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Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)

 CIAO1_HUMAN             Reviewed;         339 AA.
O76071; A0MNN9; Q53FM5;
11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
17-JUN-2020, entry version 181.
RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 {ECO:0000255|HAMAP-Rule:MF_03037};
AltName: Full=WD repeat-containing protein 39 {ECO:0000255|HAMAP-Rule:MF_03037};
Name=CIAO1 {ECO:0000255|HAMAP-Rule:MF_03037};
Synonyms=CIA1 {ECO:0000303|PubMed:23891004}, WDR39;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH WT1.
PubMed=9556563; DOI=10.1074/jbc.273.18.10880;
Johnstone R.W., Wang J., Tommerup N., Vissing H., Roberts T., Shi Y.;
"Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor
protein WT1.";
J. Biol. Chem. 273:10880-10887(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=17041588; DOI=10.1038/ncb1490;
Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H.;
"CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins
and regulates histone methylation.";
Nat. Cell Biol. 8:1277-1283(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=10493829; DOI=10.1006/geno.1999.5927;
Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
Adams M.D.;
"Genome duplications and other features in 12 Mb of DNA sequence from human
chromosome 16p and 16q.";
Genomics 60:295-308(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Gastric mucosa;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Blood, and Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
CHARACTERIZATION.
PubMed=10438340; DOI=10.1007/s002510050571;
Johnstone R.W., Tommerup N., Hansen C., Vissing H., Shi Y.;
"Structural organization, tissue expression, and chromosomal localization
of Ciao 1, a functional modulator of the Wilms' tumor suppressor, WT1.";
Immunogenetics 49:900-905(1999).
[8]
FUNCTION.
PubMed=17937914; DOI=10.1016/j.str.2007.08.009;
Srinivasan V., Netz D.J.A., Webert H., Mascarenhas J., Pierik A.J.,
Michel H., Lill R.;
"Structure of the yeast WD40 domain protein Cia1, a component acting late
in iron-sulfur protein biogenesis.";
Structure 15:1246-1257(2007).
[9]
FUNCTION, AND IDENTIFICATION IN MMXD COMPLEX.
PubMed=20797633; DOI=10.1016/j.molcel.2010.07.029;
Ito S., Tan L.J., Andoh D., Narita T., Seki M., Hirano Y., Narita K.,
Kuraoka I., Hiraoka Y., Tanaka K.;
"MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome
segregation.";
Mol. Cell 39:632-640(2010).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[11]
INTERACTION WITH CIAO2A.
PubMed=22683786; DOI=10.1107/s0907444912006592;
Chen K.E., Richards A.A., Ariffin J.K., Ross I.L., Sweet M.J., Kellie S.,
Kobe B., Martin J.L.;
"The mammalian DUF59 protein Fam96a forms two distinct types of domain-
swapped dimer.";
Acta Crystallogr. D 68:637-648(2012).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-terminal
acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
[13]
IDENTIFICATION IN THE CIA COMPLEX.
PubMed=22678362; DOI=10.1126/science.1219723;
Stehling O., Vashisht A.A., Mascarenhas J., Jonsson Z.O., Sharma T.,
Netz D.J., Pierik A.J., Wohlschlegel J.A., Lill R.;
"MMS19 assembles iron-sulfur proteins required for DNA metabolism and
genomic integrity.";
Science 337:195-199(2012).
[14]
IDENTIFICATION IN THE CIA COMPLEX.
PubMed=22678361; DOI=10.1126/science.1219664;
Gari K., Leon Ortiz A.M., Borel V., Flynn H., Skehel J.M., Boulton S.J.;
"MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.";
Science 337:243-245(2012).
[15]
FUNCTION, IDENTIFICATION IN THE CIA COMPLEX, AND INTERACTION WITH CHD1L;
CIAO2A; CIAO2B; ERCC2; IREB2; MMS19 AND POLD1.
PubMed=23891004; DOI=10.1016/j.cmet.2013.06.015;
Stehling O., Mascarenhas J., Vashisht A.A., Sheftel A.D., Niggemeyer B.,
Roesser R., Pierik A.J., Wohlschlegel J.A., Lill R.;
"Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and
maturation of different subsets of cytosolic-nuclear iron-sulfur
proteins.";
Cell Metab. 18:187-198(2013).
[16]
ERRATUM OF PUBMED:23891004.
PubMed=29320706; DOI=10.1016/j.cmet.2017.12.009;
Stehling O., Mascarenhas J., Vashisht A.A., Sheftel A.D., Niggemeyer B.,
Roesser R., Pierik A.J., Wohlschlegel J.A., Lill R.;
"Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and
Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur
Proteins.";
Cell Metab. 27:263-263(2018).
[17]
IDENTIFICATION IN THE CIA COMPLEX, SUBCELLULAR LOCATION, AND INTERACTION
WITH CIAO2B AND CIAO3.
PubMed=23585563; DOI=10.1074/jbc.m112.416602;
Seki M., Takeda Y., Iwai K., Tanaka K.;
"IOP1 protein is an external component of the human cytosolic iron-sulfur
cluster assembly (CIA) machinery and functions in the MMS19 protein-
dependent CIA pathway.";
J. Biol. Chem. 288:16680-16689(2013).
[18]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
phosphoproteome.";
J. Proteomics 96:253-262(2014).
[19]
INTERACTION WITH HSC20, ROLE OF LYR MOTIF, AND MUTAGENESIS OF
87-ILE--ARG-89 AND 176-LYS--ARG-178.
PubMed=29309586; DOI=10.1093/hmg/ddy004;
Kim K.S., Maio N., Singh A., Rouault T.A.;
"Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the
CIAO1-mediated transfer to recipients.";
Hum. Mol. Genet. 27:837-852(2018).
[20]
X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
PubMed=21468892; DOI=10.1007/s13238-011-1018-1;
Xu C., Min J.;
"Structure and function of WD40 domain proteins.";
Protein Cell 2:202-214(2011).
-!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
(CIA) complex, a multiprotein complex that mediates the incorporation
of iron-sulfur cluster into extramitochondrial Fe/S proteins
(PubMed:17937914, PubMed:23891004). As a CIA complex component,
interacts specifically with CIAO2A or CIAO2B and MMS19 to assist
different branches of iron-sulfur protein assembly, depending of its
interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates
the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A
specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems
to specifically modulate the transactivation activity of WT1
(PubMed:9556563). As part of the mitotic spindle-associated MMXD
complex it may play a role in chromosome segregation (PubMed:20797633).
{ECO:0000255|HAMAP-Rule:MF_03037, ECO:0000269|PubMed:17937914,
ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:23891004,
ECO:0000269|PubMed:9556563}.
-!- SUBUNIT: Component of the CIA complex (PubMed:22678361,
PubMed:22678362, PubMed:23585563). Interacts with CIAO2A and forms a
complex with CIAO2B and MMS19; the interactions with CIAO2A and CIAO2B
are mutually exclusive (PubMed:22683786, PubMed:23891004,
PubMed:23585563). Interacts with CHD1L, ERCC2, IREB2 and POLD1
(PubMed:23891004). Component of the MMXD complex, which includes CIAO1,
ERCC2, CIAO2B, MMS19 and SLC25A5 (PubMed:20797633). Interacts with WT1
(PubMed:9556563). Interacts with CIAO3 (PubMed:23585563). Interacts
(via LYR motif) with HSC20 (PubMed:29309586). {ECO:0000255|HAMAP-
Rule:MF_03037, ECO:0000269|PubMed:20797633,
ECO:0000269|PubMed:22678361, ECO:0000269|PubMed:22678362,
ECO:0000269|PubMed:22683786, ECO:0000269|PubMed:23585563,
ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:29309586,
ECO:0000269|PubMed:9556563}.
-!- INTERACTION:
O76071; Q3KP44: ANKRD55; NbExp=3; IntAct=EBI-725145, EBI-14493093;
O76071; Q6NX55: C19orf2; NbExp=3; IntAct=EBI-725145, EBI-18333234;
O76071; Q9H5X1: CIAO2A; NbExp=13; IntAct=EBI-725145, EBI-752069;
O76071; Q9Y3D0: CIAO2B; NbExp=21; IntAct=EBI-725145, EBI-744045;
O76071; Q68CZ6: HAUS3; NbExp=3; IntAct=EBI-725145, EBI-2558217;
O76071; P50221: MEOX1; NbExp=3; IntAct=EBI-725145, EBI-2864512;
O76071; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-725145, EBI-16439278;
O76071; Q96T76: MMS19; NbExp=10; IntAct=EBI-725145, EBI-1044169;
O76071; Q96T76-8: MMS19; NbExp=5; IntAct=EBI-725145, EBI-10190644;
O76071; O00264: PGRMC1; NbExp=5; IntAct=EBI-725145, EBI-1045534;
O76071; P41220: RGS2; NbExp=3; IntAct=EBI-725145, EBI-712388;
O76071; Q8WXG1: RSAD2; NbExp=2; IntAct=EBI-725145, EBI-12736320;
O76071; Q15637: SF1; NbExp=3; IntAct=EBI-725145, EBI-744603;
O76071; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-725145, EBI-12037847;
O76071; Q9Y6M7: SLC4A7; NbExp=3; IntAct=EBI-725145, EBI-1044546;
O76071; Q8TDR4: TCP10L; NbExp=3; IntAct=EBI-725145, EBI-3923210;
O76071; O95985: TOP3B; NbExp=3; IntAct=EBI-725145, EBI-373403;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23585563}.
-!- MISCELLANEOUS: 'Ciao' means 'bridge' in Chinese.
-!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
Rule:MF_03037}.
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EMBL; U63810; AAC24948.1; -; mRNA.
EMBL; EF011618; ABK41108.1; -; mRNA.
EMBL; AC004020; AAC23493.1; -; Genomic_DNA.
EMBL; CR456802; CAG33083.1; -; mRNA.
EMBL; AK223257; BAD96977.1; -; mRNA.
EMBL; BC001395; AAH01395.1; -; mRNA.
EMBL; BC032812; AAH32812.1; -; mRNA.
CCDS; CCDS2019.1; -.
RefSeq; NP_004795.1; NM_004804.2.
PDB; 3FM0; X-ray; 1.70 A; A=1-339.
PDBsum; 3FM0; -.
SMR; O76071; -.
BioGRID; 114791; 92.
CORUM; O76071; -.
IntAct; O76071; 40.
MINT; O76071; -.
STRING; 9606.ENSP00000418287; -.
iPTMnet; O76071; -.
MetOSite; O76071; -.
PhosphoSitePlus; O76071; -.
SwissPalm; O76071; -.
BioMuta; CIAO1; -.
EPD; O76071; -.
jPOST; O76071; -.
MassIVE; O76071; -.
MaxQB; O76071; -.
PaxDb; O76071; -.
PeptideAtlas; O76071; -.
PRIDE; O76071; -.
ProteomicsDB; 50373; -.
TopDownProteomics; O76071; -.
ABCD; O76071; 1 sequenced antibody.
Antibodypedia; 17416; 230 antibodies.
DNASU; 9391; -.
Ensembl; ENST00000488633; ENSP00000418287; ENSG00000144021.
GeneID; 9391; -.
KEGG; hsa:9391; -.
UCSC; uc002svs.4; human.
CTD; 9391; -.
DisGeNET; 9391; -.
EuPathDB; HostDB:ENSG00000144021.2; -.
GeneCards; CIAO1; -.
HGNC; HGNC:14280; CIAO1.
HPA; ENSG00000144021; Low tissue specificity.
MIM; 604333; gene.
neXtProt; NX_O76071; -.
OpenTargets; ENSG00000144021; -.
PharmGKB; PA162382269; -.
eggNOG; KOG0645; Eukaryota.
eggNOG; ENOG410XRMA; LUCA.
GeneTree; ENSGT00940000158670; -.
HOGENOM; CLU_000288_57_8_1; -.
InParanoid; O76071; -.
OMA; EFECAAV; -.
OrthoDB; 793298at2759; -.
PhylomeDB; O76071; -.
TreeFam; TF318181; -.
Reactome; R-HSA-2564830; Cytosolic iron-sulfur cluster assembly.
SignaLink; O76071; -.
BioGRID-ORCS; 9391; 602 hits in 795 CRISPR screens.
ChiTaRS; CIAO1; human.
EvolutionaryTrace; O76071; -.
GeneWiki; CIAO1; -.
GenomeRNAi; 9391; -.
Pharos; O76071; Tbio.
PRO; PR:O76071; -.
Proteomes; UP000005640; Chromosome 2.
RNAct; O76071; protein.
Bgee; ENSG00000144021; Expressed in right adrenal gland and 218 other tissues.
Genevisible; O76071; HS.
GO; GO:0097361; C:CIA complex; IDA:UniProtKB.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0071817; C:MMXD complex; IDA:UniProtKB.
GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
GO; GO:0016226; P:iron-sulfur cluster assembly; IMP:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:ProtInc.
GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IMP:UniProtKB.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; TAS:ProtInc.
Gene3D; 2.130.10.10; -; 1.
HAMAP; MF_03037; ciao1; 1.
InterPro; IPR028608; CIAO1/Cia1.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
PANTHER; PTHR19920; PTHR19920; 1.
Pfam; PF00400; WD40; 6.
SMART; SM00320; WD40; 7.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00678; WD_REPEATS_1; 1.
PROSITE; PS50082; WD_REPEATS_2; 6.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
3D-structure; Chromosome partition; Cytoplasm; Reference proteome; Repeat;
WD repeat.
CHAIN 1..339
/note="Probable cytosolic iron-sulfur protein assembly
protein CIAO1"
/id="PRO_0000051389"
REPEAT 14..53
/note="WD 1"
REPEAT 59..98
/note="WD 2"
REPEAT 103..142
/note="WD 3"
REPEAT 148..187
/note="WD 4"
REPEAT 192..231
/note="WD 5"
REPEAT 250..289
/note="WD 6"
REPEAT 301..339
/note="WD 7"
MOTIF 176..178
/note="LYR motif; required for interaction with HSC20"
/evidence="ECO:0000269|PubMed:29309586"
MUTAGEN 87..89
/note="IWK->AAA: Does not affect binding to HSC20."
/evidence="ECO:0000269|PubMed:29309586"
MUTAGEN 176..178
/note="LYR->AAA: Abolishes binding to HSC20."
/evidence="ECO:0000269|PubMed:29309586"
CONFLICT 243
/note="C -> G (in Ref. 5; BAD96977)"
/evidence="ECO:0000305"
STRAND 5..11
/evidence="ECO:0000244|PDB:3FM0"
STRAND 19..24
/evidence="ECO:0000244|PDB:3FM0"
STRAND 31..35
/evidence="ECO:0000244|PDB:3FM0"
STRAND 40..46
/evidence="ECO:0000244|PDB:3FM0"
STRAND 49..56
/evidence="ECO:0000244|PDB:3FM0"
STRAND 64..69
/evidence="ECO:0000244|PDB:3FM0"
STRAND 73..80
/evidence="ECO:0000244|PDB:3FM0"
STRAND 85..90
/evidence="ECO:0000244|PDB:3FM0"
STRAND 95..101
/evidence="ECO:0000244|PDB:3FM0"
STRAND 108..113
/evidence="ECO:0000244|PDB:3FM0"
STRAND 117..124
/evidence="ECO:0000244|PDB:3FM0"
STRAND 129..134
/evidence="ECO:0000244|PDB:3FM0"
STRAND 140..146
/evidence="ECO:0000244|PDB:3FM0"
STRAND 153..158
/evidence="ECO:0000244|PDB:3FM0"
STRAND 160..163
/evidence="ECO:0000244|PDB:3FM0"
STRAND 165..169
/evidence="ECO:0000244|PDB:3FM0"
STRAND 174..180
/evidence="ECO:0000244|PDB:3FM0"
STRAND 183..190
/evidence="ECO:0000244|PDB:3FM0"
STRAND 197..202
/evidence="ECO:0000244|PDB:3FM0"
STRAND 206..213
/evidence="ECO:0000244|PDB:3FM0"
STRAND 218..224
/evidence="ECO:0000244|PDB:3FM0"
STRAND 240..247
/evidence="ECO:0000244|PDB:3FM0"
STRAND 255..260
/evidence="ECO:0000244|PDB:3FM0"
TURN 262..264
/evidence="ECO:0000244|PDB:3FM0"
STRAND 267..271
/evidence="ECO:0000244|PDB:3FM0"
STRAND 276..281
/evidence="ECO:0000244|PDB:3FM0"
STRAND 292..298
/evidence="ECO:0000244|PDB:3FM0"
STRAND 301..304
/evidence="ECO:0000244|PDB:3FM0"
STRAND 306..311
/evidence="ECO:0000244|PDB:3FM0"
STRAND 313..315
/evidence="ECO:0000244|PDB:3FM0"
STRAND 318..323
/evidence="ECO:0000244|PDB:3FM0"
STRAND 328..333
/evidence="ECO:0000244|PDB:3FM0"
SEQUENCE 339 AA; 37840 MW; 63A8D8257A204FC8 CRC64;
MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW ICKSVLSEGH
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL
ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT QDVKHVVWHP SQELLASASY DDTVKLYREE
EDDWVCCATL EGHESTVWSL AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS
WKCICTLSGF HSRTIYDIAW CQLTGALATA CGDDAIRVFQ EDPNSDPQQP TFSLTAHLHQ
AHSQDVNCVA WNPKEPGLLA SCSDDGEVAF WKYQRPEGL


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E2007h Human ELISA Kit FOR Probable cytosolic iron-sulfur protein assembly protein CIAO1 96T
E1120r Mouse ELISA Kit FOR Probable cytosolic iron-sulfur protein assembly protein CIAO1 96T
CIB1 CIAO1 Gene cytosolic iron-sulfur protein assembly 1
CSB-EL005423RA Rat cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae) (CIAO1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL005423BO Bovine cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae) (CIAO1) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
CSB-EL005423MO Mouse cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae) (CIAO1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
Pathways :
WP1566: Citrate cycle (TCA cycle)
WP2272: Pathogenic Escherichia coli infection
WP210: Cytoplasmic Ribosomal Proteins
WP1049: G Protein Signaling Pathways
WP1692: Protein export
WP731: Sterol regulatory element binding protein related
WP1650: Fluorobenzoate degradation
WP1659: Glycine, serine and threonine metabolism
WP2203: TSLP Signaling Pathway
WP1438: Influenza A virus infection
WP1700: Selenoamino acid metabolism
WP1531: Vitamin D synthesis
WP1714: Tyrosine metabolism
WP1665: Limonene and pinene degradation
WP2292: Chemokine signaling pathway
WP1675: Nitrogen metabolism
WP2371: Parkinsons Disease Pathway
WP1613: 1,4-Dichlorobenzene degradation
WP1888: Post-translational protein modification
WP1625: Base excision repair
WP1909: Signal regulatory protein (SIRP) family interactions
WP1690: Propanoate metabolism
WP73: G Protein Signaling Pathways
WP1644: DNA replication
WP2032: TSH signaling pathway

Related Genes :
[CIAO1 CIA1 WDR39] Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)
[Ciao1 Wdr39] Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)
[CIAO1 WDR39] Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)
[Ciao1 Wdr39] Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)
[fes-1 NCU06606] Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 5) (Complex III subunit V) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c oxidoreductase iron-sulfur subunit) (Ubiquinol-cytochrome c reductase complex 25 kDa protein)
[NAR1 YNL240C N1114] Cytosolic Fe-S cluster assembly factor NAR1 (Nuclear architecture-related protein 1)
[BRIP1 BACH1 FANCJ] Fanconi anemia group J protein (Protein FACJ) (EC 3.6.4.13) (ATP-dependent RNA helicase BRIP1) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1)
[scon-2 B13M15.090 NCU08563] Probable E3 ubiquitin ligase complex SCF subunit scon-2 (Sulfur controller 2) (SCON2) (Sulfur metabolite repression control protein 2)
[RACK1A ARCA At1g18080 T10F20.9 T10O22.6] Receptor for activated C kinase 1A (Guanine nucleotide-binding protein subunit beta-like protein A) (WD-40 repeat auxin-dependent protein ARCA)
[WDPCP BBS15 C2orf86 FRITZ] WD repeat-containing and planar cell polarity effector protein fritz homolog (hFRTZ) (Bardet-Biedl syndrome 15 protein) (WD repeat-containing and planar cell polarity effector protein)
[RIP1 YEL024W] Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c oxidoreductase iron-sulfur subunit)
[WDR48 KIAA1449 UAF1] WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80)
[POLD1 POLD] DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125)
[WRAP53 TCAB1 WDR79] Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)
[WDR45 WDRX1 WDRXI4 WIPI4 JM5] WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)
[POC1B WDR51B] POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B)
[Wdr19 Ift144 Kiaa1638] WD repeat-containing protein 19 (Intraflagellar transport 144 homolog)
[WDR11 BRWD2 KIAA1351 WDR15] WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15)
[CYOP TOP2 At5g10540 F12B17.110] Probable cytosolic oligopeptidase A (EC 3.4.24.70) (Thimet metalloendopeptidase 2) (Zincin-like metalloproteases family protein 2)
[LRWD1 Orca] Leucine-rich repeat and WD repeat-containing protein 1 (ORC-associated protein) (ORCA) (Origin recognition complex-associated protein)
[WDR45B WDR45L WIPI3] WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein)
[Caf1 CG4236] Probable histone-binding protein Caf1 (Chromatin assembly factor 1 p55 subunit) (CAF-1 p55 subunit) (Nucleosome-remodeling factor 55 kDa subunit) (NURF-55) (dCAF-1)
[sel-10 egl-41 F55B12.3] F-box/WD repeat-containing protein sel-10 (Egg laying defective protein 41) (Suppressor/enhancer of lin-12 protein 10)
[RSAD2 CIG5] Radical S-adenosyl methionine domain-containing protein 2 (Cytomegalovirus-induced gene 5 protein) (Viperin) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)
[Fbxw7 Fbw7 Fbwd6 Fbxw6] F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10)
[WDR61] WD repeat-containing protein 61 (Meiotic recombination REC14 protein homolog) (SKI8 homolog) (Ski8) [Cleaved into: WD repeat-containing protein 61, N-terminally processed]
[COP1 RFWD2 RNF200] E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
[IFT80 KIAA1374 WDR56] Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56)
[WDR60] WD repeat-containing protein 60
[IFT122 SPG WDR10 WDR140] Intraflagellar transport protein 122 homolog (WD repeat-containing protein 10) (WD repeat-containing protein 140)

Bibliography :