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Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (Transcription factor Ptf1a/p48)

 PTF1A_XENLA             Reviewed;         270 AA.
Q4ZHW1;
02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
07-JUN-2005, sequence version 1.
16-JAN-2019, entry version 59.
RecName: Full=Pancreas transcription factor 1 subunit alpha;
AltName: Full=Pancreas-specific transcription factor 1a;
AltName: Full=Transcription factor Ptf1a/p48;
Name=ptf1a;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
Afelik S., Chen Y., Pieler T.;
"Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the
stable conversion of posterior endoderm into endo- and exocrine
pancreatic tissue.";
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Transcription factor implicated in the cell fate
determination in various organs. Binds to the E-box consensus
sequence 5'-CANNTG-3'. Acts together with pdx1 to induce the
pancreatic lineage within the endoderm. Plays a central role in
directing the differentiation of retinal progenitors towards
horizontal and amacrine fates. {ECO:0000269|Ref.1}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981}.
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EMBL; DQ007931; AAY23360.1; -; mRNA.
RefSeq; NP_001167491.1; NM_001174020.1.
UniGene; Xl.29862; -.
UniGene; Xl.85876; -.
ProteinModelPortal; Q4ZHW1; -.
SMR; Q4ZHW1; -.
PRIDE; Q4ZHW1; -.
GeneID; 100381084; -.
KEGG; xla:100381084; -.
CTD; 100381084; -.
Xenbase; XB-GENE-6466546; ptf1a.
HOVERGEN; HBG082224; -.
KO; K09073; -.
OrthoDB; 1269550at2759; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005667; C:transcription factor complex; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0031017; P:exocrine pancreas development; ISS:UniProtKB.
GO; GO:0048699; P:generation of neurons; ISS:UniProtKB.
GO; GO:0030902; P:hindbrain development; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; ISS:UniProtKB.
GO; GO:0009888; P:tissue development; ISS:UniProtKB.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
2: Evidence at transcript level;
DNA-binding; Nucleus; Transcription; Transcription regulation.
CHAIN 1 270 Pancreas transcription factor 1 subunit
alpha.
/FTId=PRO_0000233147.
DOMAIN 119 171 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COMPBIAS 20 69 Asp-rich.
SEQUENCE 270 AA; 30522 MW; E887B2A997F6A27E CRC64;
METVLEQLAG LESFPSPYFD EDDFFTDHSS RDALDADDFL EDDVDFLAGQ IQDYYRDSRV
LHTDDDYCDA GNFSFSSSSS GGFPYECGDG GCDLSPGMKG GSLVMKRRRR LRSDAEMQQL
RQAANVRERR RMQSINDAFE GLRSHIPTLP YEKRLSKVDT LRLAIGYINF LSEMVQSDLP
LRNPNSDSGN QPKKVIICHR GTRSPSPSDP DYGLPPLAGH SLSWTDEKQL RDQNVVRTAK
VWTPEDPRKL NKSPFSNIEN EPPLTLCLDM


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