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Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD( ) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1)

 PARP1_BOVIN             Reviewed;        1016 AA.
P18493; Q9TS00;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
13-FEB-2019, entry version 165.
RecName: Full=Poly [ADP-ribose] polymerase 1;
Short=PARP-1;
EC=2.4.2.30 {ECO:0000250|UniProtKB:P09874};
AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 1;
Short=ARTD1;
AltName: Full=DNA ADP-ribosyltransferase PARP1 {ECO:0000250|UniProtKB:P09874};
EC=2.4.2.- {ECO:0000250|UniProtKB:P09874};
AltName: Full=NAD(+) ADP-ribosyltransferase 1;
Short=ADPRT 1;
AltName: Full=Poly[ADP-ribose] synthase 1;
AltName: Full=Protein poly-ADP-ribosyltransferase PARP1 {ECO:0000250|UniProtKB:P09874};
EC=2.4.2.- {ECO:0000250|UniProtKB:P09874};
Name=PARP1; Synonyms=ADPRT;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2119324; DOI=10.1016/0378-1119(90)90187-V;
Saito I., Hatakeyama K., Kido T., Ohkubo H., Nakanishi S., Ueda K.;
"Cloning of a full-length cDNA encoding bovine thymus poly(ADP-ribose)
synthetase: evolutionarily conserved segments and their potential
functions.";
Gene 90:249-254(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 648-715 AND 839-904.
PubMed=2450019; DOI=10.1111/j.1432-1033.1988.tb13826.x;
Taniguchi T., Yamauchi K., Yamamoto T., Toyoshima K., Harada N.,
Tanaka H., Takahashi S., Yamamoto H., Fujimoto S.;
"Depression in gene expression for poly(ADP-ribose) synthetase during
the interferon-gamma-induced activation process of murine macrophage
tumor cells.";
Eur. J. Biochem. 171:571-575(1988).
-!- FUNCTION: Poly-ADP-ribosyltransferase that mediates poly-ADP-
ribosylation of proteins and plays a key role in DNA repair.
Mainly mediates glutamate and aspartate ADP-ribosylation of target
proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the
acceptor carboxyl group of glutamate and aspartate residues and
further ADP-ribosyl groups are transferred to the 2'-position of
the terminal adenosine moiety, building up a polymer with an
average chain length of 20-30 units. Mediates the poly(ADP-
ribosyl)ation of a number of proteins, including itself, APLF and
CHFR. Also mediates serine ADP-ribosylation of target proteins
following interaction with HPF1; HPF1 conferring serine
specificity. Probably also catalyzes tyrosine ADP-ribosylation of
target proteins following interaction with HPF1. Catalyzes the
poly-ADP-ribosylation of histones in a HPF1-dependent manner.
Involved in the base excision repair (BER) pathway by catalyzing
the poly-ADP-ribosylation of a limited number of acceptor proteins
involved in chromatin architecture and in DNA metabolism. ADP-
ribosylation follows DNA damage and appears as an obligatory step
in a detection/signaling pathway leading to the reparation of DNA
strand breaks. In addition to base excision repair (BER) pathway,
also involved in double-strand breaks (DSBs) repair: together with
TIMELESS, accumulates at DNA damage sites and promotes homologous
recombination repair by mediating poly-ADP-ribosylation. In
addition to proteins, also able to ADP-ribosylate DNA: catalyzes
ADP-ribosylation of DNA strand break termini containing terminal
phosphates and a 2'-OH group in single- and double-stranded DNA,
respectively. Required for PARP9 and DTX3L recruitment to DNA
damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination
promotes the rapid and specific recruitment of 53BP1/TP53BP1,
UIMC1/RAP80, and BRCA1 to DNA damage sites. Acts as a regulator of
transcription: positively regulates the transcription of MTUS1 and
negatively regulates the transcription of MTUS2/TIP150. With
EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1)
cell-specific transcription factor and binds the promoter of IFN-
gamma to directly regulate its transcription, and is thus involved
importantly in Th1 cytokine production. Involved in the synthesis
of ATP in the nucleus, together with NMNAT1, PARG and NUDT5.
Nuclear ATP generation is required for extensive chromatin
remodeling events that are energy-consuming.
{ECO:0000250|UniProtKB:P09874}.
-!- CATALYTIC ACTIVITY:
Reaction=NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide +
(ADP-D-ribosyl)(n+1)-acceptor.; EC=2.4.2.30;
Evidence={ECO:0000250|UniProtKB:P09874};
-!- CATALYTIC ACTIVITY:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-
aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424,
Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154,
ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102;
Evidence={ECO:0000250|UniProtKB:P09874};
-!- CATALYTIC ACTIVITY:
Reaction=L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-
(ADP-D-ribosyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:58236,
Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:15092, ChEBI:CHEBI:15378,
ChEBI:CHEBI:17154, ChEBI:CHEBI:46858, ChEBI:CHEBI:57540,
ChEBI:CHEBI:142557; Evidence={ECO:0000250|UniProtKB:P09874};
-!- CATALYTIC ACTIVITY:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-
glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224,
Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154,
ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540;
Evidence={ECO:0000250|UniProtKB:P09874};
-!- CATALYTIC ACTIVITY:
Reaction=L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-
(ADP-D-ribosyl)-L-seryl-[protein]; Xref=Rhea:RHEA:58232,
Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:15091, ChEBI:CHEBI:15378,
ChEBI:CHEBI:17154, ChEBI:CHEBI:29999, ChEBI:CHEBI:57540,
ChEBI:CHEBI:142556; Evidence={ECO:0000250|UniProtKB:P09874};
-!- SUBUNIT: Homo- and heterodimer with PARP2. Interacts with APTX (By
similarity). Component of a base excision repair (BER) complex,
containing at least XRCC1, PARP1, PARP2, POLB and LRIG3 (By
similarity). Interacts with SRY (By similarity). The SWAP complex
consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 (By
similarity). Interacts with PARP3; leading to activate PARP1 in
absence of DNA (By similarity). Interacts (when poly-ADP-
ribosylated) with CHD1L. Interacts with the DNA polymerase alpha
catalytic subunit POLA1; this interaction functions as part of the
control of replication fork progression. Interacts with EEF1A1 and
TXK. Interacts with RNF4. Interacts with RNF146. Interacts with
ZNF423. Interacts with APLF. Interacts with SNAI1 (via zinc
fingers); the interaction requires SNAI1 to be poly-ADP-
ribosylated and non-phosphorylated (active) by GSK3B. Interacts
(when poly-ADP-ribosylated) with PARP9 (By similarity). Interacts
with NR4A3; activates PARP1 by improving acetylation of PARP1 and
suppressing the interaction between PARP1 and SIRT1 (By
similarity). Interacts (via catalytic domain) with PUM3; the
interaction inhibits the poly-ADP-ribosylation activity of PARP1
and the degradation of PARP1 by CASP3 following genotoxic stress.
Interacts (via the PARP catalytic domain) with HPF1. Interacts
with ZNF365. Interacts with RRP1B. Interacts with TIMELESS; the
interaction is direct. Interacts with CGAS; leading to impede the
formation of the PARP1-TIMELESS complex (By similarity).
{ECO:0000250|UniProtKB:P09874, ECO:0000250|UniProtKB:P11103,
ECO:0000250|UniProtKB:P27008}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P09874}.
Nucleus, nucleolus {ECO:0000250|UniProtKB:P09874}. Chromosome
{ECO:0000250|UniProtKB:P09874}. Note=Localizes to sites of DNA
damage. {ECO:0000250|UniProtKB:P09874}.
-!- PTM: Phosphorylated by PRKDC and TXK.
{ECO:0000250|UniProtKB:P09874}.
-!- PTM: Poly-ADP-ribosylated on glutamate and aspartate residues by
autocatalysis. Poly-ADP-ribosylated by PARP2; poly-ADP-
ribosylation mediates the recruitment of CHD1L to DNA damage
sites. ADP-ribosylated on serine by autocatalysis; serine ADP-
ribosylation takes place following interaction with HPF1.
{ECO:0000250|UniProtKB:P09874}.
-!- PTM: S-nitrosylated, leading to inhibit transcription regulation
activity. {ECO:0000250|UniProtKB:P11103}.
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EMBL; D90073; BAA14114.1; -; mRNA.
EMBL; X06986; CAA30046.1; -; mRNA.
EMBL; X06987; CAA30047.1; -; mRNA.
PIR; JS0428; JS0428.
RefSeq; NP_777176.1; NM_174751.2.
UniGene; Bt.4803; -.
ProteinModelPortal; P18493; -.
SMR; P18493; -.
STRING; 9913.ENSBTAP00000001113; -.
BindingDB; P18493; -.
ChEMBL; CHEMBL5691; -.
PaxDb; P18493; -.
PeptideAtlas; P18493; -.
PRIDE; P18493; -.
GeneID; 286764; -.
KEGG; bta:286764; -.
CTD; 142; -.
eggNOG; KOG1037; Eukaryota.
eggNOG; ENOG410XP18; LUCA.
HOGENOM; HOG000030402; -.
HOVERGEN; HBG053513; -.
InParanoid; P18493; -.
KO; K10798; -.
OrthoDB; 909382at2759; -.
PRO; PR:P18493; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0005635; C:nuclear envelope; ISS:AgBase.
GO; GO:0005730; C:nucleolus; ISS:AgBase.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0090734; C:site of DNA damage; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IBA:GO_Central.
GO; GO:1990404; F:protein ADP-ribosylase activity; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:1990966; P:ATP generation from poly-ADP-D-ribose; ISS:UniProtKB.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
GO; GO:0030592; P:DNA ADP-ribosylation; ISS:UniProtKB.
GO; GO:0006302; P:double-strand break repair; ISS:UniProtKB.
GO; GO:0018424; P:peptidyl-glutamic acid poly-ADP-ribosylation; ISS:UniProtKB.
GO; GO:0018312; P:peptidyl-serine ADP-ribosylation; ISS:UniProtKB.
GO; GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.
GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
GO; GO:0006471; P:protein ADP-ribosylation; ISS:UniProtKB.
GO; GO:0070213; P:protein auto-ADP-ribosylation; ISS:UniProtKB.
GO; GO:0070212; P:protein poly-ADP-ribosylation; ISS:UniProtKB.
CDD; cd00027; BRCT; 1.
Gene3D; 1.20.142.10; -; 1.
Gene3D; 2.20.140.10; -; 1.
Gene3D; 2.20.25.630; -; 1.
Gene3D; 3.30.1740.10; -; 2.
Gene3D; 3.40.50.10190; -; 1.
InterPro; IPR001357; BRCT_dom.
InterPro; IPR036420; BRCT_dom_sf.
InterPro; IPR012982; PADR1.
InterPro; IPR038650; PADR1_dom_sf.
InterPro; IPR008288; PARP.
InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
InterPro; IPR004102; Poly(ADP-ribose)pol_reg_dom.
InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
InterPro; IPR036930; WGR_dom_sf.
InterPro; IPR008893; WGR_domain.
InterPro; IPR001510; Znf_PARP.
InterPro; IPR036957; Znf_PARP_sf.
Pfam; PF00533; BRCT; 1.
Pfam; PF08063; PADR1; 1.
Pfam; PF00644; PARP; 1.
Pfam; PF02877; PARP_reg; 1.
Pfam; PF05406; WGR; 1.
Pfam; PF00645; zf-PARP; 2.
PIRSF; PIRSF000489; NAD_ADPRT; 1.
SMART; SM00292; BRCT; 1.
SMART; SM01335; PADR1; 1.
SMART; SM00773; WGR; 1.
SMART; SM01336; zf-PARP; 2.
SUPFAM; SSF142921; SSF142921; 1.
SUPFAM; SSF47587; SSF47587; 1.
SUPFAM; SSF52113; SSF52113; 1.
PROSITE; PS50172; BRCT; 1.
PROSITE; PS51060; PARP_ALPHA_HD; 1.
PROSITE; PS51059; PARP_CATALYTIC; 1.
PROSITE; PS00347; PARP_ZN_FINGER_1; 2.
PROSITE; PS50064; PARP_ZN_FINGER_2; 2.
2: Evidence at transcript level;
Acetylation; ADP-ribosylation; Chromosome; Complete proteome;
DNA damage; DNA repair; DNA-binding; Glycosyltransferase;
Isopeptide bond; Metal-binding; NAD; Nucleus; Phosphoprotein;
Reference proteome; Repeat; Transcription; Transcription regulation;
Transferase; Ubl conjugation; Zinc; Zinc-finger.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P09874}.
CHAIN 2 1016 Poly [ADP-ribose] polymerase 1.
/FTId=PRO_0000211318.
DOMAIN 387 478 BRCT. {ECO:0000255|PROSITE-
ProRule:PRU00033}.
DOMAIN 664 781 PARP alpha-helical. {ECO:0000255|PROSITE-
ProRule:PRU00398}.
DOMAIN 790 1016 PARP catalytic. {ECO:0000255|PROSITE-
ProRule:PRU00397}.
DNA_BIND 2 375 {ECO:0000250|UniProtKB:P09874}.
ZN_FING 9 93 PARP-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00264}.
ZN_FING 116 206 PARP-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00264}.
REGION 376 526 Automodification domain.
{ECO:0000250|UniProtKB:P09874}.
MOTIF 210 212 Nuclear localization signal.
{ECO:0000250|UniProtKB:P09874}.
MOTIF 224 229 Nuclear localization signal.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 41 41 Phosphoserine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 100 100 N6-acetyllysine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 108 108 N6-acetyllysine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 134 134 N6-acetyllysine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 180 180 Phosphoserine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 188 188 Phosphoserine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 277 277 Phosphoserine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 280 280 Phosphoserine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 389 389 PolyADP-ribosyl aspartic acid.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 409 409 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 415 415 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 437 437 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 446 446 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 447 447 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 450 450 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 458 458 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 473 473 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 486 486 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 490 490 PolyADP-ribosyl glutamic acid.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 493 493 PolyADP-ribosyl glutamic acid.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 501 501 ADP-ribosylserine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 509 509 ADP-ribosylserine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 515 515 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 516 516 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 521 521 ADP-ribosylserine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 522 522 PolyADP-ribosyl glutamic acid.
{ECO:0000255}.
MOD_RES 602 602 N6-acetyllysine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 623 623 N6-acetyllysine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 784 784 Phosphoserine.
{ECO:0000250|UniProtKB:P09874}.
MOD_RES 788 788 Phosphoserine.
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 206 206 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1);
alternate.
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 206 206 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2);
alternate.
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 252 252 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 469 469 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 488 488 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1);
alternate.
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 488 488 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2);
alternate.
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 514 514 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 530 530 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 750 750 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1);
alternate.
{ECO:0000250|UniProtKB:P09874}.
CROSSLNK 750 750 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2);
alternate.
{ECO:0000250|UniProtKB:P09874}.
SEQUENCE 1016 AA; 113486 MW; 11630D94F04F5B02 CRC64;
MAESSDKLYR VEYAKSGRAS CKKCKESIPK DSIRMAFMVE SPMFDGKIPH WYHLSCFWKV
GFSIWHPDVE VEGFSELRWD DQQTIKKMAE TGGRTDVSGK GQDGVGSKTE KTLIDFGAGY
AKSNRSTCKS CMEKIDKGQV RLSKKVVYPD KPQLGMVDCW YHPKCFVQKR EELGFRPEFS
ATHLMGFSVL TAEDQETLKK QLPAIKGERK RKGDEVDGID EVTKKKSKKE KDKEIKLEKA
LKAQNDLIWN VKDELKKACS TNDLKELLIF NKQEVPSGES AILDRVADGM VFGALLPCEE
CSGQLVFKGD AYYCTGDVTA WTKCMVKTQT PNRKEWVTPK EFREISYFKK LKIKKQDRIF
PPESSTPVGA AAPPSAASAP AAVHSGPPDK PLSNMKILTL GKLSQNKDEV KATIEKLGGK
LTGTANKASL CISTKKEVDK LNKKMEEVKE ANIRVVSEDF LQDISASTKS LQELLSTHLL
SPWGAEVKVE PVEAVGPKGK SGAAPSKKSK GPVKEEGTNK SEKRMKLTLK GGAAVDPDSG
LEHNAHVLEK GGKVFSATLG LVDIVKGTNS YYKLQLLEDD KESRYWIFRS WGRVGTVIGS
NKLEQMPSKE DAIEHFMKLY EEKTGNAWHS KNFTKHPKKF YPLEIDYGQD EEAVKKLTVN
PGTKSKLPKP VQNLIKMIFD VESMKKAMVE YEIDLQKMPL GKLSKRQIQA AYSILSEVQQ
ALSQGSSDSH ILDLSNRFYT LIPHDFGMKK PPLLNNANSV QAKVEMLDNL LDIEVAYSLL
RGGSDDSSKD PIDVNYEKLK TDIKVVDKDS EEAEIIRKYV KNTHATTHNA YDLEVVDIFK
IEREGESQRY KPFKQLHNRR LLWHGSRTTN FAGILSQGLR IAPPEAPVTG YMFGKGIYFA
DMVSKSANYC HTSQGDPIGL ILLGEAALGN MYELKHARHI SKLPKGKHSV KGLGKTTPDP
SASITVDGVE VPLGTGISSG VNDTCLLYNE YIVYDIAQVH LKYLLKLKFN FKTSLW


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E0947b ELISA kit ADPRT,ADPRT 1,Bos taurus,Bovine,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
E0947b ELISA ADPRT,ADPRT 1,Bos taurus,Bovine,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
EIAAB29923 Adprt2,ADPRT-2,Adprtl2,Aspartl2,Mouse,mPARP-2,Mus musculus,NAD(+) ADP-ribosyltransferase 2,pADPRT-2,Parp2,PARP-2,Poly [ADP-ribose] polymerase 2,Poly[ADP-ribose] synthase 2
EIAAB29924 ADPRT2,ADPRT-2,ADPRTL2,Homo sapiens,hPARP-2,Human,NAD(+) ADP-ribosyltransferase 2,pADPRT-2,PARP2,PARP-2,Poly [ADP-ribose] polymerase 2,Poly[ADP-ribose] synthase 2
EIAAB29925 ADPRT3,ADPRT-3,ADPRTL3,Homo sapiens,hPARP-3,Human,IRT1,NAD(+) ADP-ribosyltransferase 3,pADPRT-3,PARP3,PARP-3,Poly [ADP-ribose] polymerase 3,Poly[ADP-ribose] synthase 3
E0947c ELISA kit ADPRT,ADPRT 1,Chicken,Gallus gallus,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
U0947c CLIA ADPRT,ADPRT 1,Chicken,Gallus gallus,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
E0947c ELISA ADPRT,ADPRT 1,Chicken,Gallus gallus,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
18-003-42429 Poly [ADP-ribose] polymerase 1 - EC 2.4.2.30; PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1 Polyclonal 0.1 mg Protein A
18-003-42430 Poly [ADP-ribose] polymerase 2 - EC 2.4.2.30; PARP-2; NAD(+) ADP-ribosyltransferase 2; Poly[ADP-ribose] synthetase 2; pADPRT-2; hPARP-2 Polyclonal 0.05 mg Aff Pur
20-272-190972 cleaved PARP - Mouse monoclonal [194C1439] to cleaved PARP; EC 2.4.2.30; PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1 Monoclonal 0.05 mg
17-001-30065 Poly [ADP- - EC 2.4.2.30; PARP-2; NAD(+) ADP-ribosyltransferase 2; Poly[ADP-ribose] synthetase 2; pADPRT-2; hPARP-2 Serum 0.1 mg
18-272-197066 cleaved PARP - Rabbit polyclonal to cleaved PARP; EC 2.4.2.30; PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1 Polyclonal 0.05 mg
18-272-197065 cleaved PARP - Rabbit polyclonal to cleaved PARP; EC 2.4.2.30; PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1 Polyclonal 0.05 mg
18-272-197067 cleaved PARP - Rabbit polyclonal to cleaved PARP; EC 2.4.2.30; PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1 Polyclonal 0.05 mg

Kits Elisa; taq POLYMERASE

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Gentaur; yes we can

Pathways :
WP1493: Carbon assimilation C4 pathway
WP1684: Pentose phosphate pathway
WP220: Ribose and Deoxyribose Phosphate Metabolism
WP1403: AMPK signaling
WP1422: Sphingolipid Metabolism
WP1423: Ganglio Sphingolipid Metabolism
WP1424: Globo Sphingolipid Metabolism
WP1438: Influenza A virus infection
WP1461: Photosynthetic Carbon Reduction
WP1621: Arginine and proline metabolism
WP1644: DNA replication
WP1663: Homologous recombination
WP1672: Mismatch repair
WP1693: Purine metabolism
WP1694: Pyrimidine metabolism
WP1699: RNA polymerase
WP1708: Terpenoid backbone biosynthesis
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1906: RNA Polymerase II Transcription
WP2199: Seed Development
WP2208: Cardiolipin Biosynthesis
WP2210: Oryzalexin S biosynthesis
WP2211: Geranylgeranyldiphosphate biosynthesis II (plastidic)
WP2248: anthocyanin biosynthesis
WP2256: Integrated Pancreatic Cancer Pathway

Related Genes :
[PARP3 ADPRT3 ADPRTL3] Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (hPARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)
[Parp3 Adprt3] Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)
[Parp CG40411] Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.30) (NAD(+) ADP-ribosyltransferase) (ADPRT) (Poly[ADP-ribose] synthase) (Protein ADP-ribosyltransferase Parp) (EC 2.4.2.-)
[PARP4 ADPRTL1 KIAA0177 PARPL] Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP)
[PARP9 BAL BAL1] Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) (Poly [ADP-ribose] polymerase 9) (PARP-9)
[PARP16 ARTD15 C15orf30] Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16)
[Parp9 Bal] Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein homolog) (Poly [ADP-ribose] polymerase 9) (PARP-9)
[Parp4 Kiaa0177] Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) (mVparp)
[ZC3HAV1 ZC3HDC2 PRO1677] Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)
[Parp16 Artd15] Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16)
[Zc3hav1] Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13)
[ADPRHL2 ARH3] ADP-ribose glycohydrolase ARH3 (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)
[Adprhl2 Arh3] ADP-ribose glycohydrolase ARH3 (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)
[adprhl2 arh3] ADP-ribose glycohydrolase ARH3 (LchARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)
[Zc3hav1 Zap] Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger antiviral protein) (ZAP) (rZAP)
[Parp16 Artd15] Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16)
[adprhl2 arh3 zgc:92867] ADP-ribose glycohydrolase ARH3 (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)
[ADPRHL2 ARH3] ADP-ribose glycohydrolase ARH3 (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)
[ADPRHL2 ARH3 RCJMB04_30e5] ADP-ribose glycohydrolase ARH3 (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)
[adprhl2 arh3 TGas084j22.1] ADP-ribose glycohydrolase ARH3 (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)
[] Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.30) (NAD(+) ADP-ribosyltransferase) (ADPRT) (Poly[ADP-ribose] synthase) (Protein ADP-ribosyltransferase) (EC 2.4.2.-)
[MACROD1 LRP16] ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.5.1.-) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)
[ART3 TMART] Ecto-ADP-ribosyltransferase 3 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 3) (ARTC3) (Mono(ADP-ribosyl)transferase 3) (NAD(P)(+)--arginine ADP-ribosyltransferase 3)
[ctxA toxA VC_1457] Cholera enterotoxin subunit A (Cholera enterotoxin, A chain) [Cleaved into: Cholera enterotoxin subunit A1 (EC 2.4.2.-) (Cholera enterotoxin A1 chain) (Cholera enterotoxin alpha chain) (NAD(+)--diphthamide ADP-ribosyltransferase); Cholera enterotoxin subunit A2 (Cholera enterotoxin A2 chain) (Cholera enterotoxin gamma chain)]
[Parg CG2864] Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143)
[] ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase) (ADPRC) (ADRC) (NAD glycohydrolase) (NAD(+) nucleosidase) (NADase)
[sdeA lpg2157] Ubiquitinating/deubiquitinating enzyme SdeA (Effector protein SdeA) [Includes: Deubiquitinase (DUB) (EC 3.4.22.-) (Deneddylase) (Deubiquitinating enzyme); Ubiquitin transferase (EC 2.3.2.-); Mono-ADP-ribosyltransferase (mART) (EC 2.4.2.31)]
[Macrod1 Lrp16] ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.5.1.-) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[hpxO ACIAD3540] FAD-dependent urate hydroxylase (EC 1.14.13.113) (Flavoprotein urate hydroxylase)

Bibliography :