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Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2)

 DTX2_HUMAN              Reviewed;         622 AA.
Q86UW9; Q4ZH49; Q6XM87; Q6XM88; Q96H69; Q9H890; Q9P200;
26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
21-JUN-2005, sequence version 3.
03-JUL-2019, entry version 150.
RecName: Full=Probable E3 ubiquitin-protein ligase DTX2;
EC=2.3.2.27 {ECO:0000250|UniProtKB:Q61010};
AltName: Full=Protein deltex-2;
Short=Deltex2;
Short=hDTX2;
AltName: Full=RING finger protein 58;
AltName: Full=RING-type E3 ubiquitin transferase DTX2 {ECO:0000305};
Name=DTX2; Synonyms=KIAA1528, RNF58;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2),
VARIANT GLU-384, SUBUNIT, AND IN VITRO UBIQUITIN LIGASE ACTIVITY.
PubMed=12670957; DOI=10.1074/jbc.M301157200;
Takeyama K., Aguiar R.C.T., Gu L., He C., Freeman G.J., Kutok J.L.,
Aster J.C., Shipp M.A.;
"The BAL-binding protein BBAP and related Deltex family members
exhibit ubiquitin-protein isopeptide ligase activity.";
J. Biol. Chem. 278:21930-21937(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-421.
Yi Z., Yi T., Wu Z.;
"cDNA cloning, characterization and expression analysis of DTX2, a
human WWE and RING-finger gene, in human embryos.";
DNA Seq. 17:175-180(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
GLU-384 AND ALA-421.
TISSUE=Brain;
PubMed=10819331; DOI=10.1093/dnares/7.2.143;
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XVII.
The complete sequences of 100 new cDNA clones from brain which code
for large proteins in vitro.";
DNA Res. 7:143-150(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
ALA-421.
TISSUE=Thyroid;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12853948; DOI=10.1038/nature01782;
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
GLU-384.
TISSUE=Brain, Lymph, and Muscle;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
SUBCELLULAR LOCATION.
PubMed=11564735; DOI=10.1074/jbc.M105245200;
Yamamoto N., Yamamoto S., Inagaki F., Kawaichi M., Fukamizu A.,
Kishi N., Matsuno K., Nakamura K., Weinmaster G., Okano H.,
Nakafuku M.;
"Role of Deltex-1 as a transcriptional regulator downstream of the
Notch receptor.";
J. Biol. Chem. 276:45031-45040(2001).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[9]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-249, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19608861; DOI=10.1126/science.1175371;
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
Walther T.C., Olsen J.V., Mann M.;
"Lysine acetylation targets protein complexes and co-regulates major
cellular functions.";
Science 325:834-840(2009).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[11]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-213; ARG-215; ARG-233 AND
ARG-256, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Colon carcinoma;
PubMed=24129315; DOI=10.1074/mcp.O113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
-!- FUNCTION: Regulator of Notch signaling, a signaling pathway
involved in cell-cell communications that regulates a broad
spectrum of cell-fate determinations. Probably acts both as a
positive and negative regulator of Notch, depending on the
developmental and cell context. Mediates the antineural activity
of Notch, possibly by inhibiting the transcriptional activation
mediated by MATCH1. Functions as a ubiquitin ligase protein in
vitro, suggesting that it may regulate the Notch pathway via some
ubiquitin ligase activity.
-!- CATALYTIC ACTIVITY:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-
cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
protein]-L-lysine.; EC=2.3.2.27;
Evidence={ECO:0000250|UniProtKB:Q61010};
-!- PATHWAY: Protein modification; protein ubiquitination.
-!- SUBUNIT: Homodimer. May form a heterodimer with other members of
the Deltex family. Interacts with NOTCH1.
{ECO:0000250|UniProtKB:Q61010}.
-!- INTERACTION:
O95870:ABHD16A; NbExp=5; IntAct=EBI-740376, EBI-348517;
Q9NXW9:ALKBH4; NbExp=9; IntAct=EBI-740376, EBI-8637516;
A0A087WVE9:ARNT2; NbExp=3; IntAct=EBI-740376, EBI-12808086;
Q6P1W5:C1orf94; NbExp=3; IntAct=EBI-740376, EBI-946029;
Q8NI60:COQ8A; NbExp=3; IntAct=EBI-740376, EBI-745535;
Q9NRA8:EIF4ENIF1; NbExp=7; IntAct=EBI-740376, EBI-301024;
Q92567:FAM168A; NbExp=6; IntAct=EBI-740376, EBI-7957930;
Q14192:FHL2; NbExp=6; IntAct=EBI-740376, EBI-701903;
Q8IVS8:GLYCTK; NbExp=5; IntAct=EBI-740376, EBI-748515;
Q08379:GOLGA2; NbExp=3; IntAct=EBI-740376, EBI-618309;
P19113:HDC; NbExp=6; IntAct=EBI-740376, EBI-10200283;
P49639:HOXA1; NbExp=4; IntAct=EBI-740376, EBI-740785;
P37235:HPCAL1; NbExp=3; IntAct=EBI-740376, EBI-749311;
Q9UM19:HPCAL4; NbExp=6; IntAct=EBI-740376, EBI-744820;
Q6P597:KLC3; NbExp=6; IntAct=EBI-740376, EBI-1643885;
Q6PEX3:KRTAP26-1; NbExp=3; IntAct=EBI-740376, EBI-3957672;
P61601:NCALD; NbExp=12; IntAct=EBI-740376, EBI-749635;
P62166:NCS1; NbExp=12; IntAct=EBI-740376, EBI-746987;
Q9H8W4:PLEKHF2; NbExp=3; IntAct=EBI-740376, EBI-742388;
P47897-2:QARS; NbExp=3; IntAct=EBI-740376, EBI-10209725;
Q93062:RBPMS; NbExp=7; IntAct=EBI-740376, EBI-740322;
Q8HWS3:RFX6; NbExp=4; IntAct=EBI-740376, EBI-746118;
Q9BQY4:RHOXF2; NbExp=3; IntAct=EBI-740376, EBI-372094;
Q9UFD9:RIMBP3; NbExp=3; IntAct=EBI-740376, EBI-10182375;
Q96IW7:SEC22A; NbExp=9; IntAct=EBI-740376, EBI-8652744;
Q15437:SEC23B; NbExp=6; IntAct=EBI-740376, EBI-742673;
Q99932:SPAG8; NbExp=3; IntAct=EBI-740376, EBI-954419;
Q9NZD8:SPG21; NbExp=6; IntAct=EBI-740376, EBI-742688;
Q86Y82:STX12; NbExp=5; IntAct=EBI-740376, EBI-2691717;
P63165:SUMO1; NbExp=3; IntAct=EBI-740376, EBI-80140;
Q9BYV2:TRIM54; NbExp=8; IntAct=EBI-740376, EBI-2130429;
Q15654:TRIP6; NbExp=3; IntAct=EBI-740376, EBI-742327;
P51668:UBE2D1; NbExp=6; IntAct=EBI-740376, EBI-743540;
P61077:UBE2D3; NbExp=8; IntAct=EBI-740376, EBI-348268;
Q9Y2X8:UBE2D4; NbExp=11; IntAct=EBI-740376, EBI-745527;
P62760:VSNL1; NbExp=9; IntAct=EBI-740376, EBI-740943;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11564735}.
Nucleus {ECO:0000269|PubMed:11564735}. Note=Predominantly
cytoplasmic. Partially nuclear. {ECO:0000269|PubMed:11564735}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=A;
IsoId=Q86UW9-1; Sequence=Displayed;
Name=2; Synonyms=B;
IsoId=Q86UW9-2; Sequence=VSP_008350;
-!- DOMAIN: The WWE domains are thought to mediate some protein-
protein interaction, and are frequently found in ubiquitin
ligases. {ECO:0000250}.
-!- SIMILARITY: Belongs to the Deltex family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAA96052.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AY225124; AAP57518.1; -; mRNA.
EMBL; AY225125; AAP57519.1; -; mRNA.
EMBL; DQ010329; AAY27263.1; -; mRNA.
EMBL; AB040961; BAA96052.1; ALT_INIT; mRNA.
EMBL; AK023924; BAB14727.1; -; mRNA.
EMBL; AC005522; AAP21881.1; -; Genomic_DNA.
EMBL; AC007078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC008856; AAH08856.1; -; mRNA.
EMBL; BC018555; AAH18555.1; -; mRNA.
EMBL; BC026059; AAH26059.1; -; mRNA.
EMBL; BC093079; AAH93079.1; -; mRNA.
CCDS; CCDS43605.1; -. [Q86UW9-2]
CCDS; CCDS5587.1; -. [Q86UW9-1]
RefSeq; NP_001096064.1; NM_001102594.1. [Q86UW9-1]
RefSeq; NP_001096065.1; NM_001102595.1. [Q86UW9-1]
RefSeq; NP_001096066.1; NM_001102596.1. [Q86UW9-2]
RefSeq; NP_065943.2; NM_020892.2. [Q86UW9-1]
RefSeq; XP_005250188.1; XM_005250131.1. [Q86UW9-1]
RefSeq; XP_005250189.1; XM_005250132.1. [Q86UW9-1]
RefSeq; XP_011514074.1; XM_011515772.1. [Q86UW9-1]
RefSeq; XP_011514075.1; XM_011515773.2. [Q86UW9-1]
RefSeq; XP_011514076.1; XM_011515774.1. [Q86UW9-1]
RefSeq; XP_011514077.1; XM_011515775.1. [Q86UW9-1]
RefSeq; XP_016867212.1; XM_017011723.1. [Q86UW9-1]
RefSeq; XP_016867213.1; XM_017011724.1. [Q86UW9-1]
RefSeq; XP_016867214.1; XM_017011725.1. [Q86UW9-1]
RefSeq; XP_016867215.1; XM_017011726.1. [Q86UW9-2]
RefSeq; XP_016867216.1; XM_017011727.1. [Q86UW9-2]
SMR; Q86UW9; -.
BioGrid; 125266; 48.
IntAct; Q86UW9; 126.
MINT; Q86UW9; -.
STRING; 9606.ENSP00000322885; -.
iPTMnet; Q86UW9; -.
PhosphoSitePlus; Q86UW9; -.
BioMuta; DTX2; -.
DMDM; 68067880; -.
EPD; Q86UW9; -.
jPOST; Q86UW9; -.
MaxQB; Q86UW9; -.
PaxDb; Q86UW9; -.
PeptideAtlas; Q86UW9; -.
PRIDE; Q86UW9; -.
ProteomicsDB; 69923; -.
ProteomicsDB; 69924; -. [Q86UW9-2]
DNASU; 113878; -.
Ensembl; ENST00000324432; ENSP00000322885; ENSG00000091073. [Q86UW9-1]
Ensembl; ENST00000413936; ENSP00000390218; ENSG00000091073. [Q86UW9-1]
Ensembl; ENST00000430490; ENSP00000411986; ENSG00000091073. [Q86UW9-1]
Ensembl; ENST00000446820; ENSP00000392545; ENSG00000091073. [Q86UW9-2]
GeneID; 113878; -.
KEGG; hsa:113878; -.
UCSC; uc003uff.5; human. [Q86UW9-1]
CTD; 113878; -.
DisGeNET; 113878; -.
GeneCards; DTX2; -.
HGNC; HGNC:15973; DTX2.
HPA; HPA042931; -.
MIM; 613141; gene.
neXtProt; NX_Q86UW9; -.
OpenTargets; ENSG00000091073; -.
PharmGKB; PA27515; -.
eggNOG; ENOG410IEMS; Eukaryota.
eggNOG; ENOG4111EY2; LUCA.
GeneTree; ENSGT00940000157641; -.
HOGENOM; HOG000007352; -.
InParanoid; Q86UW9; -.
KO; K06058; -.
OMA; ICYLPDC; -.
OrthoDB; 600021at2759; -.
PhylomeDB; Q86UW9; -.
Reactome; R-HSA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus.
UniPathway; UPA00143; -.
ChiTaRS; DTX2; human.
GeneWiki; DTX2; -.
GenomeRNAi; 113878; -.
PRO; PR:Q86UW9; -.
Proteomes; UP000005640; Chromosome 7.
Bgee; ENSG00000091073; Expressed in 142 organ(s), highest expression level in lower esophagus mucosa.
ExpressionAtlas; Q86UW9; baseline and differential.
Genevisible; Q86UW9; HS.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0031965; C:nuclear membrane; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
CDD; cd09633; Deltex_C; 1.
Gene3D; 3.30.390.130; -; 1.
Gene3D; 3.30.40.10; -; 1.
Gene3D; 3.30.720.50; -; 2.
InterPro; IPR039396; Deltex_C.
InterPro; IPR039399; Deltex_C_sf.
InterPro; IPR039398; Deltex_fam.
InterPro; IPR004170; WWE-dom.
InterPro; IPR018123; WWE-dom_subgr.
InterPro; IPR037197; WWE_dom_sf.
InterPro; IPR018957; Znf_C3HC4_RING-type.
InterPro; IPR001841; Znf_RING.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
PANTHER; PTHR12622; PTHR12622; 1.
Pfam; PF18102; DTC; 1.
Pfam; PF02825; WWE; 2.
Pfam; PF00097; zf-C3HC4; 1.
SMART; SM00184; RING; 1.
SMART; SM00678; WWE; 2.
SUPFAM; SSF117839; SSF117839; 2.
PROSITE; PS50918; WWE; 2.
PROSITE; PS50089; ZF_RING_2; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
Metal-binding; Methylation; Notch signaling pathway; Nucleus;
Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transferase;
Ubl conjugation pathway; Zinc; Zinc-finger.
CHAIN 1 622 Probable E3 ubiquitin-protein ligase
DTX2.
/FTId=PRO_0000219083.
DOMAIN 8 97 WWE 1. {ECO:0000255|PROSITE-
ProRule:PRU00248}.
DOMAIN 98 174 WWE 2. {ECO:0000255|PROSITE-
ProRule:PRU00248}.
ZN_FING 412 473 RING-type. {ECO:0000255|PROSITE-
ProRule:PRU00175}.
MOD_RES 213 213 Asymmetric dimethylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 215 215 Asymmetric dimethylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 233 233 Asymmetric dimethylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 249 249 N6-acetyllysine.
{ECO:0000244|PubMed:19608861}.
MOD_RES 256 256 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 360 360 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
VAR_SEQ 337 383 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_008350.
VARIANT 94 94 A -> T (in dbSNP:rs2462312).
/FTId=VAR_016920.
VARIANT 384 384 G -> E (in dbSNP:rs1638152).
{ECO:0000269|PubMed:10819331,
ECO:0000269|PubMed:12670957,
ECO:0000269|PubMed:15489334}.
/FTId=VAR_016921.
VARIANT 421 421 T -> A (in dbSNP:rs6979487).
{ECO:0000269|PubMed:10819331,
ECO:0000269|PubMed:14702039,
ECO:0000269|Ref.2}.
/FTId=VAR_016922.
SEQUENCE 622 AA; 67246 MW; ABE1398204F2273A CRC64;
MAMAPSPSLV QVYTSPAAVA VWEWQDGLGT WHPYSATVCS FIEQQFVQQK GQRFGLGSLA
HSIPLGQADP SLAPYIIDLP SWTQFRQDTG TMRAVRRHLF PQHSAPGRGV VWEWLSDDGS
WTAYEASVCD YLEQQVARGN QLVDLAPLGY NYTVNYTTHT QTNKTSSFCR SVRRQAGPPY
PVTTIIAPPG HTGVACSCHQ CLSGSRTGPV SGRYRHSMTN LPAYPVPQHP PHRTASVFGT
HQAFAPYNKP SLSGARSAPR LNTTNAWGAA PPSLGSQPLY RSSLSHLGPQ HLPPGSSTSG
AVSASLPSGP SSSPGSVPAT VPMQMPKPSR VQQALAGMTS VLMSAIGLPV CLSRAPQPTS
PPASRLASKS HGSVKRLRKM SVKGATPKPE PEPEQVIKNY TEELKVPPDE DCIICMEKLS
TASGYSDVTD SKAIGSLAVG HLTKCSHAFH LLCLLAMYCN GNKDGSLQCP SCKTIYGEKT
GTQPQGKMEV LRFQMSLPGH EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP
DNAQGRKVLE LLKVAWKRRL IFTVGTSSTT GETDTVVWNE IHHKTEMDRN ITGHGYPDPN
YLQNVLAELA AQGVTEDCLE QQ


Related products :

Catalog number Product name Quantity
EIAAB12010 Deltex2,DTX2,hDTX2,Homo sapiens,Human,KIAA1528,Protein deltex-2,RING finger protein 58,RNF58
EIAAB43998 GERP,Glioblastoma-expressed RING finger protein,Homo sapiens,Human,Probable E3 ubiquitin-protein ligase TRIM8,RING finger protein 27,RNF27,TRIM8,Tripartite motif-containing protein 8
EIAAB43999 Gerp,Glioblastoma-expressed RING finger protein,Mouse,Mus musculus,Probable E3 ubiquitin-protein ligase TRIM8,RING finger protein 27,Rnf27,Trim8,Tripartite motif-containing protein 8
EIAAB45299 E3 ubiquitin-protein ligase UHRF2,Homo sapiens,Human,NIRF,Np95_ICBP90-like RING finger protein,Np95-like RING finger protein,Nuclear protein 97,Nuclear zinc finger protein Np97,RING finger protein 107
EIAAB34367 CARP-2,Caspase regulator CARP2,Caspases-8 and -10-associated RING finger protein 2,E3 ubiquitin-protein ligase rififylin,Fring,FYVE-RING finger protein Sakura,Homo sapiens,Human,RFFL,RING finger and F
EIAAB43947 E3 ubiquitin-protein ligase TRIM63,Homo sapiens,Human,IRF,Iris RING finger protein,MuRF1,MURF1,MuRF-1,Muscle-specific RING finger protein 1,RING finger protein 28,RNF28,SMRZ,Striated muscle RING zinc
EIAAB35413 E3 ubiquitin-protein ligase RNF138,hNARF,Homo sapiens,HSD4,HSD-4,Human,NARF,Nemo-like kinase-associated RING finger protein,NLK-associated RING finger protein,RING finger protein 138,RNF138
EIAAB35571 CARP-1,Caspase regulator CARP1,Caspases-8 and -10-associated RING finger protein 1,E3 ubiquitin-protein ligase RNF34,FYVE-RING finger protein Momo,Homo sapiens,hRFI,Human,Human RING finger homologous
EIAAB45298 E3 ubiquitin-protein ligase UHRF2,Mouse,Mus musculus,NIRF,Nirf,Np95-like ring finger protein,Nuclear protein 97,Nuclear zinc finger protein Np97,Ubiquitin-like PHD and RING finger domain-containing pr
18-003-42502 Ubiquitin ligase protein RING2 - EC 6.3.2.-; RING finger protein 2; RING finger protein 1B; RING1b; RING finger protein BAP-1; DinG protein; Huntingtin-interacting protein 2-interacting protein 3; HIP 0.1 mg Protein A
18-003-42501 Ubiquitin ligase protein RING2 - EC 6.3.2.-; RING finger protein 2; RING finger protein 1B; RING1b; RING finger protein BAP-1; DinG protein; Huntingtin-interacting protein 2-interacting protein 3; HIP 0.05 mg Aff Pur
EIAAB35549 E3 ubiquitin-protein ligase RLIM,Homo sapiens,Human,LIM domain-interacting RING finger protein,Renal carcinoma antigen NY-REN-43,RING finger LIM domain-binding protein,RING finger protein 12,RLIM,R-LI
EIAAB45296 Ac2-121,E3 ubiquitin-protein ligase UHRF1,Liver regeneration-related protein LRRG126,Rat,Rattus norvegicus,Ubiquitin-like PHD and RING finger domain-containing protein 1,Ubiquitin-like-containing PHD
EIAAB33372 Kiaa0161,Mouse,Mus musculus,Probable E3 ubiquitin-protein ligase RNF144A,RING finger protein 144A,Rnf144,Rnf144a,Ubce7ip4,UbcM4-interacting protein 4,Ubiquitin-conjugating enzyme 7-interacting protein
EIAAB33371 Homo sapiens,Human,KIAA0161,Probable E3 ubiquitin-protein ligase RNF144A,RING finger protein 144A,RNF144,RNF144A,UBCE7IP4,UbcM4-interacting protein 4,Ubiquitin-conjugating enzyme 7-interacting protein
EIAAB24904 D15S9,Homo sapiens,Human,MKRN3,Probable E3 ubiquitin-protein ligase makorin-3,RING finger protein 63,RNF63,Zinc finger protein 127,ZNF127
EIAAB24906 Homo sapiens,Human,Makorin RING finger protein pseudogene 4,Makorin RING finger protein pseudogene 5,MKRN4,MKRN4P,MKRNP5,Putative E3 ubiquitin-protein ligase makorin-4,RING finger protein 64,RNF64,Zin
EIAAB38244 E3 ubiquitin-protein ligase SH3RF1,Homo sapiens,Human,KIAA1494,Plenty of SH3s,POSH,Protein POSH,RING finger protein 142,RNF142,SH3 domain-containing RING finger protein 1,SH3 multiple domains protein
EIAAB38246 Heart protein phosphatase 1-binding protein,HEPP1,Homo sapiens,Human,Putative E3 ubiquitin-protein ligase SH3RF2,RING finger protein 158,RNF158,SH3 domain-containing RING finger protein 2,SH3RF2
EIAAB35550 E3 ubiquitin-protein ligase RLIM,LIM domain-interacting RING finger protein,Mouse,Mus musculus,RING finger LIM domain-binding protein,RING finger protein 12,Rlim,R-LIM,Rnf12
EIAAB35482 Dorfin,Double ring-finger protein,E3 ubiquitin-protein ligase RNF19A,Gametogenesis-expressed protein GEG-154,Geg-154,Mouse,Mus musculus,RING finger protein 19A,Rnf19,Rnf19a,UBCM4-interacting protein 1
EIAAB34424 Constitutive photomorphogenesis protein 1 homolog,COP1,E3 ubiquitin-protein ligase RFWD2,hCOP1,Homo sapiens,Human,RFWD2,RING finger and WD repeat domain protein 2,RING finger protein 200,RNF200
EIAAB43861 E3 ubiquitin-protein ligase TRIM17,Homo sapiens,Human,RBCC,RING finger protein 16,RNF16,TERF,Testis RING finger protein,TRIM17,Tripartite motif-containing protein 17
EIAAB33374 E3 ubiquitin-protein ligase RNF144B,Homo sapiens,Human,IBR domain-containing protein 2,IBRDC2,p53-inducible RING finger protein,P53RFP,RING finger protein 144B,RNF144B
EIAAB12011 Deltex2,Dtx2,mDTX2,Mouse,Mus musculus,Protein deltex-2
Pathways :
WP2199: Seed Development
WP2292: Chemokine signaling pathway
WP211: BMP signaling pathway
WP1714: Tyrosine metabolism
WP1678: Nucleotide excision repair
WP2272: Pathogenic Escherichia coli infection
WP1672: Mismatch repair
WP1676: Non-homologous end-joining
WP1625: Base excision repair
WP1692: Protein export
WP1493: Carbon assimilation C4 pathway
WP1566: Citrate cycle (TCA cycle)
WP1700: Selenoamino acid metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP73: G Protein Signaling Pathways
WP232: G Protein Signaling Pathways
WP1613: 1,4-Dichlorobenzene degradation
WP1888: Post-translational protein modification
WP1624: Bacterial secretion system
WP1939: Unfolded Protein Response
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1644: DNA replication
WP1165: G Protein Signaling Pathways

Related Genes :
[Dtx2] Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (mDTX2) (RING-type E3 ubiquitin transferase DTX2)
[Dtx1] E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (FXI-T1) (Protein deltex-1) (Deltex1) (mDTX1) (RING-type E3 ubiquitin transferase DTX1)
[Rnf2 DinG Ring1b] E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
[Uhrf1 Np95] E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (RING-type E3 ubiquitin transferase UHRF1) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (mUhrf1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
[DTX3L BBAP] E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)
[MID2 FXY2 RNF60 TRIM1] Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)
[LOG2 RF215 RIG2 At3g09770 F11F8.36 F8A24.18] Probable E3 ubiquitin-protein ligase LOG2 (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase LOG2) (Protein LOSS OF GDU2) (RING finger protein 215)
[Dtx3l Bbap] E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L)
[RNF2 BAP1 DING HIPI3 RING1B] E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
[Rnf115 Zfp364 Znf364] E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rabring 7) (Zinc finger protein 364)
[COP1 RFWD2 RNF200] E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
[RAG1 RNF74] V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74) [Includes: Endonuclease RAG1 (EC 3.1.-.-); E3 ubiquitin-protein ligase RAG1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAG1)]
[CBLB RNF56 Nbla00127] E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
[RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR] E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) (RING-type E3 ubiquitin transferase RNF213)
[RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363] RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2)
[ubr-1 C32E8.11] E3 ubiquitin-protein ligase ubr-1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase ubr-1) (Ubiquitin-protein ligase E3-alpha)
[Mid1 Fxy Trim18] E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)
[slx8 SPBC3D6.11c] E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8 (EC 2.3.2.27) (RING finger protein slx8) (RING-dependent E3 ubiquitin-protein ligase slx8) (RING-type E3 ubiquitin transferase slx8) (Synthetic lethal of unknown function protein 8)
[TRIM8 GERP RNF27] E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
[RBX1 RNF75 ROC1] E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
[HOS1 At2g39810 T5I7.11] E3 ubiquitin-protein ligase HOS1 (EC 2.3.2.27) (Protein HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1) (RING finger protein HOS1) (RING-type E3 ubiquitin transferase HOS1)
[Ubr3 Kiaa2024 Zfp650 Znf650] E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650)
[SH3RF2 POSH3 POSHER PPP1R39 RNF158] E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2)
[SH3RF1 KIAA1494 POSH POSH1 RNF142 SH3MD2] E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2)
[TRIM63 IRF MURF1 RNF28 SMRZ] E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
[Sh3rf2 Posh3 Posher Ppp1r39 Rnf158] E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2)
[Traf2] TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2)
[TRIM21 RNF81 RO52 SSA1] E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (RING-type E3 ubiquitin transferase TRIM21) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
[RNF138 NARF HSD-4 HSD4] E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
[Ltn1 Kiaa0714 Lister Rnf160 Zfp294 Znf294] E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294) (Zfp-294)

Bibliography :