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Polycomb protein SCMH1 (Sex comb on midleg homolog 1)

 SCMH1_MOUSE             Reviewed;         706 AA.
Q8K214; B1AS51; Q9JME0;
01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
13-FEB-2019, entry version 131.
RecName: Full=Polycomb protein SCMH1;
AltName: Full=Sex comb on midleg homolog 1;
Name=Scmh1 {ECO:0000312|MGI:MGI:1352762};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305, ECO:0000312|EMBL:BAA90554.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY,
DEVELOPMENTAL STAGE, INDUCTION, AND INTERACTION WITH PHC1.
TISSUE=Brain {ECO:0000269|PubMed:10653359}, and
Neonatal brain {ECO:0000269|PubMed:10653359};
PubMed=10653359; DOI=10.1046/j.1432-0436.1999.6540229.x;
Tomotsune D., Takihara Y., Berger J., Duhl D., Joo S., Kyba M.,
Shirai M., Ohta H., Matsuda Y., Honda B.M., Simon J., Shimada K.,
Brock H.W., Randazzo F.;
"A novel member of murine polycomb-group proteins, Sex comb on midleg
homolog protein, is highly conserved, and interacts with RAE28/mph1 in
vitro.";
Differentiation 65:229-239(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3] {ECO:0000305, ECO:0000312|EMBL:AAH34667.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=FVB/N {ECO:0000312|EMBL:AAH34667.1};
TISSUE=Mammary gland {ECO:0000312|EMBL:AAH34667.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Associates with Polycomb group (PcG) multiprotein
complexes; the complex class is required to maintain the
transcriptionally repressive state of some genes. {ECO:0000250}.
-!- SUBUNIT: Associates with a PRC1-like complex (By similarity).
Interacts with the SAM domain of PHC1 via its SAM domain in vitro.
{ECO:0000250, ECO:0000269|PubMed:10653359}.
-!- INTERACTION:
O88513:Gmnn; NbExp=2; IntAct=EBI-445955, EBI-445922;
Q64028:Phc1; NbExp=2; IntAct=EBI-445955, EBI-927346;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1 {ECO:0000305};
IsoId=Q8K214-1; Sequence=Displayed;
Note=No experimental confirmation available. {ECO:0000305};
Name=2 {ECO:0000269|PubMed:10653359};
IsoId=Q8K214-2; Sequence=VSP_051680, VSP_051681;
-!- TISSUE SPECIFICITY: Most abundant in testis. Moderate levels
detected in heart, brain, lung, liver, skeletal muscle and kidney
and lower levels in spleen. {ECO:0000269|PubMed:10653359}.
-!- DEVELOPMENTAL STAGE: Detected throughout embryogenesis. Expressed
ubiquitously in 8.5 dpc embryos. At 10.5 dpc, strongly expressed
in nervous system including hindbrain and spinal cord, and in the
pharyngeal arches and visceral organs. By 14.5 dpc, strong
expression is detected throughout the central nervous system, and
in tongue, heart, midgut and urogenital regions.
{ECO:0000269|PubMed:10653359}.
-!- INDUCTION: By retinoic acid in F9 and F19 embryonal carcinoma cell
lines. {ECO:0000269|PubMed:10653359}.
-!- SIMILARITY: Belongs to the SCM family. {ECO:0000305}.
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EMBL; AB030906; BAA90554.1; -; mRNA.
EMBL; AL611924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC034667; AAH34667.1; -; mRNA.
CCDS; CCDS18589.1; -. [Q8K214-2]
CCDS; CCDS51292.1; -. [Q8K214-1]
RefSeq; NP_001153102.1; NM_001159630.1. [Q8K214-1]
RefSeq; NP_038911.1; NM_013883.2. [Q8K214-2]
RefSeq; XP_011238853.1; XM_011240551.1.
RefSeq; XP_017175741.1; XM_017320252.1. [Q8K214-2]
RefSeq; XP_017175742.1; XM_017320253.1. [Q8K214-2]
UniGene; Mm.427014; -.
ProteinModelPortal; Q8K214; -.
SMR; Q8K214; -.
BioGrid; 205936; 5.
DIP; DIP-32567N; -.
IntAct; Q8K214; 5.
STRING; 10090.ENSMUSP00000069813; -.
iPTMnet; Q8K214; -.
PhosphoSitePlus; Q8K214; -.
PaxDb; Q8K214; -.
PeptideAtlas; Q8K214; -.
PRIDE; Q8K214; -.
Ensembl; ENSMUST00000000087; ENSMUSP00000000087; ENSMUSG00000000085. [Q8K214-2]
Ensembl; ENSMUST00000064991; ENSMUSP00000069813; ENSMUSG00000000085. [Q8K214-1]
Ensembl; ENSMUST00000106298; ENSMUSP00000101905; ENSMUSG00000000085. [Q8K214-2]
Ensembl; ENSMUST00000106301; ENSMUSP00000101908; ENSMUSG00000000085. [Q8K214-1]
GeneID; 29871; -.
KEGG; mmu:29871; -.
UCSC; uc008und.2; mouse. [Q8K214-2]
UCSC; uc008une.2; mouse. [Q8K214-1]
CTD; 22955; -.
MGI; MGI:1352762; Scmh1.
eggNOG; ENOG410IMEZ; Eukaryota.
eggNOG; ENOG410XPKI; LUCA.
GeneTree; ENSGT00940000157999; -.
HOGENOM; HOG000236280; -.
HOVERGEN; HBG056406; -.
InParanoid; Q8K214; -.
KO; K11461; -.
OMA; KILNNAM; -.
OrthoDB; 229086at2759; -.
PhylomeDB; Q8K214; -.
TreeFam; TF106488; -.
Reactome; R-MMU-2559580; Oxidative Stress Induced Senescence.
Reactome; R-MMU-3899300; SUMOylation of transcription cofactors.
Reactome; R-MMU-4551638; SUMOylation of chromatin organization proteins.
Reactome; R-MMU-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
Reactome; R-MMU-8943724; Regulation of PTEN gene transcription.
ChiTaRS; Scmh1; mouse.
PRO; PR:Q8K214; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000000085; Expressed in 292 organ(s), highest expression level in ear vesicle.
ExpressionAtlas; Q8K214; baseline and differential.
Genevisible; Q8K214; MM.
GO; GO:0010369; C:chromocenter; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
GO; GO:0006338; P:chromatin remodeling; IMP:MGI.
GO; GO:0016458; P:gene silencing; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; NAS:UniProtKB.
GO; GO:0007283; P:spermatogenesis; IMP:MGI.
Gene3D; 1.20.1380.20; -; 1.
InterPro; IPR004092; Mbt.
InterPro; IPR001660; SAM.
InterPro; IPR013761; SAM/pointed_sf.
InterPro; IPR033763; SCML2_RBR.
InterPro; IPR021987; SLED.
InterPro; IPR038348; SLED_sf.
Pfam; PF02820; MBT; 2.
Pfam; PF17208; RBR; 1.
Pfam; PF00536; SAM_1; 1.
Pfam; PF12140; SLED; 1.
SMART; SM00561; MBT; 2.
SMART; SM00454; SAM; 1.
SUPFAM; SSF47769; SSF47769; 1.
PROSITE; PS51079; MBT; 2.
PROSITE; PS50105; SAM_DOMAIN; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Developmental protein;
Nucleus; Reference proteome; Repeat; Repressor; Transcription;
Transcription regulation.
CHAIN 1 706 Polycomb protein SCMH1.
/FTId=PRO_0000114335.
REPEAT 28 126 MBT 1.
REPEAT 134 235 MBT 2.
DOMAIN 597 662 SAM. {ECO:0000255|PROSITE-
ProRule:PRU00184}.
VAR_SEQ 662 664 VFW -> GKF (in isoform 2).
{ECO:0000303|PubMed:10653359}.
/FTId=VSP_051680.
VAR_SEQ 665 706 Missing (in isoform 2).
{ECO:0000303|PubMed:10653359}.
/FTId=VSP_051681.
SEQUENCE 706 AA; 78669 MW; CC7531B46A439E39 CRC64;
MLVCYSVLAC ESLWDLPCSI MGSPLGHFTW DKYLKETCSV PAPVHCFKQS YTPPSNEFKI
SMKLEAQDPR NTTSTCIATV VGLTGARLRL RLDGSDNKND FWRLVDSSEI QPIGNCEKNG
GMLQPPLGFR LNASSWPMFL LKTLNGAEMA PIKIFHKEPP SPSHNFFKMG MKLEAVDRKN
PHFICPATIG EVRGAEVLVT FDGWRGAFDY WCRFDSRDIF PVGWCSLTGD NLQPPGTKVV
IPKNPSPSSD VSTEKPSIHS TKTVLEHQPG QRGRKPGKKR GRTPKILIPH PTSTPSKSAE
PLKFPKKRGP KPGSKRKPRT LLSPPPTSPT TSTPEPDTST VPQDAATVPS SAMQAPTVCI
YLNKSGSTGP HLDKKKIQQL PDHFGPARAS VVLQQAVQAC IDCAYHQKTV FSFLKQGHGG
EVISAVFDRE QHTLNLPAVN SITYVLRFLE KLCHNLRSDN LFGNQPFTQT HLSLTATEYN
HNHDRYLPGE TFVLGNSLAR SLETHSDLMD SALKPANLVS TSQNLRTPGY RPLLPSCGLP
LSTVSAVRRL CSKGVLKGKK ERRDVESFWK LNHSPGSDRH LESRDPPRLS GRDPSSWTVE
DVMQFVREAD PQLGSHADLF RKHEIDGKAL LLLRSDMMMK YMGLKLGPAL KLSFHIDRLK
QVFWKRETIL WSREGLSREV WPISEDTALG HFFSGMDKVF GSLSKR


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Pathways :
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining
WP1678: Nucleotide excision repair

Related Genes :
[Spata24 Tipt Tipt2] Spermatogenesis-associated protein 24 (TATA-binding protein-like factor-interacting protein) (TLF-interacting protein) (TRF2-interacting protein in testis) (Testis protein T6441 homolog)
[UBQLN1 DA41 PLIC1] Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
[SPATA24] Spermatogenesis-associated protein 24 (Testis protein T6441 homolog)
[ASXL1 KIAA0978] Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1)
[MAGEA12 MAGE12] Melanoma-associated antigen 12 (Cancer/testis antigen 1.12) (CT1.12) (MAGE-12 antigen) (MAGE12F antigen)
[Asxl1 Kiaa0978] Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1)
[Asx CG8787] Polycomb protein Asx (Additional sex combs)
[SUZ12 CHET9 JJAZ1 KIAA0160] Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)
[ASXL2 ASXH2 KIAA1685] Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)
[Spata24] Spermatogenesis-associated protein 24 (Testis protein T6441)
[EED] Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
[CBX2] Chromobox protein homolog 2
[KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7] Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
[DNAJC2 MPHOSPH11 MPP11 ZRF1] DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed]
[CLF ICU1 PIF1 PIF2 SDG1 SET1 At2g23380 F26B6.3] Histone-lysine N-methyltransferase CLF (EC 2.1.1.43) (Polycomb group protein CURLY LEAF) (Protein INCURVATA 1) (Protein SET DOMAIN GROUP 1) (Protein photoperiod insensitive flowering)
[ph-p CG18412] Polyhomeotic-proximal chromatin protein
[SPATA24 QtsA-15191] Spermatogenesis-associated protein 24 (Testis protein T6441 homolog)
[EZH2 KMT6] Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
[Pcgf2 Mel-18 Mel18 Rnf110 Zfp144 Znf144] Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (Melanoma nuclear protein 18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144)
[DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4] DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
[Cbx2 M33] Chromobox protein homolog 2 (M33) (Modifier 3 protein)
[Ezh2 Enx1h] Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2)
[PHF19 PCL3] PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)
[NTG1 OGG2 SCR1 YAL015C FUN33] Endonuclease III homolog 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 1) (DNA glycosylase/AP lyase 1) (Endonuclease III-like glycosylase 1) (Redoxyendonuclease 1)
[EMF2 At5g51230/At5g51240 MWD22.18/MWD22.19] Polycomb group protein EMBRYONIC FLOWER 2
[fem-2 T19C3.8] Protein phosphatase fem-2 (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Feminization of XX and XO animals protein 2) (Sex-determining protein fem-2)
[BMI1 BMI-1 PCGF4] Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4)
[KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[PHF1 PCL1] PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)
[Cbx7 D15Ertd417e] Chromobox protein homolog 7

Bibliography :
[17215307] Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.
[10653359] A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro.
[10524249] The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34.
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