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Phosphonoacetate hydrolase

 A0A1H2BFI1_PSESX        Unreviewed;       125 AA.
A0A1H2BFI1;
18-JAN-2017, integrated into UniProtKB/TrEMBL.
18-JAN-2017, sequence version 1.
31-JAN-2018, entry version 9.
SubName: Full=Phosphonoacetate hydrolase {ECO:0000313|EMBL:SDM40690.1};
ORFNames=SAMN05444505_102638 {ECO:0000313|EMBL:SDM40690.1};
Pseudomonas syringae.
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
Pseudomonadaceae; Pseudomonas.
NCBI_TaxID=317 {ECO:0000313|EMBL:SDM40690.1, ECO:0000313|Proteomes:UP000183853};
[1] {ECO:0000313|EMBL:SDM40690.1, ECO:0000313|Proteomes:UP000183853}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=BS2122 {ECO:0000313|EMBL:SDM40690.1,
ECO:0000313|Proteomes:UP000183853};
de Groot N.N.;
Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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EMBL; FNHM01000002; SDM40690.1; -; Genomic_DNA.
RefSeq; WP_003365769.1; NZ_NHSZ01000254.1.
Proteomes; UP000183853; Unassembled WGS sequence.
GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
InterPro; IPR004624; PhnA.
InterPro; IPR013988; PhnA_C.
InterPro; IPR013987; PhnA_N.
PANTHER; PTHR30305:SF3; PTHR30305:SF3; 1.
Pfam; PF03831; PhnA; 1.
Pfam; PF08274; PhnA_Zn_Ribbon; 1.
TIGRFAMs; TIGR00686; phnA; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000183853};
Hydrolase {ECO:0000313|EMBL:SDM40690.1}.
SEQUENCE 125 AA; 13457 MW; 665599DF68868637 CRC64;
MHGFTLLDAR TIVSLPSCPK CNSEYTYEDG SLLICPECAH EWSADAAGAD ASDDVKVIKD
STGNMLQDGD TVTVIKDLKV KGSSLVVKVG TKVKNIRLVD GDHDIDCKID GIGAMKLKSE
FVRKV


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1000: Arachidonate Epoxygenase Epoxide Hydrolase
WP1116: Arachidonate Epoxygenase Epoxide Hydrolase
WP1250: Arachidonate Epoxygenase Epoxide Hydrolase
WP1285: Arachidonate Epoxygenase Epoxide Hydrolase
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP678: Arachidonate Epoxygenase / Epoxide Hydrolase
WP882: Arachidonate Epoxygenase Epoxide Hydrolase

Related Genes :
[phnA] Phosphonoacetate hydrolase (EC 3.11.1.2)
[] Phosphonoacetate hydrolase (PA-hydrolase) (EC 3.11.1.2) (Fragments)
[phnA] Phosphonoacetate hydrolase (EC 3.11.1.2)
[phnA] Phosphonoacetate hydrolase (EC 3.11.1.2)
[hsaD bphD Rv3569c] 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase (EC 3.7.1.17) (2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase) (HOPDA hydrolase) (EC 3.7.1.8) (Meta-cleavage product hydrolase) (MCP hydrolase)
[mhpC b0349 JW0340] 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase (EC 3.7.1.14) (2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase) (2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioic acid 5,6-hydrolase) (2-hydroxy-6-oxonona-2,4-diene-1,9-dioic acid 5,6-hydrolase)
[ndx1] Diadenosine hexaphosphate hydrolase (Ap6A hydrolase) (EC 3.6.1.61) (ATP-generating (di)nucleotide polyphosphate hydrolase) (ATP-generating Ap6A hydrolase) (Nudix protein)
[Ggt5 Ggtla1] Glutathione hydrolase 5 proenzyme (EC 3.4.19.13) (Gamma-glutamyl leukotrienase) (GGL) (Gamma-glutamyl transpeptidase-related enzyme) (GGT-rel) (Gamma-glutamyltransferase 5) (GGT 5) (EC 2.3.2.2) (Gamma-glutamyltransferase-like activity 1) (Gamma-glutamyltranspeptidase 5) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) [Cleaved into: Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain]
[GGT1 GGT] Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]
[Ggt1 Ggt Ggtp] Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]
[GGT5 GGTLA1] Glutathione hydrolase 5 proenzyme (EC 3.4.19.13) (Gamma-glutamyl transpeptidase-related enzyme) (GGT-rel) (Gamma-glutamyltransferase 5) (GGT 5) (EC 2.3.2.2) (Gamma-glutamyltransferase-like activity 1) (Gamma-glutamyltranspeptidase 5) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) [Cleaved into: Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain]
[Ggt5 Ggtla1] Glutathione hydrolase 5 proenzyme (EC 3.4.19.13) (Gamma-glutamyl leukotrienase) (GGL) (Gamma-glutamyltransferase 5) (GGT 5) (EC 2.3.2.2) (Gamma-glutamyltransferase-like activity 1) (Gamma-glutamyltranspeptidase 5) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) [Cleaved into: Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain]
[GGT1 GGT] Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]
[Ggt1 Ggt] Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]
[LTA4H LTA4] Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase)
[EPHX2] Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)]
[Ephx2] Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)]
[Ephx2 Eph2] Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)]
[LAP2 YNL045W N2535] Leucine aminopeptidase 2 (EC 3.4.11.-) (Epoxide hydrolase) (EC 3.3.2.10) (Leucyl aminopeptidase yscIV) (AP IV) (Leukotriene A-4 hydrolase homolog) (LTA-4 hydrolase)
[bphD Bxeno_C1120 Bxe_C1186] 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (HOPDA hydrolase) (EC 3.7.1.8) (2,6-dioxo-6-phenylhexa-3-enoate hydrolase)
[BPHL MCNAA] Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA)
[Lta4h] Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase)
[CD38] ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38)
[Acot7 Bach] Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase)
[ACOT7 BACH] Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase)
[Aoah] Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit]
[ggt b3447 JW3412] Glutathione hydrolase proenzyme (EC 3.4.19.13) (Gamma-glutamyltranspeptidase proenzyme) (GGT) (EC 2.3.2.2) [Cleaved into: Glutathione hydrolase large chain; Glutathione hydrolase small chain]
[ndx-4 Y37H9A.6] Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC 3.6.1.-) (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Ap4A hydrolase) (Ap4Aase) (Diadenosine tetraphosphatase) (Nudix hydrolase 4)
[AOAH] Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit]
[Acot7 Bach] Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (ACH1) (ACT) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-IIb) (CTE-II) (LACH1) (Long chain acyl-CoA thioester hydrolase) (MTE-II)

Bibliography :
[23828485] A microfluidic approach for protein structure determination at room temperature via on-chip anomalous diffraction.
[22303297] The genes and enzymes of phosphonate metabolism by bacteria, and their distribution in the marine environment.
[22035792] Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase.
[21861368] Phosphonoacetate biosynthesis: in vitro detection of a novel NADP(+)-dependent phosphonoacetaldehyde-oxidizing activity in cell-extracts of the marine Roseovarius nubinhibens ISM.
[21543322] Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021.
[21366328] Divergence of chemical function in the alkaline phosphatase superfamily: structure and mechanism of the P-C bond cleaving enzyme phosphonoacetate hydrolase.
[19956272] Evidence for phosphonate usage in the coral holobiont.
[21261917] The construction of a whole-cell biosensor for phosphonoacetate, based on the LysR-like transcriptional regulator PhnR from Pseudomonas fluorescens 23F.
[18783384] Potential for phosphonoacetate utilization by marine bacteria in temperate coastal waters.
[17584470] RT-TGGE as a guide for the successful isolation of phosphonoacetate degrading bacteria.