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Peptide receptor GPCR

 Q7YTE8_DROME            Unreviewed;       545 AA.
Q7YTE8;
01-OCT-2003, integrated into UniProtKB/TrEMBL.
01-OCT-2003, sequence version 1.
08-MAY-2019, entry version 77.
SubName: Full=Peptide receptor GPCR {ECO:0000313|EMBL:AAP50844.1};
Name=Proc-R {ECO:0000313|FlyBase:FBgn0029723};
ORFNames=CG6986 {ECO:0000313|FlyBase:FBgn0029723};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:AAP50844.1};
[1] {ECO:0000313|EMBL:AAP50844.1}
NUCLEOTIDE SEQUENCE.
PubMed=12804582; DOI=10.1016/S0006-291X(03)00997-5;
Egerod K., Reynisson E., Hauser F., Williamson M., Cazzamali G.,
Grimmelikhuijzen C.J.;
"Molecular identification of the first insect proctolin receptor.";
Biochem. Biophys. Res. Commun. 306:437-442(2003).
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000256|RuleBase:RU000688}.
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EMBL; AY268061; AAP50844.1; -; mRNA.
PRIDE; Q7YTE8; -.
FlyBase; FBgn0029723; Proc-R.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
Bgee; FBgn0029723; Expressed in 6 organ(s), highest expression level in head.
GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
GO; GO:0005887; C:integral component of plasma membrane; IDA:FlyBase.
GO; GO:0004930; F:G protein-coupled receptor activity; ISS:FlyBase.
GO; GO:0008188; F:neuropeptide receptor activity; ISM:FlyBase.
GO; GO:0035236; F:proctolin receptor activity; IDA:FlyBase.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:FlyBase.
GO; GO:0007218; P:neuropeptide signaling pathway; IDA:FlyBase.
InterPro; IPR019427; 7TM_GPCR_serpentine_rcpt_Srw.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
Pfam; PF10324; 7TM_GPCR_Srw; 1.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
Membrane {ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|RuleBase:RU000688};
Transducer {ECO:0000256|RuleBase:RU000688};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 45 65 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 77 96 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 116 137 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 157 178 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 354 383 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 420 444 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 456 480 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 57 477 G_PROTEIN_RECEP_F1_2.
{ECO:0000259|PROSITE:PS50262}.
SEQUENCE 545 AA; 61084 MW; 8031598517F56BD3 CRC64;
MTMSSTSTAT ATSTATATLD EANATVGEMF SDADMAEVRH VVQRILVPCV FVIGLLGNSV
SIYVLTRKRM RCTTNIYLTA LAITDIAYLT CQLILSLQHY DYPKYHFKLY WQLYGYFVWL
CDSFGYISIY IAVCFTIERF IAIRYPLKRQ TFCTESLAKK VIAAVAIFCL LSTLSTAFEH
TITIGTRQID DAYQPCNQTV ANISPMPPSP VAVTPPLATP PLPTPATIWQ SPDSAMESTT
SGSSNQLVDW GSGSGDGEPE NIPRHRRHWQ SSGFVTLPTL RKTLEEQDQE VADAGQGSGV
TESLLQLWRR KRSAENHNIN NTDAFAFNVT EYCQNVTYYN HGLSELGYDE LYSYLWNLFT
LLVFVVFPLL LLATFNSILI LLVHRSKNLR GDLTNASSIR RTKRKSNSGL KGSVSQENRV
TITLIAVVLM FIVCQLPWAI YLIVNQYMEI QIGTQVVAGN VCNLLASLHA ASNFFLYCVL
SDKYRKTVRE LITGYRYRRR HARNNTSLYV PHTTTTLTQI NGDHYGSNYG GAGSRRNRNT
GRLIA


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Bibliography :
[31436539] Understanding peptide binding in Class A G protein-coupled receptors.
[31421700] Structure and dynamics of dynorphin peptide and its receptor.
[31418572] O-GlcNAc engineering of GPCR peptide-agonists improves their stability and in vivo activity.
[31418558] TMT labeling facilitates RPLC-MS analysis of hydrophilic phosphopeptides.
[31416915] Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain.
[31384473] Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis.
[31359103] In vitro affinity maturation of antibody against membrane-bound GPCR molecules.
[31358824] High-throughput identification of peptide agonists against GPCRs by co-culture of mammalian reporter cells and peptide-secreting yeast cells using droplet microfluidics.
[31357423] Simultaneous Ligand and Receptor Tracking through NMR Spectroscopy Enabled by Distinct F Labels.
[31333754] A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of .