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Presenilin spe-4

 SPE4_CAEEL              Reviewed;         465 AA.
Q01608;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
13-FEB-2019, entry version 138.
RecName: Full=Presenilin spe-4;
Name=spe-4 {ECO:0000312|WormBase:ZK524.1};
ORFNames=ZK524.1 {ECO:0000312|WormBase:ZK524.1};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=Bristol N2;
PubMed=1527173; DOI=10.1083/jcb.119.1.55;
L'Hernault S.W., Arduengo P.M.;
"Mutation of a putative sperm membrane protein in Caenorhabditis
elegans prevents sperm differentiation but not its associated meiotic
divisions.";
J. Cell Biol. 119:55-68(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MUTAGENESIS OF
SER-177 AND PRO-440.
PubMed=9819355;
Arduengo P.M., Appleberry O.K., Chuang P., L'Hernault S.W.;
"The presenilin protein family member SPE-4 localizes to an ER/Golgi
derived organelle and is required for proper cytoplasmic partitioning
during Caenorhabditis elegans spermatogenesis.";
J. Cell Sci. 111:3645-3654(1998).
[4]
FUNCTION, AND MUTAGENESIS OF HIS-165.
PubMed=29879108; DOI=10.1371/journal.pbio.2005069;
Zhao Y., Tan C.H., Krauchunas A., Scharf A., Dietrich N., Warnhoff K.,
Yuan Z., Druzhinina M., Gu S.G., Miao L., Singson A., Ellis R.E.,
Kornfeld K.;
"The zinc transporter ZIPT-7.1 regulates sperm activation in
nematodes.";
PLoS Biol. 16:E2005069-E2005069(2018).
-!- FUNCTION: Potential catalytic subunit of the gamma-secretase
complex during spermatogenesis, an endoprotease complex that
catalyzes the intramembrane cleavage of integral membrane proteins
such as Notch receptors (lin-12 or glp-1) (Probable). Involved in
spermatid formation during meiosis II (PubMed:9819355,
PubMed:29879108). May be required for proper localization of
macromolecules that are subject to asymmetric partitioning during
spermatogenesis (PubMed:9819355). {ECO:0000269|PubMed:29879108,
ECO:0000269|PubMed:9819355, ECO:0000305}.
-!- SUBUNIT: Homodimer. Potential component of the gamma-secretase
complex, a complex probably composed of the presenilin homodimer
(sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2
(Probable). {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000269|PubMed:9819355}; Multi-pass membrane protein
{ECO:0000269|PubMed:9819355}. Golgi apparatus, cis-Golgi network
membrane {ECO:0000269|PubMed:9819355}; Multi-pass membrane protein
{ECO:0000269|PubMed:9819355}. Note=Predominantly located in the
endoplasmic reticulum and in the cis-Golgi.
-!- DEVELOPMENTAL STAGE: Expressed during L4 stage, during
spermatogenesis, when hermaphrodites produces sperm.
-!- DOMAIN: The PAL motif is required for normal active site
conformation. {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase A22A family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Z14066; CAA78449.1; -; mRNA.
EMBL; Z14067; CAA78450.1; -; Genomic_DNA.
EMBL; BX284601; CAA98145.1; -; Genomic_DNA.
PIR; T27885; T27885.
RefSeq; NP_492095.1; NM_059694.5.
UniGene; Cel.18295; -.
ProteinModelPortal; Q01608; -.
STRING; 6239.ZK524.1; -.
MEROPS; A22.012; -.
PaxDb; Q01608; -.
PeptideAtlas; Q01608; -.
EnsemblMetazoa; ZK524.1; ZK524.1; WBGene00004958.
GeneID; 172498; -.
KEGG; cel:CELE_ZK524.1; -.
UCSC; ZK524.1; c. elegans.
CTD; 172498; -.
WormBase; ZK524.1; CE06618; WBGene00004958; spe-4.
eggNOG; KOG2736; Eukaryota.
eggNOG; ENOG410XPZD; LUCA.
InParanoid; Q01608; -.
KO; K04505; -.
OMA; CGTFCYF; -.
OrthoDB; 797738at2759; -.
PhylomeDB; Q01608; -.
Reactome; R-CEL-1251985; Nuclear signaling by ERBB4.
Reactome; R-CEL-6798695; Neutrophil degranulation.
Reactome; R-CEL-9013507; NOTCH3 Activation and Transmission of Signal to the Nucleus.
PRO; PR:Q01608; -.
Proteomes; UP000001940; Chromosome I.
Bgee; WBGene00004958; Expressed in 3 organ(s), highest expression level in material anatomical entity.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:WormBase.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
GO; GO:0061024; P:membrane organization; IMP:WormBase.
GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO; GO:0006996; P:organelle organization; IMP:WormBase.
GO; GO:0008104; P:protein localization; IMP:WormBase.
GO; GO:0016485; P:protein processing; IEA:InterPro.
GO; GO:0007286; P:spermatid development; IMP:WormBase.
GO; GO:0048515; P:spermatid differentiation; IMP:UniProtKB.
InterPro; IPR001108; Peptidase_A22A.
InterPro; IPR006639; Preselin/SPP.
InterPro; IPR033153; SPE-4.
PANTHER; PTHR10202; PTHR10202; 1.
PANTHER; PTHR10202:SF17; PTHR10202:SF17; 1.
Pfam; PF01080; Presenilin; 1.
SMART; SM00730; PSN; 1.
1: Evidence at protein level;
Complete proteome; Differentiation; Endoplasmic reticulum;
Golgi apparatus; Membrane; Notch signaling pathway;
Reference proteome; Spermatogenesis; Transmembrane;
Transmembrane helix.
CHAIN 1 465 Presenilin spe-4.
/FTId=PRO_0000073904.
TOPO_DOM 1 18 Cytoplasmic. {ECO:0000255}.
TRANSMEM 19 39 Helical. {ECO:0000255}.
TOPO_DOM 40 71 Lumenal. {ECO:0000255}.
TRANSMEM 72 92 Helical. {ECO:0000255}.
TOPO_DOM 93 96 Cytoplasmic. {ECO:0000255}.
TRANSMEM 97 117 Helical. {ECO:0000255}.
TOPO_DOM 118 136 Lumenal. {ECO:0000255}.
TRANSMEM 137 157 Helical. {ECO:0000255}.
TOPO_DOM 158 160 Cytoplasmic. {ECO:0000255}.
TRANSMEM 161 181 Helical. {ECO:0000255}.
TOPO_DOM 182 190 Lumenal. {ECO:0000255}.
TRANSMEM 191 211 Helical. {ECO:0000255}.
TOPO_DOM 212 389 Cytoplasmic. {ECO:0000255}.
TRANSMEM 390 410 Helical. {ECO:0000255}.
TOPO_DOM 411 411 Lumenal. {ECO:0000255}.
TRANSMEM 412 432 Helical. {ECO:0000255}.
TOPO_DOM 433 439 Cytoplasmic. {ECO:0000255}.
INTRAMEM 440 460 Helical. {ECO:0000255}.
TOPO_DOM 461 465 Cytoplasmic. {ECO:0000255}.
MOTIF 440 442 PAL.
ACT_SITE 200 200 {ECO:0000250}.
ACT_SITE 394 394 {ECO:0000250}.
MUTAGEN 165 165 H->Y: In hc196; failed spermatocyte
division in a zipt-7.1 mutant (ok971)
background.
{ECO:0000269|PubMed:29879108}.
MUTAGEN 177 177 S->F: In HC78; induces an aberrant
localization of tubulin in spermatids.
{ECO:0000269|PubMed:9819355}.
MUTAGEN 440 440 P->L: In HC78; induces an aberrant
localization of tubulin in spermatids.
{ECO:0000269|PubMed:9819355}.
SEQUENCE 465 AA; 51830 MW; 65BE2A4DFDF3C844 CRC64;
MDTLRSISSE LVRSSQLRWT LFSVIANMSL TLSIWIGVYN MEVNSELSKT YFLDPSFEQT
TGNLLLDGFI NGVGTILVLG CVSFIMLAFV LFDFRRIVKA WLTLSCLLIL FGVSAQTLHD
MFSQVFDQDD NNQYYMTIVL IVVPTVVYGF GGIYAFFSNS SLILHQIFVV TNCSLISVFY
LRVFPSKTTW FVLWIVLFWD LFAVLAPMGP LKKVQEKASD YSKCVLNLIM FSANEKRLTA
GSNQEETNEG EESTIRRTVK QTIEYYTKRE AQDDEFYQKI RQRRAAINPD SVPTEHSPLV
EAEPSPIELK EKNSTEELSD DESDTSETSS GSSNLSSSDS STTVSTSDIS TAEECDQKEW
DDLVSNSLPN NDKRPATAAD ALNDGEVLRL GFGDFVFYSL LIGQAAASGC PFAVISAALG
ILFGLVVTLT VFSTEESTTP ALPLPVICGT FCYFSSMFFW EQLYG


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Kits Elisa; taq POLYMERASE

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Pathways :
WP104: Alanine and aspartate metabolism
WP106: Alanine and aspartate metabolism
WP1126: Tryptophan metabolism
WP1329: Alpha6-Beta4 Integrin Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway
WP1381: G13 Signaling Pathway
WP1530: miRNA regulation of DNA Damage Response
WP1545: miRNAs involved in DDR
WP208: Notch Signaling Pathway
WP2085: miRNAs involved in DDR
WP2087: miRNA regulation of DNA Damage Response
WP2316: PPAR signaling pathway
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2353: vitamin B9 (folate) biosynthesis pathway
WP240: Alanine and aspartate metabolism
WP270: Tryptophan metabolism
WP434: TCA Cycle
WP465: Tryptophan metabolism
WP623: Oxidative phosphorylation
WP673: ErbB signaling pathway
WP79: Tryptophan metabolism

Related Genes :
[spe-4 ZK524.1] Presenilin spe-4
[PSEN1 AD3 PS1 PSNL1] Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
[PSEN2 AD4 PS2 PSNL2 STM2] Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
[Psen1 Ad3h Psnl1] Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
[Psen1 Psnl1] Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
[PSEN1] Presenilin-1 (PS-1) (EC 3.4.23.-) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
[PSEN1] Presenilin-1 (PS-1) (EC 3.4.23.-) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
[PSEN1 PS1 PSNL1] Presenilin-1 (PS-1) (EC 3.4.23.-) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
[PSEN1 PS1 PSNL1 QflA-13153] Presenilin-1 (PS-1) (EC 3.4.23.-) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
[PSEN1] Presenilin-1 (PS-1) (EC 3.4.23.-) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
[Psen2 Ad4h Alg3 Ps-2 Psnl2] Presenilin-2 (PS-2) (EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
[PSEN1] Presenilin-1 (PS-1) (EC 3.4.23.-) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit]
[Psen2 Ps2 Psnl2] Presenilin-2 (PS-2) (EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
[SPPL3 IMP2 PSL4] Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)
[SPPL2B IMP4 KIAA1532 PSL1] Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)
[sel-12 F35H12.3] Presenilin sel-12 (Suppressor/enhancer of lin-12 protein 12)
[PSEN2] Presenilin-2 (PS-2) (EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
[PSEN2] Presenilin-2 (PS-2) (EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
[hop-1 C18E3.8] Presenilin hop-1
[psenB DDB_G0292310] Presenilin-B (PS-B) (EC 3.4.23.-)
[psen1] Presenilin-1 (PS-1) (EC 3.4.23.-) (Presenilin alpha) (PS-alpha)
[PSEN2] Presenilin-2 (PS-2) (EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
[spe-6 Y66D12A.20] Serine/threonine-protein kinase spe-6 (EC 2.7.11.1) (Defective spermatogenesis protein 6)
[Psn PS CG18803] Presenilin homolog (DmPS) (EC 3.4.23.-) (dPS)
[spe-10 AC3.10] Palmitoyltransferase spe-10 (EC 2.3.1.225) (Defective spermatogenesis protein 10)
[psen1] Presenilin-1 (PS-1) (Zf-PS1) (EC 3.4.23.-)
[HM13 H13 IMP1 PSL3 SPP MSTP086] Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase)
[SPPL2A IMP3 PSL2 PSEC0147] Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)
[PSEN1 EGM_16783] Presenilin (EC 3.4.23.-)
[spe-8 F53G12.6] Spermatocyte protein spe-8 (EC 2.7.10.2) (Defective spermatogenesis protein spe-8)

Bibliography :
[29879108] The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes.
[18430247] A novel function for the presenilin family member spe-4: inhibition of spermatid activation in Caenorhabditis elegans.
[16597736] The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
[15006138] Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans.
[9819355] The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis.
[9437013] Interaction of presenilins with the filamin family of actin-binding proteins.
[9300655] The presenilins and Alzheimer's disease.
[7604254] New Alzheimer's gene found.
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