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Polycomb protein mes-6 (ESC homolog) (Maternal-effect sterile protein 6)

 MES6_CAEEL              Reviewed;         459 AA.
Q9GYS1; O16187;
28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
24-MAY-2005, sequence version 2.
13-FEB-2019, entry version 138.
RecName: Full=Polycomb protein mes-6;
AltName: Full=ESC homolog;
AltName: Full=Maternal-effect sterile protein 6;
Name=mes-6; ORFNames=C09G4.5;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, DEVELOPMENTAL
STAGE, AND MUTAGENESIS OF GLY-188.
STRAIN=Bristol N2;
PubMed=9609830;
Korf I., Fan Y., Strome S.;
"The polycomb group in Caenorhabditis elegans and maternal control of
germline development.";
Development 125:2469-2478(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
IDENTIFICATION IN A COMPLEX WITH MES-2 AND MES-3.
PubMed=11320248; DOI=10.1073/pnas.081016198;
Xu L., Fong Y., Strome S.;
"The Caenorhabditis elegans maternal-effect sterile proteins, MES-2,
MES-3, and MES-6, are associated in a complex in embryos.";
Proc. Natl. Acad. Sci. U.S.A. 98:5061-5066(2001).
[4]
FUNCTION.
PubMed=12077420; DOI=10.1126/science.1070790;
Fong Y., Bender L., Wang W., Strome S.;
"Regulation of the different chromatin states of autosomes and X
chromosomes in the germ line of C. elegans.";
Science 296:2235-2238(2002).
[5]
FUNCTION, AND IDENTIFICATION IN A COMPLEX WITH MES-2 AND MES-3.
PubMed=15380065; DOI=10.1016/j.cub.2004.08.062;
Bender L.B., Cao R., Zhang Y., Strome S.;
"The MES-2/MES-3/MES-6 complex and regulation of histone H3
methylation in C. elegans.";
Curr. Biol. 14:1639-1643(2004).
[6]
FUNCTION.
PubMed=26365259; DOI=10.1016/j.cub.2015.07.051;
Mao H., Zhu C., Zong D., Weng C., Yang X., Huang H., Liu D., Feng X.,
Guang S.;
"The Nrde pathway mediates small-RNA-directed histone H3 lysine 27
trimethylation in Caenorhabditis elegans.";
Curr. Biol. 25:2398-2403(2015).
-!- FUNCTION: Polycomb group (PcG) protein. PcG proteins act by
forming multiprotein complexes, which are required to maintain the
transcriptionally repressive state of homeotic genes throughout
development. PcG proteins are not required to initiate repression,
but to maintain it during later stages of development. The mes-
2/mes-3/mes-6 complex may participate in the global inactivation
of the X chromosomes in germline cells. The complex may act via
methylation of histone H3 'Lys-27', rendering chromatin heritably
changed in its expressibility. This complex is required to exclude
mes-4 from the inactivated X-chromosomes in germline cells
(PubMed:12077420, PubMed:15380065). Required for small-RNA-induced
H3K27 trimethylation (PubMed:26365259).
{ECO:0000269|PubMed:12077420, ECO:0000269|PubMed:15380065,
ECO:0000269|PubMed:26365259}.
-!- SUBUNIT: Interacts directly with the N-terminal domain of mes-2.
Forms a heterotrimeric complex with mes-2 and mes-3. Does not
interact with mes-4. {ECO:0000269|PubMed:11320248,
ECO:0000269|PubMed:15380065}.
-!- INTERACTION:
O17514:mes-2; NbExp=5; IntAct=EBI-314965, EBI-11615731;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: In adults, it is predominantly expressed in
the germline, and weakly expressed in intestinal cells.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Expressed in all cells of early embryos. In late embryos and L1
larva, it is weakly expressed. {ECO:0000269|PubMed:9609830}.
-!- SIMILARITY: Belongs to the WD repeat ESC family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AF016224; AAC27121.1; -; Genomic_DNA.
EMBL; FO080478; CCD64001.1; -; Genomic_DNA.
RefSeq; NP_001021320.1; NM_001026149.4.
UniGene; Cel.9137; -.
ProteinModelPortal; Q9GYS1; -.
BioGrid; 42769; 10.
ComplexPortal; CPX-368; Polycomb Repressive Complex 2.
IntAct; Q9GYS1; 2.
STRING; 6239.C09G4.5; -.
EPD; Q9GYS1; -.
PaxDb; Q9GYS1; -.
PeptideAtlas; Q9GYS1; -.
PRIDE; Q9GYS1; -.
EnsemblMetazoa; C09G4.5; C09G4.5; WBGene00003224.
GeneID; 177657; -.
KEGG; cel:CELE_C09G4.5; -.
UCSC; C09G4.5; c. elegans.
CTD; 177657; -.
WormBase; C09G4.5; CE24796; WBGene00003224; mes-6.
eggNOG; KOG1034; Eukaryota.
eggNOG; ENOG410XRQI; LUCA.
GeneTree; ENSGT00510000047334; -.
HOGENOM; HOG000020629; -.
InParanoid; Q9GYS1; -.
KO; K11462; -.
OMA; HVCIAIF; -.
OrthoDB; 1191277at2759; -.
PhylomeDB; Q9GYS1; -.
Reactome; R-CEL-2559580; Oxidative Stress Induced Senescence.
Reactome; R-CEL-8943724; Regulation of PTEN gene transcription.
Reactome; R-CEL-8953750; Transcriptional Regulation by E2F6.
SignaLink; Q9GYS1; -.
PRO; PR:Q9GYS1; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00003224; Expressed in 3 organ(s), highest expression level in multi-cellular organism.
GO; GO:0035098; C:ESC/E(Z) complex; IBA:GO_Central.
GO; GO:0000786; C:nucleosome; IDA:WormBase.
GO; GO:0031519; C:PcG protein complex; IPI:WormBase.
GO; GO:0006342; P:chromatin silencing; IBA:GO_Central.
GO; GO:0070734; P:histone H3-K27 methylation; IMP:WormBase.
GO; GO:0016571; P:histone methylation; IDA:WormBase.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
InterPro; IPR037352; Polycomb_EED.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
PANTHER; PTHR10253; PTHR10253; 1.
Pfam; PF00400; WD40; 1.
SMART; SM00320; WD40; 4.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS50082; WD_REPEATS_2; 1.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Nucleus; Reference proteome;
Repeat; Repressor; Transcription; Transcription regulation; WD repeat.
CHAIN 1 459 Polycomb protein mes-6.
/FTId=PRO_0000051076.
REPEAT 146 186 WD 1.
REPEAT 192 231 WD 2.
REPEAT 305 346 WD 3.
REPEAT 370 409 WD 4.
REPEAT 415 454 WD 5.
MUTAGEN 188 188 G->E: In BN66; maternal-effect mutation.
Progeny show defects in gonad
proliferation. Germ cell degeneration.
{ECO:0000269|PubMed:9609830}.
SEQUENCE 459 AA; 51823 MW; 0524A674ABAB2671 CRC64;
MEHTKKFKSL NLHGFDRSTE DYGKRPFVLT AKLLEDQKKA IYGCAFNQYA GIDEEQAVAT
VGGSFLHMYS VPIDINNIEL QWSCNFPTDK SSKVEREESL FTVTWCYDTY EAENDRNPFK
VVTGGTLGHI YVIDYVSRKL SNRLRSVGWE INDIRTCPAN SNLIVCASSD QSIRIHHIRN
EACLIVIGGL ECHAGTILSV DWSTDGDFIL SCGFDHQLME WDLSVKQVKE HLERACKALH
QDKINVLTQS QDIPYVSKGT MRKSAVSRNI PDKEEDQLLE LHRELIPRPS CLLPIYTPSS
VSTDMHSDYV DCIRFLIGTN YALSKGCGNE KAIHFWRFGP PKGEVENRIH GNVLRPKSCT
TKFRTMNVPS GSAWFIKFAV DPRRRWLVCG GAGGSVMFFD LRNNEETNPT HTCSVGSRTV
RQASFSTCGR FLVLVTDEGF VCRFDRVSAS VDAKDLAKF


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Pathways :
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining
WP1678: Nucleotide excision repair

Related Genes :
[mes-1 F54F7.5] Protein mes-1 (Maternal-effect sterile protein 1)
[Mes-4 CG4976] Probable histone-lysine N-methyltransferase Mes-4 (EC 2.1.1.43) (Maternal-effect sterile 4 homolog)
[Suv39h1 Suv39h] Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
[mel-32 gly-1 C05D11.11] Serine hydroxymethyltransferase (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Glycosylation-related protein 1) (Maternal effect lethal protein 32) (Serine methylase)
[Nlrp5 Mater Nalp5] NACHT, LRR and PYD domains-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1)
[EED] Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
[EZH2 KMT6] Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
[SUZ12 CHET9 JJAZ1 KIAA0160] Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)
[mett-10 ZK1128.2] U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase (EC 2.1.1.346)
[Pld6] Mitochondrial cardiolipin hydrolase (EC 3.1.-.-) (Choline phosphatase 6) (Mitochondrial phospholipase) (MitoPLD) (Phosphatidylcholine-hydrolyzing phospholipase D6) (Phospholipase D6) (PLD 6) (Protein zucchini homolog) (mZuc)
[Notch1 Motch] Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
[MEA EMB173 FIS1 MEDEA SDG5 SET5 At1g02580 T14P4.11] Histone-lysine N-methyltransferase MEDEA (EC 2.1.1.43) (Maternal embryogenesis control protein) (Protein EMBRYO DEFECTIVE 173) (Protein FERTILIZATION-INDEPENDENT SEED 1) (Protein SET DOMAIN GROUP 5)
[Cbx2 M33] Chromobox protein homolog 2 (M33) (Modifier 3 protein)
[ERVK-6 ERVK6] Endogenous retrovirus group K member 6 Rec protein (Central open reading frame) (c-orf) (cORF) (Endogenous retrovirus K protein 6) (HERV-K(C7) Rec protein) (HERV-K(HML-2.HOM) Rec protein) (HERV-K108 Rec protein) (HERV-K_7p22.1 provirus Rec protein) (K-Rev) (Rev-like protein) (Rev/Rex homolog)
[Per1 Per Rigui] Period circadian protein homolog 1 (mPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)
[Melk Kiaa0175 Pk38] Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)
[Smad3 Madh3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[SUV39H1 KMT1A SUV39H] Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
[CBX6] Chromobox protein homolog 6
[ALKBH1 ABH ABH1 ALKBH] Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (tRNA N1-methyl adenine demethylase) (EC 1.14.11.-)
[SMAD6 MADH6] Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
[Auts2 Kiaa0442] Autism susceptibility gene 2 protein homolog
[Trpm8 Ltrpc6 Trpp8] Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8)
[Cnot6 Ccr4 Kiaa1194] CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase)
[Pard6b Par6b] Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)
[Wrn] Werner syndrome ATP-dependent helicase homolog (EC 3.6.4.12) (Exonuclease WRN) (EC 3.1.-.-)
[Cdc42] Cell division control protein 42 homolog (G25K GTP-binding protein)
[Fbxw7 Fbw7 Fbwd6 Fbxw6] F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10)
[Alkbh1 Abh Alkbh] Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (tRNA N1-methyl adenine demethylase) (EC 1.14.11.-)

Bibliography :
[9609830] The Polycomb group in Caenorhabditis elegans and maternal control of germline development.
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