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Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)] (Fragment)

 NPY_PIG                 Reviewed;          76 AA.
P01304; Q9N0M5;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
16-MAY-2003, sequence version 2.
03-JUL-2019, entry version 121.
RecName: Full=Pro-neuropeptide Y;
Contains:
RecName: Full=Neuropeptide Y;
AltName: Full=Neuropeptide tyrosine;
Short=NPY;
Contains:
RecName: Full=C-flanking peptide of NPY;
Short=CPON;
Flags: Precursor; Fragment;
Name=NPY;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Hypothalamus;
Matteri R.L.;
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
[2]
PROTEIN SEQUENCE OF 10-45, AND AMIDATION AT TYR-45.
PubMed=6957876; DOI=10.1073/pnas.79.18.5485;
Tatemoto K.;
"Neuropeptide Y: complete amino acid sequence of the brain peptide.";
Proc. Natl. Acad. Sci. U.S.A. 79:5485-5489(1982).
[3]
STRUCTURE BY NMR OF 10-45.
PubMed=2372534; DOI=10.1021/bi00471a002;
Saudek V., Pelton J.T.;
"Sequence-specific 1H NMR assignment and secondary structure of
neuropeptide Y in aqueous solution.";
Biochemistry 29:4509-4515(1990).
[4]
STRUCTURE BY NMR OF 10-45.
PubMed=1576993; DOI=10.1111/j.1432-1033.1992.tb16878.x;
Cowley D.J., Hoflack J.M., Pelton J.T., Saudek V.;
"Structure of neuropeptide Y dimer in solution.";
Eur. J. Biochem. 205:1099-1106(1992).
-!- FUNCTION: NPY is implicated in the control of feeding and in
secretion of gonadotrophin-release hormone.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: One of the most abundant peptides in the
nervous system. Also found in some chromaffin cells of the adrenal
medulla.
-!- PTM: The neuropeptide Y form is cleaved at Pro-11 by the prolyl
endopeptidase FAP (seprase) activity (in vitro).
{ECO:0000250|UniProtKB:P01303}.
-!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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EMBL; AF264083; AAF72538.1; -; mRNA.
PIR; A01573; NYPGY.
PDB; 1F8P; NMR; -; A=10-45.
PDB; 1FVN; NMR; -; A=10-45.
PDB; 1ICY; NMR; -; A=10-45.
PDB; 1TZ4; NMR; -; A=10-27, A=33-45.
PDB; 1TZ5; NMR; -; A=28-32.
PDBsum; 1F8P; -.
PDBsum; 1FVN; -.
PDBsum; 1ICY; -.
PDBsum; 1TZ4; -.
PDBsum; 1TZ5; -.
SMR; P01304; -.
STRING; 9823.ENSSSCP00000017708; -.
PaxDb; P01304; -.
PeptideAtlas; P01304; -.
PRIDE; P01304; -.
eggNOG; ENOG410J0KC; Eukaryota.
eggNOG; ENOG41128I2; LUCA.
InParanoid; P01304; -.
EvolutionaryTrace; P01304; -.
Proteomes; UP000008227; Unplaced.
Genevisible; P01304; SS.
GO; GO:0005615; C:extracellular space; ISS:HGNC.
GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
GO; GO:0008343; P:adult feeding behavior; ISS:HGNC.
GO; GO:0090275; P:negative regulation of somatostatin secretion; IMP:AgBase.
GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
GO; GO:0032100; P:positive regulation of appetite; ISS:HGNC.
GO; GO:0090274; P:positive regulation of somatostatin secretion; IMP:AgBase.
CDD; cd00126; PAH; 1.
InterPro; IPR001955; Pancreatic_hormone-like.
InterPro; IPR020392; Pancreatic_hormone-like_CS.
PANTHER; PTHR10533; PTHR10533; 1.
Pfam; PF00159; Hormone_3; 1.
PRINTS; PR00278; PANCHORMONE.
SMART; SM00309; PAH; 1.
PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
1: Evidence at protein level;
3D-structure; Amidation; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Neuropeptide;
Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL <1 9 {ECO:0000269|PubMed:6957876}.
PEPTIDE 10 45 Neuropeptide Y.
{ECO:0000269|PubMed:6957876}.
/FTId=PRO_0000025327.
PEPTIDE 49 >76 C-flanking peptide of NPY.
/FTId=PRO_0000025328.
SITE 11 12 Cleavage; by FAP.
{ECO:0000250|UniProtKB:P01303}.
MOD_RES 45 45 Tyrosine amide.
{ECO:0000269|PubMed:6957876}.
MOD_RES 64 64 Phosphothreonine.
{ECO:0000250|UniProtKB:P01303}.
NON_TER 1 1
NON_TER 76 76
TURN 22 25 {ECO:0000244|PDB:1F8P}.
HELIX 26 44 {ECO:0000244|PDB:1F8P}.
SEQUENCE 76 AA; 8596 MW; 84E40EC2A4F94B2C CRC64;
VCLCALAEAY PSKPDNPGED APAEDLARYY SALRHYINLI TRQRYGKRSS PETLISDLLM
REGTENVPRT RLEDPS


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Pathways :
WP27: Phenylalanine, Tyrosine, Tryptophan biosynthesis
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WP120: Phenylalanine and Tyrosine Biosynthesis
WP1687: Phenylalanine, tyrosine and tryptophan biosynthesi
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WP582: Cre-lox for W846X
WP1117: Peptide GPCRs
WP1338: Peptide GPCRs
WP234: Peptide GPCRs
WP538: Tyrosine Biosynthesis
WP883: Peptide GPCRs
WP1001: Peptide GPCRs
WP131: Peptide GPCRs
WP1714: Tyrosine metabolism

Related Genes :
[TAC1 NKA NKNA TAC2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
[Tac1 Nka Nkna Tac2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
[Tac1 Nka Nkna Tac2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
[TAC1 NKA NKNA TAC2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
[Pmch Mch] Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)]
[Pmch Mch] Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)]
[NPF CG10342] Neuropeptide F (NPF) (dNPF)
[] Protachykinin (Gamma-preprotachykinin) (Gamma-PPT) [Cleaved into: Substance P (SP); Neuropeptide gamma (Carassin); Neurokinin A (NKA); C-terminal-flanking peptide]
[] PBAN-type neuropeptides (Pheromone/pyrokinin biosynthesis-activating neuropeptide) [Cleaved into: Diapause hormone (DH); PBAN precursor-related peptide 1 (PBAN-PP-1); PBAN precursor-related peptide 2 (PBAN-PP-2); Alpha-subesophageal ganglion neuropeptide (Alpha-SG neuropeptide) (Alpha-SGNP); Beta-subesophageal ganglion neuropeptide (Beta-SG neuropeptide) (Beta-SGNP) (Pyrokinin-1); Pheromone biosynthesis-activating neuropeptide (Agi-PBAN) (Pyrokinin-2); Gamma-subesophageal ganglion neuropeptide (Gamma-SG neuropeptide) (Gamma-SGNP) (Pyrokinin-3); PBAN precursor-related peptide 3 (PBAN-PP-3)]
[NPFR NPFR1 CG1147] Neuropeptide F receptor (DmNPFR1)
[TAC1 NKA NKNA TAC2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide gamma; C-terminal-flanking peptide]
[TAC1 NKA NKNA TAC2] Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
[PMCH MCH] Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)]
[NPY6R NPY1RL Y2B] Putative neuropeptide Y receptor type 6 (NPY6-R) (NPY Y1-like receptor) (Putative pancreatic polypeptide receptor 2) (PP2)
[NPFFR2 GPR74 NPFF2 NPGPR] Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor)
[CCHa2 CG14375] Neuropeptide CCHamide-2
[CCHa1 CG14358] Neuropeptide CCHamide-1
[] Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (NPY); C-flanking peptide of NPY]
[Ptprn Ptp35] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[Ptprn] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (105 kDa islet cell antigen) (BEM-3) (Brain-enriched membrane-associated protein tyrosine phosphatase) (ICA105) (ICA512) (PTP IA-2) (PTPLP) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[PTPRN ICA3 ICA512] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[PTPRN] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell autoantigen 512) (ICA512) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[FAP] Prolyl endopeptidase FAP (EC 3.4.21.26) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) (Z-Pro-prolinal insensitive peptidase) (ZIP) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]
[pomca] Pro-opiomelanocortin A (POMC-A) (Corticotropin-lipotropin A) [Cleaved into: NPP 1; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha 1 (Alpha-MSH 1) (Melanotropin alpha 1); Corticotropin-like intermediary peptide 1 (CLIP-1); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta 1 (Beta-MSH 1) (Melanotropin beta 1); Beta-endorphin 1; Met-enkephalin; C-terminal peptide 1; C-terminal peptide 2]
[CXCR4] C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
[Corin Crn Lrp4] Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Low density lipoprotein receptor-related protein 4) (Pro-ANP-converting enzyme) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]
[NPFFR1 GPR147 NPFF1] Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022)
[POMC] Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]
[] Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component proteinase (HC-pro) (EC 3.4.22.45); Protein P3; 6 kDa protein 1 (6K1); Cytoplasmic inclusion protein (CI) (EC 3.6.4.-); 6 kDa protein 2 (6K2); Viral genome-linked protein (VPg); Nuclear inclusion protein A (NI-a) (NIa) (EC 3.4.22.44) (49 kDa proteinase) (49 kDa-Pro) (NIa-pro); Nuclear inclusion protein B (NI-b) (NIb) (EC 2.7.7.48) (RNA-directed RNA polymerase); Capsid protein (CP) (Coat protein)]
[CORIN CRN TMPRSS10] Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]

Bibliography :
[30191621] Predictive value of combined analysis of pro-NPY and ERG in localized prostate cancer.
[12740814] Semisynthesis and characterization of the first analogues of pro-neuropeptide y.
[9405066] Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations.
[9179294] High-level expression of the prohormones proenkephalin, pro-neuropeptide Y, proopiomelanocortin, and beta-protachykinin for in vitro prohormone processing.
[8612764] Expression of recombinant pro-neuropeptide Y, proopiomelanocortin, and proenkephalin: relative processing by 'prohormone thiol protease' (PTP).
[8020494] Comparison of the solution structures of the chimeric peptides galanin(1-12)-Ala-neuropeptide Y(25-36)amide and galanin(1-12)-Pro-neuropeptide Y(25-36)amide.
[8514771] Processing of two homologous precursors, pro-neuropeptide Y and pro-pancreatic polypeptide, in transfected cell lines expressing different precursor convertases.
[2303410] Biosynthesis and posttranslational processing of site-directed endoproteolytic cleavage mutants of pro-neuropeptide Y in mouse pituitary cells.