp1.
eggNOG; KOG0619; Eukaryota.
eggNOG; COG0631; LUCA.
eggNOG; COG4886; LUCA.
HOGENOM; HOG000115529; -.
InParanoid; Q9WTR8; -.
KO; K16340; -.
OrthoDB; 172467at2759; -.
PhylomeDB; Q9WTR8; -.
PRO; PR:Q9WTR8; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO; GO:0001917; C:photoreceptor inner segment; IBA:GO_Central.
GO; GO:0042622; C:photoreceptor outer segment membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004722; F:protein serine/threonine phosphatase activity; IDA:RGD.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0007623; P:circadian rhythm; IEP:RGD.
GO; GO:0021766; P:hippocampus development; IEP:RGD.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IMP:UniProtKB.
GO; GO:0090038; P:negative regulation of protein kinase C signaling; IMP:UniProtKB.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IMP:UniProtKB.
GO; GO:0090037; P:positive regulation of protein kinase C signaling; IMP:UniProtKB.
GO; GO:0006470; P:protein dephosphorylation; IDA:RGD.
GO; GO:0046328; P:regulation of JNK cascade; IBA:GO_Central.
GO; GO:1900744; P:regulation of p38MAPK cascade; IBA:GO_Central.
GO; GO:0001932; P:regulation of protein phosphorylation; IMP:RGD.
CDD; cd00143; PP2Cc; 1.
Gene3D; 2.30.29.30; -; 1.
Gene3D; 3.60.40.10; -; 1.
Gene3D; 3.80.10.10; -; 3.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
InterPro; IPR036457; PPM-type_dom_sf.
InterPro; IPR001932; PPM-type_phosphatase_dom.
Pfam; PF00560; LRR_1; 1.
Pfam; PF13516; LRR_6; 1.
Pfam; PF13855; LRR_8; 2.
Pfam; PF00169; PH; 1.
Pfam; PF00481; PP2C; 1.
SMART; SM00369; LRR_TYP; 9.
SMART; SM00332; PP2Cc; 1.
SUPFAM; SSF81606; SSF81606; 1.
PROSITE; PS51450; LRR; 17.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS51746; PPM_2; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Apoptosis; Cell membrane;
Complete proteome; Cytoplasm; Hydrolase; Leucine-rich repeat;
Manganese; Membrane; Metal-binding; Nucleus; Phosphoprotein;
Protein phosphatase; Reference proteome; Repeat; Tumor suppressor.
CHAIN 1 1696 PH domain leucine-rich repeat protein
phosphatase 1.
/FTId=PRO_0000057783.
DOMAIN 499 599 PH. {ECO:0000255|PROSITE-
ProRule:PRU00145}.
REPEAT 601 622 LRR 1.
REPEAT 624 645 LRR 2.
REPEAT 655 676 LRR 3.
REPEAT 678 699 LRR 4.
REPEAT 701 722 LRR 5.
REPEAT 724 746 LRR 6.
REPEAT 836 857 LRR 7.
REPEAT 858 879 LRR 8.
REPEAT 881 902 LRR 9.
REPEAT 904 925 LRR 10.
REPEAT 926 947 LRR 11.
REPEAT 950 971 LRR 12.
REPEAT 976 996 LRR 13.
REPEAT 1000 1021 LRR 14.
REPEAT 1024 1045 LRR 15.
REPEAT 1047 1068 LRR 16.
REPEAT 1069 1090 LRR 17.
REPEAT 1092 1113 LRR 18.
DOMAIN 1138 1385 PPM-type phosphatase.
{ECO:0000255|PROSITE-ProRule:PRU01082}.
MOTIF 1694 1696 PDZ-binding.
COMPBIAS 4 9 Poly-Ala.
COMPBIAS 21 28 Poly-Ala.
COMPBIAS 116 126 Poly-Ser.
COMPBIAS 339 343 Poly-Ser.
COMPBIAS 405 410 Poly-Ala.
COMPBIAS 1431 1434 Poly-Ser.
COMPBIAS 1645 1661 Poly-Gln.
COMPBIAS 1662 1669 Poly-Pro.
METAL 1173 1173 Manganese 1.
{ECO:0000250|UniProtKB:P35813}.
METAL 1173 1173 Manganese 2.
{ECO:0000250|UniProtKB:P35813}.
METAL 1174 1174 Manganese 1; via carbonyl oxygen.
{ECO:0000250|UniProtKB:P35813}.
METAL 1337 1337 Manganese 2.
{ECO:0000250|UniProtKB:P35813}.
METAL 1376 1376 Manganese 2.
{ECO:0000250|UniProtKB:P35813}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:O60346}.
MOD_RES 378 378 Phosphoserine.
{ECO:0000250|UniProtKB:O60346}.
VAR_SEQ 1 475 Missing (in isoform 2).
/FTId=VSP_057811.
SEQUENCE 1696 AA; 183364 MW; B4C3CC777B8BB6A9 CRC64;
MEPAAAAPAQ RLADPTGEDR APAAAAAAEG GRSPDSVLSA AAPSGGNGGA AREEAPCEAP
PGPLPGRAGG TGRRRRRGVP QPAAGGAAPV TAAGGGANSL LLRRGRLKRN LSAAASSSSS
PSSASSAAGG LPASCSASAS LCTRSLDRKT LLQKHRQLLQ LQPSDRDWVR HQLQRGCVHV
FDRHMASSYL RPVLCTLDTT AAEVAARLLQ LGHKGGGVVK VLGHGPPPAA APAASDQTPA
TELGRDVEPP PSSSTVGAVR GPARAPPADL PLPGGAWTRC APRVNPAPSD SSPGELFAGG
PCSPSRAPRP ASDTESFSLS PSAESVSDRL DPYSSGGGSS SSSEELEADP ATVLTGPSGP
PHHPVRSSQP RPPSPKTSAL LQPKAPTGVD GTGLVVGEGP GDDKAVAAAA PGVPLWTPGR
IRETVQKTSS PPSLYVQLHG ETTRRLEADE KPLQIQNDYL FQLGFGELWR VQEEGMDSEI
GCLIRFYAGK PHSTGSSERI QLSGMYNVRK GKMQLPVNRW TRRQVILCGT CLIVSSVKDS
SSGKMHVLPL IGGKVEEVKK HQHCLAFSSS GPQSQTYYIC FDTFTEYLRW LRQVSKVASQ
RISSVDLSCC SLEHLPANLF YSQDLTHLNL KQNFLRQNPS LPAARGLGEL QRFTKLKSLN
LSNNHLGAFP SAVCSIPTLA ELNVSCNALQ EVPAAVGAMQ NLQTFLLDGN FLQSLPAELE
NMHQLSYLGL SFNEFTDIPE VLEKLTAVDK LCMAGNCMET LRLQALRRMP HIKHVDLRLN
ILRKLITDEV DFLQHVTQLD LRDNKLGDLD AMIFNNIEVL HCERNQLVTL NICGYFLKAL
YASSNELVQL DVYPVPNYLS YMDVSRNCLE SVPEWVCESR KLEVLDIGHN QICELPARLF
CNSSLRKLLA GHNRLARLPE RLERTSVEVL DVQHNQIIEL PPNLLMKADS LRFLNASANK
LETLPPATLS EETSSILQEL YLTNNSLTDK CVPLLTGHPR LKILHMAYNR LQSFPASKMA
KLEELEEIDI SGNKLKAIPT TIMNCRRMHT VIAHSNCIEV FPEVMQLPEV KCVDLSCNEL
SEITLPENLP PKLQELDLTG NPRLALDHKS LELLNNIRCF KIDQPSAGDA SGAPAVWSHG
YTEASGVKNK LCVAALSVNN FRDNREALYG VFDGDRNVEV PYLLQCTMSD ILAEELQKTK
NEEEYMVNTF IVMQRKLGTA GQKLGGAAVL CHIRHDPVDL GGSFTLTSAN VGKCQTVLCR
NGKPLSLSRS YTMSCEEERK RIKQHKAIIT EDGKVNGVTE STRILGYTFL HPSVVPRPHV
QSVLLTPQDE FFILGSKGLW DSLSIEEAVE AVRNVPDALA AAKKLCTLAQ SYGCHDSISA
VVVQLSVTED SFCCCELSVG GSMPPPSPGI FPPSVSMVIK DRPSDGLGVP SSSSGMASEI
SSELSTSEMS SEVGSTASDE PPSGALSESS PAYPSEQRCM LHPVCLSNSF QRQLSSATFS
SAFSDNGLDS DDEEPIEGVF SNGSRVEVEV DIHCSRAKEK ERQQHLLQVP AEASDEGIVI
SANEDESGLS KKTDISAVGT IGRRRANGSV PPQERSHNVI EVATDAPLRK PGGYFAAPAQ
PDPDDQFIIP PELEEEVKEI MKHHQEQQQQ QQQQQQQQQQ QPPPPPQPPQ AQAQAQAQAQ
RPFQMDHLPD CYDTPL


Related products :

Catalog number Product name Quantity
EIAAB30917 Kiaa0606,Mouse,Mus musculus,PH domain leucine-rich repeat-containing protein phosphatase 1,PH domain-containing family E member 1,Phlpp,Phlpp1,Pleckstrin homology domain-containing family E member 1,P
EIAAB30916 PH domain leucine-rich repeat protein phosphatase 1,PH domain-containing family E member 1,Phlpp,Phlpp1,Pleckstrin homology domain-containing family E member 1,Plekhe1,Rat,Rattus norvegicus,Scop,Supra
EIAAB30915 Homo sapiens,hSCOP,Human,KIAA0606,PH domain leucine-rich repeat-containing protein phosphatase 1,PH domain-containing family E member 1,PHLPP,PHLPP1,Pleckstrin homology domain-containing family E memb
EIAAB31260 Mouse,Mus musculus,PH domain-containing adaptor PHAD47,PH domain-containing family A member 2,Pleckstrin homology domain-containing family A member 2,Plekha2,Tandem PH domain-containing protein 2,Tapp
EIAAB31275 Evectin-1,Evt1,Mouse,Mus musculus,PH domain-containing family B member 1,PH domain-containing protein in retina 1,Phr1,PHRET1,Pleckstrin homology domain retinal protein 1,Pleckstrin homology domain-co
EIAAB31257 Homo sapiens,Human,PH domain-containing family A member 1,Pleckstrin homology domain-containing family A member 1,PLEKHA1,Tandem PH domain-containing protein 1,TAPP1,TAPP-1
EIAAB31259 Homo sapiens,Human,PH domain-containing family A member 2,Pleckstrin homology domain-containing family A member 2,PLEKHA2,Tandem PH domain-containing protein 2,TAPP2,TAPP-2
EIAAB31258 Mouse,Mus musculus,PH domain-containing family A member 1,Pleckstrin homology domain-containing family A member 1,Plekha1,Tandem PH domain-containing protein 1,Tapp1,TAPP-1
EIAAB31330 Homo sapiens,Human,PH domain-containing family O member 2,PH domain-containing family Q member 1,Pleckstrin homology domain-containing family O member 2,Pleckstrin homology domain-containing family Q
EIAAB31286 Homo sapiens,Human,PH and FYVE domain-containing protein 2,PH domain-containing family F member 2,Phafin-2,Pleckstrin homology domain-containing family F member 2,PLEKHF2,ZFYVE18,Zinc finger FYVE doma
EIAAB31271 Hadp1,Heart adapter protein 1,Mouse,Mus musculus,PH domain-containing family A member 7,Pleckstrin homology domain-containing family A member 7,Plekha7
EIAAB31313 162 kDa adapter protein,AP162,Homo sapiens,Human,KIAA0356,PH domain-containing family M member 1,Pleckstrin homology domain-containing family M member 1,PLEKHM1
EIAAB31310 Gnrpx,Guanine nucleotide-releasing protein x,Mouse,Mus musculus,PH domain-containing family J member 1,Pleckstrin homology domain-containing family J member 1,Plekhj1
EIAAB31282 Lapf,Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains,Mouse,Mus musculus,PH domain-containing family F member 1,Pleckstrin homology domain-containing family F member 1,Ple
EIAAB31268 Mouse,Mus musculus,Pepp3,PEPP-3,PH domain-containing family A member 6,Phosphoinositol 3-phosphate-binding protein 3,Pleckstrin homology domain-containing family A member 6,Plekha6
EIAAB31266 Mouse,Mus musculus,Pepp1,PEPP-1,PH domain-containing family A member 4,Phosphoinositol 3-phosphate-binding protein 1,Pleckstrin homology domain-containing family A member 4,Plekha4
EIAAB31264 Pepp1,PEPP-1,PH domain-containing family A member 4,Phosphoinositol 3-phosphate-binding protein 1,Pleckstrin homology domain-containing family A member 4,Plekha4,Rat,Rattus norvegicus
EIAAB31309 GNRPX,Guanine nucleotide-releasing protein x,Homo sapiens,Human,PH domain-containing family J member 1,Pleckstrin homology domain-containing family J member 1,PLEKHJ1
EIAAB31265 Homo sapiens,Human,PEPP1,PEPP-1,PH domain-containing family A member 4,Phosphoinositol 3-phosphate-binding protein 1,Pleckstrin homology domain-containing family A member 4,PLEKHA4
EIAAB31293 Homo sapiens,Human,PH domain-containing family G member 4,Pleckstrin homology domain-containing family G member 4,PLEKHG4,PRTPHN1,Puratrophin-1,Purkinje cell atrophy-associated protein 1
EIAAB31295 Neuronal RhoA GEF protein,PH domain-containing family G member 5,Pleckstrin homology domain-containing family G member 5,Plekhg5,Rat,Rattus norvegicus,Tech,Transcript highly enriched in cortex and hip
EIAAB31269 Homo sapiens,Human,KIAA0969,PEPP3,PEPP-3,PH domain-containing family A member 6,Phosphoinositol 3-phosphate-binding protein 3,Pleckstrin homology domain-containing family A member 6,PLEKHA6
EIAAB31267 Homo sapiens,Human,KIAA1686,PEPP2,PEPP-2,PH domain-containing family A member 5,Phosphoinositol 3-phosphate-binding protein 2,Pleckstrin homology domain-containing family A member 5,PLEKHA5
EIAAB31328 Mouse,Mus musculus,PH domain-containing family O member 2,PH domain-containing family Q member 1,Pleckstrin homology domain-containing family O member 2,Pleckstrin homology domain-containing family Q
EIAAB31329 Bos taurus,Bovine,PH domain-containing family O member 2,PH domain-containing family Q member 1,Pleckstrin homology domain-containing family O member 2,Pleckstrin homology domain-containing family Q m

Kits Elisa; taq POLYMERASE

Search in Google:

google

Share this page:
share on twitter rss feedsfacebookgoogle gentaur



Quick order!
Enter catalog number :


Gentaur; yes we can

Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP1909: Signal regulatory protein (SIRP) family interactions
WP1654: gamma-Hexachlorocyclohexane degradation
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1485: Interactions between CFTR and other ion channels
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation

Related Genes :
[PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP] PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
[Plekhb1 Evt1 Phr1] Pleckstrin homology domain-containing family B member 1 (PH domain-containing family B member 1) (Evectin-1) (PH domain-containing protein in retina 1) (PHRET1) (Pleckstrin homology domain retinal protein 1)
[PHLPP2 KIAA0931 PHLPPL] PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)
[PLEKHO1 CKIP1 OC120 HQ0024c] Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)
[PLEKHM1 KIAA0356] Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)
[FERMT2 KIND2 MIG2 PLEKHC1] Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)
[FARP2 KIAA0793 PLEKHC3] FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)
[rush EG:80H7.5 CG14782] Pleckstrin homology domain-containing family F member 1 homolog (PH domain-containing family F member 1 homolog) (Protein rush hour)
[PLEKHB1 EVT1 KPL1 PHR1 PHRET1] Pleckstrin homology domain-containing family B member 1 (PH domain-containing family B member 1) (Evectin-1) (PH domain-containing protein in retina 1) (PHRET1) (Pleckstrin homology domain retinal protein 1)
[PLEKHG2] Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2)
[PLEKHG5 KIAA0720] Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)
[PLEKHG6] Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
[Pre C,C C core E PC pre-C pre-C/C PreC preC PreC/C preC/C precore-core HBVgp4] Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
[Plekho1] Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1)
[ARNTL BHLHE5 BMAL1 MOP3 PASD3] Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)
[Ppm1e Camkn Kiaa1072] Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)
[LINGO1 LERN1 LRRN6A UNQ201/PRO227] Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Sh2b1 Sh2bpsm1] SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
[KDM2B CXXC2 FBL10 FBXL10 JHDM1B PCCX2] Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[CRY2 PHH1 SEL20 At1g04400 F19P19.14] Cryptochrome-2 (Atcry2) (Blue light photoreceptor) (Protein PHR homolog 1) (AtPHH1) (Protein SUPPRESSOR OF elf3 20)
[AGAP3 CENTG3] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1)
[CELF3 BRUNOL1 CAGH4 ERDA4 TNRC4] CUGBP Elav-like family member 3 (CELF-3) (Bruno-like protein 1) (CAG repeat protein 4) (CUG-BP- and ETR-3-like factor 3) (ELAV-type RNA-binding protein 1) (ETR-1) (Expanded repeat domain protein CAG/CTG 4) (RNA-binding protein BRUNOL-1) (Trinucleotide repeat-containing gene 4 protein)
[PPM1E CAMKN KIAA1072 POPX1] Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)
[Asap1 Ddef1 Kiaa1249 Shag1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[Ppm1e Camkn] Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)

Bibliography :