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Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]

 COLI_MOUSE              Reviewed;         235 AA.
P01193; P01200; Q544U4;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
13-FEB-2019, entry version 160.
RecName: Full=Pro-opiomelanocortin;
Short=POMC;
AltName: Full=Corticotropin-lipotropin;
Contains:
RecName: Full=NPP;
Contains:
RecName: Full=Melanotropin gamma;
AltName: Full=Gamma-MSH;
Contains:
RecName: Full=Corticotropin;
AltName: Full=Adrenocorticotropic hormone;
Short=ACTH;
Contains:
RecName: Full=Melanocyte-stimulating hormone alpha;
Short=Alpha-MSH;
AltName: Full=Melanotropin alpha;
Contains:
RecName: Full=Corticotropin-like intermediary peptide;
Short=CLIP;
Contains:
RecName: Full=Lipotropin beta;
AltName: Full=Beta-LPH;
Contains:
RecName: Full=Lipotropin gamma;
AltName: Full=Gamma-LPH;
Contains:
RecName: Full=Melanocyte-stimulating hormone beta;
Short=Beta-MSH;
AltName: Full=Melanotropin beta;
Contains:
RecName: Full=Beta-endorphin;
Contains:
RecName: Full=Met-enkephalin;
Flags: Precursor;
Name=Pomc; Synonyms=Pomc1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6303853; DOI=10.1016/0014-5793(83)80250-6;
Notake M., Tobimatsu T., Watanabe Y., Takahashi H., Mishina M.,
Numa S.;
"Isolation and characterization of the mouse corticotropin-beta-
lipotropin precursor gene and a related pseudogene.";
FEBS Lett. 156:67-71(1983).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6308009;
Uhler M., Herbert E., D'Eustachio P., Ruddle F.D.;
"The mouse genome contains two nonallelic pro-opiomelanocortin
genes.";
J. Biol. Chem. 258:9444-9453(1983).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Pituitary;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pituitary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE OF 1-36.
PubMed=2536749;
Thorne B.A., Caton L.W., Thomas G.;
"Expression of mouse proopiomelanocortin in an insulinoma cell line.
Requirements for beta-endorphin processing.";
J. Biol. Chem. 264:3545-3552(1989).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 124-162.
STRAIN=C3H/HeJ; TISSUE=Lymphocyte;
PubMed=1689057; DOI=10.1073/pnas.87.3.1057;
Smith E.M., Galin F.S., Leboeuf R.D., Coppenhaver D.H., Harbour D.V.,
Blalock E.J.;
"Nucleotide and amino acid sequence of lymphocyte-derived
corticotropin: endotoxin induction of a truncated peptide.";
Proc. Natl. Acad. Sci. U.S.A. 87:1057-1060(1990).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-234.
PubMed=221916; DOI=10.1073/pnas.76.5.2153;
Roberts J.L., Seeburg P.H., Shine J., Herbert E., Baxter J.D.,
Goodman H.M.;
"Corticotropin and beta-endorphin: construction and analysis of
recombinant DNA complementary to mRNA for the common precursor.";
Proc. Natl. Acad. Sci. U.S.A. 76:2153-2157(1979).
[8]
SUBCELLULAR LOCATION, AND INDUCTION BY CANNABINOID.
PubMed=25707796; DOI=10.1038/nature14260;
Koch M., Varela L., Kim J.G., Kim J.D., Hernandez-Nuno F.,
Simonds S.E., Castorena C.M., Vianna C.R., Elmquist J.K.,
Morozov Y.M., Rakic P., Bechmann I., Cowley M.A., Szigeti-Buck K.,
Dietrich M.O., Gao X.B., Diano S., Horvath T.L.;
"Hypothalamic POMC neurons promote cannabinoid-induced feeding.";
Nature 519:45-50(2015).
-!- FUNCTION: Corticotropin: Stimulates the adrenal glands to release
cortisol.
-!- FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic
peptide. Increases the pigmentation of skin by increasing melanin
production in melanocytes.
-!- FUNCTION: Melanocyte-stimulating hormone beta: Increases the
pigmentation of skin by increasing melanin production in
melanocytes.
-!- FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.
-!- FUNCTION: Met-enkephalin: Endogenous opiate.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25707796}.
Note=Melanocyte-stimulating hormone alpha and beta-endorphin are
stored in separate granules in hypothalamic POMC neurons,
suggesting that secretion may be under the control of different
regulatory mechanisms. {ECO:0000269|PubMed:25707796}.
-!- TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary
gland.
-!- INDUCTION: Beta-endorphin: In hypothalamic paraventricular nucleus
(PVN), up-regulated by cannabinoids, including the CNR1/CB1R
agonist arachidonyl-29-chloroethylamide (ACEA) (at protein level).
{ECO:0000269|PubMed:25707796}.
-!- PTM: Specific enzymatic cleavages at paired basic residues yield
the different active peptides.
-!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; J00612; AAB59729.1; -; Genomic_DNA.
EMBL; J00611; AAB59729.1; JOINED; Genomic_DNA.
EMBL; V01528; CAA24769.1; -; Genomic_DNA.
EMBL; V01529; CAA24770.1; -; Genomic_DNA.
EMBL; AK017492; BAB30771.1; -; mRNA.
EMBL; AK017581; BAB30818.1; -; mRNA.
EMBL; AK030714; BAC27095.1; -; mRNA.
EMBL; AK077426; BAC36795.1; -; mRNA.
EMBL; AK133592; BAE21739.1; -; mRNA.
EMBL; AK133646; BAE21764.1; -; mRNA.
EMBL; AK133740; BAE21815.1; -; mRNA.
EMBL; AK133776; BAE21833.1; -; mRNA.
EMBL; AK133800; BAE21850.1; -; mRNA.
EMBL; BC061215; AAH61215.1; -; mRNA.
EMBL; M30489; AAA37169.1; -; mRNA.
EMBL; V00831; -; NOT_ANNOTATED_CDS; mRNA.
CCDS; CCDS25785.1; -.
PIR; A91312; CTMSP.
RefSeq; NP_001265510.1; NM_001278581.1.
RefSeq; NP_001265511.1; NM_001278582.1.
RefSeq; NP_001265512.1; NM_001278583.1.
RefSeq; NP_001265513.1; NM_001278584.1.
RefSeq; NP_032921.1; NM_008895.4.
UniGene; Mm.277996; -.
ProteinModelPortal; P01193; -.
ELM; P01193; -.
STRING; 10090.ENSMUSP00000020990; -.
GlyConnect; 112; -.
PhosphoSitePlus; P01193; -.
UniCarbKB; P01193; -.
PaxDb; P01193; -.
PeptideAtlas; P01193; -.
PRIDE; P01193; -.
Ensembl; ENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660.
Ensembl; ENSMUST00000218089; ENSMUSP00000151367; ENSMUSG00000020660.
Ensembl; ENSMUST00000219543; ENSMUSP00000151504; ENSMUSG00000020660.
GeneID; 18976; -.
KEGG; mmu:18976; -.
UCSC; uc007mxe.2; mouse.
CTD; 5443; -.
MGI; MGI:97742; Pomc.
eggNOG; ENOG410IKR5; Eukaryota.
eggNOG; ENOG410Z5R4; LUCA.
GeneTree; ENSGT00390000016811; -.
HOGENOM; HOG000111887; -.
HOVERGEN; HBG004341; -.
InParanoid; P01193; -.
KO; K05228; -.
OMA; VMSHFRW; -.
OrthoDB; 1168862at2759; -.
PhylomeDB; P01193; -.
TreeFam; TF333215; -.
Reactome; R-MMU-111885; Opioid Signalling.
Reactome; R-MMU-193048; Androgen biosynthesis.
Reactome; R-MMU-194002; Glucocorticoid biosynthesis.
Reactome; R-MMU-202040; G-protein activation.
Reactome; R-MMU-209952; Peptide hormone biosynthesis.
Reactome; R-MMU-211976; Endogenous sterols.
Reactome; R-MMU-375276; Peptide ligand-binding receptors.
Reactome; R-MMU-418555; G alpha (s) signalling events.
Reactome; R-MMU-418594; G alpha (i) signalling events.
ChiTaRS; Pomc; mouse.
PMAP-CutDB; P01193; -.
PRO; PR:P01193; -.
Proteomes; UP000000589; Chromosome 12.
Bgee; ENSMUSG00000020660; Expressed in 132 organ(s), highest expression level in pituitary gland.
ExpressionAtlas; P01193; baseline and differential.
Genevisible; P01193; MM.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005576; C:extracellular region; ISO:MGI.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0030141; C:secretory granule; IDA:MGI.
GO; GO:0001664; F:G protein-coupled receptor binding; ISS:UniProtKB.
GO; GO:0005179; F:hormone activity; IDA:MGI.
GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
GO; GO:0070996; F:type 1 melanocortin receptor binding; ISS:UniProtKB.
GO; GO:0031781; F:type 3 melanocortin receptor binding; ISO:MGI.
GO; GO:0031782; F:type 4 melanocortin receptor binding; ISO:MGI.
GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB.
GO; GO:0033059; P:cellular pigmentation; ISS:UniProtKB.
GO; GO:0006091; P:generation of precursor metabolites and energy; ISS:UniProtKB.
GO; GO:0042593; P:glucose homeostasis; IMP:MGI.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:UniProtKB.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0032098; P:regulation of appetite; ISS:UniProtKB.
GO; GO:0008217; P:regulation of blood pressure; IGI:MGI.
GO; GO:2000852; P:regulation of corticosterone secretion; IMP:MGI.
GO; GO:0070873; P:regulation of glycogen metabolic process; IMP:MGI.
GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
InterPro; IPR013531; Mcrtin_ACTH_cent.
InterPro; IPR013593; Melanocortin_N.
InterPro; IPR013532; Opioid_neuropept.
InterPro; IPR001941; PMOC.
Pfam; PF00976; ACTH_domain; 3.
Pfam; PF08384; NPP; 1.
Pfam; PF08035; Op_neuropeptide; 1.
PRINTS; PR00383; MELANOCORTIN.
SMART; SM01363; ACTH_domain; 2.
SMART; SM01364; NPP; 1.
SMART; SM01365; Op_neuropeptide; 1.
1: Evidence at protein level;
Acetylation; Amidation; Cleavage on pair of basic residues;
Complete proteome; Endorphin; Glycoprotein; Hormone; Phosphoprotein;
Reference proteome; Secreted; Signal.
SIGNAL 1 26 {ECO:0000250}.
PEPTIDE 27 100 NPP.
/FTId=PRO_0000024996.
PEPTIDE 77 87 Melanotropin gamma.
/FTId=PRO_0000024997.
PROPEP 103 121
/FTId=PRO_0000024998.
PEPTIDE 124 162 Corticotropin.
/FTId=PRO_0000024999.
PEPTIDE 124 136 Melanocyte-stimulating hormone alpha.
/FTId=PRO_0000025000.
PEPTIDE 142 162 Corticotropin-like intermediary peptide.
/FTId=PRO_0000025001.
PEPTIDE 165 235 Lipotropin beta.
/FTId=PRO_0000025002.
PEPTIDE 165 202 Lipotropin gamma.
/FTId=PRO_0000025003.
PEPTIDE 185 202 Melanocyte-stimulating hormone beta.
/FTId=PRO_0000025004.
PEPTIDE 205 235 Beta-endorphin.
/FTId=PRO_0000025005.
PEPTIDE 205 209 Met-enkephalin.
/FTId=PRO_0000025006.
MOD_RES 87 87 Phenylalanine amide. {ECO:0000250}.
MOD_RES 124 124 N-acetylserine; in Corticotropin.
{ECO:0000250|UniProtKB:P01191}.
MOD_RES 136 136 Valine amide. {ECO:0000250}.
MOD_RES 154 154 Phosphoserine.
{ECO:0000250|UniProtKB:P01189}.
CARBOHYD 91 91 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 152 152 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 176 176 Q -> H (in Ref. 2; CAA24770).
{ECO:0000305}.
SEQUENCE 235 AA; 26707 MW; EF98C0A95D6B4991 CRC64;
MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC KLDLSLETPV
FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ RRAEEEAVWG DGSPEPSPRE
GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA ENESAEAFPL EFKRELEGER PLGLEQVLES
DAEKDDGPYR VEHFRWSNPP KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ


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Pathways :
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP262: EBV LMP1 signaling
WP32: Translation Factors
WP537: Translation Factors
WP1722: Th1/Th2
WP542: Electron Transport Chain
WP1434: Osteopontin Signaling
WP1566: Citrate cycle (TCA cycle)
WP1571: EBV LMP1 signaling
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP1835: Interferon alpha/beta signaling
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP210: Cytoplasmic Ribosomal Proteins
WP215: noncanonical wnt pathway
WP219: Cytoplasmic tRNA Synthetases
WP244: Alpha 6 Beta 4 signaling pathway
WP433: tRNA Synthetases
WP566: canonical wnt - zebrafish
WP2199: Seed Development
WP2355: Corticotropin-releasing hormone
WP1045: TGF-beta Receptor Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP105: Fatty Acid Beta Oxidation 2

Related Genes :
[POMC] Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]
[pomca] Pro-opiomelanocortin A (POMC-A) (Corticotropin-lipotropin A) [Cleaved into: NPP 1; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha 1 (Alpha-MSH 1) (Melanotropin alpha 1); Corticotropin-like intermediary peptide 1 (CLIP-1); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta 1 (Beta-MSH 1) (Melanotropin beta 1); Beta-endorphin 1; Met-enkephalin; C-terminal peptide 1; C-terminal peptide 2]
[pomcb] Pro-opiomelanocortin B (POMC-B) (Corticotropin-lipotropin B) [Cleaved into: NPP 2; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha 2 (Alpha-MSH 2) (Melanotropin alpha 2); Corticotropin-like intermediary peptide 2 (CLIP-2); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta 2 (Beta-MSH 2) (Melanotropin beta 2); Beta-endorphin 2; Met-enkephalin]
[MC1R MSHR] Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R)
[APP A4 AD1] Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[App] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[] PBAN-type neuropeptides (Pheromone/pyrokinin biosynthesis-activating neuropeptide) [Cleaved into: Diapause hormone (DH); PBAN precursor-related peptide 1 (PBAN-PP-1); PBAN precursor-related peptide 2 (PBAN-PP-2); Alpha-subesophageal ganglion neuropeptide (Alpha-SG neuropeptide) (Alpha-SGNP); Beta-subesophageal ganglion neuropeptide (Beta-SG neuropeptide) (Beta-SGNP) (Pyrokinin-1); Pheromone biosynthesis-activating neuropeptide (Agi-PBAN) (Pyrokinin-2); Gamma-subesophageal ganglion neuropeptide (Gamma-SG neuropeptide) (Gamma-SGNP) (Pyrokinin-3); PBAN precursor-related peptide 3 (PBAN-PP-3)]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF) (CTF-beta); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF) (CTF-alpha); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[App] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99) (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[APP QccE-15949] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[FSHB] Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain)
[TSHB] Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (Thyrotropin alfa)
[CRHR1 CRFR CRFR1 CRHR] Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
[Hsd3b1] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1)
[Cgamma] Gamma conglutin 1 (Conglutin gamma 32) (allergen Lup a gamma-conglutin) [Cleaved into: Gamma conglutin 1 beta subunit (Gamma conglutin 1 17 kDa subunit) (Gamma conglutin 1 small subunit); Gamma conglutin 1 alpha subunit (Gamma conglutin 1 29 kDa subunit) (Gamma conglutin 1 large subunit)]
[CRH] Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone)
[HSD3B1 3BH HSDB3A] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1) (Trophoblast antigen FDO161G)
[C3 CPAMD1] Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[Crhr1 Crhr] Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
[TMPO LAP2] Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]
[Hsd3b1 Hsd3b] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1)
[HSD3B1] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1)
[C3] Complement C3 (HSE-MSF) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[C3] Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[C3] Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; C3-beta-c (C3bc); Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[C3] Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc) (Neutrophil chemotactic factor-2) (ENCF-2); Complement C3 alpha chain; C3a anaphylatoxin (Neutrophil chemotactic factor-1) (ENCF-1); Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[HSD3B1] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1)

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