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Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase)

 B7R3W0_9EURY            Unreviewed;       191 AA.
B7R3W0;
10-FEB-2009, integrated into UniProtKB/TrEMBL.
10-FEB-2009, sequence version 1.
16-JAN-2019, entry version 43.
RecName: Full=Probable molybdenum cofactor guanylyltransferase {ECO:0000256|HAMAP-Rule:MF_00316};
Short=MoCo guanylyltransferase {ECO:0000256|HAMAP-Rule:MF_00316};
EC=2.7.7.77 {ECO:0000256|HAMAP-Rule:MF_00316};
AltName: Full=GTP:molybdopterin guanylyltransferase {ECO:0000256|HAMAP-Rule:MF_00316};
AltName: Full=Mo-MPT guanylyltransferase {ECO:0000256|HAMAP-Rule:MF_00316};
AltName: Full=Molybdopterin guanylyltransferase {ECO:0000256|HAMAP-Rule:MF_00316};
AltName: Full=Molybdopterin-guanine dinucleotide synthase {ECO:0000256|HAMAP-Rule:MF_00316};
Short=MGD synthase {ECO:0000256|HAMAP-Rule:MF_00316};
Name=mobA {ECO:0000256|HAMAP-Rule:MF_00316};
ORFNames=TAM4_1391 {ECO:0000313|EMBL:EEB73642.1};
Thermococcus sp. AM4.
Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
Thermococcus.
NCBI_TaxID=246969 {ECO:0000313|EMBL:EEB73642.1, ECO:0000313|Proteomes:UP000009277};
[1] {ECO:0000313|EMBL:EEB73642.1, ECO:0000313|Proteomes:UP000009277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AM4 {ECO:0000313|EMBL:EEB73642.1};
PubMed=22123768; DOI=10.1128/JB.06259-11;
Oger P., Sokolova T.G., Kozhevnikova D.A., Chernyh N.A.,
Bartlett D.H., Bonch-Osmolovskaya E.A., Lebedinsky A.V.;
"Complete Genome Sequence of the Hyperthermophilic Archaeon
Thermococcus sp. Strain AM4, Capable of Organotrophic Growth and
Growth at the Expense of Hydrogenogenic or Sulfidogenic Oxidation of
Carbon Monoxide.";
J. Bacteriol. 193:7019-7020(2011).
-!- FUNCTION: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-
MPT) cofactor (Moco or molybdenum cofactor) to form Mo-
molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
{ECO:0000256|HAMAP-Rule:MF_00316}.
-!- CATALYTIC ACTIVITY:
Reaction=GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-
molybdopterin guanine dinucleotide; Xref=Rhea:RHEA:34243,
ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565,
ChEBI:CHEBI:71302, ChEBI:CHEBI:71310; EC=2.7.7.77;
Evidence={ECO:0000256|HAMAP-Rule:MF_00316};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_00316};
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00316}.
-!- DOMAIN: The N-terminal domain determines nucleotide recognition
and specific binding, while the C-terminal domain determines the
specific binding to the target protein. {ECO:0000256|HAMAP-
Rule:MF_00316}.
-!- SIMILARITY: Belongs to the MobA family. {ECO:0000256|HAMAP-
Rule:MF_00316}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00316}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; CP002952; EEB73642.1; -; Genomic_DNA.
RefSeq; WP_014122936.1; NC_016051.1.
ProteinModelPortal; B7R3W0; -.
STRING; 246969.TAM4_1391; -.
EnsemblBacteria; EEB73642; EEB73642; TAM4_1391.
GeneID; 7420230; -.
KEGG; tha:TAM4_1391; -.
eggNOG; arCOG01872; Archaea.
eggNOG; COG0746; LUCA.
KO; K03752; -.
OrthoDB; 78708at2157; -.
BioCyc; TSP246969:G1GNJ-1812-MONOMER; -.
Proteomes; UP000009277; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0061603; F:molybdenum cofactor guanylyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
CDD; cd02503; MobA; 1.
Gene3D; 3.90.550.10; -; 1.
HAMAP; MF_00316; MobA; 1.
InterPro; IPR025877; MobA-like_NTP_Trfase.
InterPro; IPR013482; Molybde_CF_guanTrfase.
InterPro; IPR029044; Nucleotide-diphossugar_trans.
Pfam; PF12804; NTP_transf_3; 1.
SUPFAM; SSF53448; SSF53448; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000009277};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00316};
GTP-binding {ECO:0000256|HAMAP-Rule:MF_00316};
Magnesium {ECO:0000256|HAMAP-Rule:MF_00316};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00316};
Molybdenum cofactor biosynthesis {ECO:0000256|HAMAP-Rule:MF_00316};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00316};
Transferase {ECO:0000256|HAMAP-Rule:MF_00316}.
DOMAIN 3 156 NTP_transf_3. {ECO:0000259|Pfam:PF12804}.
NP_BIND 6 8 GTP. {ECO:0000256|HAMAP-Rule:MF_00316}.
METAL 92 92 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_00316}.
BINDING 18 18 GTP. {ECO:0000256|HAMAP-Rule:MF_00316}.
BINDING 67 67 GTP. {ECO:0000256|HAMAP-Rule:MF_00316}.
BINDING 92 92 GTP. {ECO:0000256|HAMAP-Rule:MF_00316}.
SEQUENCE 191 AA; 21438 MW; FD494750DC35F929 CRC64;
MIGAVLAGGR GKRFGGDKLL YKINGRPLIL YTIERLETAK RIDEIILVAS KDNAEKLKRL
GYRVVVDNLL IGPMGGVYTA LSLGDAFVVA GDMPLLVREF VDFIVSEFEK SGKIACVPRW
SNGYLEPLHA AYSKAFREIL EEKIKTGNYA LNRAIREANP CYLPIESLPE EWRESFFNVN
TREDLGRIQK G


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1403: AMPK signaling
WP1422: Sphingolipid Metabolism
WP1423: Ganglio Sphingolipid Metabolism
WP1424: Globo Sphingolipid Metabolism
WP1461: Photosynthetic Carbon Reduction
WP1621: Arginine and proline metabolism
WP1708: Terpenoid backbone biosynthesis
WP2199: Seed Development
WP2208: Cardiolipin Biosynthesis
WP2210: Oryzalexin S biosynthesis
WP2211: Geranylgeranyldiphosphate biosynthesis II (plastidic)
WP2248: anthocyanin biosynthesis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP296: TCA Cycle - biocyc
WP626: Abscisic Acid Biosynthesis
WP668: Octadecanoid Pathway
WP677: Momilactone biosynthesis
WP2292: Chemokine signaling pathway

Related Genes :
[mobA chlB mob narB b3857 JW3829] Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide biosynthesis protein A) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (Protein FA)
[moaC/mobA slr0902] Molybdenum cofactor biosynthesis bifunctional protein [Includes: Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C); Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase)]
[moaA mobA NCTC10702_03574] Multifunctional fusion protein [Includes: Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase); GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A)]
[moaC mobA NCTC11159_03445] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]
[mobA moaC CSQ88_05755] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]
[moaC mobA WG78_20755] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]
[moaC mobA SAMN05216229_109138] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]
[mobA moaC SAMN05216201_10757] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]
[moaC mobA SAMN05216221_2742] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]
[mobA A2W85_16655] Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase)
[mobA CVT99_08280] Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase)
[mobA CO098_04280] Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase)
[mobA chlB mob narB Z5389 ECs4780] Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase)
[fdhD mobA mobA-2 GSU0780] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD mobA OR1_01893] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD-2 fdhD mobA DSOUD_1086] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD-1 fdhD mobA DSOUD_0542] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD mobA ABB02_01535] Multifunctional fusion protein [Includes: Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Mo-MPT guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (Molybdopterin guanylyltransferase) (GTP:molybdopterin guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD mobA TherJR_2345] Multifunctional fusion protein [Includes: Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Mo-MPT guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (Molybdopterin guanylyltransferase) (GTP:molybdopterin guanylyltransferase); Sulfur carrier protein FdhD]
[mobA fdhD KQ78_00874] Multifunctional fusion protein [Includes: Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Mo-MPT guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (Molybdopterin guanylyltransferase) (GTP:molybdopterin guanylyltransferase); Sulfur carrier protein FdhD]
[mobA fdhD GM18_1965] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD mobA Gura_3370] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD mobA Gmet_1062] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[mobA fdhD Gbem_2264] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD mobA Gura_3385] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD mobA GM21_1958] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]
[mobA fdhD Tfer_2860] Multifunctional fusion protein [Includes: Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Mo-MPT guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (Molybdopterin guanylyltransferase) (GTP:molybdopterin guanylyltransferase); Sulfur carrier protein FdhD]
[fdhD mobA CVT67_11285] Multifunctional fusion protein [Includes: Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Mo-MPT guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (Molybdopterin guanylyltransferase) (GTP:molybdopterin guanylyltransferase); Sulfur carrier protein FdhD]
[mobA fdhD EUAN_22860] Multifunctional fusion protein [Includes: Probable molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Mo-MPT guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (Molybdopterin guanylyltransferase) (GTP:molybdopterin guanylyltransferase); Sulfur carrier protein FdhD]
[mobA fdhD A2X90_06265] Multifunctional fusion protein [Includes: Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase); Sulfur carrier protein FdhD]

Bibliography :