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Potassium voltage-gated channel subfamily Q member 2

 H2QKS4_PANTR            Unreviewed;       871 AA.
H2QKS4;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 2.
02-JUN-2021, entry version 49.
SubName: Full=Potassium voltage-gated channel subfamily Q member 2 {ECO:0000313|Ensembl:ENSPTRP00000023658};
Name=KCNQ2 {ECO:0000313|Ensembl:ENSPTRP00000023658,
ECO:0000313|VGNC:VGNC:14253};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000023658, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000023658, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the human
genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000023658}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
{ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
{ECO:0000256|ARBA:ARBA00004141}.
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EMBL; AACZ04058737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ04058738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ04058739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ04058740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9598.ENSPTRP00000023658; -.
PaxDb; H2QKS4; -.
Ensembl; ENSPTRT00000025630; ENSPTRP00000023658; ENSPTRG00000013736.
VGNC; VGNC:14253; KCNQ2.
eggNOG; KOG1419; Eukaryota.
GeneTree; ENSGT00940000160093; -.
HOGENOM; CLU_011722_8_3_1; -.
InParanoid; H2QKS4; -.
TreeFam; TF315186; -.
Proteomes; UP000002277; Chromosome 20.
Bgee; ENSPTRG00000013736; Expressed in cerebellum and 5 other tissues.
GO; GO:0043194; C:axon initial segment; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
GO; GO:0005251; F:delayed rectifier potassium channel activity; IBA:GO_Central.
GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
InterPro; IPR020969; Ankyrin-G_BS.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
InterPro; IPR003947; K_chnl_volt-dep_KCNQ2.
InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
InterPro; IPR028325; VG_K_chnl.
PANTHER; PTHR11537; PTHR11537; 1.
PANTHER; PTHR11537:SF6; PTHR11537:SF6; 1.
Pfam; PF00520; Ion_trans; 1.
Pfam; PF03520; KCNQ_channel; 1.
Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
PRINTS; PR01461; KCNQ2CHANNEL.
PRINTS; PR01459; KCNQCHANNEL.
4: Predicted;
Ion channel {ECO:0000256|ARBA:ARBA00022826, ECO:0000256|ARBA:ARBA00022882};
Ion transport {ECO:0000256|ARBA:ARBA00022826,
ECO:0000256|ARBA:ARBA00022882};
Membrane {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|SAM:Phobius};
Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
Potassium {ECO:0000256|ARBA:ARBA00022826};
Potassium channel {ECO:0000256|ARBA:ARBA00022826};
Potassium transport {ECO:0000256|ARBA:ARBA00022826};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Transmembrane {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
ECO:0000256|SAM:Phobius};
Transport {ECO:0000256|ARBA:ARBA00022826, ECO:0000256|ARBA:ARBA00022882};
Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
TRANSMEM 93..112
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 124..146
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 167..186
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 233..251
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 292..317
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 96..317
/note="Ion_trans"
/evidence="ECO:0000259|Pfam:PF00520"
DOMAIN 465..648
/note="KCNQ_channel"
/evidence="ECO:0000259|Pfam:PF03520"
REGION 401..421
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 441..487
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 597..618
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 658..679
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 692..748
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 768..787
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 837..871
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 458..478
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 871 AA; 95763 MW; 20157A06AC5D015D CRC64;
MVQKSRNGGV YPGPSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSILSKPRAG
GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK
SSEGLYILEI VTIVVFGVEY FVRIWAAGCC CRYRGWRGRL KFARKPFCVI DIMVLIASIA
VLAAGSQGNV FATSALRSLR FLQILRMIRM DRRGGTWKLL GSVVYAHSKE LVTAWYIGFL
CLILASFLVY LAEKGENDHF DTYADALWWG LITLTTIGYG DKYPQTWNGR LLAATFTLIG
VSFFALPAGI LGSGFALKVQ EQHRQKHFEK RRNPAAGLIQ SAWRFYATNL SRTDLHSTWQ
YYERTVTVPM YSSQTQTYGA SRLIPPLNQL ELLRNLKSKS GLAFRKDPPP EPSPSKGSPC
RGPLCGCCPG RSSQKVSLKD RVFSSPRGVA AKGKGSPQAQ TVRRSPSADQ SLEDSPSKVP
KSWSFGDRSR ARQAFRIKGA ASRQNSEEAS LPGEDIVDDK SCPCEFVTED LTPGLKVSIR
AVCVMRFLVS KRKFKESLRP YDVMDVIEQY SAGHLDMLSR IKSLQSRVDQ IVGRGPAITD
KDRTKGPAEA ELPEDPSMMG RLGKVEKQVL SMEKKLDFLV NIYMQRMGIP PTETEAYFGA
KEPEPAPPYH SPEDSREHVD RHGCIVKIVR SSSSTGQKNF SAPPAAPPVQ CPPSTSWQPQ
SHPRQGHGTS PVGDHGSLVR IPPPPAHERS LSAYGGGNRA SMEFLRQEDT PGCRPPEGTL
RDSDTSISIP SVDHEELERS FSGFSISQSK ENLDALNSCY AAVAPCAKVR PYIAEGESDT
DSDLCTPCGP PPRSATGEGP FGDVGWAGPR K


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WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP1039: Glutathione metabolism
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WP1362: Homologous recombination
WP1385: Nuclear Receptors
WP730: Glutathione and one carbon metabolism
WP1126: Tryptophan metabolism
WP1386: Integrin-mediated cell adhesion
WP1378: Senescence and Autophagy
WP2313: Aging
WP1371: G Protein Signaling Pathways
WP17: daf-2 or insulin signaling pathway
WP465: Tryptophan metabolism
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP1363: p38 MAPK Signaling Pathway
WP153: Urea cycle and metabolism of amino groups
WP100: Glutathione metabolism
WP240: Alanine and aspartate metabolism
WP246: TNF-alpha NF-kB Signaling Pathway
WP1370: TGF Beta Signaling Pathway
WP1344: Wnt Signaling Pathway and Pluripotency
WP1354: B Cell Receptor Signaling Pathway

Related Genes :
[Kcnc2] Potassium voltage-gated channel subfamily C member 2 (Potassium channel voltage-gated Shaw-related subfamily C member 2) (Shaw-like potassium channel) (Voltage-gated potassium channel subunit Kv3.2)
[KCNA4 KCNA4L] Potassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4)
[Kcnc1] Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
[KCNA2] Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2)
[KCNA5] Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)
[Kcnb1] Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)
[KCNC2] Potassium voltage-gated channel subfamily C member 2 (Shaw-like potassium channel) (Voltage-gated potassium channel Kv3.2)
[KCNH2 ERG ERG1 HERG] Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)
[KCNQ1 KVLQT1] Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
[KCNA1] Potassium voltage-gated channel subfamily A member 1 (Voltage-gated K(+) channel HuKI) (Voltage-gated potassium channel HBK1) (Voltage-gated potassium channel subunit Kv1.1)
[KCNB1] Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1)
[Kcna2] Potassium voltage-gated channel subfamily A member 2 (RAK) (RBK2) (RCK5) (Voltage-gated potassium channel subunit Kv1.2)
[KCNQ2] Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
[Kcnd2] Potassium voltage-gated channel subfamily D member 2 (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2)
[KCND2 KIAA1044] Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2)
[KCNQ1 KCNA8 KCNA9 KVLQT1] Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
[Kcnc1] Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
[KCNC1] Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
[Kcnq1 Kcna9 Kvlqt1] Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
[KCNH6 ERG2] Potassium voltage-gated channel subfamily H member 6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Voltage-gated potassium channel subunit Kv11.2)
[KCNH3 KIAA1282] Potassium voltage-gated channel subfamily H member 3 (Brain-specific eag-like channel 1) (BEC1) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Voltage-gated potassium channel subunit Kv12.2)
[Kcnh6 Erg2] Potassium voltage-gated channel subfamily H member 6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (Voltage-gated potassium channel subunit Kv11.2)
[Kcnc2] Potassium voltage-gated channel subfamily C member 2 (Shaw-like potassium channel) (Voltage-gated potassium channel Kv3.2)
[Kcnq2 Kqt2] Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
[KCNB1] Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)
[Kcnq2] Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
[KCNH5 EAG2] Potassium voltage-gated channel subfamily H member 5 (Ether-a-go-go potassium channel 2) (hEAG2) (Voltage-gated potassium channel subunit Kv10.2)
[Kcna6] Potassium voltage-gated channel subfamily A member 6 (RCK2) (Voltage-gated potassium channel subunit Kv1.6) (Voltage-gated potassium channel subunit Kv2)
[Kcnh2 Erg Merg1] Potassium voltage-gated channel subfamily H member 2 (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (MERG) (Voltage-gated potassium channel subunit Kv11.1)
[Kcnh2 Erg] Potassium voltage-gated channel subfamily H member 2 (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (RERG) (r-ERG) (Voltage-gated potassium channel subunit Kv11.1)

Bibliography :
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