Pancreas associated transcription factor 1a

 G5E6S8_BOVIN            Unreviewed;       326 AA.
 G5E6S8;
 14-DEC-2011, integrated into UniProtKB/TrEMBL.
 10-APR-2019, sequence version 2.
 07-APR-2021, entry version 60.
 SubName: Full=Pancreas associated transcription factor 1a {ECO:0000313|Ensembl:ENSBTAP00000056491};
 Name=PTF1A {ECO:0000313|Ensembl:ENSBTAP00000056491,
 ECO:0000313|VGNC:VGNC:33498};
 Bos taurus (Bovine).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
 Bovinae; Bos.
 NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000056491, ECO:0000313|Proteomes:UP000009136};
 [1] {ECO:0000313|Ensembl:ENSBTAP00000056491}
 IDENTIFICATION.
 STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056491};
 Ensembl;
 Submitted (MAR-2016) to UniProtKB.
 [2] {ECO:0000313|Ensembl:ENSBTAP00000056491, ECO:0000313|Proteomes:UP000009136}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056491,
 ECO:0000313|Proteomes:UP000009136};
 Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
 Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
 Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
 "ARS-UCD1.2.";
 Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
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 RefSeq; XP_002707767.1; XM_002707721.4.
 RefSeq; XP_015321380.1; XM_015465894.1.
 SMR; G5E6S8; -.
 STRING; 9913.ENSBTAP00000056491; -.
 PaxDb; G5E6S8; -.
 Ensembl; ENSBTAT00000062968; ENSBTAP00000056491; ENSBTAG00000047315.
 GeneID; 781540; -.
 KEGG; bta:781540; -.
 CTD; 256297; -.
 VGNC; VGNC:33498; PTF1A.
 eggNOG; KOG4029; Eukaryota.
 GeneTree; ENSGT00940000161000; -.
 HOGENOM; CLU_053709_0_0_1; -.
 InParanoid; G5E6S8; -.
 OMA; YCCEAGA; -.
 TreeFam; TF315153; -.
 Proteomes; UP000009136; Chromosome 13.
 GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
 GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
 GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
 GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
 GO; GO:0070888; F:E-box binding; IEA:Ensembl.
 GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
 GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
 GO; GO:0035881; P:amacrine cell differentiation; IEA:Ensembl.
 GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
 GO; GO:0032502; P:developmental process; IBA:GO_Central.
 GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
 GO; GO:0031016; P:pancreas development; IEA:Ensembl.
 GO; GO:0061074; P:regulation of neural retina development; IEA:Ensembl.
 GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
 GO; GO:0010842; P:retina layer formation; IEA:Ensembl.
 GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
 GO; GO:0009888; P:tissue development; IEA:Ensembl.
 Gene3D; 4.10.280.10; -; 1.
 InterPro; IPR011598; bHLH_dom.
 InterPro; IPR036638; HLH_DNA-bd_sf.
 Pfam; PF00010; HLH; 1.
 SMART; SM00353; HLH; 1.
 SUPFAM; SSF47459; SSF47459; 1.
 PROSITE; PS50888; BHLH; 1.
 4: Predicted;
 Reference proteome {ECO:0000313|Proteomes:UP000009136}.
 DOMAIN          161..213
                 /note="BHLH"
                 /evidence="ECO:0000259|PROSITE:PS50888"
 REGION          78..100
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          227..277
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 REGION          294..326
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 SEQUENCE   326 AA;  35183 MW;  80B1E42FA768A4DA CRC64;
 MDAVLLEHFP GGLDAFPSSY FDEEDFFTDQ SSRDPLEDGD ELLADEQAEV EFLSHQLHEY
 CYRDEACLLL QSAPPAAPHA LAPPPPGGPG EPEDSGGGGY CCEAGAPPGG FPYSPGSPPS
 CLAYRCAGAA ALSPRARLRG LSGAAAARRR RRVRSEAELQ QLRQAANVRE RRRMQSINDA
 FEGLRSHIPT LPYEKRLSKV DTLRLAIGYI NFLSELVQAD LPLRGGGAGG GRGPGGGGRL
 GADSPSSQAQ KVIICHRGTR SPSPSDPDYG LPPLAGHSLS WTDEKQLKEQ NIIRTAKVWT
 PEDPRKLNSK PSFNNIENEP PFEFVS

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