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Porin (PorB)

 Q51056_NEIGO            Unreviewed;       327 AA.
Q51056;
01-NOV-1996, integrated into UniProtKB/TrEMBL.
01-NOV-1996, sequence version 1.
03-JUL-2019, entry version 91.
SubName: Full=Porin (PorB) {ECO:0000313|EMBL:CAA93250.1};
Name=porB {ECO:0000313|EMBL:CAA93250.1};
Neisseria gonorrhoeae.
Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
Neisseriaceae; Neisseria.
NCBI_TaxID=485 {ECO:0000313|EMBL:CAA93250.1};
[1] {ECO:0000313|EMBL:CAA93250.1}
NUCLEOTIDE SEQUENCE.
STRAIN=MS11 {ECO:0000313|EMBL:CAA93250.1};
PubMed=8616894; DOI=10.1016/S0092-8674(00)81117-4;
Rudel T., Schmid A., Benz R., Kolb H.A., Lang F., Meyer T.F.;
"Modulation of Neisseria porin (PorB) by cytosolic ATP/GTP of target
cells: parallels between pathogen accommodation and mitochondrial
endosymbiosis.";
Cell 85:391-402(1996).
[2] {ECO:0000213|PDB:4AUI}
X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) IN COMPLEX WITH ATP.
PubMed=23095086; DOI=10.1042/BJ20121025;
Zeth K., Kozjak-Pavlovic V., Faulstich M., Fraunholz M., Hurwitz R.,
Kepp O., Rudel T.;
"Structure and function of the PorB porin from disseminating Neisseria
gonorrhoeae.";
Biochem. J. 449:631-642(2013).
-!- SUBUNIT: Homotrimer. {ECO:0000256|RuleBase:RU000469}.
-!- SUBCELLULAR LOCATION: Cell outer membrane
{ECO:0000256|RuleBase:RU000469}; Multi-pass membrane protein
{ECO:0000256|RuleBase:RU000469}.
-!- SIMILARITY: Belongs to the Gram-negative porin family.
{ECO:0000256|RuleBase:RU000469}.
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EMBL; Z69259; CAA93250.1; -; Genomic_DNA.
PDB; 4AUI; X-ray; 3.20 A; A/B/C=1-327.
PDBsum; 4AUI; -.
SMR; Q51056; -.
GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
CDD; cd00342; gram_neg_porins; 1.
Gene3D; 2.40.160.10; -; 1.
InterPro; IPR033900; Gram_neg_porin_domain.
InterPro; IPR023614; Porin_dom_sf.
InterPro; IPR001702; Porin_Gram-ve.
InterPro; IPR013793; Porin_Gram-ve_CS.
InterPro; IPR002299; Porin_Neis.
Pfam; PF00267; Porin_1; 1.
PRINTS; PR00182; ECOLNEIPORIN.
PRINTS; PR00184; NEISSPPORIN.
PROSITE; PS00576; GRAM_NEG_PORIN; 1.
1: Evidence at protein level;
3D-structure {ECO:0000213|PDB:4AUI};
ATP-binding {ECO:0000213|PDB:4AUI};
Cell outer membrane {ECO:0000256|RuleBase:RU000469};
Ion transport {ECO:0000256|RuleBase:RU000469};
Membrane {ECO:0000256|RuleBase:RU000469};
Nucleotide-binding {ECO:0000213|PDB:4AUI};
Porin {ECO:0000256|RuleBase:RU000469};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|RuleBase:RU000469};
Transport {ECO:0000256|RuleBase:RU000469}.
SIGNAL 1 19 {ECO:0000256|SAM:SignalP}.
CHAIN 20 327 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5004248228.
NP_BIND 77 79 ATP. {ECO:0000213|PDB:4AUI}.
NP_BIND 94 95 ATP. {ECO:0000213|PDB:4AUI}.
BINDING 28 28 ATP. {ECO:0000213|PDB:4AUI}.
BINDING 57 57 ATP; via carbonyl oxygen.
{ECO:0000213|PDB:4AUI}.
BINDING 113 113 ATP. {ECO:0000213|PDB:4AUI}.
BINDING 117 117 ATP. {ECO:0000213|PDB:4AUI}.
BINDING 143 143 ATP. {ECO:0000213|PDB:4AUI}.
SEQUENCE 327 AA; 35713 MW; FFEF682DF4EE084B CRC64;
MKKSLIALTL AALPVAAMAD VTLYGTIKAG VETSRSVAHH GAQADRVKTA TEIADLGSKI
GFKGQEDLGN GLKAIWQLEQ KAYVSGTDTG WGNRQSFIGL KGGFGKVRVG RLNNILKDTG
GFNPWEGKSY YSGLSNIAQP EERHVSVRYD SPEFAGFSGS VQYVPNDNSG KNRSESYHAG
FNYKNSGFFV QYAGSYKRHN YTTEKHQVHR LVGGYDHDAL YASVAVQQQD AKLTWRDDNS
HNSQTEVATT VAYRFGNVTP RVSYAHGFKG SVYDADHDNT YDQVVVGAEY DFSKRTSALV
SAGWLQKGKG AEKFVATVGG VGLRHKF


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Pathways :
No related Items

Related Genes :
[PORB At4g27440 F27G19.40] Protochlorophyllide reductase B, chloroplastic (PCR B) (EC 1.3.1.33) (NADPH-protochlorophyllide oxidoreductase B) (POR B)
[VDAC1 VDAC] Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)
[Vdac1 Vdac5] Voltage-dependent anion-selective channel protein 1 (VDAC-1) (mVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Voltage-dependent anion-selective channel protein 5) (VDAC-5) (mVDAC5)
[ompA con tolG tut b0957 JW0940] Outer membrane protein A (OmpA) (Outer membrane porin A) (Outer membrane protein 3A) (Outer membrane protein B) (Outer membrane protein II*) (Outer membrane protein d)
[POR1 OMP2 VDAC1 YNL055C N2441 YNL2441C] Mitochondrial outer membrane protein porin 1 (Voltage-dependent anion-selective channel protein 1) (VDAC-1)
[VDAC3 HSR2 At5g15090 F2G14.210] Mitochondrial outer membrane protein porin 3 (Protein HYPERSENSITIVE RESPONSE 2) (Athsr2) (Voltage-dependent anion-selective channel protein 3) (AtVDAC3) (VDAC-3)
[VDAC1 At3g01280 T22N4.9] Mitochondrial outer membrane protein porin 1 (Voltage-dependent anion-selective channel protein 1) (AtVDAC1) (VDAC-1)
[VDAC2] Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
[Vdac1] Voltage-dependent anion-selective channel protein 1 (VDAC-1) (rVDAC1) (Outer mitochondrial membrane protein porin 1)
[ppnP OR1_03385] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[arfA ompA Rv0899 MTCY31.27] Peptidoglycan-binding protein ArfA (Outer membrane porin A) (Outer membrane protein A) (OmpATb) (Outer membrane protein ArfA)
[ribA ribB OR37_01047] Multifunctional fusion protein [Includes: GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II); 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12)]
[ppnP OR214_03073] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[ppnP OR16_09104] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[ompA SF0957] Outer membrane protein A (Outer membrane porin A)
[Vdac2 Vdac6] Voltage-dependent anion-selective channel protein 2 (VDAC-2) (mVDAC2) (Outer mitochondrial membrane protein porin 2) (Voltage-dependent anion-selective channel protein 6) (VDAC-6) (mVDAC6)
[glmU OR221_2794] Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]
[glmU OR1_01412] Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]
[nnrE nnrD OR37_00116] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrE nnrD OR214_00542] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[ompC c2758] Outer membrane porin C (Outer membrane protein 1B) (Outer membrane protein C) (Porin OmpC)
[nnr nnrD nnrE OR1_02963] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[ompA ompP5] Outer membrane protein P5 (OMP P5) (Fimbrin) (Outer membrane porin A) (Outer membrane protein A)
[glmU OR37_01460] Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]
[VDAC1] Voltage-dependent anion-selective channel protein 1 (VDAC-1) (Outer mitochondrial membrane protein porin 1)
[mspA MSMEG_0965 MSMEI_0939] Porin MspA
[ribBA OR1_02316] Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]
[glmU OR214_03857] Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]
[murE OR1_01796] UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase)
[Vdac2] Voltage-dependent anion-selective channel protein 2 (VDAC-2) (B36-VDAC) (Outer mitochondrial membrane protein porin 2)

Bibliography :
[31208304] Immunoenhancement of recombinant Neisseria meningitides PorB protein on porcine circovirus type 2 and Mycoplasma hyopneumo-niae genetically engineered vaccines.
[31112447] Neisserial PorB immune enhancing activity and use as a vaccine adjuvant.
[30718567] High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB.
[30697344] Evolution of the exclusively human pathogen : Human-specific engagement of immunoregulatory Siglecs.
[30381152] Meningococcal PorB induces a robust and diverse antigen specific T cell response as a vaccine adjuvant.
[29992304] Association of Neisseria gonorrhoeae genogroups and specific PBP2/MtrR/PorB mutation patterns with susceptibility to penicillin in a susceptible gonococcal population.
[29883770] Tetracycline resistance of Neisseria gonorrhoeae in Russia, 2015-2017.
[29752412] Properly folded and functional PorB from inhibits dendritic cell stimulation of CD4 T cell proliferation.
[29605532] Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil.
[29601598] Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis.