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Pancreas associated transcription factor 1a

 G5E6S8_BOVIN            Unreviewed;       326 AA.
G5E6S8;
14-DEC-2011, integrated into UniProtKB/TrEMBL.
10-APR-2019, sequence version 2.
07-APR-2021, entry version 60.
SubName: Full=Pancreas associated transcription factor 1a {ECO:0000313|Ensembl:ENSBTAP00000056491};
Name=PTF1A {ECO:0000313|Ensembl:ENSBTAP00000056491,
ECO:0000313|VGNC:VGNC:33498};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000056491, ECO:0000313|Proteomes:UP000009136};
[1] {ECO:0000313|Ensembl:ENSBTAP00000056491}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056491};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
[2] {ECO:0000313|Ensembl:ENSBTAP00000056491, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056491,
ECO:0000313|Proteomes:UP000009136};
Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
"ARS-UCD1.2.";
Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
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RefSeq; XP_002707767.1; XM_002707721.4.
RefSeq; XP_015321380.1; XM_015465894.1.
SMR; G5E6S8; -.
STRING; 9913.ENSBTAP00000056491; -.
PaxDb; G5E6S8; -.
Ensembl; ENSBTAT00000062968; ENSBTAP00000056491; ENSBTAG00000047315.
GeneID; 781540; -.
KEGG; bta:781540; -.
CTD; 256297; -.
VGNC; VGNC:33498; PTF1A.
eggNOG; KOG4029; Eukaryota.
GeneTree; ENSGT00940000161000; -.
HOGENOM; CLU_053709_0_0_1; -.
InParanoid; G5E6S8; -.
OMA; YCCEAGA; -.
TreeFam; TF315153; -.
Proteomes; UP000009136; Chromosome 13.
GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
GO; GO:0070888; F:E-box binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0035881; P:amacrine cell differentiation; IEA:Ensembl.
GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
GO; GO:0032502; P:developmental process; IBA:GO_Central.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0031016; P:pancreas development; IEA:Ensembl.
GO; GO:0061074; P:regulation of neural retina development; IEA:Ensembl.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0010842; P:retina layer formation; IEA:Ensembl.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
GO; GO:0009888; P:tissue development; IEA:Ensembl.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000009136}.
DOMAIN 161..213
/note="BHLH"
/evidence="ECO:0000259|PROSITE:PS50888"
REGION 78..100
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 227..277
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 294..326
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 326 AA; 35183 MW; 80B1E42FA768A4DA CRC64;
MDAVLLEHFP GGLDAFPSSY FDEEDFFTDQ SSRDPLEDGD ELLADEQAEV EFLSHQLHEY
CYRDEACLLL QSAPPAAPHA LAPPPPGGPG EPEDSGGGGY CCEAGAPPGG FPYSPGSPPS
CLAYRCAGAA ALSPRARLRG LSGAAAARRR RRVRSEAELQ QLRQAANVRE RRRMQSINDA
FEGLRSHIPT LPYEKRLSKV DTLRLAIGYI NFLSELVQAD LPLRGGGAGG GRGPGGGGRL
GADSPSSQAQ KVIICHRGTR SPSPSDPDYG LPPLAGHSLS WTDEKQLKEQ NIIRTAKVWT
PEDPRKLNSK PSFNNIENEP PFEFVS


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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP948: Eukaryotic Transcription Initiation
WP1983: Splicing factor NOVA regulated synpatic proteins
WP272: Blood Clotting Cascade
WP1182: Eukaryotic Transcription Initiation
WP1238: Eukaryotic Transcription Initiation
WP405: Eukaryotic Transcription Initiation
WP491: Eukaryotic Transcription Initiation
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1930: Transcription
WP2313: Aging
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP344: Eukaryotic Transcription Initiation
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP177: Eukaryotic Transcription Initiation
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP567: Eukaryotic Transcription Initiation
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP2148: Brain derived neurotrophic factor
WP1066: Eukaryotic Transcription Initiation

Related Genes :

Bibliography :
[31586069] Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23.
[31441606] The clinical and genetic characteristics of permanent neonatal diabetes (PNDM) in the state of Qatar.
[30143652] The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α.
[30057318] HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell.
[29442225] Feeder-cell-independent culture of the pig embryonic stem cell-derived exocrine pancreatic cell line, PICM-31.
[28593826] Exposure to static magnetic fields increases insulin secretion in rat INS-1 cells by activating the transcription of the insulin gene and up-regulating the expression of vesicle-secreted proteins.
[26382709] Mutations in the noncoding genome.
[26257060] GNAS(R201H) and Kras(G12D) cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm.
[24668915] Evidence for annular pancreas as an associated anomaly in the VATER/VACTERL association and investigation of the gene encoding pancreas specific transcription factor 1A as a candidate gene.
[23867319] KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants.