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PH-interacting protein (PHIP) (IRS-1 PH domain-binding protein) (Neuronal differentiation-related protein) (NDRP) (WD repeat-containing protein 11)

 PHIP_MOUSE              Reviewed;        1821 AA.
Q8VDD9; Q3TS96; Q80VI6; Q9EPY1; Q9ESL6;
21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
21-AUG-2007, sequence version 2.
22-APR-2020, entry version 133.
RecName: Full=PH-interacting protein;
Short=PHIP;
AltName: Full=IRS-1 PH domain-binding protein;
AltName: Full=Neuronal differentiation-related protein;
Short=NDRP;
AltName: Full=WD repeat-containing protein 11;
Name=Phip; Synonyms=Ndrp, Phip1, Wdr11;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-1779.
Antonarakis S.;
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-999, TISSUE SPECIFICITY, DEVELOPMENTAL
STAGE, AND INDUCTION.
STRAIN=Swiss Webster / NIH;
PubMed=11098134; DOI=10.1093/oxfordjournals.jbchem.a022843;
Kato H., Chen S., Kiyama H., Ikeda K., Kimura N., Nakashima K., Taga T.;
"Identification of a novel WD repeat-containing gene predominantly
expressed in developing and regenerating neurons.";
J. Biochem. 128:923-932(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-893.
STRAIN=Czech II; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 745-1458.
STRAIN=C57BL/6J; TISSUE=Egg;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 924-1821, FUNCTION, INTERACTION WITH IRS1 AND
IRS2, AND TISSUE SPECIFICITY.
PubMed=11018022; DOI=10.1074/jbc.c000611200;
Farhang-Fallah J., Yin X., Trentin G., Cheng A.M., Rozakis-Adcock M.;
"Cloning and characterization of PHIP, a novel insulin receptor substrate-1
pleckstrin homology domain interacting protein.";
J. Biol. Chem. 275:40492-40497(2000).
[6]
PROTEIN SEQUENCE OF 1589-1596, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=OF1; TISSUE=Hippocampus;
Lubec G., Sunyer B., Chen W.-Q.;
Submitted (JAN-2009) to UniProtKB.
[7]
FUNCTION.
PubMed=12242307; DOI=10.1128/mcb.22.20.7325-7336.2002;
Farhang-Fallah J., Randhawa V.K., Nimnual A., Klip A., Bar-Sagi D.,
Rozakis-Adcock M.;
"The pleckstrin homology (PH) domain-interacting protein couples the
insulin receptor substrate 1 PH domain to insulin signaling pathways
leading to mitogenesis and GLUT4 translocation.";
Mol. Cell. Biol. 22:7325-7336(2002).
[8]
FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
PubMed=17636024; DOI=10.1128/mcb.02409-06;
Podcheko A., Northcott P., Bikopoulos G., Lee A., Bommareddi S.R.,
Kushner J.A., Farhang-Fallah J., Rozakis-Adcock M.;
"Identification of a WD40 repeat-containing isoform of PHIP as a novel
regulator of beta-cell growth and survival.";
Mol. Cell. Biol. 27:6484-6496(2007).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1281 AND SER-1283, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1281 AND SER-1283, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1281; SER-1283; SER-1315 AND
SER-1783, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[12]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1533, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic
pathways.";
Mol. Cell 50:919-930(2013).
-!- FUNCTION: Probable regulator of the insulin and insulin-like growth
factor signaling pathways. Stimulates cell proliferation through
regulation of cyclin transcription and has an anti-apoptotic activity
through AKT1 phosphorylation and activation. Plays a role in the
regulation of cell morphology and cytoskeletal organization.
{ECO:0000269|PubMed:11018022, ECO:0000269|PubMed:12242307,
ECO:0000269|PubMed:17636024}.
-!- SUBUNIT: Interacts (via bromo domain) with acetylated lysine residues
on histone H1.4, histone H3 and H4 (in vitro) (By similarity).
Interacts with IRS1 and IRS2. {ECO:0000250,
ECO:0000269|PubMed:11018022}.
-!- INTERACTION:
Q8VDD9; P35570: Irs1; Xeno; NbExp=2; IntAct=EBI-1369766, EBI-520230;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17636024}.
-!- TISSUE SPECIFICITY: Widely expressed with most abundant expression
detected in pancreatic islets, brain and skeletal muscle. Predominantly
expressed in developing and regenerating neurons. Expressed in adult
brain (granular layer of the olfactorium bulb, hippocampus, dentate
gyrus and cerebellum internal granular layer). Expressed in the CA3
region of adult hippocampus, adult and fetal retina, perinatal dorsal
root ganglion and embryonal olfactory epithelia (at protein level).
{ECO:0000269|PubMed:11018022, ECO:0000269|PubMed:11098134,
ECO:0000269|PubMed:17636024}.
-!- DEVELOPMENTAL STAGE: Expressed at highest levels at 17.5 dpc in the
neural layer of the retina and olfactory epithelia.
{ECO:0000269|PubMed:11098134}.
-!- INDUCTION: In motor neurons after injury.
{ECO:0000269|PubMed:11098134}.
-!- SEQUENCE CAUTION:
Sequence=AAG45146.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5' end and extensively differs from that shown.; Evidence={ECO:0000305};
Sequence=AAH49950.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=BAB16299.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 3' end and extensively differs from that shown.; Evidence={ECO:0000305};
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EMBL; AJ303103; CAC83119.1; -; mRNA.
EMBL; AB049460; BAB16299.1; ALT_SEQ; mRNA.
EMBL; BC049950; AAH49950.1; ALT_TERM; mRNA.
EMBL; AK162189; BAE36779.1; -; mRNA.
EMBL; AF310251; AAG45146.1; ALT_SEQ; mRNA.
CCDS; CCDS40706.1; -.
IntAct; Q8VDD9; 6.
MINT; Q8VDD9; -.
STRING; 10090.ENSMUSP00000034787; -.
iPTMnet; Q8VDD9; -.
PhosphoSitePlus; Q8VDD9; -.
EPD; Q8VDD9; -.
jPOST; Q8VDD9; -.
MaxQB; Q8VDD9; -.
PaxDb; Q8VDD9; -.
PRIDE; Q8VDD9; -.
UCSC; uc009qvw.1; mouse.
MGI; MGI:1932404; Phip.
eggNOG; KOG0644; Eukaryota.
eggNOG; ENOG410YCD8; LUCA.
InParanoid; Q8VDD9; -.
PhylomeDB; Q8VDD9; -.
ChiTaRS; Phip; mouse.
PRO; PR:Q8VDD9; -.
Proteomes; UP000000589; Unplaced.
RNAct; Q8VDD9; protein.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
GO; GO:0070577; F:lysine-acetylated histone binding; ISS:UniProtKB.
GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO; GO:0008286; P:insulin receptor signaling pathway; IDA:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:UniProtKB.
GO; GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IDA:UniProtKB.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; IMP:UniProtKB.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:MGI.
GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IDA:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006606; P:protein import into nucleus; IMP:MGI.
GO; GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
GO; GO:0040008; P:regulation of growth; IMP:MGI.
GO; GO:0001932; P:regulation of protein phosphorylation; IDA:UniProtKB.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
Gene3D; 1.20.920.10; -; 2.
Gene3D; 2.130.10.10; -; 2.
InterPro; IPR001487; Bromodomain.
InterPro; IPR036427; Bromodomain-like_sf.
InterPro; IPR018359; Bromodomain_CS.
InterPro; IPR028738; PHIP.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
PANTHER; PTHR16266:SF4; PTHR16266:SF4; 1.
Pfam; PF00439; Bromodomain; 2.
Pfam; PF00400; WD40; 5.
PRINTS; PR00503; BROMODOMAIN.
SMART; SM00297; BROMO; 2.
SMART; SM00320; WD40; 8.
SUPFAM; SSF47370; SSF47370; 2.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00633; BROMODOMAIN_1; 1.
PROSITE; PS50014; BROMODOMAIN_2; 2.
PROSITE; PS00678; WD_REPEATS_1; 2.
PROSITE; PS50082; WD_REPEATS_2; 5.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
Acetylation; Bromodomain; Direct protein sequencing; Isopeptide bond;
Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation;
WD repeat.
CHAIN 1..1821
/note="PH-interacting protein"
/id="PRO_0000297758"
REPEAT 181..222
/note="WD 1"
REPEAT 224..262
/note="WD 2"
REPEAT 265..310
/note="WD 3"
REPEAT 319..360
/note="WD 4"
REPEAT 363..402
/note="WD 5"
REPEAT 422..461
/note="WD 6"
REPEAT 464..504
/note="WD 7"
REPEAT 512..551
/note="WD 8"
DOMAIN 1176..1246
/note="Bromo 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
DOMAIN 1333..1403
/note="Bromo 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
REGION 924..1129
/note="Mediates interaction with IRS1"
/evidence="ECO:0000269|PubMed:11018022"
COMPBIAS 867..923
/note="Lys-rich"
COMPBIAS 1752..1758
/note="Poly-Glu"
MOD_RES 136
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 641
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 659
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 674
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 677
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 683
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 692
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 879
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 880
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 881
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 911
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1281
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:17242355,
ECO:0000244|PubMed:19144319, ECO:0000244|PubMed:21183079"
MOD_RES 1283
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:17242355,
ECO:0000244|PubMed:19144319, ECO:0000244|PubMed:21183079"
MOD_RES 1296
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1315
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:21183079"
MOD_RES 1359
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1405
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1479
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1497
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1525
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1533
/note="N6-acetyllysine"
/evidence="ECO:0000244|PubMed:23806337"
MOD_RES 1560
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1651
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1762
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
MOD_RES 1783
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:21183079"
CROSSLNK 421
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2)"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
CROSSLNK 1470
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO1); alternate"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
CROSSLNK 1470
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2); alternate"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
CROSSLNK 1644
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2)"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
CROSSLNK 1670
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2)"
/evidence="ECO:0000250|UniProtKB:Q8WWQ0"
CONFLICT 672
/note="R -> G (in Ref. 3; AAH49950)"
/evidence="ECO:0000305"
CONFLICT 1065
/note="P -> R (in Ref. 4; BAE36779 and 5; AAG45146)"
/evidence="ECO:0000305"
CONFLICT 1155
/note="E -> D (in Ref. 5; AAG45146)"
/evidence="ECO:0000305"
CONFLICT 1392
/note="F -> S (in Ref. 4; BAE36779 and 5; AAG45146)"
/evidence="ECO:0000305"
CONFLICT 1776
/note="A -> T (in Ref. 5; AAG45146)"
/evidence="ECO:0000305"
SEQUENCE 1821 AA; 206726 MW; 92E8DF0833F60FFA CRC64;
MSRERKGLSE LRSELYFLIA RFLEDGPCQQ AAQVLIREVA EKELLPRRTD WTGKEHPRTY
QNLVKYYRHL APDHLLQICH RLGPLLEQEI PQSVPGVQTL LGAGRQSLLR TNKSCKHVVW
KGSALAALHC GRPPESPVNY GSPPSIADTL FSRKLNGKYR LERLVPTAVY QHMKMHKRIL
GHLSSVYCVT FDRTGRRIFT GSDDCLVKIW ATDDGRLLAT LRGHAAEISD MAVNYENTMI
AAGSCDKMIR VWCLRTCAPL AVLQGHSASI TSLQFSPLCS GSKRYLSSTG ADGTICFWLW
DAGTLKINPR PTKFTERPRP GVQMICSSFS AGGMFLATGS TDHIIRVYFF GSGQPEKISE
LEFHTDKVDS IQFSNTSNRF VSGSRDGTAR IWQFKRREWK SILLDMATRP AGQNLQGIED
KITKMKVTMV AWDRHDNTVI TAVNNMTLKV WNSYTGQLIH VLMGHEDEVF VLEPHPFDPR
VLFSAGHDGN VIVWDLARGV KVRSYFNMIE GQGHGAVFDC KCSPDGQHFA CTDSHGHLLI
FGFGSSSKYD KIADQMFFHS DYRPLIRDAN NFVLDEQTQQ APHLMPPPFL VDVDGNPHPS
RYQRLVPGRE NCREEQLIPQ MGVTSSGLNQ VLSQQANQDI SPLDSMIQRL QQEQDLRRSG
EAGVSNASRV NRGSVSSTSE VHSPPNIGLR RSGQIEGVRQ MHSNAPRSEI ATERDLVAWS
RRVVVPELSA GVASRQEEWR TAKGEEEIKS YRSEEKRKHL TVAKENKILT VSKNHAHEHF
LDLGDSKKQQ ANQHNYRTRS ALEETPRPLE ELENGTSSSD EGEVLAVSGG TSEEEERAWH
SDGSSSDYSS DYSDWTADAG INLQPPKKVP KHKTKKPESS SDEEEESENQ KQKHIKKERK
KANEEKDGPT SPKKKKPKER KQKRLAVGEL TENGLTLEEW LPSAWITDTL PRRCPFVPQM
GDEVYYFRQG HEAYVEMARK NKIYSINPKK QPWHKMELRE QELMKIVGIK YEVGLPTLCC
LKLAFLDPDT GKLTGGSFTM KYHDMPDVID FLVLRQQFDD AKYRPWNIGD RFRSVIDDAW
WFGTIESQEP LQPEYPDSLF QCYNVCWDNG DTEKMSPWDM ELIPNNAVFP EELGTSVPLT
DVECRSLIYK PLDGEWGANP RDEECERIVG GINQLMTLDI ASAFVAPVDL QAYPMYCTVV
AYPTDLSTIK QRLENRFYRR FSSLMWEVRY IEHNTRTFNE PGSPIVKSAK FVTDLLLHFI
KDQTCYNIIP LYNSMKKKVL SDSEEEEKDA DVPGTSTRKR KDHQPRRRLR NRAQSYDIQA
WKKQCQELLN LIFQCEDSEP FRQPVDLLEY PDYRDIIDTP MDFATVRETL EAGNYESPME
LCKDVRLIFS NFKAYTPSKR SRIYSMSLRL SAFFEEHISS VLSDYKSALR FHKRNTISKK
RKKRNRSSSL SSSAASSPER KKRILKPQLK SEVSTSPFSI PTRSVLPRHN AAQMNGKPES
SSVVRTRSNR VAVDPVVTEQ PSTSSATKAF VSKTNTSAMP GKAMLENSVR HSKALSTLSS
PDPLTFSHAT KNNSAKENME KEKPVKRKMK SSVFSKASPL PKSAAVIEQG ECKNNVLIPG
TIQVNGHGGQ PSKLVKRGPG RKPKVEVNTS SGEVTHKKRG RKPKNLQCAK QENSEQNNMH
PIRADVLPSS TCNFLSETNA VKEDLLQKKS RGGRKPKRKM KTHNLDSELI VPTNVKVLRR
SNRKKTDDPI DEEEEFEELK GSEPHMRTRN QGRRTAFYNE DDSEEEQRQL LFEDTSLTFG
TSSRGRVRKL TEKAKANLIG W


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Catalog number Product name Quantity
EIAAB30881 IRS-1 PH domain-binding protein,Mouse,Mus musculus,NDRP,Ndrp,Neuronal differentiation-related protein,PH-interacting protein,PHIP,Phip,Phip1,WD repeat-containing protein 11,Wdr11
EIAAB30882 Homo sapiens,Human,IRS-1 PH domain-binding protein,PH-interacting protein,PHIP,PHIP,WD repeat-containing protein 11,WDR11
EIAAB30470 Papin,PDZ domain-containing protein 2,PDZ domain-containing protein 3,Pdzd2,Pdzk3,Pin1,Plakophilin-related armadillo repeat protein-interacting PDZ protein,Rat,Rattus norvegicus
EIAAB37714 Homo sapiens,Human,MDA9,MDA-9,Melanoma differentiation-associated protein 9,Pro-TGF-alpha cytoplasmic domain-interacting protein 18,Scaffold protein Pbp1,SDCBP,SYCL,Syndecan-binding protein 1,Syntenin
EIAAB46365 Homo sapiens,Human,WD repeat domain phosphoinositide-interacting protein 3,WD repeat-containing protein 45-like,WDR45L,WDR45-like protein,WIPI3,WIPI-3,WIPI49-like protein
EIAAB46358 Atg18 protein homolog,Homo sapiens,Human,WD repeat domain phosphoinositide-interacting protein 1,WD40 repeat protein interacting with phosphoinositides of 49 kDa,WIPI 49 kDa,WIPI1,WIPI-1,WIPI49
EIAAB39603 54 kDa VacA-interacting protein,90 kDa N-WASP-interacting protein,90 kDa SH3 protein interacting with Nck,Mouse,Mus musculus,NCK-interacting protein with SH3 domain,Nckipsd,N-WASP-binding protein,SH3
EIAAB31218 Homo sapiens,hPIP1,Human,p21-activated protein kinase-interacting protein 1,PAK_PLC-interacting protein 1,PAK1-interacting protein 1,PAK1IP1,PIP1,WD repeat-containing protein 84,WDR84
EIAAB44014 CEV14,Clonal evolution-related gene on chromosome 14 protein,GMAP-210,Golgi-associated microtubule-binding protein 210,Homo sapiens,Human,Thyroid receptor-interacting protein 11,TR-interacting protein
EIAAB26847 Amyloid beta A4 protein-binding family A member 2-binding protein,APBA2BP,Homo sapiens,Human,NECAB3,Nek2-interacting protein 1,Neuronal calcium-binding protein 3,NIP1,N-terminal EF-hand calcium-bindin
EIAAB46364 Mouse,Mus musculus,WD repeat domain phosphoinositide-interacting protein 3,WD repeat-containing protein 45-like,Wdr45l,WDR45-like protein,Wipi3,WIPI-3
EIAAB46368 DXImx38e,Mouse,Mus musculus,WD repeat domain phosphoinositide-interacting protein 4,WD repeat domain X-linked 1,WD repeat-containing protein 45,Wdr45,Wdrx1,Wipi4,WIPI-4
EIAAB46352 Homo sapiens,Human,PP10631,WAS_WASL-interacting protein family member 2,WASP-interacting protein-related protein,WICH,WIP- and CR16-homologous protein,WIPF2,WIP-related protein,WIRE
EIAAB31325 Casein kinase 2-interacting protein 1,C-Jun-binding protein,CK2-interacting protein 1,CKIP1,CKIP-1,Homo sapiens,HQ0024c,Human,JBP,OC120,Osteoclast maturation-associated gene 120 protein,PH domain-cont
EIAAB29754 Homo sapiens,HSPC218,Human,PABP-interacting protein 2,PAIP2,PAIP-2,PAIP2A,Poly(A)-binding protein-interacting protein 2,Polyadenylate-binding protein-interacting protein 2
EIAAB29748 Homo sapiens,Human,KIAA1155,PABP-interacting protein 2B,PAIP2B,PAIP-2B,Poly(A)-binding protein-interacting protein 2B,Polyadenylate-binding protein-interacting protein 2B
EIAAB29747 Kiaa1155,Mouse,Mus musculus,PABP-interacting protein 2B,Paip2b,PAIP-2B,Poly(A)-binding protein-interacting protein 2B,Polyadenylate-binding protein-interacting protein 2B
EIAAB29749 Homo sapiens,Human,PABP-interacting protein 1,PAIP1,PAIP-1,Poly(A)-binding protein-interacting protein 1,Polyadenylate-binding protein-interacting protein 1
EIAAB29752 Bos taurus,Bovine,PABP-interacting protein 2,PAIP2,PAIP-2,Poly(A)-binding protein-interacting protein 2,Polyadenylate-binding protein-interacting protein 2
EIAAB29755 Mouse,Mus musculus,PABP-interacting protein 2,Paip2,PAIP-2,Poly(A)-binding protein-interacting protein 2,Polyadenylate-binding protein-interacting protein 2
EIAAB29750 Mouse,Mus musculus,PABP-interacting protein 1,Paip1,PAIP-1,Poly(A)-binding protein-interacting protein 1,Polyadenylate-binding protein-interacting protein 1
EIAAB29751 PABP-interacting protein 2,Paip2,PAIP-2,Poly(A)-binding protein-interacting protein 2,Polyadenylate-binding protein-interacting protein 2,Rat,Rattus norvegicus
EIAAB39347 Mouse,Mus musculus,Spata24,Spermatogenesis-associated protein 24,TATA-binding protein-like factor-interacting protein,Testis protein T6441 homolog,Tipt,Tipt2,TLF-interacting protein,TRF2-interacting p
EIAAB34872 ANKRD3,Ankyrin repeat domain-containing protein 3,DIK,Homo sapiens,Human,PKC-delta-interacting protein kinase,Receptor-interacting serine_threonine-protein kinase 4,RIPK4
EIAAB46363 Chicken,Gallus gallus,RCJMB04_8d21,WD repeat domain phosphoinositide-interacting protein 3,WD repeat protein 45-like,WDR45L,WDR45-like protein,WIPI3,WIPI-3
Pathways :
WP731: Sterol regulatory element binding protein related
WP2292: Chemokine signaling pathway
WP1689: Porphyrin and chlorophyll metabolism
WP1616: ABC transporters
WP2199: Seed Development
WP2272: Pathogenic Escherichia coli infection
WP1531: Vitamin D synthesis
WP1654: gamma-Hexachlorocyclohexane degradation
WP1049: G Protein Signaling Pathways
WP1694: Pyrimidine metabolism
WP2218: sGC
WP1438: Influenza A virus infection
WP1714: Tyrosine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1672: Mismatch repair
WP1502: Mitochondrial biogenesis
WP2371: Parkinsons Disease Pathway
WP1566: Citrate cycle (TCA cycle)
WP1888: Post-translational protein modification
WP35: G Protein Signaling Pathways
WP1676: Non-homologous end-joining
WP210: Cytoplasmic Ribosomal Proteins
WP1624: Bacterial secretion system
WP1909: Signal regulatory protein (SIRP) family interactions
WP73: G Protein Signaling Pathways

Related Genes :
[Sh2b1 Sh2-b Sh2bpsm1] SH2B adapter protein 1 (FceRI gamma-chain-interacting protein SH2-B) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
[Asap1 Ddef1 Kiaa1249 Shag1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[ASAP1 DDEF1 KIAA1249] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[PLEKHO1 CKIP1 OC120 HQ0024c] Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)
[LINGO1 LERN1 LRRN6A UNQ201/PRO227] Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1) (pp185)
[Irs1 Irs-1] Insulin receptor substrate 1 (IRS-1)
[PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP] PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
[Asap1 Ddef1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[APPL1 APPL DIP13A KIAA1428] DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)
[Appl1 Dip13a Kiaa1428] DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)
[Wdfy3] WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1)
[AGAP3 CENTG3] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1)
[Dok2 Frip] Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
[PHLPP2 KIAA0931 PHLPPL] PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)
[IRS1] Insulin receptor substrate 1 (IRS-1)
[APBA1 MINT1 X11] Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)
[APPL2 DIP13B] DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)
[APBA3 MINT3 X11L2] Amyloid-beta A4 precursor protein-binding family A member 3 (Adapter protein X11gamma) (Neuron-specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3)
[Appl2] DCC-interacting protein 13-beta (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)
[Cit Crik] Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Rho-interacting, serine/threonine-protein kinase 21)
[EGLN3] Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)
[Sh2b1 Sh2bpsm1] SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
[WDR45B WDR45L WIPI3] WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein)
[Appl2 Dip13b Dip3b] DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)
[WDR45 WDRX1 WDRXI4 WIPI4 JM5] WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)
[ASAP1 DDEF1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[Pre C,C C core E PC pre-C pre-C/C PreC preC PreC/C preC/C precore-core HBVgp4] Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
[Mapk8ip1 Ib1 Jip1 Mapk8ip] C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JIP-1-related protein) (JRP) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
[EGLN2 EIT6] Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)

Bibliography :